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Merck
CN

V900731

Sigma-Aldrich

Dimethyl fumarate

Vetec™, reagent grade, 97%

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About This Item

Linear Formula:
CH3OCOCH=CHCOOCH3
CAS Number:
624-49-7
Molecular Weight:
144.13
Beilstein:
774590
EC Number:
210-849-0
MDL number:
MFCD00064438
UNSPSC Code:
12352100
PubChem Substance ID:
329830103

Key Documents

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grade

reagent grade

product line

Vetec™

Assay

97%

bp

192-193 °C (lit.)

mp

102-106 °C (lit.)

SMILES string

[H]\C(=C(\[H])C(=O)OC)C(=O)OC

InChI

1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+

InChI key

LDCRTTXIJACKKU-ONEGZZNKSA-N

Gene Information

human ... KEAP1(9817)

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Legal Information

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H312,H315,H317,H335,H411

Hazard Classifications

Acute Tox. 4 Dermal - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
WXBB1011
BCBH2507V

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Alexander J Gill et al.
Critical reviews in immunology, 33(4), 307-359 (2013-08-27)
The persistence of chronic immune activation and oxidative stress in human immunodeficiency virus (HIV)-infected, antiretroviral drug-treated individuals are major obstacles to fully preventing HIV disease progression. The immune modulator and antioxidant dimethyl fumarate (DMF) is effective in treating immune-mediated diseases
Hui Chen et al.
The Journal of clinical investigation, 124(5), 2188-2192 (2014-04-03)
Taken orally, the drug dimethyl fumarate (DMF) has been shown to improve functional outcomes for patients with MS; however, it is unclear how DMF mediates a protective effect. DMF and, more so, its active metabolite, monomethyl fumarate, are known agonists
Christiane Reick et al.
Experimental neurology, 257, 50-56 (2014-04-16)
Despite recent advances in development of treatments for multiple sclerosis, there is still an unmet need for more effective and also safe therapies. Based on the modes of action of interferon-beta (IFN-β) and dimethyl fumarate (DMF), we hypothesized that anti-inflammatory
Markus Meissner et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 10(11), 793-801 (2012-08-18)
Fumaric acid esters have been used successfully in the therapy of psoriasis vulgaris since 1959. In the last 17 years, many of the underlying mechanisms of anti-psoriatic action, such as a Th1/Th2 shift, a suppression of important leukocyte adhesion molecules
Michael D Carrithers
Clinical therapeutics, 36(12), 1938-1945 (2014-09-15)
The purpose of this review is to discuss the selection and use of disease- modifying treatments for patients with relapsing forms of multiple sclerosis (MS). PubMed was searched (1966-2014) using the terms multiple sclerosis, treatment, interferon, glatiramer acetate, dimethyl fumarate
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