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Showing 31-60 of 181 results for "50484" within Papers
Edward Chang et al.
Journal of medicinal chemistry, 52(11), 3539-3547 (2009-05-13)
A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine bridge length, and the nature of meso- and N-substituents. One potent member of the series
Ashok A Kumar et al.
American journal of hematology, 90(1), 31-36 (2014-09-30)
This paper demonstrates the enrichment of reticulocytes by centrifuging whole blood through aqueous multiphase systems (AMPSs)-immiscible phases of solutions of polymers that form step-gradients in density. The interfaces of an AMPS concentrate cells; this concentration facilitates the extraction of blood
Bo-Kuan Wu et al.
Cell cycle (Georgetown, Tex.), 13(20), 3222-3231 (2014-12-09)
Site-specific hypermethylation of tumor suppressor genes accompanied by genome-wide hypomethylation are epigenetic hallmarks of malignancy. However, the molecular mechanisms that drive these linked changes in DNA methylation remain obscure. DNA methyltransferase 1 (DNMT1), the principle enzyme responsible for maintaining methylation
Wolfgang Witt et al.
Journal of molecular and cellular cardiology, 74, 127-138 (2014-05-21)
Valvular interstitial cells (VICs), the fibroblast-like cellular constituents of aortic heart valves, maintain structural integrity of valve tissue. Activation into contractile myofibroblasts occurs under pathological situations and under standard cell culture conditions of isolated VICs. Reversal of this phenotype switch
J Fisher et al.
Clinical toxicology (Philadelphia, Pa.), 52(1), 63-65 (2013-12-25)
Methylene blue inhibits the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, decreasing vasodilation and increasing responsiveness to vasopressors. It is reported to improve haemodynamics in distributive shock from various causes including septicaemia and post-cardiac surgery. Reports of use in overdose are
Michael E El-Kommos et al.
Journal of AOAC International, 96(4), 737-744 (2013-09-05)
A simple, rapid, sensitive, and accurate extractive spectrophotometric method has been developed for the determination of seven nonsteroidal anti-inflammatory drugs (NSAIDs)--namely diclofenac sodium, ibuprofen, indomethacin, ketoprofen, ketorolac tromethamine, mefenamic acid, and naproxen-in pure forms as well as their pharmaceutical dosage
PharmGKB summary: methylene blue pathway.
Ellen M McDonagh et al.
Pharmacogenetics and genomics, 23(9), 498-508 (2013-08-06)
Vilmos Kertesz et al.
Rapid communications in mass spectrometry : RCM, 28(13), 1553-1560 (2014-05-28)
Droplet-based liquid extraction approaches for spatially resolved surface sampling coupled with high-performance liquid chromatography/mass spectrometry (HPLC/MS) provide the ability to deal with complex sample matrices and to identify isomeric compounds not distinguishable by MS methods alone. Improvements in sampling reliability
Magne S Sivertsen et al.
Journal of neurophysiology, 112(7), 1628-1643 (2014-06-20)
Using optical recording of synaptically mediated calcium transients and selective spinal lesions, we investigated the pattern of activation of spinal motoneurons (MNs) by the pontine reticulospinal projection in isolated brain stem-spinal cord preparations from the neonatal mouse. Stimulation sites throughout
Husniye Kantarci et al.
PLoS genetics, 11(3), e1005037-e1005037 (2015-03-18)
Neurons of the statoacoustic ganglion (SAG) transmit auditory and vestibular information from the inner ear to the hindbrain. SAG neuroblasts originate in the floor of the otic vesicle. New neuroblasts soon delaminate and migrate towards the hindbrain while continuing to
R Nivea et al.
Journal of nanoscience and nanotechnology, 14(6), 4383-4386 (2014-04-18)
The removal of dye from industrial effluents is prime important, photo-catalysis is a finest method to combat dye from effluents. This study concerns about the investigation of photocatalytic activity of TiO2-HPAs (Hetropolyacids) nanocomposite namely TiO2-Phosphomolybdic nanocomposite [TiO2-HMA] and TiO2-Phosphotungstic nanocomposite
Z Ioannou et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(8), 1688-1694 (2013-04-13)
Mixtures of novolac resin and olive stone biomass (20/80 and 40/60 w/w) were cured, pyrolyzed up to 1,000 °C and activated with CO2 under a continuous flow operation (named N20B-cCa and N40B-cCa respectively). Commercial activated charcoal was similarly re-activated with
Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury.
Kang Kwang Lee et al.
Hepatology (Baltimore, Md.), 61(1), 326-336 (2014-08-22)
Acetaminophen (APAP) overdose is a frequent cause of drug-induced liver injury and the most frequent cause of acute liver failure in the Western world. Previous studies with mouse models have revealed that impairment of mitochondrial respiration is an early event
Xavier Bofill-De Ros et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(9), 1665-1677 (2014-06-05)
Oncolytic virotherapy shows promise for pancreatic ductal adenocarcinoma (PDAC) treatment, but there is the need to minimize associated-toxicities. In the current work, we engineered artificial target sites recognized by miR-216a and/or miR-148a to provide pancreatic tumor-selectivity to replication-competent adenoviruses (Ad-miRTs)
Thomas C Baddeley et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 110-118 (2014-10-17)
Methylthioninium (MT) is a tau aggregation inhibitor with therapeutic potential in Alzheimer's disease (AD). MT exists in equilibrium between reduced [leucomethylthioninium (LMT)] and oxidized (MT(+)) forms; as a chloride salt [methylthioninium chloride (MTC), "methylene blue"], it is stabilized in its
Marcel Gehrung et al.
Journal of biomedical optics, 24(12), 1-11 (2019-10-19)
Photoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo. However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely challenging. We have developed a low-cost flow phantom to facilitate validation of
W Yang et al.
European cells & materials, 27, 350-364 (2014-06-11)
In the context of skeletal tissue development and repair, endochondral ossification has inspired a new approach to regenerate bone tissue in vivo using a cartilage intermediate as an osteoinductive template. The aim of this study was to investigate the behavior
Zalilah Tapsir et al.
The journal of contemporary dental practice, 14(1), 47-50 (2013-04-13)
To evaluate and compare the microleakage of various restorative materials used as coronal barriers between endodontic appointments. Eighty extracted human permanent posterior teeth were prepared for standardized access cavities with dimensions of 4 × 4 × 4 mm. The teeth
Alex Crowe et al.
The Journal of biological chemistry, 288(16), 11024-11037 (2013-02-28)
Alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein Tau. Tau is normally a soluble protein that stabilizes microtubules, with splice isoforms that contain either three (3-R) or four (4-R)
F Langner-Viviani et al.
Revue medicale suisse, 10(426), 876-880 (2014-05-20)
In medicine, vital blue dyes are mainly used for the evaluation of sentinel lymph nodes in oncologic surgery. Perioperative anaphylaxis to blue dyes is a rare but significant complication. Allergic reactions to blue dyes are supposedly IgE-mediated and mainly caused
Kathrin Buchholz et al.
Antimicrobial agents and chemotherapy, 52(1), 183-191 (2007-10-31)
Methylene blue (MB) has experienced a renaissance mainly as a component of drug combinations against Plasmodium falciparum malaria. Here, we report biochemically relevant pharmacological data on MB such as rate constants for the uncatalyzed reaction of MB at pH 7.4
Malaria (Plasmodium).
Robin B McFee
Disease-a-month : DM, 59(12), 441-442 (2013-12-10)
M Ghaedi et al.
Ecotoxicology and environmental safety, 96, 110-117 (2013-07-16)
In the present study, activated carbon (AC) simply derived from Pistacia khinjuk and characterized using different techniques such as SEM and BET analysis. This new adsorbent was used for methylene blue (MB) adsorption. Fitting the experimental equilibrium data to various
Xiaoyong Fu et al.
Breast cancer research : BCR, 16(5), 430-430 (2014-09-13)
Activation of the phosphatidylinositol 3-kinase (PI3K) pathway in estrogen receptor α (ER)-positive breast cancer is associated with reduced ER expression and activity, luminal B subtype, and poor outcome. Phosphatase and tensin homolog (PTEN), a negative regulator of this pathway, is
Cécile Voisset et al.
Disease models & mechanisms, 7(4), 435-444 (2014-02-22)
Epstein-Barr virus (EBV) is tightly associated with certain human cancers, but there is as yet no specific treatment against EBV-related diseases. The EBV-encoded EBNA1 protein is essential to maintain viral episomes and for viral persistence. As such, EBNA1 is expressed
Kimberly N Herman et al.
Journal of biochemical and molecular toxicology, 28(12), 568-577 (2014-08-29)
Elevated levels of reactive oxygen species (ROS) can be induced by exposure to various chemicals and radiation. One type of damage in DNA produced by ROS is modification of guanine to 7,8-dihydro-8-oxoguanine (8-oxoG). This particular alteration to the chemistry of
Jonel Steffen et al.
The British journal of ophthalmology, 98(1), 13-15 (2013-10-26)
To evaluate the diagnostic accuracy of methylene blue used as a non-invasive in vivo stain to detect ocular surface squamous neoplasia (OSSN). A test validation study was performed according to Standards for the reporting of diagnostic accuracy studies (STARD) guidelines
Catherine Kamtchueng et al.
PloS one, 9(7), e102399-e102399 (2014-07-16)
The TAF6δ pathway of apoptosis can dictate life versus death decisions independently of the status of p53 tumor suppressor. TAF6δ is an inducible pro-apoptotic subunit of the general RNA polymerase II (Pol II) transcription factor TFIID. Alternative splice site choice
Farook Adam et al.
Journal of colloid and interface science, 406, 209-216 (2013-06-27)
Titania and ceria incorporated rice husk silica based catalyst was synthesized via sol-gel method using CTAB and glycerol as surface directing agents at room temperature and labeled as RHS-50Ti10Ce. The catalyst was used to study the adsorption and photodegradation of
Jennifer Malon et al.
Journal of neuroimmunology, 279, 64-70 (2015-02-12)
C57BL/6 (B6) mice develop peripheral neuropathy post-LP-BM5 infection, a murine model of HIV-1 infection, along with the up-regulation of select spinal cord cytokines. We investigated if calcitonin gene-related peptide (CGRP) contributed to the development of peripheral neuropathy by stimulating glial
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