V900411
Histamine dihydrochloride
Vetec™, reagent grade, 98%
Synonym(s):
2-(4-Imidazolyl)ethylamine dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C5H9N3 · 2HCl
CAS Number:
Molecular Weight:
184.07
EC Number:
200-298-4
UNSPSC Code:
12352116
PubChem Substance ID:
Beilstein/REAXYS Number:
3624116
MDL number:
InChI
1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI key
PPZMYIBUHIPZOS-UHFFFAOYSA-N
SMILES string
Cl[H].Cl[H].NCCc1c[nH]cn1
grade
reagent grade
product line
Vetec™
assay
98%
mp
249-252 °C (lit.)
storage temp.
2-8°C
Gene Information
human ... HRH1(3269)
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Biochem/physiol Actions
Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yuki Bessho et al.
Neuroscience letters, 578, 106-110 (2014-07-06)
In mammals, it is established that histamine is a neurotransmitter and/or neuromodulator in the central nervous system. It is produced by the enzyme histidine decarboxylase (HDC) in the tuberomammillary nucleus of the posterior hypothalamus. However, HDC as well as histaminergic
Chayon Goswami et al.
PloS one, 10(6), e0131554-e0131554 (2015-06-27)
Motilin and ghrelin constitute a peptide family, and these hormones are important for the regulation of gastrointestinal motility. In this study, we examined the effect of motilin and ghrelin on gastric acid secretion in anesthetized suncus (house musk shrew, Suncus
Kevin B Freeman et al.
Psychopharmacology, 231(12), 2395-2403 (2014-01-09)
Recent research has demonstrated that the drug, histamine, can function as a punisher of cocaine self-administration. However, little is known about how drug punishers affect the maximum reinforcing effectiveness of drugs as reinforcers. The goal of the present study was
Guadalupe-Elide Morales-Figueroa et al.
ACS chemical neuroscience, 5(8), 637-645 (2014-06-03)
High levels of histamine H3 receptors (H3Rs) are found in the globus pallidus (GP), a neuronal nucleus in the basal ganglia involved in the control of motor behavior. By using rat GP isolated nerve terminals (synaptosomes), we studied whether H3R
Carlos Daniel Zappia et al.
Scientific reports, 5, 17476-17476 (2015-12-05)
Histamine H1 receptor (H1R) antagonists and glucocorticoid receptor (GR) agonists are used to treat inflammatory conditions such as allergic rhinitis, atopic dermatitis and asthma. Consistent with the high morbidity levels of such inflammatory conditions, these receptors are the targets of
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