High-Throughput Screening

Gray-colored 4x6 well plate used for high throughput screening.

High-throughput 24-well plate

High-throughput screening (HTS) is a technique used to run many reactions simultaneously in parallel synthesis. Also known as high-throughput experimentation (HTE), this technique is especially useful for quick and efficient screening of compounds to find the ideal reactants for your reaction. High-throughput screening methods often use automated systems such as robotic plating systems, automated data collection/analysis, and computer programs to identify the potential reactants. HTS has revolutionized the drug discovery process and is used by pharmaceutical companies, academic institutions, and research laboratories to quickly identify new potential drug candidates. ​

We offer a variety of products to give researchers a one-stop shop for all their high throughput needs. 

KitAlysis™- high-throughput screening kits

ChemBeads – catalyst coated glass beads designed for HTE to remove the issues with solid handling in automation

KitAlysis™ Screening Kits

The KitAlysis™ screening kit platform allows for 24 unique chemical reactions to be performed with ~100 mg of user-provided substrate. While utilizing the KitAlysis™ Benchtop Inertion Box, these reactions can be conducted in an inert atmosphere without the use of a glovebox. KitAlysis™ screening kits are available pre-plated for seven different reaction types:

KitAlysis™ screening kit (Z742108) including 24-well reaction block, inertion box and screwdriver set used for high-throughput experimentation.

KitAlysis™ starter kit

Base Screening – 11 bases, 2 vials of each, and 2 open vials for additional bases to be added at the chemist’s discretion to quickly and efficiently screen bases for cross-coupling reactions

Buchwald-Hartwig Amination Screening - 12 catalysts, 2 vials of each, for multiple base and solvent systems for quick screening of Buchwald-Hartwig C-N cross-coupling

Medium (5, 6, 7) Ring Closing Metathesis Screening - 6 catalysts, 4 vials of each, for quickly and efficient screening of 5, 6, and 7 membered ring forming reactions of two intramolecular terminal alkenes

Miyaura Borylation Screening - 6 catalysts, 4 vials of each, and 2 diboron compounds for favorable palladium-catalyzed borylation conditions

24 Pd Precatalyst Screening – 24 cross-coupling precatalysts allowing the researcher to narrow their selection to more specified kits

Copper C-N Cross-Coupling Screening – 6 catalysts, 4 vials of each, for multiple base and solvent systems for quick screening of Copper C-N cross-coupling reactions

Suzuki-Miyaura Cross-Coupling Screening –6 catalysts, 4 vials of each, for favorable cross-coupling conditions


ChemBeads catalyst-coated glass beads in red.

ChemBeads catalyst-coated glass beads in red.


ChemBeads are catalyst-coated glass beads used for separation and purification processes in high-throughput experimentation. These catalyst beads are ideal for automated screening methods because sub-milligram amounts of solids can be accurately weighed and dispensed robotically. In addition, ChemBeads can be measured volumetrically to eliminate wasted material. ChemBeads have a high surface area-to-volume ratio and uniform size and shape, which ensures that the separation process is consistent and efficient, leading to reliable results. 

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