V56485
N-Hydroxysulfosuccinimide sodium salt
≥98% (HPLC), for peptide synthesis, Vetec™
Synonym(s):
Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt, Sulfo-NHS
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About This Item
Empirical Formula (Hill Notation):
C4H4NNaO6S
CAS Number:
Molecular Weight:
217.13
Beilstein:
6359129
MDL number:
UNSPSC Code:
12352005
Quality Level
Assay
≥98% (HPLC)
form
solid
composition
carbon, 21.57-22.68 (anhydrous)
nitrogen, 6.28-6.61 (anhydrous)
reaction suitability
reaction type: Addition Reactions
impurities
≤4 water
application(s)
peptide synthesis
functional group
imide
sulfonic acid
SMILES string
[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O
InChI
1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1
InChI key
RPENMORRBUTCPR-UHFFFAOYSA-M
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General description
N-Hydroxysulfosuccinimide sodium salt is a water-soluble sulfonated analog of N-hydroxysuccinimide. It can undergo a coupling reaction with carboxylic acids in the presence of carbodiimides such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC) to form hydrophilic N-hydroxysulfosuccinimide active esters. These esters are useful in protein cross-linking experiments.
Application
Sulfo-NHS is used for preparing hydrophilic active esters, e.g. for crosslinking agents.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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