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Showing 31-60 of 181 results for "50484" within Papers
Thomas C Baddeley et al.
The Journal of pharmacology and experimental therapeutics, 352(1), 110-118 (2014-10-17)
Methylthioninium (MT) is a tau aggregation inhibitor with therapeutic potential in Alzheimer's disease (AD). MT exists in equilibrium between reduced [leucomethylthioninium (LMT)] and oxidized (MT(+)) forms; as a chloride salt [methylthioninium chloride (MTC), "methylene blue"], it is stabilized in its
W Yang et al.
European cells & materials, 27, 350-364 (2014-06-11)
In the context of skeletal tissue development and repair, endochondral ossification has inspired a new approach to regenerate bone tissue in vivo using a cartilage intermediate as an osteoinductive template. The aim of this study was to investigate the behavior
Turan Yildiz et al.
International journal of surgery (London, England), 15, 17-22 (2015-02-02)
The aim of this study is to investigate the expected adhesion-modifying effect of clinoquinol which has metal-chelating feature that limits the inflammation and fibroblastic activity. A total of 40 Wistar Albino rats were included, which were divided into 5 groups.
Aihua Li et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(40), 12945-12953 (2014-08-12)
The preparation of thermoresponsive drug carriers with a self-destruction property is presented. These drug carriers were fabricated by incorporation of drug molecules and thermoresponsive copolymer, poly(N-isopropylacrylamide-co-acrylamide), into silica nanoparticles in a one-pot preparation process. The enhanced drug release was primarily
Ad de Ruiter et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 42(5), 460-468 (2013-07-16)
The purpose of this study was to evaluate the use of synthetic bone graft material as a filling material at the mandibular symphysis donor site of autologous bone in children. A blinded patient group comprised 20 patients with unilateral (UCLP)
F Gonzalez-Lima et al.
Biochemical pharmacology, 88(4), 584-593 (2013-12-10)
This paper focuses on brain mitochondrial respiration as a therapeutic target for neuroprotection and cognitive enhancement. We propose that improving brain mitochondrial respiration is an important future direction in research and treatment of Alzheimer's disease (AD) and other conditions associated
José Chibebe Junior et al.
PloS one, 8(2), e55926-e55926 (2013-03-05)
Enterococcus faecium has emerged as one of the most important pathogens in healthcare-associated infections worldwide due to its intrinsic and acquired resistance to many antibiotics, including vancomycin. Antimicrobial photodynamic therapy (aPDT) is an alternative therapeutic platform that is currently under
Regina Lohmayer et al.
Analytical chemistry, 87(6), 3388-3395 (2015-02-25)
Molybdenum precipitates preferentially under reducing conditions; therefore, its occurrence in sediment records is used as an indicator of paleoredox conditions. Although thiomolybdates (MoO4-xSx(2-) with x = 1-4) supposedly are necessary intermediates in the process of molybdenum precipitation under anoxic conditions
Kathrin Buchholz et al.
Antimicrobial agents and chemotherapy, 52(1), 183-191 (2007-10-31)
Methylene blue (MB) has experienced a renaissance mainly as a component of drug combinations against Plasmodium falciparum malaria. Here, we report biochemically relevant pharmacological data on MB such as rate constants for the uncatalyzed reaction of MB at pH 7.4
Jonel Steffen et al.
The British journal of ophthalmology, 98(1), 13-15 (2013-10-26)
To evaluate the diagnostic accuracy of methylene blue used as a non-invasive in vivo stain to detect ocular surface squamous neoplasia (OSSN). A test validation study was performed according to Standards for the reporting of diagnostic accuracy studies (STARD) guidelines
Juan J Nogueira et al.
Biochemistry, 53(14), 2391-2412 (2014-03-26)
The understanding of interactions between small molecules and DNA is crucial to design new anticancer drugs targeted to DNA. Methylene blue (MB) is a phenothiazinium dye that has shown promising results in photodynamic therapy treatment. The noncovalent binding of methylene
Xiaoyong Fu et al.
Breast cancer research : BCR, 16(5), 430-430 (2014-09-13)
Activation of the phosphatidylinositol 3-kinase (PI3K) pathway in estrogen receptor α (ER)-positive breast cancer is associated with reduced ER expression and activity, luminal B subtype, and poor outcome. Phosphatase and tensin homolog (PTEN), a negative regulator of this pathway, is
Zalilah Tapsir et al.
The journal of contemporary dental practice, 14(1), 47-50 (2013-04-13)
To evaluate and compare the microleakage of various restorative materials used as coronal barriers between endodontic appointments. Eighty extracted human permanent posterior teeth were prepared for standardized access cavities with dimensions of 4 × 4 × 4 mm. The teeth
Alex Crowe et al.
The Journal of biological chemistry, 288(16), 11024-11037 (2013-02-28)
Alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein Tau. Tau is normally a soluble protein that stabilizes microtubules, with splice isoforms that contain either three (3-R) or four (4-R)
Rizwan Khan et al.
The West Virginia medical journal, 109(3), 24-26 (2013-06-27)
Methemoglobin is formed upon iron oxidation of the heme molecule from ferrous (Fe2+) to its ferric (Fe3+) state. Normal methemoglobin levels in the body vary between 1-2% of the total hemoglobin. Cause of methemoglobinemia can be inherited or acquired. Inherited
K F Wong et al.
American journal of clinical pathology, 141(2), 280-284 (2014-01-18)
To report the demonstration of double minutes with MYC amplification in a case of myeloproliferative neoplasm with monocytosis in transformation by a combination of standard karyotyping and interphase and metaphase fluorescence in situ hybridization (FISH). To determine the lineage involvement
Zhenxuan Zhao et al.
Journal of environmental sciences (China), 25(10), 2138-2149 (2014-02-06)
Porous S-doped bismuth vanadate with an olive-like morphology and its supported iron oxide (y wt.% FeOx/BiVO4-deltaS0.08, y = 0.06, 0.76, and 1.40) photocatalysts were fabricated using the dodecylamine-assisted alcohol-hydrothermal and incipient wetness impregnation methods, respectively. It is shown that the
Malaria (Plasmodium).
Robin B McFee
Disease-a-month : DM, 59(12), 441-442 (2013-12-10)
M Ghaedi et al.
Ecotoxicology and environmental safety, 96, 110-117 (2013-07-16)
In the present study, activated carbon (AC) simply derived from Pistacia khinjuk and characterized using different techniques such as SEM and BET analysis. This new adsorbent was used for methylene blue (MB) adsorption. Fitting the experimental equilibrium data to various
Angad Malhotra et al.
Tissue engineering. Part A, 20(19-20), 2614-2633 (2014-03-29)
On activation, platelets secrete an array of growth factors that contribute to bone regeneration. Combining platelet-rich plasma (PRP) with bone graft substitutes has the potential to reduce or replace the reliance on autografts. Lack of standardization and improper use may
Stephanie Supper et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 361-373 (2014-05-27)
Chitosan (CS)-based thermosensitive solutions that turn into semi-solid hydrogels upon injection at body temperature have increasingly drawn attention over the last decades as an attractive new type of in situ forming depot (ISFD) drug delivery system. Despite the great potential
Natalie Fekete et al.
Tissue engineering. Part C, Methods, 21(2), 112-122 (2014-06-12)
Cell therapy using multipotent mesenchymal stromal cells (MSCs) is of high interest in various indications. As the pleiotropic effects mediated by MSCs rely mostly on their unique secretory profile, long-term persistence of ex-vivo-expanded cells in the recipient may not always
Ching-Chi Lee et al.
The American journal of emergency medicine, 32(10), 1241-1247 (2014-08-31)
The objective of this study is to analyze the differences in clinical presentation and outcome of community-onset bacteremia between human immunodeficiency virus (HIV)-infected adults and HIV-uninfected adults visiting the emergency department (ED). A multicenter, case-control study with a ratio of
Lorenz Kulzer et al.
Journal of immunotoxicology, 11(4), 328-336 (2014-02-12)
Despite the transient immunosuppressive properties of local radiotherapy (RT), this classical treatment modality of solid tumors is capable of inducing immunostimulatory forms of tumor-cell death. The resulting 'immunotoxicity' in the tumor, but not in healthy tissues, may finally lead to
A Chithambararaj et al.
Physical chemistry chemical physics : PCCP, 15(35), 14761-14769 (2013-08-02)
A detailed study on visible light photocatalytic degradation of methylene blue (MB) has been investigated in aqueous heterogeneous media containing hexagonal phase molybdenum oxide (h-MoO3) nanocrystals (NCs) which was identified as a new material for visible light driven photocatalysis. A
Jonas Josef Peter Mark et al.
Analytical and bioanalytical chemistry, 406(24), 6069-6073 (2014-07-12)
A method for conducting fast and efficient capillary electrophoresis (CE) based on short separation capillaries in vertical alignment was developed. The strategy enables for high-throughput analysis from small sample vials (low microliter to nanoliter range). The system consists of a
[Methylene blue stopped metformin-associated lactic acidosis and refractory vasodilatation].
Jonas Höjer et al.
Lakartidningen, 110(42), 1865-1866 (2013-12-04)
Toru Aoyama et al.
The American journal of surgical pathology, 39(2), 266-273 (2014-10-31)
Harvesting lymph nodes (LNs) after gastrectomy is essential for accurate staging. This trial evaluated the efficiency and quality of a conventional method and a methylene blue-assisted method in a randomized manner. The key eligibility criteria were as follows: (i) histologically
Gajalakshmi Dakshinamoorthy et al.
PloS one, 9(11), e112982-e112982 (2014-11-18)
Lymphatic filariasis affects 120 million people worldwide and another 1.2 billion people are at risk of acquiring the infection. Chemotherapy with mass drug administration is substantially reducing the incidence of the infection. Nevertheless, an effective vaccine is needed to prevent
Judith Luiza Eisenbacher et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 6102-6110 (2014-05-06)
Simple stress or necrotic cell death with subsequent release of damage-associated molecular patterns (DAMPs) is a characteristic feature of most advanced tumors. DAMPs within the tumor microenvironment stimulate tumor-associated cells, including dendritic cells and mesenchymal stromal cells (MSCs). The presence
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