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1370270

USP

Loratadine

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine
Empirical Formula (Hill Notation):
C22H23N2O2Cl
CAS Number:
79794-75-5
Molecular Weight:
382.88
MDL number:
MFCD00672869
PubChem Substance ID:
329750256
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

loratadine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Loratadine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Non-sedating histamine H1-receptor antagonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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1370280

Loratadine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1370291

Loratadine Related Compound B, United States Pharmacopeia (USP) Reference Standard

Y0000603

Loratadine for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0000688

Loratadine, European Pharmacopoeia (EP) Reference Standard

Y0000604

Loratadine impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000605

Loratadine impurity H, European Pharmacopoeia (EP) Reference Standard

1370269

Loratadine Related Compound C, United States Pharmacopeia (USP) Reference Standard

BP874

Loratadine, British Pharmacopoeia (BP) Reference Standard

BP875

Loratadine impurity standard, British Pharmacopoeia (BP) Reference Standard

PHR2308

Loratadine Related Compound B

PHR2309

Loratadine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Standard

PHR2313

Loratadine Impurity H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2310

Loratadine Impurity A, certified reference material, pharmaceutical secondary standard

PHR2311

Loratadine Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Prescrire international, 19(105), 26-28 (2010-05-12)
Some antihistamines, such as mizolastine and ebastine, can prolong the QT interval and provoke severe cardiac arrhythmias. This review examines the effects of two widely used antihistamines, cetirizine and loratadine, on the QT interval. As of mid 2009 very few
J A Hey et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 29 Suppl 3, 197-199 (1999-08-12)
The extremely low reporting rate of cardiovascular adverse events for loratadine, the possible preferential use of loratadine in patients with pre-existing cardiovascular disorders, and the impressive lack of cardiovascular effects at extremely high concentrations in clinical and preclinical studies demonstrate
H A Barenholtz et al.
DICP : the annals of pharmacotherapy, 23(6), 445-450 (1989-06-01)
Loratadine is an addition to the class of nonsedating antihistamines which includes terfenadine, astemizole, and acrivastine. Loratadine is chemically related to the tricyclic antidepressants. Animal data have shown that insignificant amounts of loratadine enter the brain, and it has a
J L Menardo et al.
Clinical therapeutics, 19(6), 1278-1293 (1998-01-28)
Patients with seasonal or allergic bronchial asthma experience an immediate allergic response caused by allergen-specific immunoglobulin E-mediated histamine release. The release of histamine and other chemical mediators may trigger airway hyperresponsiveness and exaggerated bronchoconstriction, characteristic features of allergic bronchial asthma.
Eleanor B Schwarz et al.
Drug safety, 31(9), 775-788 (2008-08-19)
Loratadine, a second-generation antihistamine, is commonly used to treat seasonal allergies. Some studies have suggested that use of loratadine by pregnant women increases the risk of hypospadias in male offspring. This meta-analysis was designed to assess the strength of the
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