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Showing 1-30 of 89 results for "220051" within Papers
Development of GSK's reagent guides ? embedding sustainability into reagent selection
Adams JP, et al.
Green Chemistry, 15, 220051-220051 (2013)
H Lee et al.
Mucosal immunology, 8(5), 1083-1098 (2015-02-12)
Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, have not been studied in detail. Here, by using a variety of parameters, we define
Anup M Jawalekar et al.
Chemical communications (Cambridge, England), 47(10), 2796-2798 (2011-02-03)
2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.
Chen Yao et al.
Oncology reports, 34(1), 59-66 (2015-05-09)
Since the sodium/iodide symporter (NIS) stimulates the iodine uptake in normal lactating breast, our study aimed to study the effect of NIS-mediated radioiodide therapy on ER-negative breast cancers. A recombinant lentivirus plasmid encoding the human NIS (hNIS) gene and firefly
Yuko Mishima et al.
British journal of haematology, 169(3), 423-434 (2015-02-25)
Proteasome inhibition induces the accumulation of aggregated misfolded/ubiquitinated proteins in the aggresome; conversely, histone deacetylase 6 (HDAC6) inhibition blocks aggresome formation. Although this rationale has been the basis of proteasome inhibitor (PI) and HDAC6 inhibitor combination studies, the role of
Luchuan Li et al.
Biochemical and biophysical research communications, 462(4), 314-321 (2015-05-12)
Dedifferentiated thyroid carcinoma (DTC) with the loss of radioiodine uptake (RAIU) is often observed in clinical practice under radioiodine therapy, indicating the challenge for poor prognosis. MicroRNA (miRNA) has emerged as a promising therapeutic target in many diseases; yet, the
Subroto Paul et al.
Chest, 146(6), 1505-1512 (2014-05-09)
Robotic-assisted lobectomy is being offered increasingly to patients. However, little is known about its safety, complication profile, or effectiveness. Patients undergoing lobectomy in in the United States from 2008 to 2011 were identified in the Nationwide Inpatient Sample. In-hospital mortality
Thoudam Debraj Singh et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(11), 1690-1696 (2015-09-05)
Anaplastic thyroid cancer (ATC), a rare thyroid cancer with poor prognosis, is associated with insufficient function of the sodium iodide symporter (NIS). Estrogen-related receptor γ (ERRγ) is a member of the orphan nuclear receptors with important functions in cell development
Aparna Lakshmanan et al.
Endocrine-related cancer, 22(1), 11-21 (2014-11-19)
Na(+)/I(-) symporter (NIS)-mediated radioiodide uptake (RAIU) serves as the basis for targeted ablation of thyroid cancer remnants. However, many patients with thyroid cancer have reduced NIS expression/function and hence do not benefit from radioiodine therapy. microRNA (miR) has emerged as
Christopher J T Hyland et al.
The Journal of organic chemistry, 71(22), 8658-8660 (2006-10-27)
Chiral gamma-substituted allenamides have been shown to undergo efficient gold-catalyzed and N-iodosuccinimide-mediated cyclization to highly functionalized dihydrofurans. These reactions proceed rapidly and without loss of stereochemistry.
Yuanxun Zhu et al.
Organic letters, 13(5), 1024-1027 (2011-01-28)
An efficient and straightforward strategy for the synthesis of N-(2-haloinden-1-yl)arenesulfonamides from propargylic alcohols and sulfonamides is described. Allenesulfonamide is postulated to be the key intermediate for this tandem transformation.
Canadian Journal of Chemistry, 84, 66-66 (2006)
Tetsuya Kajimoto et al.
Bioorganic & medicinal chemistry letters, 16(22), 5736-5739 (2006-09-15)
p-Octyloxybenzenethiol (2) was synthesized as a new odorless benzenethiol. Moreover, preparation of thioglycosides using 2 and their application for glycosylation reactions were attempted. As a result, it was found that the thioglycosides were as excellent glycosyl donors as 4-dodecylphenyl 1-thio-glycosides
Ana Paula Santin Bertoni et al.
International journal of endocrinology, 2015, 864852-864852 (2015-06-20)
Thyroid cancer and thyroid nodules are more prevalent in women than men, so female sex hormones may have an etiological role in these conditions. There are no data about direct effects of progesterone on thyroid cells, so the aim of
Shuo Shi et al.
Current gene therapy, 15(5), 460-471 (2015-04-22)
Heart tissue has a diminished ability to repair after myocardial infarction (MI). Bone marrow- derived mesenchymal stem cells (BMSCs) have been used effectively to heal damaged tissue after MI. Hypoxia-inducible factor-1α (HIF-1α) can induce transcription of numerous pro-angiogenic genes and
Danielle L Gainor et al.
JAMA otolaryngology-- head & neck surgery, 141(8), 739-744 (2015-06-05)
Sodium iodide symporter (NIS) expression in adenoid cystic carcinoma (ACC) has not been fully elucidated in the literature, and it is unclear whether radioactive iodine may be a potential therapeutic modality. To our knowledge, the present study includes the largest
Elisabeth Holen et al.
Fish & shellfish immunology, 45(2), 695-703 (2015-05-25)
Future feed for farmed fish are based on untraditional feed ingredients, which will change nutrient profiles compared to traditional feed based on marine ingredients. To understand the impact of oils from different sources on fish health, n-6 and n-3 polyunsaturated
Kristin M Lefebvre et al.
Vascular medicine (London, England), 20(1), 51-59 (2015-02-11)
The purpose of this study was to examine trends in racial and gender disparities in the severity of lower extremity amputation among individuals with peripheral artery disease (PAD) over the period of a decade (2002-2011). This is a longitudinal secondary
Xiaoyun Dai et al.
Molecular oncology, 9(4), 818-833 (2015-01-28)
Deregulated activation of oncogenic transcription factors such as signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in proliferation and survival of hepatocellular carcinoma (HCC). Thus, agents which can inhibit STAT3 activation may have an enormous potential
Hongwei Guo et al.
Journal of applied toxicology : JAT, 35(9), 992-998 (2015-02-04)
Polychlorinated biphenyls (PCBs) are typical persistent organic pollutants that can interfere with multiple organ systems of humans. Previously, we concluded that persistent exposure to low doses of PCB118 could severely damage the thyroidal structure, dramatically decrease the concentration of serum
Abby J Isaacs et al.
The Journal of thoracic and cardiovascular surgery, 149(5), 1262-1269 (2015-03-21)
Substantial controversy surrounds the choice between a mechanical versus bioprosthetic prosthesis for aortic valve replacement (AVR), based on age. This study aims to investigate national trends and in-hospital outcomes of the 2 prosthesis choices. All patients aged >18 years in
Jessica L Mellinger et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 13(3), 577-584 (2014-09-30)
Little is known about geographic variations in health care for patients with cirrhosis. We studied geographic and hospital-level variations in care of patients with cirrhosis in the United States by using inpatient mortality as an outcome for comparing hospitals. We
Cong-Ying Zhou et al.
Organic letters, 12(9), 2104-2107 (2010-04-15)
Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)(3) at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR
Rohan Khera et al.
JAMA internal medicine, 175(6), 941-950 (2015-03-31)
Percutaneous ventricular assist devices (PVADs) provide robust hemodynamic support compared with intra-aortic balloon pumps (IABPs), but clinical use patterns are unknown. To examine contemporary patterns in PVAD use in the United States and compare them with use of IABPs. Retrospective
N V Yaglova et al.
Bulletin of experimental biology and medicine, 160(2), 231-233 (2015-12-02)
The mechanism of disruptive action of dichlorodiphenyltrichloroethane (DDT) on the function of thyroid follicular epitheliocytes was examined in mature male Wistar rats administered with a daily dose of DDT (2 μg/kg) for 6 or 10 weeks. In 6 weeks, the
André Uchimura Bastos et al.
European journal of endocrinology, 173(4), 525-540 (2015-09-05)
Thyroid cancer incidence has dramatically increased worldwide over the last two decades. The rise is mostly due to an increased detection of small papillary thyroid carcinomas (PTCs) (≤20 mm), predominantly microPTC (≤10 mm). Although small tumors generally have an excellent
Taichi Kano et al.
Journal of the American Chemical Society, 130(12), 3728-3729 (2008-03-07)
A direct asymmetric iodination reaction of aldehydes with NIS was found to be catalyzed by the novel axially chiral bifunctional amino alcohol (S)-1d. This method represents the rare example of the catalytic and highly enantioselective synthesis of optically active alpha-iodoaldehydes.
Carmel M McVicar et al.
Diabetologia, 58(5), 1129-1137 (2015-02-18)
The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. The objective of this study was to assess the potential modulatory role of RAGE in diabetic retinopathy. Diabetes was induced in wild-type (WT) and Rage
Mark C Bagley et al.
Molecules (Basel, Switzerland), 15(5), 3211-3227 (2010-07-27)
Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2,3,6-trisubstituted pyridines in high yield and with total regiocontrol.
Efficient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide.
Daishirou Minato et al.
Angewandte Chemie (International ed. in English), 47(49), 9458-9461 (2008-11-01)
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