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Showing 1-30 of 975 results for "49152" within Papers
Debra Rossouw et al.
Applied and environmental microbiology, 75(20), 6600-6612 (2009-08-25)
Commercial wine yeast strains of the species Saccharomyces cerevisiae have been selected to satisfy many different, and sometimes highly specific, oenological requirements. As a consequence, more than 200 different strains with significantly diverging phenotypic traits are produced globally. This genetic
Monsicha Pongpom et al.
Infection and immunity, 83(3), 923-933 (2014-12-24)
In Aspergillus nidulans, the AcuK and AcuM transcription factors form a complex that regulates gluconeogenesis. In Aspergillus fumigatus, AcuM governs gluconeogenesis and iron acquisition in vitro and virulence in immunosuppressed mice. However, the function of AcuK was previously unknown. Through
Pierre-Yves Collart-Dutilleul et al.
Nanoscale research letters, 9(1), 564-564 (2014-11-12)
The way cells explore their surrounding extracellular matrix (ECM) during development and migration is mediated by lamellipodia at their leading edge, acting as an actual motor pulling the cell forward. Lamellipodia are the primary area within the cell of actin
Chrissy M Leopold Wager et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4060-4071 (2014-09-10)
Nonprotective immune responses to highly virulent Cryptococcus neoformans strains, such as H99, are associated with Th2-type cytokine production, alternatively activated macrophages, and inability of the host to clear the fungus. In contrast, experimental studies show that protective immune responses against
K A Taylor et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 987-998 (2014-03-25)
Pannexin-1 (Panx1) forms an anion-selective channel with a permeability up to ~1 kDa and represents a non-lytic, non-vesicular ATP release pathway in erythrocytes, leukocytes and neurons. Related connexin gap junction proteins have been reported in platelets; however, the expression and
Susanne Herbst et al.
EMBO molecular medicine, 7(3), 240-258 (2015-02-01)
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of
Ioannis A Papaioannou et al.
Current genetics, 60(3), 135-148 (2013-11-22)
Group-I introns are widespread--though irregularly distributed--in eukaryotic organisms, and they have been extensively used for discrimination and phylogenetic analyses. Within the Verticillium genus, which comprises important phytopathogenic fungi, a group-I intron was previously identified in the SSU-rRNA (18S) gene of
Jide Tian et al.
PloS one, 6(9), e25338-e25338 (2011-10-04)
Adipocyte and β-cell dysfunction and macrophage-related chronic inflammation are critical for the development of obesity-related insulin resistance and type 2 diabetes mellitus (T2DM), which can be negatively regulated by Tregs. Our previous studies and those of others have shown that
Phing-How Lou et al.
Anesthesia and analgesia, 120(2), 329-340 (2014-12-02)
The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown. Hearts of healthy and type-2 diabetic rats (generated by fructose
Tadahiro Suzuki et al.
Toxins, 7(1), 187-200 (2015-01-23)
Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synthesized by grain uridine diphosphate-glucosyltransferase, and is found worldwide, although information on its toxicity is lacking.
Ike C dela Peña et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(2), 338-346 (2014-11-27)
Treatment with tissue plasminogen activator (tPA) beyond the therapeutic time window (>4.5 hours post stroke) may produce hemorrhagic transformation (HT). Strategies that could extend the narrow time window of tPA will benefit a significant number of stroke patients. Male Sprague-Dawley
Frederika Maria Byrne et al.
Journal of diabetes research, 2015, 752481-752481 (2015-03-12)
Chronic pain is a common complication of diabetes. The aim of the present study was to characterise pain behaviour in a high fat diet/streptozotocin (HFD/STZ) model of diabetes in the rat, investigate spinal mechanisms, and determine the effects of antidiabetic
Kyra-Melinda Alexacou et al.
Bioorganic & medicinal chemistry, 19(17), 5125-5136 (2011-08-09)
Electrophilic halogenation of C-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl) 1,4-dimethoxybenzene (1) afforded regioselectively products halogenated at the para position to the D-glucosyl moiety (8, 9) that were deacetylated to 3 (chloride) and 16 (bromide). For preparing meta regioisomers, 1 was efficiently oxidized with CAN to
E M Faioni et al.
Thrombosis and haemostasis, 112(6), 1182-1189 (2014-08-12)
Arachidonic acid (AA), when cleaved from phospholipids by cytosolic phospholipase A2 alpha (cPLA2a), generates eicosanoids, with pro-hemostatic, pro-inflammatory, vasoactive and gastro-protective functions. We describe a patient (27-year-old man) and his twin-sister with early-onset bleeding diathesis and recurrent gastro-intestinal (GI) ulcers.
H-T Dou et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(4), 753-762 (2014-12-05)
The purpose of this study was to investigate the molecular characteristics of 83 clinical Cryptococcus neoformans/C. gattii species complex isolated in Beijing, China, between 2007 and 2013. Restriction fragment length polymorphism of the gene URA5 (URA5-RFLP), multilocus sequence typing (MLST)
Carlo Giuseppe Rizzello et al.
Applied and environmental microbiology, 81(9), 3192-3204 (2015-03-01)
Triticum turgidum subsp. durum was grown according to four farming systems: conventional (CONV), organic with cow manure (OMAN) or green manure (OLEG), and without inputs (NOINPUT). Some chemical and technological characteristics differed between CONV and organic flours. As shown by
Rachael K Nelson et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 39(7), 811-818 (2014-04-30)
Although regular exercise is associated with reduced cardiometabolic disease risk among overweight adults, it remains unclear whether much of the health benefits of exercise are derived from the most recent session(s) of exercise or if they are the result of
Jinzeng Yang
Progress in molecular biology and translational science, 121, 133-163 (2014-01-01)
As the single largest organ in the body, the skeletal muscle is the major site of insulin-stimulated glucose uptake in the postprandial state. Skeletal muscles provide the physiological foundation for physical activities and fitness. Reduced muscle mass and strength is
Daifeng Cheng et al.
Scientific reports, 4, 7489-7489 (2014-12-17)
Reproduction is an important life process in insects; however, few studies have attempted to demonstrate the association between reproductive activity and energy metabolism. To address this problem, we focused on the reproductive changes in Bactrocera dorsalis males. We analyzed B.
Ramu Adela et al.
PloS one, 10(4), e0125270-e0125270 (2015-04-22)
We have previously reported that increased glucose levels were associated with higher serum nitric oxide (NO) levels in fructose-fed insulin resistant rats. However, the relationship between hyperglycemia and serum NO level was not clear. Therefore, the present study was designed
Sima Panahirad et al.
Journal of the science of food and agriculture, 94(9), 1758-1763 (2013-11-26)
One of the most important saprophytic infections in fresh pistachio fruits after harvesting is Aspergillus flavus colonization, which significantly reduces fruit quality. Salicylic acid plays a crucial role in plant tissues and has a suppression effect on some fungi. The
Youjun Zhang et al.
FEBS letters, 588(20), 3726-3731 (2014-09-01)
Changes in carbon flow and sink/source activities can affect floral, architectural, and reproductive traits of plants. In potato, overexpression (OE) of the purple acid phosphatase 2 of Arabidopsis (AtPAP2) resulted in earlier flowering, faster growth rate, increased tubers and tuber
Cong-Fei Xu et al.
Biomaterials, 51, 1-11 (2015-03-17)
Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer cells, leading to severe side effects. In this study, we report
Jianxiong Jiang et al.
Neurobiology of disease, 76, 126-136 (2015-01-21)
As a prominent inflammatory effector of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2) mediates brain inflammation and injury in many chronic central nervous system (CNS) conditions including seizures and epilepsy, largely through its receptor subtype EP2. However, EP2 receptor activation might also
V N Titov et al.
Terapevticheskii arkhiv, 82(10), 71-77 (2011-02-24)
If a lot of carbohydrates cannot be in vivo stored as glycogen, the synthesis of palmitic fatty acid (FA) from glucose and its adipocyte deposition as triglycerides are under way in phylogenesis. With impaired biological function of exotrophy (fasting, early
Miho Maeda et al.
PloS one, 9(9), e106818-e106818 (2014-09-06)
Proximal spinal muscular atrophy (SMA) is an early onset, autosomal recessive motor neuron disease caused by loss of or mutation in SMN1 (survival motor neuron 1). Despite understanding the genetic basis underlying this disease, it is still not known why
Fábio H Silva et al.
The journal of sexual medicine, 11(11), 2661-2670 (2014-09-10)
Cardiovascular and endocrine-metabolic diseases associated with increased oxidative stress such as obesity lead to erectile dysfunction (ED). Activators of soluble guanylyl cyclase (sGC) such as BAY 60-2770 reactivate the heme-oxidized sGC in vascular diseases. This study aimed to evaluate the
Yunyi Hong et al.
Neurochemical research, 40(4), 837-842 (2015-03-31)
Nicotinamide adenine dinucleotide (NAD(+)) plays critical roles in energy metabolism, mitochondrial functions, calcium homeostasis and immunological functions. Our previous studies have found that NAD(+) administration can profoundly decrease ischemic brain injury and traumatic brain injury. Our recent study has also
Stephan Pinheiro Frankenfeld et al.
The Journal of endocrinology, 220(2), 143-153 (2014-01-10)
The use of anabolic-androgenic steroids to improve physical performance or appearance has increased notably. The doses used are 10- to 100- fold higher than the therapeutic dose (TD), and this abuse can cause several side effects. Glucose metabolism is significantly
Nripendra Nath Mishra et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 18(3), 287-293 (2014-01-07)
Candida albicans utilizes arachidonic acid (AA) released during the course of infection (Candidiasis) from phospholipids of infected host cell membranes and synthesizes extracellular prostaglandin(s) which play an important role in hyphae formation and host cell damage. C. albicans biofilms secrete
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