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1458019

USP

Neomycin B

Name: Neomycin B
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-b-L-idopyranosyl)-b-D-ribofuranosyl]-D-streptamine sulfate)

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₄₆N₆O₁₃ · xH₂SO₄

CAS Number:

28002-70-2

Molecular Weight:

614.64 (free base basis)

MDL number:

MFCD00037007

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical primary standard

API family

neomycin

form

solid

packaging

pkg of 150 mg

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical

format

neat

storage temp.

−20°C

SMILES string

[S](=O)(=O)(O)O.N[C@H]1[C@H](O[C@H]([C@H]([C@@H]1O)O)CN)O[C@@H]2[C@H](O[C@H]([C@@H]2O)O[C@H]3[C@@H]([C@H](C[C@H]([C@@H]3O)N)N)O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O)CN)CO

InChI

1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key

OIXVKQDWLFHVGR-WQDIDPJDSA-N

Description

General description

Neomycin B is one of the major components of neomycin sulfate, an aminoglycoside antibiotic produced by Streptomyces fradiae. It exerts bactericidal effects by binding to the 30S ribosomal subunit, leading to inhibition of protein synthesis and misreading of mRNA. The USP standard supports identification and quantification of this individual neomycin component in complex mixtures.The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
Find answers to frequently asked questions on USP products in USP FAQs.

Application

Neomycin B USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monograph such as Neomycin Sulfate

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

This product is part of the USP Biologics program.

USP issued SDS can be found here.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c