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Showing 1-30 of 7647 results for "41639" within Papers
Mimi C Yung et al.
Journal of bacteriology, 197(19), 3160-3172 (2015-07-22)
The ubiquitous aquatic bacterium Caulobacter crescentus is highly resistant to uranium (U) and facilitates U biomineralization and thus holds promise as an agent of U bioremediation. To gain an understanding of how C. crescentus tolerates U, we employed transposon (Tn)
Jae Ho Jo et al.
Biomedical materials (Bristol, England), 10(4), 045007-045007 (2015-07-15)
This study was undertaken to evaluate the effects of different rhBMP-2 release profiles in defect areas around dental implants on osseointegration and bone regeneration. Four beagle dogs (13-15 kg) were used. The defect was 3 mm deep and there was a 1 mm
Chantal Zevenbergen et al.
The Journal of clinical endocrinology and metabolism, 99(11), E2429-E2436 (2014-08-21)
Thyroid hormones (TH) are important for normal brain development and abnormal TH regulation in the brain results in neurocognitive impairments. The type 2 deiodinase (D2) is important for local TH control in the brain by generating the active hormone T3
Servet Tural et al.
Chirality, 27(9), 635-642 (2015-07-07)
In this study, the combined use of the selectivity of metal chelate affinity chromatography with the capacity of epoxy supports to immobilize poly-His-tagged recombinant benzoylformate decarboxylase from Pseudomonas putida (BFD, E.C. 4.1.1.7) via covalent attachment is shown. This was achieved
Ahmadreza Sardarian et al.
Toxicology mechanisms and methods, 25(2), 98-104 (2014-11-25)
Cyclosporine A (CsA) is an immunosuppressive agent administered to transplant patients. A well-known reported oral side effect of CsA consumption is gingival overgrowth (GO). Changes in the expression of integrins occurring in the gingiva following CsA treatment have been reported
Benito Campos et al.
Glia, 63(10), 1850-1859 (2015-05-07)
Measuring concentrations of the differentiation-promoting hormone retinoic acid (RA) in glioblastoma tissues would help to understand the reason why RA treatment has been inefficient in clinical trials involving brain tumor patients. Here, we apply a recently established extraction and measurement
[Dimethyl sulfoxide in experimental and clinical medicine. The achievements and prospects].
G M Iakovlev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 55(4), 74-76 (1992-07-01)
Mingliang Fan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 268-273 (2015-03-18)
The nonspecific toxicity of anticancer drug doxorubicin (DOX) toward both tumor and normal cells can result in serious side effects, thereby limiting its clinical applications. In this wok, epidermal growth factor receptor (EGFR) antagonist peptide GE11 was introduced into DOX
Influence of a survivin suppressor YM155 on the chemoresistance of canine histiocytic sarcoma cells.
Hiroki Yamazaki et al.
Veterinary journal (London, England : 1997), 205(3), 375-380 (2015-06-07)
Histiocytic sarcoma (HS) in dogs exhibits aggressive biological behaviors and currently few effective treatments are available. Survivin could serve as a potential therapeutic target in several cancers. Sepantronium bromide (YM155) is a potential novel survivin-targeting agent and in this study
Anke Doller et al.
Experimental cell research, 330(1), 66-80 (2014-09-23)
The impact of the RNA-binding protein HuR for the post-transcriptional deregulation of tumor-relevant genes is well established. Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high grade of malignancy.
Xiao-Long Hu et al.
Environmental toxicology and pharmacology, 40(1), 230-240 (2015-07-15)
Oxidative stress mediates the cell damage in several neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease (AD) and Parkinson's disease (PD). This study aimed at investigating the protective effects of Kukoamine B (KuB) against hydrogen peroxide (H2O2) induced cell injury and
Minjia Sheng et al.
Journal of peptide science : an official publication of the European Peptide Society, 20(10), 803-810 (2014-06-27)
LfcinB9 is a peptide derived from lactoferricin B. In the present study, the effect and relative mechanism of LfcinB9 on human ovarian cancer cell line (SK-OV-3) in vitro and in vivo was investigated. The data obtained indicated that LfcinB9 exhibited
Daniel Paull et al.
Nature methods, 12(9), 885-892 (2015-08-04)
Induced pluripotent stem cells (iPSCs) are an essential tool for modeling how causal genetic variants impact cellular function in disease, as well as an emerging source of tissue for regenerative medicine. The preparation of somatic cells, their reprogramming and the
Tian-Yu Fan et al.
International journal of clinical and experimental pathology, 7(10), 6662-6670 (2014-11-18)
Glioblastoma remains among the most devastating cancers with a median survival of less than 15 months and virtually no survival beyond five years. Currently, the treatment of glioma includes surgery, radiation therapy, chemotherapy, and comprehensive treatment. Intrinsic or acquired resistance
Jannatul Firdous et al.
Acta biomaterialia, 10(11), 4606-4617 (2014-08-12)
Respiratory syncytial virus (RSV) is one of the most common causes of viral deaths in infants worldwide, yet no effective vaccines are available. Here, we report an osmotically active polysaccharide-based polysorbitol transporter (PST) prepared from sorbitol diacrylate and low-molecular-weight polyethylenimine
Xi Tang et al.
Oncotarget, 5(5), 1352-1362 (2014-03-25)
The development of effective therapies inhibiting prostate cancer progression and metastasis may substantially impact prostate cancer mortality and potentially reduce the rates of invasive treatments by enhancing the safety of active surveillance strategies. Hepsin (HPN) is a cell surface serine
Zhuo-heng Li et al.
Photochemistry and photobiology, 90(6), 1368-1375 (2014-07-30)
Hypericin (HY) is a promising photosensitizer (PS) for use in photodynamic therapy (PDT). Port-wine stains (PWSs) are congenital superficial dermal capillary malformations. In this study, we evaluated the photocytotoxic effects of HY for PDT in human vascular endothelial cells and
Haiyan Qi et al.
CNS neuroscience & therapeutics, 20(11), 991-998 (2014-10-21)
The immunosuppressant drug rapamycin was reported to have an antiaging activity, which was attributed to the TORC1 inhibition that inhibits cell proliferation and increases autophagy. However, rapamycin also exhibits a number of harmful adverse effects. Whether rapamycin can be developed
Hideki Mizusako et al.
Journal of pharmaceutical sciences, 104(9), 2934-2940 (2015-05-06)
Active drug targeting is an effective therapeutic approach for the treatment of malignant cancers and novel types of drug carriers have been developed. In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-β-CD-ss-DOX, which has folic acid
Roger A J Habets et al.
The Journal of biological chemistry, 290(23), 14705-14716 (2015-04-29)
Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in
Brandon S Bentzley et al.
The European journal of neuroscience, 41(9), 1149-1156 (2015-03-11)
The orexin/hypocretin system is involved in multiple cocaine addiction processes that involve drug-associated environmental cues, including cue-induced reinstatement of extinguished cocaine seeking and expression of conditioned place preference. However, the orexin system does not play a role in several behaviors
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)
Hayato Nishida et al.
Regulatory toxicology and pharmacology : RTP, 72(3), 578-585 (2015-06-07)
Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not be evaluated because their molecular weight
Devin H Currie et al.
BMC systems biology, 9, 30-30 (2015-06-27)
Thermoanaerobacterium saccharolyticum is a hemicellulose-degrading thermophilic anaerobe that was previously engineered to produce ethanol at high yield. A major project was undertaken to develop this organism into an industrial biocatalyst, but the lack of genome information and resources were recognized
Chia-Chun Yu et al.
Journal of biomedical science, 22, 2-2 (2015-01-08)
Hormone-refractory prostate cancer (HRPC), which is resistant to hormone therapy, is a major obstacle in clinical treatment. An approach to inhibit HRPC growth and ultimately to kill cancers is highly demanded. KUD773 induced the anti-proliferative effect and subsequent apoptosis in
Chester E Chamberlain et al.
The Journal of clinical investigation, 124(9), 4093-4101 (2014-08-19)
Endocrine cell proliferation fluctuates dramatically in response to signals that communicate hormone demand. The genetic alterations that override these controls in endocrine tumors often are not associated with oncogenes common to other tumor types, suggesting that unique pathways govern endocrine
Matthew T Balmer et al.
Cancer biology & therapy, 15(8), 1000-1012 (2014-05-08)
The chemotherapeutic agents doxorubicin (dox) or 5-fluorouracil (5FU) are used to treat cancer cells as they cause irreparable DNA damage, inducing these aberrant cells to undergo cell death. The mediator of this process is presumed to be in part the
Daniel Grenier et al.
PloS one, 10(6), e0131758-e0131758 (2015-06-30)
Periodontitis that affects the underlying structures of the periodontium, including the alveolar bone, is a multifactorial disease, whose etiology involves interactions between specific bacterial species of the subgingival biofilm and the host immune components. In the present study, we investigated
Diletta Fontana et al.
Cancer medicine, 4(7), 953-965 (2015-03-03)
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor involved in both solid and hematological tumors. About 80% of ALK-positive anaplastic large-cell lymphoma (ALCL) cases are characterized by the t(2;5)(p23;q35) translocation, encoding for the aberrant fusion protein nucleophosmin (NPM)-ALK, whereas
Emanuela Santini et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(49), 16213-16220 (2015-12-15)
Angelman syndrome (AS) is a neurodevelopmental disorder associated with developmental delay, lack of speech, motor dysfunction, and epilepsy. In the majority of the patients, AS is caused by the deletion of small portions of maternal chromosome 15 harboring the UBE3A
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