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1514008

USP

Phenacetin Melting Point Standard

Name: Phenacetin Melting Point Standard
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Phenacetin, 1-Acetyl-p-phenetidin, 4′-Ethoxyacetanilide, N-(4-Ethoxyphenyl)acetamide, p-Acetophenetidide, Acetophenetidin

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About This Item

Linear Formula:

CH₃CONHC₆H₄OC₂H₅

CAS Number:

62-44-2

Molecular Weight:

179.22

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329750741

EC Number:

200-533-0

Beilstein/REAXYS Number:

1869238

MDL number:

MFCD00009094

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Properties

grade

pharmaceutical primary standard

API family

phenacetin

manufacturer/tradename

USP

mp

133-136 °C

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCOc1ccc(NC(C)=O)cc1

InChI

1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

InChI key

CPJSUEIXXCENMM-UHFFFAOYSA-N

Description

General description

Phenacetin Melting Point Standard (Phenacetin) is a lipid-soluble drug with moderate solubility with aqueous solvents. Its oral absorption is based on formulation factors like particle size. Its major metabolic route is O-dealkylation to paracetamol and its minor pathways are deacetylation and hydroxylation to form pphenetidine, 2-hydroxyphenetidine, 2- and 3-hydroxyphenacetin and N-hydroxyphenacetin.

Application

Phenacetin Melting Point Standard USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Substrate of CYP1A2 and CYP2D6.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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Danger

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1 - Water-react. 2

Storage Class

4.3 - Hazardous materials which set free flammable gases upon contact with water

Regulatory Information

涉药品监管产品

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Kinetics and metabolism of paracetamol and phenacetin

Prescott, L.F.

British Journal of Clinical Pharmacology (1980)

Paracetamol and phenacetin.

S P Clissold

Drugs, 32 Suppl 4, 46-59 (1986-01-01)

Since their synthesis in the late 1800s paracetamol (acetaminophen) and phenacetin have followed divergent pathways with regard to their popularity as mild analgesic/antipyretic drugs. Initially, paracetamol was discarded in favour of phenacetin because the latter drug was supposedly less toxic.

[Phenacetin abuse I. Occurrence, per capita consumption and costs of treatment].

M J Mihatsch et al.

Schweizerische medizinische Wochenschrift, 110(4), 108-115 (1980-01-28)

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Global Trade Item Number

SKU	GTIN
1514008-1G	04061838739193