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Merck
CN

V900396

Histamine

Vetec™, reagent grade, ≥97%

Synonym(s):

2-(4-Imidazolyl)ethylamine

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About This Item

Empirical Formula (Hill Notation):
C5H9N3
CAS Number:
51-45-6
Molecular Weight:
111.15
EC Number:
200-100-6
UNSPSC Code:
12352116
PubChem Substance ID:
329829805
Beilstein/REAXYS Number:
2012
MDL number:
MFCD00005210

Key Documents

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Product Name

Histamine, Vetec™, reagent grade, ≥97%

InChI key

NTYJJOPFIAHURM-UHFFFAOYSA-N

InChI

1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

SMILES string

NCCc1c[nH]cn1

grade

reagent grade

product line

Vetec™

assay

≥97%

bp

167 °C/0.8 mmHg (lit.)

mp

83-84 °C (lit.)

storage temp.

−20°C

Gene Information

human ... HRH1(3269)

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Biochem/physiol Actions

Endogenous H1 and H2 histamine receptor agonist; H1 activation mobilizes Ca2+; H2 activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.
Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF5818V
WXBF5472V
WXBF3245V
WXBD7602V
WXBD4698V

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Lena Böhn et al.
The American journal of gastroenterology, 108(5), 634-641 (2013-05-07)
Despite the fact that food and diet are central issues, that concern patients with irritable bowel syndrome (IBS), the current understanding about the association between the intake of certain foods/food groups and the gastrointestinal (GI) symptom pattern, psychological symptoms, and
Marieke Smit et al.
The Journal of pharmacology and experimental therapeutics, 348(2), 303-310 (2013-12-07)
The novel once-daily β₂-agonist bronchodilator drug olodaterol has recently been shown to be effective in patients with allergic asthma for >24 hours. An increased cholinergic tone common to these patients may decrease the effectiveness of β₂-agonists. This could provide a
David P Roberson et al.
Nature neuroscience, 16(7), 910-918 (2013-05-21)
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct pruritogens activate the same or different afferent fibers. Using a strategy of reversibly silencing specific
Pertti Panula et al.
Nature reviews. Neuroscience, 14(7), 472-487 (2013-06-21)
Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important role in the maintenance of wakefulness, and dysfunction in the histaminergic system has been linked to narcolepsy. Recent evidence suggests that aberrant histamine signalling in the
Franziska Glatzer et al.
The Journal of allergy and clinical immunology, 132(6), 1358-1367 (2013-08-13)
Epidermal hyperproliferation resulting in acanthosis is an important clinical observation in patients with atopic dermatitis, and its underlying mechanisms are not completely understood. Because increased levels of histamine are present in lesional skin, we investigated the effect of histamine, especially
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