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1441301

USP

Metoprolol tartrate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(±)-Metoprolol (+)-tartrate salt, (±)1-(Isopropylamino)-3-[p-(β-methoxyethyl)phenoxy]-2-propanol (+)-tartrate salt, Lopressor

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About This Item

Linear Formula:
(C15H25NO3)2 · C4H6O6
CAS Number:
56392-17-7
Molecular Weight:
684.81
NACRES:
NA.24
PubChem Substance ID:
329750297
UNSPSC Code:
41116107
MDL number:
MFCD00056257
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grade

pharmaceutical primary standard

API family

metoprolol

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2

InChI

1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

InChI key

YGULWPYYGQCFMP-CEAXSRTFSA-N

Gene Information

human ... ADRB1(153)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metoprolol tartrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Metoprolol Tartrate and Hydrochlorothiazide Tablets
  • Metoprolol Tartrate Compounded Oral Solution
  • Metoprolol Tartrate Compounded Oral Suspension
  • Metoprolol Tartrate Injection
  • Metoprolol Tartrate Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Warning

Hazard Classifications

Aquatic Chronic 2 - Repr. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

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Design and evaluation of mucoadhesive buccal drug delivery systems containing metoprolol tartrate.
Ramana, M. V., C. Nagda, and M. Himaja.
Indian Journal of Pharmaceutical Sciences, 69.4, 515-515 (2007)
C Narendra et al.
AAPS PharmSciTech, 7(2), E34-E34 (2006-06-27)
The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 2(3) factorial design was employed in formulating the GFDDS with
Reply: Carvedilol versus metoprolol, but which metoprolol? Effect on inappropriate cardioverter-defibrillator therapy.
Martin H Ruwald et al.
Journal of the American College of Cardiology, 63(18), 1933-1934 (2014-02-04)
V M Raju et al.
Clinical radiology, 69(7), 739-744 (2014-05-16)
To evaluate the usage, safety, and efficacy of high-dose intravenous metoprolol for heart rate reduction in computer tomographic (CT) coronary angiography. As this was retrospective analysis of anonymous data, medical ethics committee approval was waived by the regional health research
Wenhuan Li et al.
Medicine, 93(28), e329-e329 (2014-12-20)
The sensitivity and specificity of 5 different image sets of dual-energy computed tomography (DECT) for the detection of first-pass myocardial perfusion defects have not systematically been compared using positron emission tomography (PET) as a reference standard. Forty-nine consecutive patients, with
View All Related Papers

Global Trade Item Number

SKUGTIN
1441301-200MG04061838735416

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