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Merck
CN

V56485

N-Hydroxysulfosuccinimide sodium salt

≥98% (HPLC), for peptide synthesis, Vetec

Synonym(s):

Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid sodium salt, Sulfo-NHS

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About This Item

Empirical Formula (Hill Notation):
C4H4NNaO6S
CAS Number:
Molecular Weight:
217.13
UNSPSC Code:
12352005
Beilstein/REAXYS Number:
6359129
MDL number:
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Product Name

N-Hydroxysulfosuccinimide sodium salt, ≥98% (HPLC), for peptide synthesis, Vetec

InChI key

RPENMORRBUTCPR-UHFFFAOYSA-M

SMILES string

[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O

InChI

1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1

assay

≥98% (HPLC)

form

solid

composition

carbon, 21.57-22.68 (anhydrous)
nitrogen, 6.28-6.61 (anhydrous)

reaction suitability

reaction type: Addition Reactions

impurities

≤4 water

application(s)

peptide synthesis

functional group

imide
sulfonic acid

Quality Level

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Application

Sulfo-NHS is used for preparing hydrophilic active esters, e.g. for crosslinking agents.

General description

N-Hydroxysulfosuccinimide sodium salt is a water-soluble sulfonated analog of N-hydroxysuccinimide. It can undergo a coupling reaction with carboxylic acids in the presence of carbodiimides such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(EDC) to form hydrophilic N-hydroxysulfosuccinimide active esters. These esters are useful in protein cross-linking experiments.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

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