431311

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Phase I and phase II reductive metabolism simulation of nitro aromatic xenobiotics with electrochemistry coupled with high resolution mass spectrometry.

Ugo Bussy et al.

Analytical and bioanalytical chemistry, 406(28), 7253-7260 (2014-09-23)

Electrochemistry combined with (liquid chromatography) high resolution mass spectrometry was used to simulate the general reductive metabolism of three biologically important nitro aromatic molecules: 3-trifluoromethyl-4-nitrophenol (TFM), niclosamide, and nilutamide. TFM is a pesticide used in the Laurential Great Lakes while

Mercury concentrations in different tissues of turtle and caiman species from the Rio Purus, Amazonas, Brazil.

Sam Eggins et al.

Environmental toxicology and chemistry, 34(12), 2771-2781 (2015-09-22)

Total mercury (Hg) concentrations of muscle, liver, blood, and epidermal keratin were measured in typically consumed, economically and culturally important species of turtle (Podocnemis unifilis and Podocnemis expansa) and caiman (Melanosuchus niger and Caiman crocodilus) from the Rio Purus in

Immobilized pepsin microreactor for rapid peptide mapping with nanoelectrospray ionization mass spectrometry.

Ying Long et al.

Journal of the American Society for Mass Spectrometry, 26(1), 194-197 (2014-11-07)

Most enzymatic microreactors for protein digestion are based on trypsin, but proteins with hydrophobic segments may be difficult to digest because of the paucity of Arg and Lys residues. Microreactors based on pepsin, which is less specific than trypsin, can

Quantitative analysis of phenylalanine, tyrosine, tryptophan and kynurenine in rat model for tauopathies by ultra-high performance liquid chromatography with fluorescence and mass spectrometry detection.

Jaroslav Galba et al.

Journal of pharmaceutical and biomedical analysis, 117, 85-90 (2015-09-08)

We developed and validated a simple and sensitive ultra-high performance liquid chromatography (UHPLC) method for the analysis of phenylalanine (Phe), tyrosine (Tyr), tryptophan (Trp) and kynurenine (Kyn) in rat plasma. Analytes were separated on Acquity UPLC HSS T3 column (2.1

Using sheath-liquid reagents for capillary electrophoresis-mass spectrometry: application to the analysis of phenolic plant extracts.

Leila Maringer et al.

Electrophoresis, 36(2), 348-354 (2014-10-14)

The combination of CE and MS is now a widely used tool that can provide a combination of high resolution separations with detailed structural information. Recently, we highlighted the benefits of an approach to add further functionality to this well-established

Metabolic profiling of Gynostemma pentaphyllum extract in rat serum, urine and faeces after oral administration.

Dao-Jin Chen et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 42-52 (2014-08-26)

Folk drug Gynostemma pentaphyllum (Thunb.) Makino contains many biologically active phytochemicals which have been demonstrated to be effective against chronic diseases. As in vivo anti-tumor experiments of G. pentaphyllum extract (GP) show much stronger antitumor activities than in vitro, it

Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.

Sarah Afshordel et al.

Pharmacological research, 91, 69-77 (2014-12-17)

Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production

Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.

Yong-Gang Zhao et al.

Journal of chromatography. A, 1345, 17-28 (2014-05-02)

A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) procedure combined with ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS). The excellent core-shell

Sensitive and accurate liquid chromatography-tandem mass spectrometry methods for quantitative determination of a novel hepatitis C NS5B inhibitor BMS-791325 and its active metabolite in human plasma and urine.

Hao Jiang et al.

Journal of pharmaceutical and biomedical analysis, 107, 17-23 (2015-01-07)

BMS-791325 is a novel hepatitis C NS5B inhibitor which is currently in clinical development. To support pharmacokinetic (PK) assessments, sensitive, accurate, precise, and reproducible liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been developed and validated for the quantitation of BMS-791325

Screening and confirmation of myo-inositol trispyrophosphate (ITPP) in human urine by hydrophilic interaction liquid chromatography high resolution / high accuracy mass spectrometry for doping control purposes.

Christian Görgens et al.

Drug testing and analysis, 6(11-12), 1102-1107 (2014-07-30)

Myo-inositol trispyrophosphate (ITPP) is a novel allosteric effector of haemoglobin with high permeation selectivity across the red blood cell plasma membrane. Due to its potential to reduce the oxygen affinity of haemoglobin, ITPP application results in an enhanced oxygen release

Stereoselective inhibition of human butyrylcholinesterase by the enantiomers of bambuterol and their intermediates.

Marco Pistolozzi et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(3), 344-352 (2014-12-17)

This work describes the sequential hydrolysis of bambuterol enantiomers and their monocarbamate metabolites (MONO) catalyzed by human butyrylcholinesterase (BChE) as well as the enzyme inhibition resulting from this process. Particular emphasis is given to the contribution given by MONO to

Microminipigs as a new experimental animal model for toxicological studies: comparative pharmacokinetics of perfluoroalkyl acids.

Keerthi S Guruge et al.

Journal of applied toxicology : JAT, 36(1), 68-75 (2015-04-17)

In this study, we evaluated the efficacy of a novel minipig strain, the Microminipig (MMPig), as an animal model for studying the pharmacokinetics of a mixture of 10 perfluoroalkyl acids (PFAAs). After a single oral dose was given, we found

An UPLC-MS/MS method for quantitative profiling of bile acids in sea lamprey plasma and tissues.

Huiyong Wang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 72-78 (2015-01-16)

Bile acids (BAs) have recently gained more attention because of their diverse roles from digestion to signaling. Simultaneous analyses of various BAs in biological samples are challenging due to their structural similarity, relatively low concentrations, and the presence of isomeric

Evaluation of changes induced in rice metabolome by Cd and Cu exposure using LC-MS with XCMS and MCR-ALS data analysis strategies.

Meritxell Navarro-Reig et al.

Analytical and bioanalytical chemistry, 407(29), 8835-8847 (2015-09-26)

The comprehensive analysis of untargeted metabolomics data acquired using LC-MS is still a major challenge. Different data analysis tools have been developed in recent years such as XCMS (various forms (X) of chromatography mass spectrometry) and multivariate curve resolution alternating

Pharmacoproteomics-based reconstruction of in vivo P-glycoprotein function at blood-brain barrier and brain distribution of substrate verapamil in pentylenetetrazole-kindled epilepsy, spontaneous epilepsy, and phenytoin treatment models.

Yasuo Uchida et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1719-1726 (2014-07-26)

The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of

A single step reversed-phase high performance liquid chromatography separation of polar and non-polar lipids.

Petter Olsson et al.

Journal of chromatography. A, 1369, 105-115 (2014-12-03)

This paper reports a simple chromatographic system to separate lipids classes as well as their molecular species. By the use of phenyl coated silica as stationary phase in combination with a simple mobile phase consisting of methanol and water, all

Conjugated bisphenol A in maternal serum in relation to miscarriage risk.

Ruth B Lathi et al.

Fertility and sterility, 102(1), 123-128 (2014-04-22)

To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk. Retrospective cohort of prospectively collected serum samples. Academic fertility center. Women presenting for early pregnancy monitoring with

Comparative pharmacokinetic profiles of five poorly soluble pulchinenosides in different formulations from Pulsatilla chinensis saponins extracts for enhanced bioavailability.

Jun Huang et al.

Biomedical chromatography : BMC, 29(12), 1885-1892 (2015-05-29)

Pulsatilla chinensis, a traditional Chinese medicine (TCM), has been used for treating amoebic diseases, vaginal trichomoniasis and bacterial infections over a long history. Now growing attention has been attracted to its antitumor activities. The purpose of this work was to

Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions.

Anna C Susa et al.

Journal of the American Chemical Society, 136(37), 12912-12919 (2014-08-22)

Human islet amyloid polypeptide (hIAPP or Amylin) is a 37 residue hormone that is cosecreted with insulin from the pancreatic islets. The aggregation of hIAPP plays a role in the progression of type 2 diabetes and contributes to the failure

Evaluation of a nonpeptidic ligand for imaging of cholecystokinin 2 receptor-expressing cancers.

Charity Wayua et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(1), 113-119 (2014-12-17)

Tumor-specific targeting ligands were recently exploited to deliver both imaging and therapeutic agents selectively to cancer tissues in vivo. Because the cholecystokinin 2 receptor (CCK2R) is overexpressed in various human cancers (e.g., lung, medullary thyroid, pancreatic, colon, and gastrointestinal stromal

Stability indicating LC method for rapid determination of related substances of O-desmethyl venlafaxine in active pharmaceutical ingredients and pharmaceutical formulations.

Karri Visweswara Rao et al.

Journal of chromatographic science, 52(10), 1247-1254 (2014-01-30)

A simple, precise and accurate stability-indicating reversed phase-high performance liquid chromatography method was developed for the quantitative determination of O-desmethyl venlafaxine (ODV) and its related substances in active pharmaceutical ingredient and pharmaceutical formulation. The method was developed using YMC-pack ODS-A

Identification of metabolic markers in coronary artery disease using an untargeted LC-MS based metabolomic approach.

Trayambak Basak et al.

Journal of proteomics, 127(Pt A), 169-177 (2015-03-21)

Coronary artery disease (CAD), a complex metabolic disorder, is one of the largest causes of death worldwide. Both environmental and genetic factors contribute to the etiology of this metabolic disease. The gene-environment interaction could lead to modulation of various metabolic

Quantification of recombinant human erythropoietin by amino acid analysis using isotope dilution liquid chromatography-tandem mass spectrometry.

Jung-Hyuk Yim et al.

Analytical and bioanalytical chemistry, 406(18), 4401-4409 (2014-05-21)

Herein, we describe an accurate method for protein quantification based on conventional acid hydrolysis and an isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry method. The analyte protein, recombinant human erythropoietin (rhEPO), was effectively hydrolyzed by incubation with 8 mol/L hydrochloric

Utilization of molasses based distillery effluent for fertigation of sugarcane.

P C Srivastava et al.

Biodegradation, 23(6), 897-905 (2012-08-14)

A field study was carried out to monitor the effect of application of molasses based distillery effluent on yields of sugarcane and soil properties. The treatments consisted of main plots: control (I0), first pre-sowing irrigation with undiluted effluent (I1), one

Electrospray ionization-induced protein unfolding.

Hong Lin et al.

Journal of the American Society for Mass Spectrometry, 23(12), 2122-2131 (2012-09-21)

Electrospray ionization mass spectrometry (ESI-MS) measurements were performed under a variety of solution conditions on a highly acidic sub-fragment (B3C) of the C-terminal carbohydrate-binding repeat region of Clostridium difficile toxin B, and two mutants (B4A and B4B) containing fewer acidic

Emerging organic contaminants in coastal waters: anthropogenic impact, environmental release and ecological risk.

Jheng-Jie Jiang et al.

Marine pollution bulletin, 85(2), 391-399 (2014-01-21)

This study provides a first estimate of the sources, distribution, and risk presented by emerging organic contaminants (EOCs) in coastal waters off southwestern Taiwan. Ten illicit drugs, seven nonsteroidal anti-inflammatory drugs (NSAIDs), five antibiotics, two blood lipid regulators, two antiepileptic

Untargeted metabolomic analysis using liquid chromatography quadrupole time-of-flight mass spectrometry for non-volatile profiling of wines.

M Arbulu et al.

Analytica chimica acta, 858, 32-41 (2015-01-20)

The current study presents a method for comprehensive untargeted metabolomic fingerprinting of the non-volatile profile of the Graciano Vitis vinifera wine variety, using liquid chromatography/electrospray ionization time of flight mass spectrometry (LC-ESI-QTOF). Pre-treatment of samples, chromatographic columns, mobile phases, elution

Enhanced electrospray ionization mass spectrometric detection of hexamethylene triperoxide diamine (HMTD) after oxidation to tetramethylene diperoxide diamine dialdehyde (TMDDD).

Tomasz Krawczyk

Rapid communications in mass spectrometry : RCM, 29(23), 2257-2262 (2015-11-03)

Hexamethylene triperoxide diamine (HMTD) is one of the peroxide-based explosives that are difficult to detect using standard analytical methodologies. It was analyzed by electrospray ionization mass spectrometry (ESI-MS) on a UPLC-TOF instrument. Alkali metal salts were used to promote the

Determination of nonpolar and polar lipid classes in human plasma, erythrocytes and plasma lipoprotein fractions using ultrahigh-performance liquid chromatography-mass spectrometry.

Michal Holčapek et al.

Journal of chromatography. A, 1377, 85-91 (2014-12-30)

A novel normal-phase (NP) ultrahigh-performance liquid chromatography-mass spectrometry (UHPLC/MS) method is developed for a separation and quantitation of nonpolar lipid classes occurring in human plasma, erythrocytes and plasma lipoprotein fractions. The baseline class separation of cholesteryl esters (CE), cholesterol, triacylglycerols

An eco-friendly regeneration of aldehydes exploiting ammonium acetate under microwave irradiation.

Mitra AK, et al.

J. Chem. Res. (M), 2004(3), 237-239 (2004)

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