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Merck
CN

1682206

USP

Triclosan

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Triclosan, 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Irgasan

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About This Item

Empirical Formula (Hill Notation):
C12H7Cl3O2
CAS Number:
Molecular Weight:
289.54
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2057142
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Product Name

Triclosan, United States Pharmacopeia (USP) Reference Standard

InChI key

XEFQLINVKFYRCS-UHFFFAOYSA-N

SMILES string

Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl

InChI

1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H

grade

pharmaceutical primary standard

API family

triclosan

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

A component of cefsulodin-irgasan-novobiocin selection medium for Yersinia, a human pathogen that may contaminate animal-source food products.

Biochem/physiol Actions

It is an inhibitor of the enoyl-ACP (acyl-carrier protein) reductase component of type II fatty acid synthase (FAS-II) in bacteria and Plasmodium. It also inhibits mammalian fatty acid synthase (FASN), and may have anticarcinogenic activity.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Nanhua Chen et al.
Antimicrobial agents and chemotherapy, 58(8), 4773-4781 (2014-06-11)
Artemisinin (ART)-based combination therapy (ACT) is used as the first-line treatment of uncomplicated falciparum malaria worldwide. However, despite high potency and rapid action, there is a high rate of recrudescence associated with ART monotherapy or ACT long before the recent
M Périamé et al.
International journal of cosmetic science, 36(4), 386-395 (2014-05-16)
The aim of this study was to obtain a better understanding regarding the origin of recurrent contamination by Enterobacter gergoviae in diverse cosmetic formula. We studied 65 isolates collected from various sources (clinical, food, cosmetics). RAPD analysis using AP12H, REP
Leyre Lavilla Lerma et al.
Food microbiology, 44, 249-257 (2014-08-03)
Enterococcus faecalis and Enterococcus faecium isolated from various traditional fermented foods of both animal and vegetable origins have shown multidrug resistance to several antibiotics and tolerance to biocides. Reduced susceptibility was intra and inter-species dependent and was due to specific
Lorillee C Tallorin et al.
Bioorganic & medicinal chemistry, 22(21), 6053-6061 (2014-10-07)
Enoyl-acyl carrier protein reductase (ENR), a critical enzyme in type II fatty acid biosynthesis, is a promising target for drug discovery against hepatocyte-stage Plasmodium falciparum. In order to identify PfENR-specific inhibitors, we docked 70 FDA-approved, bioactive, and/or natural product small
Likou Zou et al.
The Journal of antimicrobial chemotherapy, 69(10), 2644-2649 (2014-06-09)
To examine the distribution of all genes known to be responsible for resistance to quaternary ammonium compounds (QACs), and their association with resistance to QACs and other antimicrobials, in Escherichia coli recovered from retail meats. A total of 570 strains

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