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Sung Ho Jang et al.
Neural plasticity, 2015, 679815-679815 (2015-08-01)
The red nucleus (RN) is involved in motor control and it is known to have potential to compensate for injury of the corticospinal tract (CST). We investigated the change of connectivity of the RN (RNc) and its relation to motor
Maria Scaturro et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(4), 330-341 (2015-01-06)
Legionella pneumophila is a pathogen widespread in aquatic environment, able to multiply both within amoebae and human macrophages. The aim of this study was to identify genes differently expressed in a spontaneous avirulent Legionella pneumophila serogroup 6 mutant, named Vir-
Chan Hee Park et al.
International journal of cancer, 136(10), 2273-2283 (2014-10-28)
In recent years, characterization of cancer and its environment has become necessary. However, studies of the cancer microenvironment remain insufficient. Copy number variations (CNVs) occur in 40% of cancer-related genes, but few studies have reported the correlation between CNVs in
Jonathan Lo et al.
Journal of bacteriology, 197(18), 2920-2929 (2015-07-01)
NfnAB catalyzes the reversible transfer of electrons from reduced ferredoxin and NADH to 2 NADP(+). The NfnAB complex has been hypothesized to be the main enzyme for ferredoxin oxidization in strains of Thermoanaerobacterium saccharolyticum engineered for increased ethanol production. NfnAB
Janet K Horton et al.
Radiation research, 184(5), 456-469 (2015-10-22)
Although a standardized approach to radiotherapy has been used to treat breast cancer, regardless of subtype (e.g., luminal, basal), recent clinical data suggest that radiation response may vary significantly among subtypes. We hypothesized that this clinical variability may be due
Benjamin J Reed et al.
The Journal of biological chemistry, 290(33), 20601-20612 (2015-07-08)
In the canonical view of protein function, it is generally accepted that the three-dimensional structure of a protein determines its function. However, the past decade has seen a dramatic growth in the identification of proteins with extensive intrinsically disordered regions
Jeremy S Toma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 1291-1306 (2015-01-23)
Induced pluripotent cell-derived motoneurons (iPSCMNs) are sought for use in cell replacement therapies and treatment strategies for motoneuron diseases such as amyotrophic lateral sclerosis (ALS). However, much remains unknown about the physiological properties of iPSCMNs and how they compare with
Si Li et al.
The Journal of clinical endocrinology and metabolism, 99(11), E2298-E2307 (2014-07-26)
BAG3 plays a regulatory role in a number of cellular processes. Recent studies have attracted much attention on its role in activation of selective autophagy. In addition, we have very recently reported that BAG3 is implicated in a BECN1-independent autophagy
Bogdan I Fedeles et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(33), E4571-E4580 (2015-08-06)
During chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the genomic accumulation of 5-chlorocytosine (5ClC), a known inflammation biomarker. Although 5ClC has been shown to promote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetrates a
Inga Klimczak et al.
Food chemistry, 175, 100-105 (2015-01-13)
Ultra performance liquid chromatography (UPLC) and high-performance liquid chromatography (HPLC) methods for determination of ascorbic acid (AA) and total AA (TAA) contents (as the sum of AA and dehydroascorbic acid (DHAA) after its reduction to AA) in fruit beverages and
Youjun Xiao et al.
Rheumatology (Oxford, England), 53(7), 1291-1300 (2014-03-07)
Increasing evidence indicates that the cytoskeletal protein ezrin may play a critical role in cell motility. This study aims to investigate the role of ezrin in regulating the migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with RA. Synovial
Salah Edin El Meshri et al.
Journal of molecular biology, 427(6 Pt B), 1480-1494 (2015-02-04)
The Pr55 Gag of human immunodeficiency virus type 1 orchestrates viral particle assembly in producer cells, which requires the genomic RNA and a lipid membrane as scaffolding platforms. The nucleocapsid (NC) domain with its two invariant CCHC zinc fingers flanked
Michael B Murphy et al.
Journal of leukocyte biology, 98(6), 963-974 (2015-08-28)
Development of endotoxin tolerance in macrophages during sepsis reprograms Toll-like receptor 4 signaling to inhibit proinflammatory cytokines without suppressing anti-inflammatory and antimicrobial mediators and protects the host from excessive inflammation and tissue damage. However, endotoxin tolerance renders septic patients immunocompromised
Ayten Hijazi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4968-4977 (2015-08-19)
Developmental exposure to bisphenol A (BPA) is associated with lung dysfunction and diseases. However, it is unknown if this association has a fetal origin. The present study addressed this important question by examining the effects of BPA on fetal lung
Hsiang-En Hsu et al.
The Journal of biological chemistry, 290(27), 16786-16796 (2015-05-08)
Snf1, a member of the AMP-activated protein kinase family, plays a critical role in metabolic energy control in yeast cells. Snf1 activity is activated by phosphorylation of Thr-210 on the activation loop of its catalytic subunit; following activation, Snf1 regulates
Yu Zhao et al.
The Plant cell, 27(9), 2469-2483 (2015-08-27)
Crown roots are the main components of the fibrous root system in rice (Oryza sativa). WOX11, a WUSCHEL-related homeobox gene specifically expressed in the emerging crown root meristem, is a key regulator in crown root development. However, the nature of
A Rak-Mardyła et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(7), 493-498 (2014-03-15)
In a previous study, we showed that resistin expression increased during ovarian follicle development in prepubertal pigs and had direct effects on steroidogenesis, suggesting an important role for resistin in the ovary during puberty. To determine its potential regulatory role
Tobias Ettl et al.
Oral oncology, 51(2), 158-163 (2014-12-17)
Induction of apoptosis is a major mechanism of radiosensitivity in different types of cancer. In contrast, EGFR/PI3K/AKT signalling and recently the presence of so-called cancer stem cells are discussed as reasons for radioresistance. The study investigates mechanisms of apoptosis, key
Stephan Benke et al.
Nature communications, 6, 6198-6198 (2015-02-06)
Pore-forming toxins are protein assemblies used by many organisms to disrupt the membranes of target cells. They are expressed as soluble monomers that assemble spontaneously into multimeric pores. However, owing to their complexity, the assembly processes have not been resolved
Masaki Hiramoto et al.
International journal of molecular medicine, 36(1), 222-230 (2015-05-09)
Although recent genome-wide association studies (GWAS) have been extremely successful, it remains a big challenge to functionally annotate disease‑associated single nucleotide polymorphisms (SNPs), as the majority of these SNPs are located in non‑coding regions of the genome. In this study
Fabrice Jean-Pierre et al.
Microbiology (Reading, England), 161(9), 1889-1896 (2015-08-25)
RsmA is a post-transcriptional RNA-binding protein that acts as a pleiotropic global regulator of mRNAs in the opportunistic pathogen Pseudomonas aeruginosa. Upon binding to its target, RsmA impedes the translation of the mRNA by the ribosome. The RsmA regulon affects
Xudong Dai et al.
Applied microbiology and biotechnology, 99(19), 8151-8161 (2015-08-01)
Site-specific protein labeling are powerful means of protein research and engineering; however, new and improved labeling methods are greatly needed. Split inteins catalyze a protein trans-splicing reaction that can be used for enzymatic and nearly seamless protein labeling. Non-canonical S11
Haotian Wu et al.
BioTechniques, 58(6), 293-300 (2014-01-01)
The unique DNA packaging of spermatozoa renders them resistant to DNA isolation techniques used for somatic cells, requiring alternative methods that are slow and labor intensive. Here we present a rapid method for isolating high-quality sperm DNA. Isolated human sperm
Richard C Silva et al.
PloS one, 10(7), e0131070-e0131070 (2015-07-16)
The Saccharomyces cerevisiae protein Yih1, when overexpressed, inhibits the eIF2 alpha kinase Gcn2 by competing for Gcn1 binding. However, deletion of YIH1 has no detectable effect on Gcn2 activity, suggesting that Yih1 is not a general inhibitor of Gcn2, and
Jae Sue Choi et al.
Journal of ethnopharmacology, 171, 28-36 (2015-06-02)
Rhizoma Coptidis (the rhizome of Coptis chinensis Franch) has commonly been used for treatment of diabetes mellitus in traditional Chinese medicine due to its blood sugar-lowering properties and therapeutic benefits which highly related to the alkaloids therein. However, a limited
Karine Meisser Redeuil et al.
Journal of chromatography. A, 1422, 89-98 (2015-11-03)
This manuscript reports a validated analytical approach for the quantification of 21 water soluble vitamins and their main circulating forms in human plasma. Isotope dilution-based sample preparation consisted of protein precipitation using acidic methanol enriched with stable isotope labelled internal
Ann Brinkmalm et al.
Molecular neurodegeneration, 9, 53-53 (2014-11-25)
Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor synaptic degeneration directly in patients. We previously showed that synaptic
Gaku Oguri et al.
American journal of physiology. Heart and circulatory physiology, 307(9), H1339-H1352 (2014-08-31)
Cardiac fibroblasts contribute to the pathogenesis of cardiac remodeling. Methylglyoxal (MG) is an endogenous carbonyl compound produced under hyperglycemic conditions, which may play a role in the development of pathophysiological conditions including diabetic cardiomyopathy. However, the mechanism by which this
Patompon Wongtrakoongate et al.
PLoS genetics, 11(10), e1005615-e1005615 (2015-10-27)
Long non-coding RNAs (lncRNAs) have been recognized as key players in transcriptional regulation. We show that the lncRNA steroid receptor RNA activator (SRA) participates in regulation through complex formation with trithorax group (TrxG) and polycomb repressive complex 2 (PRC2) complexes.
Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.
Gary S Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(20), E2602-E2610 (2015-05-01)
In eukaryotes, receptor tyrosine kinases (RTKs) and trimeric G proteins are two major signaling hubs. Signal transduction via trimeric G proteins has long been believed to be triggered exclusively by G protein-coupled receptors (GPCRs). This paradigm has recently been challenged
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