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1478505

USP

Omeprazole

Name: Omeprazole
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec

Empirical Formula (Hill Notation):

C₁₇H₁₉N₃O₃S

CAS Number:

73590-58-6

Molecular Weight:

345.42

MDL number:

MFCD00083192

PubChem Substance ID:

329750610

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

omeprazole

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C

InChI

1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChI key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

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Analytical Reference Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.Omeprazole is a benzimidazole derivative, which exhibits antisecretory and antiulcer properties. It is a drug with selective and irreversible proton pump inhibition activity, widely used in the treatment of duodenal, gastric ulcers, reflux oesophagitis, and against other acid-related diseases.

Application

Omeprazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using various analytical techniques.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302 - H317 - H411

Precautionary Statements

P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Determination of omeprazole in bulk and injectable preparations by liquid chromatography

Schubert A, et al.

Journal of AOAC (Association of Official Analytical Chemists) International, 86(3), 501-504 (2003)

Extractive spectrophotometric determination of omeprazole in pharmaceutical preparations

Bhandage A, et al.

Tropical Journal of Pharmaceutical Research, 8(5) (2009)

Development and validation of a RP-HPLC method for the quantification of omeprazole in pharmaceutical dosage form

Kayesh R, et al.

Journal of Scientific Research, 5(2), 335-342 (2013)

The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel

Ogilvie BW, et al.

Drug Metabolism and Disposition, 39(11), 2020-2033 (2011)

Analytical method development and validation for the determination of omeprazole and aspirin using reverse phase hplc method in bulk and dosage form

Vani, R and Sunitha, M

Journal of Pharmacological Sciences, 2(4), 25-29 (2017)

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