V900931
Trichostatin A
From Streptomyces sp., ≥98%, HDAC inhibitor
Synonym(s):
Trichostatin A, TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
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About This Item
Empirical Formula (Hill Notation):
C17H22N2O3
CAS Number:
Molecular Weight:
302.37
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98%
Product Name
Trichostatin A , Vetec™, reagent grade, from Streptomyces sp., ≥98%
biological source
Streptomyces sp.
grade
reagent grade
product line
Vetec™
assay
≥98%
storage temp.
−20°C
SMILES string
C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
InChI key
RTKIYFITIVXBLE-QEQCGCAPSA-N
Biochem/physiol Actions
Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.
Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk
WGK 3
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Masato Yuasa et al.
The Journal of clinical investigation, 125(8), 3117-3131 (2015-07-28)
Bone formation during fracture repair inevitably initiates within or around extravascular deposits of a fibrin-rich matrix. In addition to a central role in hemostasis, fibrin is thought to enhance bone repair by supporting inflammatory and mesenchymal progenitor egress into the
Gavin Rumbaugh et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(10), 2307-2316 (2015-04-04)
Histone deacetylases (HDACs) are promising therapeutic targets for neurological and psychiatric disorders that impact cognitive ability, but the relationship between various HDAC isoforms and cognitive improvement is poorly understood, particularly in mouse models of memory impairment. A goal shared by
Anni Niskakoski et al.
Epigenetics, 9(12), 1577-1587 (2015-01-28)
Diagnosis and treatment of epithelial ovarian cancer is challenging due to the poor understanding of the pathogenesis of the disease. Our aim was to investigate epigenetic mechanisms in ovarian tumorigenesis and, especially, whether tumors with different histological subtypes or hereditary
Global Trade Item Number
| SKU | GTIN |
|---|---|
| V900931-5MG | 04061826746080 |
| V900931-1MG | 04061826746073 |