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Merck
CN

V900422

Folic acid

Vetec™, reagent grade, ≥97%

Synonym(s):

PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
59-30-3
Molecular Weight:
441.40
Beilstein:
100781
EC Number:
200-419-0
MDL number:
MFCD00079305
UNSPSC Code:
12352106
PubChem Substance ID:
329829830

Key Documents

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grade

reagent grade

product line

Vetec™

Assay

≥97%

form

powder

technique(s)

HPLC: suitable

color

yellow to orange

mp

>285 °C

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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General description

Folic acid belongs to vitamin B group and is also called as vitamin B9 or folate. It is present as 5-methyltetrahydrofolate in humans. Grains, fruits and vegetables are dietary sources of folate. Pteroylmonoglutamate is a synthetic folate which comprises single glutamate and exists in the oxidized state.

Biochem/physiol Actions

Folic acid is essential for cell growth, brain functioning and plays a key role on serine production from glycine. It also coordinates with vitamin B12 in maintaining iron levels. Deficiency of folate is implicated in megaloblastic anemia. Folic acid aids in the repair and synthesis of DNA. Dietary supplementation and fortification of folate in foods is recommended for pregnant women especially in the first trimester to avoid congenital malformation and neural tube defects (NTDs). However, folate fortification may also impose a moderate risk of developing prostate cancer. Supplementation of folate to colon cancer cells diminishes iron levels and impairs the cell division.

Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF1638V
WXBD7665V
WXBD2527V
WXBC7820V
WXBC7507V

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Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update
Chitayat D, et al.
Journal of Clinical Pharmacology, 56(2), 170-175 (2016)
Cancer risk with folic acid supplements: a systematic review and meta-analysis
Wien TN, et al.
BMJ Open, 2(1), e000653-e000653 (2012)
The metabolic processes of folic acid and Vitamin B12 deficiency
Mahmood L
Journal of Health Research and Reviews, 1(1), 5-5 (2014)
High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells
Pellis L, et al.
The British Journal of Nutrition, 99(4), 703-708 (2008)
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age
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