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Showing 1-30 of 321 results for "49449" within Papers
Sebastien Alaux et al.
Journal of medicinal chemistry, 48(25), 7980-7992 (2005-12-13)
A series of nine L-2,4-syn-4-alkylglutamic acid analogues (1a-i) were synthesized in high yield and high enantiomeric excess (>99% ee) from their corresponding 4-substituted ketoglutaric acids (2a-i), using the enzyme aspartate aminotransferase (AAT) from pig heart or E. coli. The synthesized
K Mross et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 6(3), 517-526 (1988-03-01)
Pharmacokinetics of doxorubicin (DOX), epidoxorubicin (EPI), and their metabolites in plasma have been performed in eight patients receiving 40 to 56 mg/m2 of both anthracyclines as a bolus injection in two sequential cycles. Terminal half-life and volume of distribution appeared
Jill Harned et al.
Biochimica et biophysica acta, 1840(10), 3138-3144 (2014-06-28)
Blood-barrier systems are essential in controlling iron levels in organs such as the brain and eye, both of which experience hypoxia in pathological conditions. While hypoxia's effects on numerous iron regulatory and storage proteins have been studied, little is known
Yohei Okubo
Brain and nerve = Shinkei kenkyu no shinpo, 65(6), 651-658 (2013-06-06)
Glutamate is the major excitatory neurotransmitter in the mammalian brain. The conventional view is that glutamate mediates synaptically confined point-to-point transmission at excitatory synapses. However, glutamate has also been suggested to escape from the synaptic cleft and mediate volume transmission
Shin-Ichi Akanuma et al.
Biological & pharmaceutical bulletin, 38(6), 901-908 (2015-06-02)
L-Glutamate (L-Glu) is known to be a relaxant of pericytes and to induce changes in microcirculatory hemodynamics. Since the concentration of L-Glu which induces the dilation of retinal capillaries is reported to be high compared with the estimated concentration in
K Aktories et al.
Biochimie, 77(5), 326-332 (1995-01-01)
Various C3-like ADP-ribosyltransferases like Clostridium botulinum exoenzyme C3, C limosum transferase, B cereus transferase and a transferase from Staphylococcus aureus (EDIN) selectively modify the low-molecular mass GTP-binding proteins RhoA,B,C. UV-irradiation of C limosum transferase in the presence of [carbonyl-14C]NAD resulted
Qing Cheng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(1), 124-133 (2014-01-02)
Nicotinic acetylcholine receptors (nAChRs) are expressed widely in the CNS, and mediate both synaptic and perisynaptic activities of endogenous cholinergic inputs and pharmacological actions of exogenous compounds (e.g., nicotine and choline). Behavioral studies indicate that nicotine improves such cognitive functions
Christopher M Brennan et al.
PloS one, 9(10), e109879-e109879 (2014-10-31)
The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing bacterium Shewanella oneidensis strain MR-1 results in slow exponential phase growth and a reduced terminal cell
S M Evans et al.
The West Indian medical journal, 44(4), 119-123 (1995-12-01)
The role of glutamic acid (glutamate) in the pathogenesis of stroke is now fairly well established. As a result, many drugs which act on glutamate receptors are currently under investigation for their ability to prevent the damage induced by glutamate
Benjamin B Holloway et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(48), 18792-18805 (2013-11-29)
The C1 neurons, located in the rostral ventrolateral medulla (VLM), are activated by pain, hypotension, hypoglycemia, hypoxia, and infection, as well as by psychological stress. Prior work has highlighted the ability of these neurons to increase sympathetic tone, hence peripheral
Vladimir N Noskov et al.
Biological procedures online, 13(1), 8-8 (2011-10-11)
We describe here a method to rapidly convert any desirable DNA fragment, as small as 100 bp, into long tandem DNA arrays up to 140 kb in size that are inserted into a microbe vector. This method includes rolling-circle phi29
Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey.
Medalla M and Luebke JI
The Journal of Neuroscience, 35(1), 112-127 (2015)
Jiangqu Liu et al.
Journal of neurochemistry, 130(3), 408-418 (2014-04-08)
Drosophila larvae innately show light avoidance behavior. Compared with robust blue-light avoidance, larvae exhibit relatively weaker green-light responses. In our previous screening for genes involved in larval light avoidance, compared with control w(1118) larvae, larvae with γ-glutamyl transpeptidase 1 (Ggt-1)
C Zupke et al.
Applied microbiology and biotechnology, 44(1-2), 27-36 (1995-12-01)
Quantitative estimates of intracellular fluxes and measurements of intracellular concentrations were used to evaluate the effect of dissolved oxygen (DO) concentration on CRL 1606 hybridoma cells in batch culture. The estimates of intracellular fluxes were generated by combining material balances
Sebastián Montoro-Molina et al.
Proteomics. Clinical applications, 9(5-6), 630-635 (2014-12-05)
The aim of this work is to demonstrate if urinary excretion of glutamyl aminopeptidase (GluAp) can be quantified by immunological methods. Urine samples from control and cisplatin-treated rats (n = 10 each group) were obtained at 1, 8, and 15
Sunyoung Kim et al.
Biological & pharmaceutical bulletin, 37(6), 938-946 (2014-06-03)
Red ginseng has long been used as a traditional medicine in many East Asian countries including Korea. It is known to exhibit various pharmacological effects, including anti-oxidant, anti-cancer, anti-stress and anti-diabetes activities. To further explore its actions, the present study
Hua Xian et al.
Life sciences, 103(1), 34-40 (2014-03-19)
To investigate the anti-apoptotic effect of MADP, an analog of salidroside, against glutamate induced apoptosis in the cultured rat hippocampal neurons. Cytotoxicity was determined by the MTT method and lactate dehydrogenase release to the medium. Cell apoptosis was evaluated by
Thomas Palm et al.
Scientific reports, 5, 16321-16321 (2015-11-07)
Induced pluripotent stem cell bear the potential to differentiate into any desired cell type and hold large promise for disease-in-a-dish cell-modeling approaches. With the latest advances in the field of reprogramming technology, the generation of patient-specific cells has become a
Silvia Pérez-Magariño et al.
Journal of agricultural and food chemistry, 63(23), 5670-5681 (2015-06-02)
In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effect of several commercial dry yeast autolysates on
The role of taurine and glutamic acid in the epileptic process: a genetic predisposition.
N M van Gelder
Reviews in pure & applied pharmacological sciences, 2(4), 293-316 (1981-10-01)
Ai Kaneko et al.
PloS one, 9(7), e102703-e102703 (2014-07-18)
The primary culture of neuronal cells plays an important role in neuroscience. There has long been a need for methods enabling the long-term culture of primary neurons at low density, in defined serum-free medium. However, the lower the cell density
Katarzyna Rogoz et al.
Molecular pharmacology, 85(2), 322-334 (2013-11-28)
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is known as a thermosensor and integrator of inflammation-induced hyperalgesia. TRPV1 is expressed in a subpopulation of primary afferent neurons that express several different neurotransmitters. The role of the
Steffen Gonda et al.
Frontiers in neuroanatomy, 14, 571351-571351 (2020-12-08)
NMDA receptors are important players for neuronal differentiation. We previously reported that antagonizing NMDA receptors with APV blocked the growth-promoting effects evoked by the overexpression of specific calcium-permeable or flip-spliced AMPA receptor subunits and of type I transmembrane AMPA receptor
Karin Ortmayr et al.
The Analyst, 140(22), 7687-7695 (2015-10-10)
The sulfur metabolic pathway is involved in basic modes of cellular metabolism, including methylation, cell division, respiratory oscillations and stress responses. Hence, the implicated high reactivity of the sulfur pathway intermediates entails challenges for their quantitative analysis. In particular the
Andrea Pinto et al.
Journal of medicinal chemistry, 51(7), 2311-2315 (2008-03-15)
The two enantiomeric pairs of erythro- and threo-amino-(3'-hydroxy-4',5'-dihydro-isoxazol-5'-yl)-acetic acids were synthesized via the 1,3-dipolar cycloaddition of bromonitrile oxide to ( R)- or ( S)-3-( tert-butoxycarbonyl)-2,2-dimethyl-4-vinyloxazolidine. The pharmacological profiles of the studied amino acids reflect the relationship between the activity/selectivity and
A Ormazabal et al.
Neuropediatrics, 36(6), 380-385 (2006-01-24)
Previous studies in Rett syndrome (RS) patients suggested various abnormalities in biogenic amines, pterins, and folate values in cerebrospinal fluid (CSF). Our aim was to analyse these metabolites in CSF of 16 RS patients (age range: 2 - 23 years).
Rasmus P Clausen et al.
Journal of medicinal chemistry, 51(14), 4179-4187 (2008-06-27)
A series of analogues based on N-hydroxypyrazole as a bioisostere for the distal carboxylate group of aspartate have been designed, synthesized, and pharmacologically characterized. Affinity studies on the major glutamate receptor subgroups show that these 4-substituted N-hydroxypyrazol-5-yl glycine (NHP5G) derivatives
Jennifer Shih et al.
Journal of neurochemistry, 131(5), 573-581 (2014-09-10)
Glutamate transport is a critical process in the brain that maintains low extracellular levels of glutamate to allow for efficient neurotransmission and prevent excitotoxicity. Loss of glutamate transport function is implicated in epilepsy, traumatic brain injury, and amyotrophic lateral sclerosis.
Patrizia Minetti et al.
Journal of medicinal chemistry, 48(22), 6887-6896 (2005-10-28)
Two types of adenosine receptor ligands were designed, i.e., 9H-purine and 1H-imidazo[4,5-c]pyridines, to obtain selective A(2A) antagonists, and we report here their synthesis and binding affinities for the four adenosine receptor subtypes A(1), A(2A), A(2B) and A(3). The design was
J K Nicholson et al.
The Biochemical journal, 217(2), 365-375 (1984-01-15)
Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of
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