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Showing 31-60 of 6397 results for "05030" within Papers
Su Yao et al.
The Journal of pathology, 236(1), 65-77 (2014-12-19)
The epidermal growth factor receptor (EGFR) is implicated in many types of cancer, including colorectal cancer (CRC), and has become one of the most common candidates for targeted therapy. Here, we found that Erbin, a member of the leucine-rich repeat
Helen L May-Simera et al.
Development (Cambridge, England), 142(3), 555-566 (2015-01-22)
Primary cilia have been implicated in the generation of planar cell polarity (PCP). However, variations in the severity of polarity defects in different cilia mutants, coupled with recent demonstrations of non-cilia-related actions of some cilia genes, make it difficult to
Noritada Yoshikawa et al.
Biochemical and biophysical research communications, 453(3), 600-605 (2014-10-11)
Pulmonary hypertension (PH) sustains elevation of pulmonary vascular resistance and ultimately leads to right ventricular (RV) hypertrophy and failure and death. Recently, proangiogenic factors hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) have been known to promote left
Valentina Fodale et al.
PloS one, 9(12), e112262-e112262 (2014-12-03)
In Huntington's disease, expansion of a CAG triplet repeat occurs in exon 1 of the huntingtin gene (HTT), resulting in a protein bearing>35 polyglutamine residues whose N-terminal fragments display a high propensity to misfold and aggregate. Recent data demonstrate that
Maria Bexten et al.
Molecular pharmaceutics, 12(1), 171-178 (2014-12-04)
The cationic, water-soluble quaternary trospium chloride (TC) is incompletely absorbed from the gut and undergoes wide distribution but does not pass the blood-brain barrier. It is secreted by the kidneys, liver, and intestine. To evaluate potential transport mechanisms for TC
Shuji Sugiura et al.
The Journal of investigative dermatology, 135(3), 776-785 (2014-10-15)
Human prolactin-induced protein (PIP) is a major protein found in exocrine fluids such as saliva and sweat. Intriguingly, PIP possesses residues (human PIP (hPIP): PIP (29-63)) that display similarity to the aspartic peptidase candidapepsin. Here, we aimed to determine the
Xiaoping Su et al.
Cancer research, 75(14), 2875-2885 (2015-06-13)
microRNA (miRNA) dysregulation is involved in the development and progression of various human cancers, including hepatocellular carcinoma (HCC). However, how to identify the miRNAs targeting specific mRNA in cells is a significant challenge because of the interaction complexity and the
Qingguang Wang et al.
Molecular medicine reports, 12(1), 475-481 (2015-03-12)
Serine/threonine-protein kinase-1 (SMG-1) belongs to the phosphatidylinositol 3‑kinase‑related kinase family. Altered expression of SMG-1 contributes to human carcinogenesis and cancer progression. The present study detected the expression levels of SMG-1 in normal and cancerous pancreatic tissues and then assessed the
Tatiana Ederich Lehnen et al.
Clinical and experimental pharmacology & physiology, 41(12), 986-994 (2014-09-17)
Statins have a beneficial effect after myocardial infarction, but the relationship between glucose transporters and their use before the event has not yet been studied. We assessed the effects of atorvastatin treatment pre- and post-myocardial infarction on cardiovascular function and
Udi Gluschnaider et al.
Cancer research, 74(23), 6991-7002 (2014-10-12)
Obesity and type 2 diabetes (T2D) are associated with increased breast cancer incidence and mortality, whereas carbohydrate-restricted ketogenic diets ameliorate T2D and suppress breast cancer. These observations suggest an inherent efficacy of nonesterified long-chain fatty acids (LCFA) in suppressing T2D
Xian Yang et al.
Journal of ethnopharmacology, 157, 105-113 (2014-09-28)
Abacopteris penangiana (Hook.) Ching (AP) is a member of parathelypteris glanduligera and used in folk medicine for the treatment of blood circulation and blood stasis, edema and inflammation as recorded in the ″Chinese Materia Medica″. The purpose of this study
L Garcia-Valdes et al.
International journal of obesity (2005), 39(4), 571-578 (2015-01-24)
Obesity is associated with decreased iron status, possibly due to a rise in hepcidin, an inflammatory protein known to reduce iron absorption. In animals, we have shown that maternal iron deficiency is minimised in the foetus by increased expression of
Wei Hong et al.
Acta pharmacologica Sinica, 36(12), 1487-1496 (2015-11-26)
Apolipoprotein E (ApoE) plays an important role in the transport and metabolism of lipids. Recent studies show that bone mass is increased in young apoE(-/-) mice. In this study we investigated the bone phenotype and metabolism in aged apoE(-/-) mice.
M M Singer et al.
Reviews of environmental contamination and toxicology, 133, 95-149 (1993-01-01)
Sodium dodecyl sulfate is the most widely used of the anionic alkyl sulfate surfactants. Its surface-active properties make it important in hundreds of household and industrial cleaners, personal care products, and cosmetics. It is also used in several types of
Bin Pan et al.
Journal of neuroscience research, 93(3), 443-453 (2014-10-21)
Thrombospondin-4 (TSP4) belongs to a family of large, oligomeric extracellular matrix glycoproteins that mediate interactions between cells and interactions of cells with underlying matrix components. Recent evidence shows that TSP4 might contribute to the generation of neuropathic pain. However, there
Yuan Liu et al.
PloS one, 10(7), e0133068-e0133068 (2015-07-21)
Sex-biased genes are considered to account for most of phenotypic differences between males and females. In order to explore the sex-biased gene expression in crab, we performed the whole-body transcriptome analysis in male and female juveniles of the Chinese mitten
Chun-Hua Wang et al.
Oncotarget, 6(39), 42118-42129 (2015-10-31)
Leucine-rich-alpha-2-glycoprotein1 (LRG1) is a novel oncogene-associated protein which has been clarified vital to the progression of human cancers, but its role in hepatocellular carcinoma (HCC) remains unclear. Here, we showed that the expression of LRG1 was noticeably increased in HCC
B Chen et al.
Placenta, 36(8), 847-853 (2015-06-02)
N-Myc downstream-regulated gene 1 (NDRG1) expression is increased in placentas of human pregnancies with intrauterine growth restriction and in hypoxic cultured primary trophoblasts. We previously showed that elevated NDRG1 decreases trophoblast apoptosis induced by hypoxia. Separately, we found that pomegranate
Ashutosh Kumar et al.
Mutagenesis, 30(2), 237-245 (2014-11-09)
Zinc oxide (ZnO) nanoparticles are the mostly used engineered metal oxide nanoparticles in consumer products. This has increased the likelihood of human exposure to this engineered nanoparticle (ENPs) through different routes. At present, the majority of the studies concerning ZnO
Development of an ATP measurement method suitable for xenobiotic treatment activated sludge biomass.
Lan Huong Nguyen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 69-76 (2015-07-27)
Activated sludge consumes a large amount of energy to degrade a xenobiotic organic compound. By tracking the energy inventory of activated sludge biomass during the sludge's degradation of a xenobiotic, any disadvantageous effect on the sludge's performance caused by energy
Kiyohiko Hotta et al.
Oncology reports, 34(2), 648-654 (2015-06-03)
Prostate cancer antigen-1 (PCA-1)/ALKBH3 has been recently identified in human prostate cancer and its expression is correlated with disease progression and prognosis. However, the precise role and function of PCA-1/ALKBH3 in human malignancies are largely unknown. In the present study
Xiao-chun Wang et al.
Oral oncology, 51(7), 674-682 (2015-05-13)
The aim of this study was to determine expression levels of miR-433 in oral squamous cell carcinomas (OSCCs) and adjacent normal tissues, and explore its biological functions in OSCCs. miR-433 level in oral squamous cell carcinomas (OSCCs) and adjacent normal
Linjuan Zeng et al.
Pancreas, 44(2), 250-259 (2014-11-18)
The objective of this study was to establish an efficient carrier for small interfering RNA (siRNA) delivery targeting pancreatic tumor cells. A copolymer consisting of a single-chain variable fragment targeted to human CD44 variant 6 (scFv(CD44v6)) functional group conjugated to
Masoumeh Emadpour et al.
Nucleic acids research, 43(10), e66-e66 (2015-04-01)
Riboswitches are RNA sensors that regulate gene expression in response to binding of small molecules. Although they conceptually represent simple on/off switches and, therefore, hold great promise for biotechnology and future synthetic biology applications, the induction of gene expression by
Jin Meng et al.
Molecular medicine reports, 12(1), 581-586 (2015-02-20)
It was previously reported that the histone deacetylase inhibitor (HDACI) trichostatin A (TSA) induced B cell lymphoma 2 (Bcl-2)-associated X protein (Bax)-dependent apoptosis in colorectal cancer (CRC) cells. In addition, Ku70 has been identified as a regulator of apoptosis, the
Malihe Davudabadi Farahani et al.
Journal of AOAC International, 97(6), 1682-1688 (2015-01-30)
A simple and rapid method for the separation and preconcentration of trace amounts of Cd(ll) and Pb(ll) in milk powder and water samples by magnetic SPE has been developed. The application of silica- coated magnetite nanoparticles (SCMNPs), modified with an
Prathima Arvind et al.
Journal of cardiology, 64(5), 339-346 (2014-03-29)
Genetic regulation of plasma lipids has been shown to influence the risk of coronary artery disease (CAD). We analyzed the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their
W J M Landman et al.
Avian pathology : journal of the W.V.P.A, 43(4), 345-356 (2014-06-20)
Escherichia coli colonies isolated from the bone marrow of fresh dead hens of laying flocks with the E. coli peritonitis syndrome (EPS) were genotyped using pulsed-field gel electrophoresis (PFGE). Typing is important from an epidemiological point of view and also
Yong-Wan Kim et al.
Oncology reports, 33(4), 1675-1682 (2015-01-31)
Bee venom (BV) therapy is a type of alternative medical treatment used to treat various diseases in oriental medicine. The mechanisms underlying the effects of BV remain poorly understood. In the present study, we evaluated the antiviral effect of BV
Jiajia Hu et al.
Scientific reports, 5, 17426-17426 (2015-12-01)
The normal epithelial cell-specific-1 (NES1) gene, also named as KLK10, is recognised as a novel putative tumour suppressor in breast cancer, but few studies have focused on the function of KLK10 in human prostate cancer. Our study confirms that the
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