- The effect of LfcinB9 on human ovarian cancer cell SK-OV-3 is mediated by inducing apoptosis.
The effect of LfcinB9 on human ovarian cancer cell SK-OV-3 is mediated by inducing apoptosis.
Journal of peptide science : an official publication of the European Peptide Society (2014-06-27)
Minjia Sheng, Yanjie Zhao, Aichen Zhang, Liyan Wang, Guizhen Zhang
PMID24965354
ABSTRACT
LfcinB9 is a peptide derived from lactoferricin B. In the present study, the effect and relative mechanism of LfcinB9 on human ovarian cancer cell line (SK-OV-3) in vitro and in vivo was investigated. The data obtained indicated that LfcinB9 exhibited low hemolysis activity and significantly inhibited the proliferation of SK-OV-3 cells in vitro. In addition, the apoptosis of SK-OV-3 cells was induced through up-regulating the production of reactive oxygen species and activating caspase-3, caspase-9 on both transcription and translation level. Finally, LfcinB9 significantly prevented the tumor growth in the SK-OV-3-bearing mice model. These results indicated that LfcinB9 could be a potential agent for the treatment of ovarian cancer.
MATERIALS
Product Number
Brand
Product Description
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