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Showing 1-30 of 49 results for "439770" within Papers
Mirandeli Bautista et al.
Molecules (Basel, Switzerland), 16(10), 8319-8331 (2011-10-01)
It is well known that gadolinium chloride (GD) attenuates drug-induced hepatotoxicity by selectively inactivating Kupffer cells. In the present study the effect of GD in reference to cell cycle and postnecrotic liver regeneration induced by thioacetamide (TA) in rats was
Sonja M Mueller-Tribbensee et al.
PloS one, 10(7), e0128242-e0128242 (2015-07-25)
Various transient receptor potential (TRP) channels in sensory neurons contribute to the transduction of mechanical stimuli in the colon. Recently, even the cold-sensing menthol receptor TRPM(melastatin)8 was suggested to be involved in murine colonic mechano-nociception. To analyze the roles of
Comparison study on the influence of the central metal ions in palladium (II)-and gadolinium (III)-porphyrins for phosphorescence-based oxygen sensing
Lixin Zang, et al.
Journal of Materials Chemistry, 4, 9581-9587 (2016)
Ying-Ying Yang et al.
Clinical science (London, England : 1979), 123(12), 669-680 (2012-06-28)
Cirrhotic portal hypertension is characterized by increased hepatic oxidative stress, AA (arachidonic acid)-derived TXA(2) (thromboxane A(2)) release and exaggerated hepatic response to the α-adrenergic agonist MTX (methoxamine). Besides promoting hepatic fibrosis, the role of hyperleptinaemia in the modulation of vascular
Daqin Chen et al.
The journal of physical chemistry letters, 6(14), 2833-2840 (2015-08-13)
A strategy to achieve 808 nm excited single-band red upconversion luminescence of Ho(3+) via the core-shell nanoarchitecture design was provided. Specifically, the synthesized Yb/Ho/Ce: NaGdF4@Yb/Nd: NaYF4 active-core@active-shell nanoparticles were evidenced to enable high-content doping of Nd(3+) (∼10 mol %) in
Chikara Abe et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(1), 28-36 (2012-11-10)
Water drinking is known to induce the pressor response. The efferent pathway in this response involves sympathoexcitation, because the pressor response was completely abolished by ganglionic blockade or an α(1)-adrenergic antagonist. However, the afferent pathway in this response has not
Netanya Y Spencer et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(1), G84-G94 (2013-05-04)
Cell line studies have previously demonstrated that hypoxia-reoxygenation (H/R) leads to the production of NADPH oxidase 1 and 2 (NOX1 and NOX2)-dependent reactive oxygen species (ROS) required for the activation of c-Src and NF-κB. We now extend these studies into
Bryan T Martin et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 218, 147-152 (2012-03-31)
The use of susceptibility matching to minimize spectral distortion of biphasic samples layered in a standard 5 mm NMR tube is described. The approach uses magic angle spinning (MAS) to first extract chemical shift differences by suppressing bulk magnetization. Then
Hiroaki Kito et al.
Biochemical and biophysical research communications, 459(3), 457-462 (2015-03-10)
Store-operated Ca(2+) entry (SOCE) via Orai1 and STIM1 complex is supposed to have obligatory roles in the regulation of cellular functions of vascular endothelial cells, while little is known about the contribution of Orai2. Quantitative PCR and Western blot analyses
Alfredo Mijares et al.
Biochemical and biophysical research communications, 452(4), 1054-1059 (2014-09-23)
Duchenne muscular dystrophy (DMD) is a lethal X-inherited disease caused by dystrophin deficiency. Besides the relatively well characterized skeletal muscle degenerative processes, DMD is also associated with a dilated cardiomyopathy that leads to progressive heart failure at the end of
X H Su et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(3), 417-424 (2014-06-17)
Rubus chingii Hu (Rosaceae) is an important traditional Chinese medicine that has been used to improve function of the kidney and treat excessive polyuria. However, the effects of Rubus chingii on the cardiovascular system and its pharmacological mechanisms of action
T Hasezaki et al.
Die Pharmazie, 66(9), 698-703 (2011-10-27)
Nanomaterials have potential toxicity that is not found in micromaterials, and it is therefore essential to understand their biological activity and potential toxicity. We focused on silica nanoparticles, since it was previously reported that the intravenous administration of silica nanoparticles
Mohamad Kurdi et al.
PloS one, 7(9), e45111-e45111 (2012-10-11)
Factor X (FX), a plasma glycoprotein playing a central role in coagulation has a long circulatory half-life compared to closely related coagulation factors. The activation peptide of FX has been shown to influence its clearance with two N-glycans as key
Georg Singer et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 62(2), 155-164 (2012-10-19)
Hepatic microvascular dysfunction is a critical event in the development of liver failure during sepsis. Activated blood cells and reactive oxygen and nitrogen species (RONS) have been implicated in the pathogenesis of sepsis. Intravital-videomicroscopy was used to determine whether RONS
Biao Wang et al.
PloS one, 8(1), e52743-e52743 (2013-01-24)
Activation of Kupffer cell (KC) is acknowledged as a key event in the initiation and perpetuation of bile duct warm ischemia/reperfusion injury. The inhibitory effect of gadolinium chloride (GdCl(3)) on KC activation shows potential as a protective intervention in liver
Yi-Wei Huang et al.
Journal of cellular physiology, 230(9), 2086-2097 (2015-02-03)
Ca(2+) -mediated formation of cell polarity is essential for directional migration which plays an important role in physiological and pathological processes in organisms. To examine the critical role of store-operated Ca(2+) entry, which is the major form of extracellular Ca(2+)
Kengo Hattori et al.
Medical physics, 40(3), 032303-032303 (2013-03-08)
A 3.0-T MRI phantom (called the CAGN-3.0T phantom) having human-equivalent relaxation times and human-equivalent conductivity was developed. The ingredients of the phantom are carrageenan (as a gelatinizer), agarose (as a T2-relaxation modifier), GdCl3 (as a T1-relaxation modifier), NaCl (as a
Yan Xiao et al.
Magnetic resonance imaging, 33(6), 822-828 (2015-04-04)
A new biodegradable and biocompatible gadolinium (III) -copolymer (ACL-A2-DOTA-Gd) has been developed as a potential liver magnetic resonance imaging (MRI) contrast agent. ACL-A2-DOTA-Gd consisted of a poly (aspartic acid-co-leucine) unit bound with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (Gd-DOTA) via the linkage of ethylenediamine.
Yun Luo et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(10), 2136-2144 (2014-05-14)
Rare-earth-element (Y, Gd) modified Pt nanoparticles (NPs) supported on a carbon substrate (Vulcan XC-72) are synthesized via a water-in-oil chemical route. In both cases, X-ray diffraction (XRD) measurements show the non-formation of an alloyed material. Photoemission spectroscopy (XPS) results reveal
Stefanie Gödecke et al.
American journal of physiology. Cell physiology, 302(6), C915-C923 (2011-12-14)
ATP and its degradation products play an important role as signaling molecules in the vascular system, and endothelial cells are considered to be an important source of nucleotide release. To investigate the mechanism and physiological significance of endothelial ATP release
Hideko Ohama et al.
The American journal of pathology, 185(2), 420-431 (2014-12-09)
Alcohol abuse was found to predispose persons to opportunistic infections. In this study, we tried to improve the host antibacterial resistance of chronic alcohol-consuming (CAC) mice to opportunistic infections. Bactericidal macrophages with functions to produce IL-12 and to express mRNAs
Runtao Gan et al.
Molecular and cellular biochemistry, 361(1-2), 123-134 (2011-10-11)
Our previous studies demonstrated that caclium-sensing receptor (CaR) stimulation elicited phospholipase C (PLC)-mediated inositol triphosphate (IP(3)) formation, leading to an elevation in [Ca(2+)](i) released from the endo(sarco)plasmic reticulum (ER) to induce ER stress and perturbations of ER function, which cause
Shohei Takai et al.
Journal of applied toxicology : JAT, 36(1), 35-47 (2015-04-23)
Drug-induced liver injury (DILI) is the most frequent cause of post-marketing warnings and withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans, and its metabolites, formed by cytochrome P450 3A4, are likely more toxic to hepatocytes
Minako Hara et al.
American journal of physiology. Cell physiology, 302(12), C1741-C1750 (2012-03-31)
When skeletal muscle is stretched or injured, satellite cells, resident myogenic stem cells positioned beneath the basal lamina of mature muscle fibers, are activated to enter the cell cycle. This signaling pathway is a cascade of events including calcium-calmodulin formation
C Jones et al.
International journal of surgery (London, England), 11(1), 46-51 (2012-11-22)
Depletion of Kupffer cells by gadolinium chloride (GdCl(3)) reduces the systemic response during sepsis. The study aim was to investigate the effect of this depletion on hepatic proinflammatory cytokine response to portal endotoxaemia. Sixteen Wistar rats were randomised to receive
Mohammad Mehdi Maneshi et al.
Journal of neurotrauma, 32(13), 1020-1029 (2014-12-03)
Traumatic brain injury (TBI) refers to brain damage resulting from external mechanical force, such as a blast or crash. Our current understanding of TBI is derived mainly from in vivo studies that show measurable biological effects on neurons sampled after
Monique Michels et al.
Clinical science (London, England : 1979), 134(7), 765-776 (2020-03-29)
In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of
Sébastien Hayoz et al.
BMC neuroscience, 13, 53-53 (2012-05-30)
ATP is an extracellular signaling molecule with many ascribed functions in sensory systems, including the olfactory epithelium. The mechanism(s) by which ATP is released in the olfactory epithelium has not been investigated. Quantitative luciferin-luciferase assays were used to monitor ATP
Tingting Li et al.
Molecular immunology, 53(4), 414-420 (2012-10-30)
The calcium-sensing receptor (CaSR) has been reported to play an important role in many tissues and organs. However, studies about the expression and function of CaSR in T lymphocytes are still not very lucid. In this study, we investigated the
Quirin Zangl et al.
Anesthesiology, 121(6), 1217-1225 (2014-09-17)
Liver damage by ischemia and reperfusion injury is a risk factor for morbidity and mortality after liver surgery. Postoperative oxygen treatment is routinely applied in the postanesthesia and intensive care unit after liver surgery. The risks of aggravating the injury
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