Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.

Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.

Annali dell'Istituto superiore di sanita (2005-10-26)

Beatrice Bocca, Giovanni Forte, Francesco Petrucci, Anna Pino, Francesca Marchione, Giuseppe Bomboi, Oreste Senofonte, Franco Giubilei, Alessandro Alimonti

PMID16244393

ABSTRACT

The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p < or = 0.05) discrepancies were found: i) increment of Ca, Cd, Hg, Mg, Si and Sn, and decrement of Al, Co, Fe and Zn in serum; ii) higher concentrations of Cu, Li, Mn, Sn and Zr and lower of Fe, Hg, Mo in blood; iii) overproduction of oxidant species (SOS) and decrease of the anti-oxidant capacity (SAC) (p < or = 0.001, for both). Variables that, joined, better discriminated between patients and controls resulted to be Si, SOS, SAC, Co, Ca, Al in serum (94% of cases correctly classified) and Cu, Zr, Mo and Fe in blood (90% of cases properly categorized).

MATERIALS

Product Number

Brand

Product Description

93693

Supelco

L-Proline, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

697745

Sigma-Aldrich

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Sorbitol, European Pharmacopoeia (EP) Reference Standard

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357553

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349151

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