438081

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Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.

Catalin Koro et al.

European journal of immunology, 44(11), 3403-3412 (2014-08-19)

Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase-dependent cyanate (CNO-) formation. We analyzed the pattern of human IgG1 carbamylation under

Rapid quantitative determination of related substances and degradants in milnacipran.

Surya Prakash Rao Pydimarry et al.

Journal of chromatographic science, 52(1), 42-51 (2012-12-22)

A simple, sensitive, precise and accurate stability-indicating ultra-performance liquid chromatography (UPLC) method was developed for the quantitative determination of the purity of the active pharmaceutical ingredient of milnacipran hydrochloride (MCP) and its pharmaceutical dosage form in the presence of its

A grape seed extract increases active glucagon-like peptide-1 levels after an oral glucose load in rats.

Noemi González-Abuín et al.

Food & function, 5(9), 2357-2364 (2014-08-05)

We have previously reported that procyanidins, a class of flavonoids, improve glycemia and exert an incretin-like effect, which was linked to their proven inhibitory effect on the dipeptidyl-peptidase 4 (DPP4) activity. However, their actual effect on incretin levels has not

Universal or Multi-mode Adhesives: Why and How?

Jorge Perdigão et al.

The journal of adhesive dentistry, 16(2), 193-194 (2014-04-24)

Production of monosaccharides from napier grass by hydrothermal process with phosphoric acid.

Eri Takata et al.

Bioresource technology, 143, 53-58 (2013-06-20)

The production of monosaccharides from napier grass was investigated in the presence of acid catalysts using the hydrothermal process. When the napier grass was treated with 3 wt.% phosphoric acid at 160°C for 15min, the xylose yield reached 10.3 wt.%

Enantioselective synthesis of multisubstituted biaryl skeleton by chiral phosphoric acid catalyzed desymmetrization/kinetic resolution sequence.

Keiji Mori et al.

Journal of the American Chemical Society, 135(10), 3964-3970 (2013-02-19)

Described herein is the enantioselective synthesis of multisubstituted biaryl derivatives by chiral phosphoric acid catalyzed asymmetric bromination. Two asymmetric reactions (desymmetrization and kinetic resolution) proceeded successively to afford chiral biaryls in excellent enantioselectivities (up to 99% ee). Both experimental and

Microparticles of rifampicin: comparison of pulmonary route with oral route for drug uptake by alveolar macrophages, phagocytosis activity and toxicity study in albino rats.

Rajesh Parikh et al.

Drug delivery, 21(6), 406-411 (2013-11-13)

Tuberculosis (TB) is a chronic infectious disease with increasing incidence of drug resistance. Oral treatment for TB and multidrug resistance (MDR)-TB can have serious side effects. The causative agent of TB, Mycobacterium tuberculosis, resides in alveolar macrophages (AM). Pulmonary administration

Determination of chlorophenols in honey samples using in-situ ionic liquid-dispersive liquid-liquid microextraction as a pretreatment method followed by high-performance liquid chromatography.

Chen Fan et al.

Food chemistry, 174, 446-451 (2014-12-23)

In-situ ionic liquid-dispersive liquid-liquid microextraction (IL-DLLME) method was developed as a pretreatment method for the detection of six chlorophenols (CPs) in honey samples. The hydrophobic ionic liquid [C4MIM][NTf2], formed in-situ by the hydrophilic ionic liquid [C4MIM][BF4] and the ion exchange

Development of a CZE method for the quantification of pseudoephedrine and cetirizine.

Ahmed O Alnajjar et al.

Journal of chromatographic science, 52(9), 1104-1108 (2013-09-24)

Pseudoephedrine and cetirizine have been combined in dosage forms with more therapeutic benefits when compared with single-drug treatment. The current manuscript reports the development of the first capillary zone electrophoresis (CZE) assay method for that combination. The effects of pH

Stability of a highly concentrated solution of epirubicin for conventional transcatheter arterial chemoembolization.

Youssef Bennis et al.

International journal of pharmaceutics, 495(2), 956-962 (2015-10-11)

Epirubicin is widely used for conventional transcatheter arterial chemoembolization (cTACE) in patients with hepatocellular-carcinoma. However, there is no data about its stability in solution at concentration higher than 2 mg/L, yet needed when mixing it with a standard volume of

Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts.

Kwang-Jin Kim et al.

Bone, 81, 208-216 (2015-07-26)

Bone sustains its structure through dynamic interaction between osteoblastic cells and osteoclastic cells. But imbalance may lead to osteoporosis caused by overactivated osteoclast cells that have bone-resorbing function. Recently, herbs have been researched as major sources of medicines in many

Novel cerium doped glass-reinforced hydroxyapatite with antibacterial and osteoconductive properties for bone tissue regeneration.

D S Morais et al.

Biomedical materials (Bristol, England), 10(5), 055008-055008 (2015-09-24)

The aim of this work was to develop a bioactive bone substitute with an effective antibacterial ability based on a cerium (Ce) doped glass-reinforced hydroxyapatite (GR-HA) composite. Developed composites were physicochemically characterized, using x-ray diffraction (XRD) analysis, SEM, energy dispersive

Levels of nicotine in Ethiopian tobacco leaves.

Zebasil Tassew et al.

SpringerPlus, 4, 649-649 (2015-11-07)

Tobacco is a valuable cash crop. It is the most widely grown non-food crop in the world. Tobacco use is widespread due to its addictive nature of its main constituent nicotine. Therefore, the knowledge of nicotine level in tobacco is

Differentiation of degrees of ripeness of Catuai and Tipica green coffee by chromatographical and statistical techniques.

Samo Smrke et al.

Food chemistry, 174, 637-642 (2014-12-23)

The quality of green coffee is influenced by the degree of ripeness of the fruit at harvest. The aim of this study was to identify chemical markers differentiating between degrees of ripeness. Two coffee varieties, Catuai and Tipica, from the

Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events.

Jürgen Borlak et al.

BMC genomics, 16, 124-124 (2015-04-16)

Hepatocellular carcinoma (HCC) is on the rise and the sixth most common cancer worldwide. To combat HCC effectively research is directed towards its early detection and the development of targeted therapies. Given the fact that epidermal growth factor (EGF) is

Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity.

Hongrui Xia et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(6), 906-911 (2014-02-20)

Salvianolic acid A (Sal A), an important constituent of Radix Salviae Miltiorrhizae (RSM), is effective for the treatment of myocardial infarction (MI) and coronary heart disease due to its potential in the improvement of acute myocardial ischemia. However, its content

Positioning self-etching adhesives: versus or in addition to phosphoric acid etching?

Claus-Peter Ernst

Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 16(1), 57-69 (2004-07-21)

High affinity anti-Internalin B VHH antibody fragments isolated from naturally and artificially immunized repertoires.

Robert W Gene et al.

Journal of immunological methods, 416, 29-39 (2014-12-03)

The need for rapid and easy technologies for the detection of food-borne and environmental pathogens is essential for safeguarding the health of populations. Furthermore, distribution of tainted food and water can have consequences which can affect whole economies. Antibodies and

Rapid screening of oleuropein from olive leaves using matrix solid-phase dispersion and high-performance liquid chromatography.

Marzieh Rashidipour et al.

Journal of AOAC International, 97(4), 1109-1113 (2014-08-26)

Matrix solid-phase dispersion (MSPD) methodology as a quick and easy extraction method has been developed to extract oleuropein from Olea europaea leaves. This method has been compared with conventional maceration and Soxhlet extraction (SOXE) methods. Variables affecting MSPD, such as

Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice.

Amit Naskar et al.

Journal of pineal research, 58(3), 262-274 (2015-01-30)

L-3,4-dihydroxyphenylalanine (L-DOPA) reduces symptoms of Parkinson's disease (PD), but suffers from serious side effects on long-term use. Melatonin (10-30 mg/kg, 6 doses at 10 hr intervals) was investigated to potentiate L-DOPA therapeutic effects in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in mice. Striatal

Protective Effect of Lavandula stoechas and Rosmarinus officinalis essential oils against reproductive damage and oxidative stress in alloxan-induced diabetic rats.

Hichem Sebai et al.

Journal of medicinal food, 18(2), 241-249 (2014-08-12)

The authors aimed in the present study to assess the protective effect of Rosmarinus officinalis essential oils (ROEO) and Lavandula stoechas essential oils (LSEO) against reproductive damage and oxidative stress in alloxan-induced diabetic male rats. Essential oil samples were obtained

Application of Plant Extracts for the Prevention of Dental Erosion: An in situ/in vitro Study.

Marie-Theres Weber et al.

Caries research, 49(5), 477-487 (2015-08-01)

Antiadherent and antibacterial effects of certain plant extracts have been proven to be beneficial in preventive dentistry. In the present in situ/in vitro crossover study, the impact of plant extracts rich in polyphenols on the erosion-protective properties of the in

Determining canine skin concentrations of terbinafine to guide the treatment of Malassezia dermatitis.

Jacqueline R Gimmler et al.

Veterinary dermatology, 26(6), 411-416 (2015-08-20)

Terbinafine (TBF) is known to concentrate and persist in human skin. Its use is increasing in veterinary medicine, but there are limited data concerning its tissue concentration and efficacy in dogs. (i) Describe TBF accumulation in canine skin; (ii) Integrate

Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment.

Atsushi Saito et al.

Science translational medicine, 7(313), 313ra181-313ra181 (2015-11-13)

Pulmonary alveolar microlithiasis (PAM) is a rare, autosomal recessive lung disorder associated with progressive accumulation of calcium phosphate microliths. Inactivating mutations in SLC34A2, which encodes the NPT2b sodium-dependent phosphate cotransporter, has been proposed as a cause of PAM. We show

Spectrophotometric and spectrofluorimetric determination of indacaterol maleate in pure form and pharmaceutical preparations: application to content uniformity.

S M El-Ashry et al.

Luminescence : the journal of biological and chemical luminescence, 30(6), 891-897 (2015-01-27)

Two simple, rapid, sensitive and precise spectrophotometric and spectrofluorimetric methods were developed for the determination of indacaterol maleate in bulk powder and capsules. Both methods were based on the direct measurement of the drug in methanol. In the spectrophotometric method

Optimization of polyphenols extraction from dried chokeberry using maceration as traditional technique.

Nada Ćujić et al.

Food chemistry, 194, 135-142 (2015-10-17)

Traditional maceration method was used for the extraction of polyphenols from chokeberry (Aronia melanocarpa) dried fruit, and the effects of several extraction parameters on the total phenolics and anthocyanins contents were studied. Various solvents, particle size, solid-solvent ratio and extraction

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway.

Dennis Y Chuang et al.

Journal of neuroinflammation, 12, 199-199 (2015-11-02)

Oxidative stress and inflammation are important factors contributing to the pathophysiology of numerous neurological disorders, including Alzheimer's disease, Parkinson's disease, acute stroke, and infections of the brain. There is well-established evidence that proinflammatory cytokines and glutamate, as well as reactive

Budesonide dry powder for inhalation: effects of leucine and mannitol on the efficiency of delivery.

Teerarat Rattanupatam et al.

Drug delivery, 21(6), 397-405 (2014-01-10)

The aim of this study was to develop a budesonide dry powder for inhalation using l-leucine and l-leucine - sieved mannitol as a carrier. Budesonide and l-leucine were co-spray dried at a mass ratio of 1:50 then blended with various

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Bing Li et al.

mAbs, 6(5), 1255-1264 (2014-12-18)

Pharmacokinetic (PK) testing of a humanized (κI, VH3 framework) and affinity matured anti-hepatitis C virus E2-glycoprotein (HCV-E2) antibody (hu5B3.κ1VH3.v3) in rats revealed unexpected fast clearance (34.9 mL/day/kg). This antibody binds to the rat recycling receptor FcRn as expected for a human

Protective effect of Euterpe oleracea Mart (açaí) extract on programmed changes in the adult rat offspring caused by maternal protein restriction during pregnancy.

Graziele Freitas de Bem et al.

The Journal of pharmacy and pharmacology, 66(9), 1328-1338 (2014-04-15)

This study examined the effect of açaí (Euterpe oleracea Mart.) seed extract (ASE) on cardiovascular and renal alterations in adult offspring, whose mothers were fed a low-protein (LP) diet during pregnancy. Four groups of rats were fed: control diet (20% protein);

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