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Showing 1-30 of 89 results for "220051" within Papers
Chen Yao et al.
Oncology reports, 34(1), 59-66 (2015-05-09)
Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers. A recombinant lentivirus plasmid encoding the human NIS (hNIS) gene and firefly
Development of GSK's reagent guides ? embedding sustainability into reagent selection
Adams JP, et al.
Green Chemistry, 15, 220051-220051 (2013)
H Lee et al.
Mucosal immunology, 8(5), 1083-1098 (2015-02-12)
Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, have not been studied in detail. Here, by using a variety of parameters, we define
Subroto Paul et al.
Chest, 146(6), 1505-1512 (2014-05-09)
Robotic-assisted lobectomy is being offered increasingly to patients. However, little is known about its safety, complication profile, or effectiveness. Patients undergoing lobectomy in in the United States from 2008 to 2011 were identified in the Nationwide Inpatient Sample. In-hospital mortality
Christopher J T Hyland et al.
The Journal of organic chemistry, 71(22), 8658-8660 (2006-10-27)
Chiral gamma-substituted allenamides have been shown to undergo efficient gold-catalyzed and N-iodosuccinimide-mediated cyclization to highly functionalized dihydrofurans. These reactions proceed rapidly and without loss of stereochemistry.
Xiaoyun Dai et al.
Molecular oncology, 9(4), 818-833 (2015-01-28)
Deregulated activation of oncogenic transcription factors such as signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in proliferation and survival of hepatocellular carcinoma (HCC). Thus, agents which can inhibit STAT3 activation may have an enormous potential
Luchuan Li et al.
Biochemical and biophysical research communications, 462(4), 314-321 (2015-05-12)
Dedifferentiated thyroid carcinoma (DTC) with the loss of radioiodine uptake (RAIU) is often observed in clinical practice under radioiodine therapy, indicating the challenge for poor prognosis. MicroRNA (miRNA) has emerged as a promising therapeutic target in many diseases; yet, the
Kristin M Lefebvre et al.
Vascular medicine (London, England), 20(1), 51-59 (2015-02-11)
The purpose of this study was to examine trends in racial and gender disparities in the severity of lower extremity amputation among individuals with peripheral artery disease (PAD) over the period of a decade (2002-2011). This is a longitudinal secondary
Elisabeth Holen et al.
Fish & shellfish immunology, 45(2), 695-703 (2015-05-25)
Future feed for farmed fish are based on untraditional feed ingredients, which will change nutrient profiles compared to traditional feed based on marine ingredients. To understand the impact of oils from different sources on fish health, n-6 and n-3 polyunsaturated
Yuanxun Zhu et al.
Organic letters, 13(5), 1024-1027 (2011-01-28)
An efficient and straightforward strategy for the synthesis of N-(2-haloinden-1-yl)arenesulfonamides from propargylic alcohols and sulfonamides is described. Allenesulfonamide is postulated to be the key intermediate for this tandem transformation.
Canadian Journal of Chemistry, 84, 66-66 (2006)
Danielle L Gainor et al.
JAMA otolaryngology-- head & neck surgery, 141(8), 739-744 (2015-06-05)
Sodium iodide symporter (NIS) expression in adenoid cystic carcinoma (ACC) has not been fully elucidated in the literature, and it is unclear whether radioactive iodine may be a potential therapeutic modality. To our knowledge, the present study includes the largest
Yuko Mishima et al.
British journal of haematology, 169(3), 423-434 (2015-02-25)
Proteasome inhibition induces the accumulation of aggregated misfolded/ubiquitinated proteins in the aggresome; conversely, histone deacetylase 6 (HDAC6) inhibition blocks aggresome formation. Although this rationale has been the basis of proteasome inhibitor (PI) and HDAC6 inhibitor combination studies, the role of
Abby J Isaacs et al.
The Journal of thoracic and cardiovascular surgery, 149(5), 1262-1269 (2015-03-21)
Substantial controversy surrounds the choice between a mechanical versus bioprosthetic prosthesis for aortic valve replacement (AVR), based on age. This study aims to investigate national trends and in-hospital outcomes of the 2 prosthesis choices. All patients aged >18 years in
Thoudam Debraj Singh et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(11), 1690-1696 (2015-09-05)
Anaplastic thyroid cancer (ATC), a rare thyroid cancer with poor prognosis, is associated with insufficient function of the sodium iodide symporter (NIS). Estrogen-related receptor γ (ERRγ) is a member of the orphan nuclear receptors with important functions in cell development
Hongwei Guo et al.
Journal of applied toxicology : JAT, 35(9), 992-998 (2015-02-04)
Polychlorinated biphenyls (PCBs) are typical persistent organic pollutants that can interfere with multiple organ systems of humans. Previously, we concluded that persistent exposure to low doses of PCB118 could severely damage the thyroidal structure, dramatically decrease the concentration of serum
Jessica L Mellinger et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 13(3), 577-584 (2014-09-30)
Little is known about geographic variations in health care for patients with cirrhosis. We studied geographic and hospital-level variations in care of patients with cirrhosis in the United States by using inpatient mortality as an outcome for comparing hospitals. We
Ana Paula Santin Bertoni et al.
International journal of endocrinology, 2015, 864852-864852 (2015-06-20)
Thyroid cancer and thyroid nodules are more prevalent in women than men, so female sex hormones may have an etiological role in these conditions. There are no data about direct effects of progesterone on thyroid cells, so the aim of
Shuo Shi et al.
Current gene therapy, 15(5), 460-471 (2015-04-22)
Heart tissue has a diminished ability to repair after myocardial infarction (MI). Bone marrow- derived mesenchymal stem cells (BMSCs) have been used effectively to heal damaged tissue after MI. Hypoxia-inducible factor-1α (HIF-1α) can induce transcription of numerous pro-angiogenic genes and
Anup M Jawalekar et al.
Chemical communications (Cambridge, England), 47(10), 2796-2798 (2011-02-03)
2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.
Aparna Lakshmanan et al.
Endocrine-related cancer, 22(1), 11-21 (2014-11-19)
Na(+)/I(-) symporter (NIS)-mediated radioiodide uptake (RAIU) serves as the basis for targeted ablation of thyroid cancer remnants. However, many patients with thyroid cancer have reduced NIS expression/function and hence do not benefit from radioiodine therapy. microRNA (miR) has emerged as
Yuxin Qian et al.
The Journal of organic chemistry, 77(1), 96-107 (2011-12-07)
A novel class of 1-C-arylglycals was developed and subjected to N-iodosuccinimide-mediated glycosylations with alcohols. Unexpectedly, all reactions provided 2-iodo-β-D-ketopyranosides in high yields and excellent stereoselectivity. After removal of the 2-iodide by radical conditions, the aryl group was smoothly oxidized to
Shuo Shi et al.
PloS one, 10(1), e0116531-e0116531 (2015-01-27)
Despite recent improvements in the survival rates for nasopharyngeal carcinoma (NPC), novel treatment strategies are required to improve distant metastasis-free survival. The sodium iodine symporter (NIS) gene has been applied for in vivo imaging and cancer therapy. In this study
Hakim Bouamar et al.
Molecular and cellular biology, 35(8), 1329-1340 (2015-02-04)
In biological processes, the balance between positive and negative inputs is critical for an effective physiological response and to prevent disease. A case in point is the germinal center (GC) reaction, wherein high mutational and proliferation rates are accompanied by
Juan Pablo Nicola et al.
The Journal of clinical endocrinology and metabolism, 100(10), E1353-E1361 (2015-07-24)
Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene. Mutations in slc5a5 cause I(-) transport defects (ITDs), autosomal-recessive disorders
Noriyasu Hada et al.
Carbohydrate research, 343(13), 2315-2324 (2008-06-07)
Novel neutral glycosphingolipids (NGSLs) containing Gal-alpha1-->6Gal, previously found in the Zygomycetes species Mucor hiemalis, were synthesized. The structures of these compounds are different from those of other fungal GSLs, and they are expected to be involved in host-parasite interactions. A
Tetsuya Kajimoto et al.
Bioorganic & medicinal chemistry letters, 16(22), 5736-5739 (2006-09-15)
p-Octyloxybenzenethiol (2) was synthesized as a new odorless benzenethiol. Moreover, preparation of thioglycosides using 2 and their application for glycosylation reactions were attempted. As a result, it was found that the thioglycosides were as excellent glycosyl donors as 4-dodecylphenyl 1-thio-glycosides
Rohan Khera et al.
JAMA internal medicine, 175(6), 941-950 (2015-03-31)
Percutaneous ventricular assist devices (PVADs) provide robust hemodynamic support compared with intra-aortic balloon pumps (IABPs), but clinical use patterns are unknown. To examine contemporary patterns in PVAD use in the United States and compare them with use of IABPs. Retrospective
Majed Afana et al.
Clinical cardiology, 38(1), 13-19 (2014-10-23)
Acute coronary syndromes account for half of all deaths secondary to cardiovascular disease and represent a significant economic burden in the United States. Therefore, assessing hospitalization costs relative to Medicare reimbursement for these patients is important in understanding the impact
André Uchimura Bastos et al.
European journal of endocrinology, 173(4), 525-540 (2015-09-05)
Thyroid cancer incidence has dramatically increased worldwide over the last two decades. The rise is mostly due to an increased detection of small papillary thyroid carcinomas (PTCs) (≤20 mm), predominantly microPTC (≤10 mm). Although small tumors generally have an excellent
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