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Showing 31-60 of 138 results for "366986" within Papers
S Engelborghs et al.
Neurochemical research, 28(8), 1145-1150 (2003-07-02)
To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n =
Radioisotopes: The medical testing crisis.
Richard Van Noorden
Nature, 504(7479), 202-204 (2013-12-18)
Rima Obeid et al.
Clinical chemistry, 53(6), 1129-1136 (2007-03-27)
Increased plasma total homocysteine (tHcy) is a risk factor for neurological diseases, but the underlying pathophysiology has not been adequately explained. We evaluated concentrations of tHcy, S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM), folate, and vitamin B(12) in cerebrospinal fluid (CSF)
Courtney E Sparacino-Watkins et al.
The Journal of biological chemistry, 289(15), 10345-10358 (2014-02-07)
Mitochondrial amidoxime reducing component (mARC) proteins are molybdopterin-containing enzymes of unclear physiological function. Both human isoforms mARC-1 and mARC-2 are able to catalyze the reduction of nitrite when they are in the reduced form. Moreover, our results indicate that mARC
Ralf R Mendel
Plant cell reports, 30(10), 1787-1797 (2011-06-11)
The transition element molybdenum (Mo) is of essential importance for (nearly) all biological systems as it is required by enzymes catalyzing important reactions within the cell. The metal itself is biologically inactive unless it is complexed by a special cofactor.
María Rodríguez de la Flor et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(12), 2025-2031 (2013-07-31)
The elevation of metal levels in serum and urine during post-operative follow-up is a frequent find following the implantation of certain models of metal-on-metal hip prostheses. Among 45 patients with the same resurfacing prostheses, chromium (Cr) and cobalt (Co) levels
Joyee Mitra et al.
Inorganic chemistry, 52(6), 3032-3042 (2013-03-07)
A series of [Mo(IV)O(mnt)(SR)(N-N)](-) (mnt = maleonitriledithiolate; R = Ph, nap, p-Cl-Ph, p-CO2H-Ph, and p-NO2-Ph; N-N = 2,2'-bipyridine (bipy) and 1,10-phenanthroline (phen)) complexes analogous to the reduced active site of enzymes of the sulfite oxidase family has been synthesized and
Stefan Reschke et al.
Biochemistry, 52(46), 8295-8303 (2013-10-24)
Sulfite oxidase (SO) is an essential molybdoenzyme for humans, catalyzing the final step in the degradation of sulfur-containing amino acids and lipids, which is the oxidation of sulfite to sulfate. The catalytic site of SO consists of a molybdenum ion
A N Fonteh et al.
Amino acids, 32(2), 213-224 (2006-10-13)
Our aim was to determine changes in free amino acid (FAA) and dipeptide (DP) concentrations in probable Alzheimer's disease (pAD) subjects compared with control (CT) subjects using liquid chromatography and electrospray ionization tandem mass spectrometry (LCMS2). We recruited gender- and
Susan B Goldhaber
Regulatory toxicology and pharmacology : RTP, 38(2), 232-242 (2003-10-11)
Risk assessment of essential trace elements examines high intakes resulting in toxicity and low intakes resulting in nutritional deficiencies. This paper analyzes the risk assessments carried out by several U.S. governmental and private organizations for eight essential trace elements: chromium
Phillip Ringel et al.
The Journal of biological chemistry, 288(20), 14657-14671 (2013-03-30)
Nitrate reductase (NR) is a complex molybdenum cofactor (Moco)-dependent homodimeric metalloenzyme that is vitally important for autotrophic organism as it catalyzes the first and rate-limiting step of nitrate assimilation. Beside Moco, eukaryotic NR also binds FAD and heme as additional
Takashi Abe et al.
Neuroscience letters, 336(2), 105-108 (2002-12-25)
In order to investigate the possible role of oxidative RNA damage in the pathogenesis of Parkinson's disease (PD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with
Reijo Sillanpää et al.
Acta crystallographica. Section C, Crystal structure communications, 69(Pt 5), 509-512 (2013-05-01)
The title cocrystal contains two chiral conformational diastereomers, viz. (1S,2R,RN)- and (1S,2R,SN)-, of [2,4-di-tert-butyl-6-{[(1-oxido-1-phenylpropan-2-yl)(methyl)amino]methyl}phenolato](methanol)-cis-dioxidomolybdenum(VI), [Mo(C25H35NO2)O2(CH3OH)], representing the first example of a structurally characterized molybdenum complex with enantiomerically pure ephedrine derivative ligands. The Mo(VI) cations exhibit differently distorted octahedral coordination environments
Jian-Ming Lü et al.
Biochemical pharmacology, 86(9), 1328-1337 (2013-09-03)
Hyperuricemia, excess of uric acid in the blood, is a clinical problem that causes gout and is also considered a risk factor for cardiovascular disease. The enzyme xanthine oxidase (XO) produces uric acid during the purine metabolism; therefore, discovering novel
Goran Gajski et al.
Biochimica et biophysica acta, 1840(1), 565-576 (2013-10-22)
The main objective of the present study was to investigate chemical composition and possible cyto/genotoxic potential of several medical implant materials commonly used in total hip joint replacement. Medical implant metal alloy (Ti6Al4V and CoCrMo) and high density polyethylene particles
Humberto Terrones et al.
Scientific reports, 3, 1549-1549 (2013-03-27)
Although bulk hexagonal phases of layered semiconducting transition metal dichalcogenides (STMD) such as MoS2, WS2, WSe2 and MoSe2 exhibit indirect band gaps, a mono-layer of STMD possesses a direct band gap which could be used in the construction of novel
Shigeyuki Kitamura et al.
Drug metabolism and pharmacokinetics, 21(2), 83-98 (2006-05-17)
Molybdenum hydroxylases, which include aldehyde oxidase and xanthine oxidoreductase, are involved in the metabolism of some medicines in humans. They exhibit oxidase activity towards various heterocyclic compounds and aldehydes. The liver cytosol of various mammals also exhibits a significant reductase
Luis M Rubio et al.
Annual review of microbiology, 62, 93-111 (2008-04-24)
The iron-molybdenum cofactor (FeMo-co), located at the active site of the molybdenum nitrogenase, is one of the most complex metal cofactors known to date. During the past several years, an intensive effort has been made to purify the proteins involved
Costanza Baldisserotto et al.
Plant physiology and biochemistry : PPB, 70, 387-395 (2013-07-09)
The aquatic plant Trapa natans L. is highly resistant to Mn and moderately resistant to Mo, mainly thanks to its ability to sequestrate the metals by chelation in the vacuole. Excess of Mn and Mo causes somewhat aspecific toxicity symptoms
Ya Yan et al.
Nanoscale, 5(17), 7768-7771 (2013-07-26)
In this work, a networked MoS2/CNT nanocomposite has been synthesized by a facile solvothermal method. The as-prepared sample exhibits high catalytic activity for electrocatalytic hydrogen evolution.
Russ Hille
Archives of biochemistry and biophysics, 433(1), 107-116 (2004-12-08)
Unlike monooxygenases, molybdenum-containing hydroxylases catalyze the hydroxylation of carbon centers using oxygen derived ultimately from water, rather than O(2), as the source of the oxygen atom incorporated into the product, and do not require an external source of reducing equivalents.
John H Enemark et al.
Dalton transactions (Cambridge, England : 2003), (29)(29), 3501-3514 (2006-07-21)
Sulfite oxidizing enzymes (SOEs) are physiologically vital and occur in all forms of life. During the catalytic cycle the five-coordinate square-pyramidal oxo-molybdenum active site passes through the Mo(v) state, and intimate details of the structure can be obtained from pulsed
Haotian Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(49), 19701-19706 (2013-11-20)
The ability to intercalate guest species into the van der Waals gap of 2D layered materials affords the opportunity to engineer the electronic structures for a variety of applications. Here we demonstrate the continuous tuning of layer vertically aligned MoS2
Marie-Christine Hoffmann et al.
Journal of bacteriology, 196(3), 633-640 (2013-11-26)
Rhodobacter capsulatus is able to grow with N2 as the sole nitrogen source using either a molybdenum-dependent or a molybdenum-free iron-only nitrogenase whose expression is strictly inhibited by ammonium. Disruption of the fdxD gene, which is located directly upstream of
Beatrice Bocca et al.
Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)
The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <
Mohammad-Reza Rashidi et al.
Expert opinion on drug metabolism & toxicology, 6(2), 133-152 (2010-01-26)
Molybdenum hydroxylases, aldehyde oxidase and xanthine oxidase, are metalloflavoproteins that catalyze both oxidation and reduction of a broad range of drugs and other xenobiotics indicating the importance of these enzymes in drug oxidation, detoxification and activation. Both enzymes are also
Anna Panagiotidou et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 31(12), 2032-2039 (2013-08-24)
Widespread concern exists about adverse tissue reactions after metal-on-metal (MoM) total hip replacement (THR). Concerns have also been expressed with wear and corrosion of taper junctions in THR. We report the effect of surface finish and contact area associated with
Rupert Purchase
Science progress, 96(Pt 1), 19-32 (2013-06-07)
Wilson's disease is a rare autosomal recessive disease characterised by the deposition of copper in the brain, liver; cornea, and other organs. The overload of copper inevitably leads to progressive liver and neurological dysfunction. Copper overload in patients with Wilson's
Maria João Romão
Dalton transactions (Cambridge, England : 2003), (21)(21), 4053-4068 (2009-05-20)
Molybdenum and tungsten enzymes which contain the pyranopterin cofactor are ubiquitous in Nature and perform a wide variety of biological functions. They catalyze a diversity of mostly two-electron oxidation-reduction reactions crucial in the metabolism of nitrogen, sulfur and carbon. These
Pulakesh Maity et al.
Organic letters, 15(24), 6246-6249 (2013-11-12)
α-Stannylated and α-iodinated enamides can easily be obtained by molybdenum-catalyzed regio- and stereoselective hydrostannation and subsequent tin-iodine exchange. These functionalized enamides are interesting building blocks for a wide range of cross-coupling reactions giving access to various types of α-substituted enamides.
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