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Showing 1-30 of 214 results for "48877" within Papers
Ren-Chao Zheng et al.
Applied microbiology and biotechnology, 94(4), 969-976 (2012-03-01)
Biocatalytic asymmetric preparation of (R)-1,3-butanediol has been attracting much attention in pharmaceuticals industry. A new ideal strain, ZJB-09162, which exhibited high reduction activity and excellent (R)-stereospecificity towards 4-hydroxy-2-butanone, has been successfully isolated from soil samples. Based on morphology, physiological tests
Federico Mele et al.
Nature communications, 6, 6431-6431 (2015-03-17)
T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we show that miR-181a is selectively induced
Angela Kolodziej et al.
NeuroImage, 103, 171-180 (2014-09-23)
Electrical and optogenetic methods for brain stimulation are widely used in rodents for manipulating behavior and analyzing functional connectivities in neuronal circuits. High-resolution in vivo imaging of the global, brain-wide, activation patterns induced by these stimulations has remained challenging, in
Hun Sub Lim et al.
Investigative ophthalmology & visual science, 55(11), 7441-7450 (2014-10-25)
The aim of this study was to determine the effect of hyaluronic acid (HA) on cyclooxygenase (COX)-2 expression in orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO). Primary cultured orbital fibroblasts were obtained from patients with TAO and non-TAO subjects.
Yunpeng Xie et al.
International journal of molecular sciences, 15(12), 23345-23358 (2014-12-19)
Mammalian embryo implantation is an extremely complex process and requires endometrial receptivity. In order to establish this receptivity, sequential proliferation and differentiation during the menstrual cycle is necessary. Forkhead box M1 (FoxM1) is described as a major oncogenic transcription factor
Ingeborg Bednar et al.
Journal of chromatography. A, 1220, 115-121 (2011-12-27)
Hydrophobicity of hydrophobic interaction chromatography media is currently ranked according to retention of reference proteins. A new method, suitable for porous media, is presented here to determine the surface energy and its Lifshitz-van-der-Waals, Lewis acid and Lewis base contributions. The
Judith Müller et al.
Nature communications, 5, 5712-5712 (2014-12-17)
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence
The toxicology of methyl ethyl ketone.
R S Yang
Residue reviews, 97, 121-143 (1986-01-01)
Xue-Hai Guan et al.
Experimental neurology, 263, 39-49 (2014-10-05)
Previously, we showed that activation of the spinal CXCL9, 10/CXCR3 pathway mediated bone cancer pain (BCP) in rats. However, the cellular mechanism involved is poorly understood. Here, we found that the activated CXCR3 was co-localized with either neurons, microglia, and
D K Dastur et al.
The British journal of nutrition, 36(2), 143-159 (1976-09-01)
1. The B-vitamin status of fifty-nine patients, mainly from the lower socio-economic classes in Bombay, with a history of chronic malnutrition, and of alcoholism of 1-5-20 years' duration, was studied before and during treatment, and in relation to their clinical
Occupational assessment of exposure to organic solvents in an adhesive producing company in Sfax, Tunisia.
Imed Gargouri et al.
Journal of occupational and environmental hygiene, 9(4), D71-D76 (2012-04-04)
Sung Ho Lee et al.
Molecular and cellular endocrinology, 400, 32-40 (2014-12-03)
Osterix is an essential transcription factor for osteoblast differentiation and bone formation. The mechanism of regulation of Osterix by post-translational modification remains unknown. Peptidyl-prolyl isomerase 1 (Pin1) catalyzes the isomerization of pSer/Thr-Pro bonds and induces a conformational change in its
Chundi Xu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(43), 14517-14532 (2015-10-30)
How extracellular cues direct axon-dendrite polarization in mouse developing neurons is not fully understood. Here, we report that the radial glial cell (RGC)-cortical neuron interaction directs axon formation at the opposite side of the neuron from the contact site. N-cadherin
Hong Zhao et al.
The Science of the total environment, 408(17), 3607-3613 (2010-06-01)
Carbonyl compound emissions from two passenger cars fueled with different methanol/gasoline blends (M15 and M100) and operated with three-way catalytic converters (TWC) were investigated. The tests were performed on a chassis dynamometer with constant volume sampling over the New European
Justin W Kenney et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 3034-3047 (2015-02-24)
The rapid regulation of cell signaling in response to calcium in neurons is essential for real-time processing of large amounts of information in the brain. A vital regulatory component, and one of the most energy-intensive biochemical processes in cells, is
Margot Van der Jeught et al.
Cellular reprogramming, 17(3), 170-180 (2015-06-09)
In mice, inhibition of both the fibroblast growth factor (FGF) mitogen-activated protein kinase kinase/extracellular-signal regulated kinase (MEK/Erk) and the Wnt signaling inhibitor glycogen synthase-3β (GSK3β) enables the derivation of mouse embryonic stem cells (mESCs) from nonpermissive strains in the presence
Yubin Li et al.
Theranostics, 5(12), 1363-1377 (2015-10-31)
Poly-amidoamine (PAMAM) dendrimers are proposed to be one of the most promising drug-delivery nanomaterials. However, the toxicity of PAMAM dendrimers on the central nervous system seriously hinders their medical applications. The relationship between oxidative stress and autophagy induced by PAMAM
Mei Jing Piao et al.
Biomolecules & therapeutics, 23(6), 557-563 (2015-11-05)
Skin aging is the most readily observable process involved in human aging. Ultraviolet B (UVB) radiation causes photo-oxidation via generation of reactive oxygen species (ROS), thereby damaging the nucleus and cytoplasm of skin cells and ultimately leading to cell death.
Leili Ran et al.
Cancer discovery, 5(3), 304-315 (2015-01-13)
Gastrointestinal stromal tumor (GIST), originating from the interstitial cells of Cajal (ICC), is characterized by frequent activating mutations of the KIT receptor tyrosine kinase. Despite the clinical success of imatinib, which targets KIT, most patients with advanced GIST develop resistance
The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells.
Sebastio Perrini et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(10), G826-G840 (2015-09-05)
The p66Shc protein mediates oxidative stress-related injury in multiple tissues. Steatohepatitis is characterized by enhanced oxidative stress-mediated cell damage. The role of p66Shc in redox signaling was investigated in human liver cells and alcoholic steatohepatitis. HepG2 cells with overexpression of
Victoria L Luchenko et al.
Molecular oncology, 8(8), 1379-1392 (2014-06-24)
Romidepsin and vorinostat are histone deacetylase inhibitors (HDACis) that have activity in T-cell lymphomas, but have not gained traction in solid tumors. To gain deeper insight into mechanisms of HDACi efficacy, we systematically surveyed 19 cell lines with different molecular
Shou-Qing Li et al.
IUBMB life, 67(10), 768-777 (2015-09-25)
MicroRNA-199a/b-3p is downregulated in several types of aggressive cancer, and its decrement significantly correlates with poor survival. Here, we aim to investigate the biological function of miR-199a/b-3p and its regulation of target genes in breast cancer cells with highly metastatic
Lifang Zhu et al.
Cell proliferation, 48(2), 231-238 (2015-02-04)
The aim of this study was to investigate whether in vitro stimulation of dental pulp stem cells (DPSCs) by tumour necrosis factor alpha (TNF-α) would induce secretion of EphB2/ephrin-B1 signalling. Dental pulp stem cells isolated from human dental pulp were
Ikumi Hayashi et al.
Biological & pharmaceutical bulletin, 38(11), 1765-1771 (2015-11-03)
We previously demonstrated that rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), protects against N-methyl-D-aspartic acid (NMDA)-induced retinal neurotoxicity, but the mechanism underlying this protection is not fully understood. The present study aimed to examine the effects of
A W Jones et al.
Forensic science international, 37(4), 277-285 (1988-06-01)
Headspace gas chromatography was used to determine the concentration of ethanol and methanol in blood samples from 519 individuals suspected of drinking and driving in Sweden where the legal alcohol limit is 0.50 mg/g in whole blood (11 mmol/l). The
Methyl ethyl ketone.
Reviews of environmental contamination and toxicology, 106, 165-174 (1988-01-01)
Brinda Alagesan et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 396-404 (2014-10-29)
Improved therapeutic approaches are needed for the treatment of pancreatic ductal adenocarcinoma (PDAC). As dual MEK and PI3K inhibition is presently being used in clinical trials for patients with PDAC, we sought to test the efficacy of combined targeting of
Suruchi Mittal et al.
Molecular cancer therapeutics, 13(12), 3198-3209 (2014-09-26)
Aberrant activation of Notch and Ras pathways has been detected in breast cancers. A synergy between these two pathways has also been shown in breast cell transformation in culture. Yet, the clinical relevance of Notch-Ras cooperation in breast cancer progression
Benchun Miao et al.
Cancer discovery, 5(3), 274-287 (2014-12-30)
BRAF(V600E) is the most common oncogenic lesion in melanoma and results in constitutive activation of the MAPK pathway and uncontrolled cell growth. Selective BRAF inhibitors such as vemurafenib have been shown to neutralize oncogenic signaling, restrain cellular growth, and improve
Corey A Carter et al.
Postgraduate medicine, 126(7), 139-148 (2014-11-12)
Non-small-cell lung cancer (NSCLC) is a growing concern worldwide, and its incidence continues to increase in developing countries. It has a strong association with smoking. Lung cancer remains the leading cause of cancer-related deaths in most industrialized countries and in
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