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Showing 31-60 of 6397 results for "05030" within Papers
Aleksandra Kasperczyk et al.
Magnesium research, 28(1), 14-22 (2015-05-15)
The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. The study population consisted of 57 healthy
Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells.
Kerri-Ann Norton et al.
OncoTargets and therapy, 7, 1571-1582 (2014-09-18)
Angiogenesis, the formation of new blood vessels, is an essential step for cancer progression, but antiangiogenic therapies have shown limited success. Therefore, a better understanding of the effects of antiangiogenic treatments on endothelial cells is necessary. In this study, we
Alex Rajput et al.
European journal of human genetics : EJHG, 23(6), 887-888 (2014-08-15)
Exome-sequencing analyses have identified vacuolar protein sorting 35 homolog (VPS35) and DnaJ (Hsp40) homolog, subfamily C, member 13 (DNAJC13) harboring disease-causing variants for Parkinson disease (PD). Owing to the suggested clinical, pathological and genetic overlap between PD and essential tremor
Masaya Yamaguchi et al.
Journal of molecular biology, 427(8), 1748-1764 (2014-12-10)
The anaphase-promoting complex/cyclosome (APC/C) is a massive E3 ligase that controls mitosis by catalyzing ubiquitination of key cell cycle regulatory proteins. The APC/C assembly contains two subcomplexes: the "Platform" centers around a cullin-RING-like E3 ligase catalytic core; the "Arc Lamp"
Andrei V Chernov et al.
The Journal of biological chemistry, 290(18), 11771-11784 (2015-03-21)
To shed light on the early immune response processes in severed peripheral nerves, we performed genome-wide transcriptional profiling and bioinformatics analyses of the proximal (P, regenerating) and distal (D, degenerating) nerve stumps on day 1 in the sciatic nerve axotomy
Ge Yang et al.
Molecular medicine reports, 12(3), 3930-3936 (2015-06-06)
MicroRNAs (miRNAs) are small non-coding RNAs, which are important in the development of multidrug resistance in cancer by regulating gene expression at the post‑transcriptional level. The present study investigated the functional effects of miR‑522 in chemoresistant colon cancer cells. The
B Reuss et al.
Journal of molecular neuroscience : MN, 57(1), 123-138 (2015-06-18)
Antibacterial antibodies can cause neurologic side-effects by cross-reactivity with cellular antigens. Here we investigated interactions of antibodies to Neisseria gonorrhoeae (α-NG) - maternal infections by which increases the offspring's risk for later psychosis-with HIBCPP cells, a cell culture model of
Piyun Sun et al.
Neuroscience letters, 583, 32-36 (2014-09-23)
Global cerebral ischemia (GCI) causes energy deficiency results in excessive release of glutamate from neurons. Astrocytic glutamate transporters play a predominant role in keeping extracellular glutamate concentrations below excitotoxic levels. Glutamate transporter 1 (GLT-1) may account for more than 90%
Yellela S R Krishnaiah et al.
International journal of pharmaceutics, 475(1-2), 110-122 (2014-08-05)
The effect of process variability on physicochemical characteristics and in vitro performance of qualitatively (Q1) and quantitatively (Q2) equivalent generic acyclovir topical dermatological creams was investigated to develop a matrix of standards for determining their in vitro bioequivalence with reference
Toshiyuki Matsunaga et al.
Biological & pharmaceutical bulletin, 38(9), 1309-1319 (2015-09-04)
Doxorubicin (DOX) is widely used for the treatment of a wide range of cancers such as breast and lung cancers, and malignant lymphomas, but is generally less efficacious in gastrointestinal cancers. The most accepted explanation for the DOX refractoriness is
Zachary DeLoughery et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 54-63 (2014-10-08)
Hexavalent chromium is a human respiratory carcinogen that undergoes intracellular activation in vivo primarily via reduction with ascorbate. Replication of Cr-adducted DNA triggers mismatch repair that generates toxic DNA double-strand breaks (DSBs) as secondary lesions. Here, we examined the intranuclear distribution
Guillaume Desnoyers et al.
Molecular cancer research : MCR, 13(10), 1421-1430 (2015-06-10)
The eIF3e protein is a component of the multisubunit eIF3 complex, which is essential for cap-dependent translation initiation. Decreased eIF3e expression is often observed in breast and lung cancer and has been shown to induce epithelial-to-mesenchymal transition (EMT) in breast
Tanusree Paul et al.
European journal of cancer (Oxford, England : 1990), 50(11), 1855-1863 (2014-05-27)
Epidermal growth factor receptor inhibitor (EGFRI) induced skin toxicity has a prognostic value suggesting skin toxicity can be a useful surrogate marker for successful epidermal growth factor receptor (EGFR) inhibition, improved response and survival. But the pathophysiology of EGFRI induced
Ryo Hatano et al.
Journal of immunology (Baltimore, Md. : 1950), 194(3), 960-972 (2014-12-31)
CD26 is associated with T cell signal transduction processes as a costimulatory molecule, and CD26(+) T cells have been suggested to be involved in the pathophysiology of diverse autoimmune diseases. Although the cellular and molecular mechanisms involved in CD26-mediated T
Rui Liang et al.
Scientific reports, 5, 8078-8078 (2015-01-30)
Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK, MAP3K) family member that plays an important role in oxidative stress-induced cell apoptosis. In this
Rodrigo J Carbajo et al.
The FEBS journal, 282(2), 341-360 (2014-11-05)
Extant disintegrins, as found in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes, represent a family of polypeptides that block the function of β1 and β3 integrin receptors, both potently and with a high degree of selectivity. This
Xiaobin Yang et al.
European journal of pharmacology, 765, 209-216 (2015-08-25)
This work aimed to investigate the therapeutic effect of curcumin on sublesional bone loss induced by spinal cord injury (SCI) in rats. SCI model in this work was generated in rats by surgical transaction of the cord at the T10-12
Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis.
Vinod Sundaramoorthy et al.
Human molecular genetics, 24(13), 3830-3846 (2015-04-11)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder primarily affecting motor neurons. Mutations in optineurin cause a small proportion of familial ALS cases, and wild-type (WT) optineurin is misfolded and forms inclusions in sporadic ALS patient motor neurons. However
Fang He et al.
The Journal of thoracic and cardiovascular surgery, 150(2), 398-406 (2015-06-21)
Micro ribonucleic acids (miRNAs) are involved in a wide range of biological functions, in multiple tissues, including the central nervous system. We investigated a novel neuroprotective strategy of down-regulation of miR-320 in the spinal cord under the condition of transient
Xi Chen et al.
The New phytologist, 208(2), 531-543 (2015-05-27)
As molecular interactions of plants with N2 -fixing endophytes are largely uncharacterized, we investigated whether the common signaling pathway (CSP) shared by root nodule symbioses (RNS) and arbuscular mycorrhizal (AM) symbioses may have been recruited for the endophytic Azoarcus sp.-rice
Zhe Wang et al.
Stem cells (Dayton, Ohio), 33(2), 456-467 (2014-10-28)
Traumatic brain injury (TBI) is the leading cause of death and disability worldwide. Mesenchymal stem cells (MSCs) are promising for the treatment of various diseases and injuries. Many strategies have been applied to attract MSCs to injury site after systemic
Lijuan Ma et al.
Nucleic acids research, 43(15), 7349-7359 (2015-07-02)
Meiotic programmed DNA double-strand break (DSB) repair is essential for crossing-over and viable gamete formation and requires removal of Spo11-oligonucleotide complexes from 5' ends (clipping) and their resection to generate invasive 3'-end single-stranded DNA (resection). Ctp1 (Com1, Sae2, CtIP homolog)
T Xie et al.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 17(7), 504-510 (2015-01-13)
The aim of this study was to investigate whether miR-15a has prognostic relevance in human gliomas. The expression levels of miR-15a were analyzed in glioma surgical resection tissues by microarray and quantitative real-time PCR. Survival analysis by the Kaplan-Meier method
Hao Wei et al.
Journal of lipid research, 56(12), 2337-2347 (2015-10-23)
In addition to triacylglycerols, adipocytes contain a large reserve of unesterified cholesterol. During adipocyte lipolysis and cell death seen during severe obesity and weight loss, free fatty acids and cholesterol become available for uptake and processing by adipose tissue macrophages
Astrid Brull et al.
The Journal of physiology, 593(12), 2693-2706 (2015-04-16)
This is the first study to analyse the effect of muscle glycogen phosphorylase depletion in metabolically different muscle types. In McArdle mice, muscle glycogen phosphorylase is absent in both oxidative and glycolytic muscles. In McArdle mice, the glycogen debranching enzyme
Yunhui Hu et al.
Breast cancer research and treatment, 151(2), 269-280 (2015-04-23)
Multidrug resistance (MDR) remains one of the most significant obstacles in breast cancer treatment, and this process often involves dysregulation of a great number of microRNAs (miRNAs). Some miRNAs are indicators of drug resistance and confer resistance to chemotherapeutic drugs
Deepti Thete et al.
Virology, 483, 291-301 (2015-05-26)
During cell entry, reovirus particles disassemble to generate ISVPs. ISVPs undergo conformational changes to form ISVP(*) and this conversion is required for membrane penetration. In tissues where ISVP formation occurs within endosomes, ISVP-to-ISVP(*) conversion occurs at low pH. In contrast
Hong Ma et al.
Oncology reports, 33(3), 1161-1170 (2015-01-13)
The aim of the present study was to explore the efficacy and mechanism of the radiosensitisation of icotinib hydrochloride (IH), a novel oral epidermal growth factor receptor-tyrosine kinase activity inhibitor, by evaluating the changes in tumour cell double-strand breaks (DSBs)
Kumaran Sundaram et al.
Bone, 71, 137-144 (2014-12-03)
Receptor activator of nuclear factor kappa-B ligand (RANKL) is a critical osteoclastogenic factor expressed in bone marrow stromal/osteoblast lineage cells. Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) levels are elevated in pathologic conditions such as multiple myeloma and inflammatory
Kine S N Dervola et al.
Neurotoxicology, 50, 38-45 (2015-07-29)
Polychlorinated biphenyls (PCBs) are present as ortho- and non-ortho-substituted PCBs, with most of the ortho-substituted congeners being neurotoxic. The present study examined effects of the ortho-substituted PCB 153 on dopamine, serotonin and amino acid neurotransmitters in the neostriatum of both
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