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Showing 1-30 of 975 results for "49152" within Papers
Jinfang Zhao et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 53(4), 328-337 (2013-07-19)
In this study, we constructed a recombinant Escherichia coli strain for the production of high-purity L-lactic acid, using a homoethanol fermenting mutant E. coli SZ470 (deltafrdBC deltaldhA deltaackA deltafocA-pflB deltapdhR: :pflBp6-pflBrbs-aceEF-lpd) as the starting strain. By using homologous recombination, we
Ekta Lachmandas et al.
PloS one, 10(2), e0117941-e0117941 (2015-02-11)
Type 2 diabetes mellitus is an established risk factor for tuberculosis but the underlying mechanisms are largely unknown. We examined the effects of hyperglycaemia, a hallmark of diabetes, on the cytokine response to and macrophage infection with Mycobacterium tuberculosis. Increasing
Victor Castro-Fernandez et al.
The FEBS journal, 281(8), 2017-2029 (2014-05-27)
In some archaea, the phosphorylation of glucose and fructose 6-phosphate (fructose 6P) is carried out by enzymes that are specific for either substrate and that use ADP as phosphoryl donor. In the hyperthermophilic archaeon Methanocaldococcus jannaschii, a bifunctional enzyme able
D A Gálico et al.
Journal of inorganic biochemistry, 140, 160-166 (2014-08-12)
Solid-state compounds of the general formulae [ML3] (M=Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y; L=ketoprofen) were synthesized and characterized using infrared, diffuse reflectance and luminescence spectroscopies. IR data suggested that the carboxylate group in ketoprofen is coordinated to
Andrew N Carley et al.
Circulation. Heart failure, 8(1), 119-127 (2014-11-27)
The failing heart displays increased glycolytic flux that is not matched by a commensurate increase in glucose oxidation. This mismatch induces increased anaplerotic flux and inefficient glucose metabolism. We previously found adult transgenic mouse hearts expressing the fetal troponin I
Girish Ramachandran et al.
PLoS neglected tropical diseases, 9(1), e3394-e3394 (2015-01-09)
Invasive non-typhoidal Salmonella (iNTS) are an important cause of septicemia in children under the age of five years in sub-Saharan Africa. A novel genotype of Salmonella enterica subsp. enterica serovar Typhimurium (multi-locus sequence type [ST] 313) circulating in this geographic
Accidental hypoglycaemia caused by an arterial flush drug error.
M Thirugnanam et al.
Anaesthesia, 69(5), 524-525 (2014-04-18)
David Wilkinson et al.
Diving and hyperbaric medicine, 45(1), 30-36 (2015-05-13)
The onset of insulin resistance is an important metabolic event in the development of type 2 diabetes. For patients with type 2 diabetes, we recently showed that peripheral insulin sensitivity was increased during hyperbaric oxygen treatment (HBOT). This study aims
Misato Iwashita et al.
Development (Cambridge, England), 141(19), 3793-3798 (2014-09-25)
Accumulating evidence implicates the significance of the physical properties of the niche in influencing the behavior, growth and differentiation of stem cells. Among the physical properties, extracellular stiffness has been shown to have direct effects on fate determination in several
L Ia Timen et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (5)(5), 89-92 (2014-02-08)
Glucose and ascorbate used for endoscopic hemostasis metabolic preventive to prevent recurrent ulcer bleeding. Unacceptable joint use in endohemostasis ascorbate and hydrogen peroxide.
I N Kurchenko et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 75(5), 47-51 (2014-02-01)
A comparative study of growth characteristics and peculiarities of glucose utilization by Fusarium poae and Penicillium funiculosum strains isolated from different habitats was conducted. It was found that F. poae and P. funiculosum strains differ as to their growth characteristics.
Abdelali Agouni et al.
Biochemical pharmacology, 92(4), 607-617 (2014-12-03)
Growing evidence suggests that hepatic-insulin resistance is sufficient to promote progression to cardiovascular disease. We have shown previously that liver-specific protein-tyrosine-phosphatase 1B (PTP1B) deficiency improves hepatic-insulin sensitivity and whole-body glucose homeostasis. The aim of this study was to investigate the
Sihyung Yang et al.
Antimicrobial agents and chemotherapy, 58(7), 4064-4074 (2014-05-07)
Human African trypanosomiasis (HAT), a neglected tropical disease, is fatal without treatment. Pentamidine, a cationic diamidine, has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system [CNS]) infection.
Yoichi Maekawa et al.
Nature medicine, 21(1), 55-61 (2014-12-17)
CD4+ T cells differentiate into memory T cells that protect the host from subsequent infection. In contrast, autoreactive memory CD4+ T cells harm the body by persisting in the tissues. The underlying pathways controlling the maintenance of memory CD4+ T
A Wagner et al.
European journal of clinical nutrition, 69(4), 436-441 (2014-10-23)
The omega-3 index (the summed percentage content of eicosapentaenoic and docosahexaenoic acids in red blood cells) is associated with a lower risk of fatal coronary heart disease and sudden cardiac death. We aimed to determine which socio-demographic, behavioural or clinical
Isabel Mirones et al.
Stem cells (Dayton, Ohio), 32(9), 2529-2538 (2014-05-09)
As the nervous system exerts direct and indirect effects on stem cells mobilization and catecholamines mobilize hematopoietic stem cells, we hypothesized that dopamine might induce mesenchymal progenitor cells (MPCs) mobilization. We show that dopamine induced in vitro MPCs migration through
Peter Gergics et al.
Molecular endocrinology (Baltimore, Md.), 29(4), 597-612 (2015-02-11)
Defects in the Lhx4, Lhx3, and Pitx2 genes can cause combined pituitary hormone deficiency and pituitary hypoplasia in both humans and mice. Not much is known about the mechanism underlying hypoplasia in these mutants beyond generally increased cell death and
Matthew D Greseth et al.
PLoS pathogens, 10(3), e1004021-e1004021 (2014-03-22)
The poxvirus life cycle, although physically autonomous from the host nucleus, is nevertheless dependent upon cellular functions. A requirement for de novo fatty acid biosynthesis was implied by our previous demonstration that cerulenin, a fatty acid synthase inhibitor, impaired vaccinia
Zhong Wang et al.
Acta pharmacologica Sinica, 35(11), 1402-1410 (2014-10-07)
To investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on high glucose-induced mouse endothelial cell damage in vitro. Mouse brain microvascular endothelial bEND.3 cells were exposed to different glucose concentrations (5.56, 25 and 40 mmol/L) for 24 or
Maria Luisa Rojo et al.
Life sciences, 108(2), 116-121 (2014-06-15)
A high consumption of fructose leads not only to peripheral changes in insulin sensitivity and vascular function, but also to central changes in several brain regions. Given the role of the endogenous cannabinoid system in the control of energy intake
Deborah M Muoio
Cell, 159(6), 1253-1262 (2014-12-07)
Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation, as the mitochondrial machinery responsible for carbon combustion switches freely between alternative fuels according to physiological and nutritional circumstances. These transitions in fuel choice are orchestrated by
Julie A Vrana et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(2), 338-351 (2014-05-16)
The rapid pharmacodynamic response of cells to toxic xenobiotics is primarily coordinated by signal transduction networks, which follow a simple framework: the phosphorylation/dephosphorylation cycle mediated by kinases and phosphatases. However, the time course from initial pharmacodynamic response(s) to cell death
Musiliyu A Musa et al.
Anticancer research, 35(2), 653-659 (2015-02-11)
Coumarins are naturally-occurring compounds with diverse and interesting biological activities. In the present study, we evaluated the in vitro cytotoxic effect of 8-(acetyloxy)-3-[4-(acetyloxy)phenyl]-2-oxo-2H-chromen-7-yl acetate (6); 8-(acetyloxy)-3-(4-methanesulfonyl phenyl)-2-oxo-2H-chromen-7-yl acetate (7); 4-(2-oxo-2H-chromen-3-yl)phenyl acetate (8); 3-(4-methanesulfonylphenyl)-2H-chromen-2-one (9); 4-(4-methyl-2-oxo-2H-chromen-3-yl)phenyl acetate (10); 3-(4-methanesulfonylphenyl)-4-methyl-2H-chromen-2-one (11); 8-(acetyloxy)-3-[4-(acetyloxy)phenyl]-4-methyl-2-oxo-2H-chromen-7-yl
L M Wuescher et al.
Journal of thrombosis and haemostasis : JTH, 13(2), 303-313 (2014-11-25)
Platelets are critical cells for maintaining vascular hemostasis, but their activities in other processes are becoming apparent. Specifically, the ability of platelets to recognize and respond to infectious agents is an important area of investigation. To understand the physiologic roles
Sangkyu Park et al.
PloS one, 9(10), e109453-e109453 (2014-10-07)
Sesquiterpenoid capsidiol, exhibiting antifungal activity against pathogenic fungus, is accumulated in infected ripe pepper fruits. In this study, we found a negative relation between the capsidiol level and lesion size in fruits infected with Colletotrichum gloeosporioides, depending on the stage
Marc R Mansour et al.
British journal of haematology, 168(2), 230-238 (2014-09-27)
Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independent activation
Marisa Freitas et al.
European journal of medicinal chemistry, 86, 153-164 (2014-08-26)
Neutrophils are considered the central cells of acute inflammation. Flavonoids have been suggested as therapeutic agents to avoid damages induced by inflammatory processes. It is well known the reactivity of flavonoids with hypochlorous acid produced by neutrophils, to form stable
Peter Stein et al.
Metabolism: clinical and experimental, 63(10), 1296-1303 (2014-08-12)
Canagliflozin is a sodium glucose co-transporter 2 inhibitor approved for treating patients with type 2 diabetes. This study evaluated renal and non-renal effects of canagliflozin on postprandial plasma glucose (PG) excursion in patients with type 2 diabetes inadequately controlled with
Neha Kaushik et al.
Scientific reports, 5, 8726-8726 (2015-03-05)
In this study, we show the selective and efficient anti-cancer effects of plasma (at a low dose) when cell metabolic modifiers are also included. 2-deoxy-D-glucose (2-DG), a glycolytic inhibitor, was used with effective doses of non-thermal plasma, synergistically attenuating cell
Rachel P L van Swelm et al.
Journal of applied toxicology : JAT, 34(9), 993-1001 (2013-09-17)
Drug-induced liver injury is one of the leading causes of drug withdrawal from the market. In this study, we investigated the applicability of protein profiling of the incubation medium of human, mouse and rat precision-cut liver slices (PCLS) exposed to
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