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Showing 1-30 of 978 results for "02487" within Papers
Snezana Agatonovic-Kustrin et al.
Journal of chromatography. A, 1385, 103-110 (2015-02-11)
The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical as a post-chromatographic derivatization agent to compare the free radical scavenging activities
Nolwenn Callac et al.
Extremophiles : life under extreme conditions, 19(3), 597-617 (2015-03-18)
Active hydrothermal chimneys host diverse microbial communities exhibiting various metabolisms including those involved in various biogeochemical cycles. To investigate microbe-mineral-fluid interactions in hydrothermal chimney and the driver of microbial diversity, a cultural approach using a gas-lift bioreactor was chosen. An
Cordula Stillhart et al.
Pharmaceutical research, 31(12), 3426-3444 (2014-06-26)
In vitro lipolysis is widely utilized for predicting in vivo performance of oral lipid-based formulations (LBFs). However, evaluation of LBFs in the absence of an absorption sink may have limited in vivo relevance. This study aimed at employing biopharmaceutical modeling
B E Butterworth et al.
Toxicology letters, 82-83, 23-26 (1995-12-01)
Chloroform produces cancer by a nongenotoxic-cytotoxic mode of action, with no increased cancer risk expected at noncytotoxic doses. The default risk assessment for inhaled chloroform relies on liver tumor incidence from a gavage study with female B6C3F1 mice and estimates
Michalina Kosiorek et al.
PloS one, 9(6), e99118-e99118 (2014-06-07)
The bulk of human genes undergo alternative splicing (AS) upon response to physiological stimuli. AS is a great source of protein diversity and biological processes and is associated with the development of many diseases. Pheochromocytoma is a neuroendocrine tumor, characterized
Kwan Wee Tan et al.
ACS nano, 8(5), 4730-4739 (2014-04-02)
Structure control in solution-processed hybrid perovskites is crucial to design and fabricate highly efficient solar cells. Here, we utilize in situ grazing incidence wide-angle X-ray scattering and scanning electron microscopy to investigate the structural evolution and film morphologies of methylammonium
Keisuke Ohsumi et al.
The Journal of antibiotics, 67(10), 707-711 (2014-05-29)
A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent
Zhisheng Her et al.
EMBO molecular medicine, 7(1), 24-41 (2014-12-03)
RNA-sensing toll-like receptors (TLRs) mediate innate immunity and regulate anti-viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection. Susceptibility to CHIKV infection is markedly increased in human
Naoya Miura et al.
Nucleic acids research, 43(3), 1317-1331 (2015-01-22)
Technologies that delivery antigen-encoded plasmid DNA (pDNA) to antigen presenting cell and their immune-activation are required for the success of DNA vaccines. Here we report on an artificial nanoparticle that can achieve these; a multifunctional envelope-type nanodevice modified with KALA
A Jafarian et al.
Andrologia, 46(10), 1098-1106 (2013-12-12)
Busulfan is a chemotherapeutic drug that induces sterility, azoospermia and testicular atrophy. To induce degeneration of spermatogenesis, we used different amounts of busulfan. Adult male C57Bl/6 mice were treated with 15, 30 and 45 mg kg(-1) of busulfan. After 5 weeks, animals had
Conghui Chen et al.
International journal of pharmaceutics, 480(1-2), 116-127 (2015-01-24)
In the present study, we constructed a tumor-targeting and pH-sensitive lipoprotein-mimic nanocarrier containing paclitaxel (FA-BSA-LC/DOPE-PTX), by adding 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and oleic acid as pH-sensitive components into the formulation of lipid core and then coating with folic acid modified bovine serum
Jatin Mehta et al.
PloS one, 10(3), e0120622-e0120622 (2015-03-18)
Androgen Receptor (AR) is an essential transcription factor for the development of secondary sex characteristics, spermatogenesis and carcinogenesis. Recently AR has been implicated in the development and progression of breast and prostate cancers. Although some of the functions of the
Takuya Uchino et al.
Carbohydrate research, 402, 118-123 (2014-12-17)
The 3,6-O-(o-xylylene) bridge locks the conformation of glucopyranose to an axial-rich form. Although the conformational lock induces complete β-selectivity in a glycosylation reaction, the leaving group of the glycosyl donor is limited to fluorine. On the other hand, the bridge
Olivier Morales et al.
British journal of haematology, 166(6), 875-890 (2014-07-22)
Epstein-Barr Virus (EBV) is present in the neoplastic cells of around 20-30% of patients with Hodgkin Lymphoma (HL). Although, an immunosuppressive environment is currently described in HL patients, little is known concerning the regulatory mechanism induced by EBV proteins expression
Anke C Stöhr et al.
PloS one, 10(2), e0118633-e0118633 (2015-02-24)
Ranaviruses in amphibians and fish are considered emerging pathogens and several isolates have been extensively characterized in different studies. Ranaviruses have also been detected in reptiles with increasing frequency, but the role of reptilian hosts is still unclear and only
Joseph D Fleming et al.
Epigenetics & chromatin, 8, 7-7 (2015-03-19)
Transient induction of the Src oncoprotein in a non-transformed breast cell line can initiate an epigenetic switch to a cancer cell via a positive feedback loop that involves activation of the signal transducer and activator of transcription 3 protein (STAT3)
Juliana B Madeira et al.
Molecular and cellular biology, 35(4), 737-746 (2014-12-17)
Lipid droplets (LDs) are intracellular structures that regulate neutral lipid homeostasis. In mammals, LD synthesis is inhibited by rapamycin, a known inhibitor of the mTORC1 pathway. In Saccharomyces cerevisiae, LD dynamics are modulated by the growth phase; however, the regulatory
Robert T Dauchy et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(1), 40-50 (2015-02-05)
Early studies on rodents showed that short-term exposure to high-intensity light (> 70 lx) above 600 nm (red-appearing) influences circadian neuroendocrine and metabolic physiology. Here we addressed the hypothesis that long-term, low-intensity red light exposure at night (rLEN) from a
Yung-Chih Kuo et al.
Journal of pharmaceutical sciences, 103(8), 2484-2497 (2014-07-22)
Liposomes with Cereport (RMP-7) and transferrin (Tf) (RMP-7/Tf/liposomes) were employed to target the blood-brain barrier (BBB) and to inhibit the degeneration of neurons insulted with fibrillar β-amyloid peptide 1-42 (Aβ1-42). Neuron growth factor (NGF)-encapsulated RMP-7/Tf/liposomes (RMP-7/Tf/NGF-liposomes) were used to permeate
Javier Casas et al.
Nature communications, 5, 5624-5624 (2014-11-28)
The earliest molecular events in T-cell recognition have not yet been fully described, and the initial T-cell receptor (TCR)-triggering mechanism remains a subject of controversy. Here, using total internal reflection/Forster resonance energy transfer microscopy, we observe a two-stage interaction between
Anna Färnert et al.
Malaria journal, 13, 459-459 (2014-11-27)
Assessments of the epidemiology of malaria over time are needed to understand changes in transmission and guide control and elimination strategies. A longitudinal population study was established in 1985 in Nyamisati village in the Rufiji River Delta, Tanzania. A physician
A Ahmad et al.
Letters in applied microbiology, 60(1), 8-19 (2014-10-28)
Studies describing the use of essential oil constituents as antimicrobial agents have steadily increased; however, some phyto-constituents are often overlooked due to unfavourable minimum inhibitory concentration (MIC) values. Virulence depends on transcriptional factors which are regulated by cell-to-cell communication called
Deok-Seon Ryu et al.
International journal of oncology, 45(1), 459-469 (2014-05-03)
We investigated the anticancer mechanisms of the ethylacetate (EtOAc) fraction from Orostachys japonicus in human gastric cancer (AGS) cells. Flow cytometric analysis revealed that the number of total apoptotic cells following treatment with the EtOAc fraction increased in a dose-dependent
Vladimir Lesnyak et al.
ACS nano, 8(8), 8407-8418 (2014-07-23)
We report the synthesis of alloyed quaternary and quinary nanocrystals based on copper chalcogenides, namely, copper zinc selenide-sulfide (CZSeS), copper tin selenide-sulfide (CTSeS), and copper zinc tin selenide-sulfide (CZTSeS) nanoplatelets (NPLs) (∼20 nm wide) with tunable chemical composition. Our synthesis
David Bates et al.
PloS one, 9(5), e97220-e97220 (2014-05-14)
In this study we developed, characterized and validated in vitro a functional superparagmagnetic iron-oxide based magnetic resonance contrast agent by conjugating a commercially available iron oxide nanoparticle, Molday ION Rhodamine-B Carboxyl (MIRB), with a deimmunized mouse monoclonal antibody (muJ591) targeting
Jan Baeten et al.
PloS one, 9(11), e113142-e113142 (2014-11-13)
Frankincense, the oleogum resin from Boswellia sp., has been an early luxury good in both Western and Eastern societies and is particularly used in Christian funerary and liturgical rites. The scant grave goods in late medieval burials comprise laterally perforated
Zaher Merhi et al.
The Journal of clinical endocrinology and metabolism, 99(6), E1137-E1145 (2014-03-19)
Vitamin D deficiency is common among reproductive-aged women and has a role in female reproduction. This study evaluated the role of 1,25-dihydroxyvitamin D3 (vit D3) in ovarian follicular development and steroidogenesis by using a human granulosa cell (GC) model. Fifty-four
Haotian Wang et al.
Nuclear medicine and biology, 42(1), 65-70 (2014-10-04)
Iron-oxide nanoparticles can act as contrast agents in magnetic resonance imaging (MRI), while radiolabeling the same platform with nuclear medicine isotopes allows imaging with positron emission tomography (PET) or single-photon emission computed tomography (SPECT), modalities that offer better quantification. For
Elisabeth Kastner et al.
International journal of pharmaceutics, 477(1-2), 361-368 (2014-12-03)
Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows for reproducible mixing in miliseconds on the nanoliter scale. Here we investigate microfluidics-based manufacturing of liposomes. The aim of these studies was to assess the parameters in
Øystein Wessel et al.
Veterinary research, 46, 26-26 (2015-04-19)
Piscine orthoreovirus (PRV) is a reovirus that has predominantly been detected in Atlantic salmon (Salmo salar L.). PRV is associated with heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon, and recently erythrocytes were identified as major target cells.
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