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Jie Ma et al.
Pharmacology, 93(5-6), 220-224 (2014-07-12)
It is significant for patients with traumatic brain injury (TBI) to receive prehospital emergency treatment as early as possible to reduce mortality. Therefore, a new prefilled multi-drug injector was developed to improve the treatment of TBI. Here, we studied the
Katherine A Rempe et al.
mBio, 6(4) (2015-08-27)
Glycosylation is a widespread mechanism employed by both eukaryotes and bacteria to increase the functional diversity of their proteomes. The nontypeable Haemophilus influenzae glycosyltransferase HMW1C mediates unconventional N-linked glycosylation of the adhesive protein HMW1, which is encoded in a two-partner
Minjie Jiang et al.
PloS one, 10(2), e0116010-e0116010 (2015-02-26)
A rapid, sensitive and selective high-performance liquid chromatography-tandem mass spectrometric method (HPLC-MS) was developed and validated to determine the 14-(3-methylbenzyl)matrine (3MBM) and 14-(4-methylbenzyl)matrine (4MBM) levels in rat plasma in the present study. The analytes were separated using a C18 column
Yoshiaki Yamanaka et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(10), 1531-1536 (2015-07-16)
This study aimed to clarify the association between abnormal Wnt signaling and the cause of idiopathic carpal tunnel syndrome (ICTS) and whether an association exists between Wnt signaling and cell proliferation in the flexor tenosynovium. The subjects included nine patients
Dao-Jin Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 42-52 (2014-08-26)
Folk drug Gynostemma pentaphyllum (Thunb.) Makino contains many biologically active phytochemicals which have been demonstrated to be effective against chronic diseases. As in vivo anti-tumor experiments of G. pentaphyllum extract (GP) show much stronger antitumor activities than in vitro, it
Peta A Neale et al.
Chemosphere, 135, 20-23 (2015-04-16)
There is increasing recognition of the importance of assessing both agonism and antagonism in parallel for environmental samples. Cell-based in vitro assays have the advantage over receptor binding assays as they are able to differentiate between agonist and antagonist activity
Can Liu et al.
Journal of agricultural and food chemistry, 63(26), 6009-6018 (2015-06-09)
Bacillus subtilis strain B154, isolated from Agaricus bisporus mushroom compost infected by red bread mold, exhibited antagonistic activities against Neurospora sitophila. Antifungal activity against phytopathogenic fungi was also observed. The maximum antifungal activity was reached during the stationary phase. This
Jae Kyoo Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), 3898-3903 (2015-03-17)
We investigated the fusion of high-speed liquid droplets as a way to record the kinetics of liquid-phase chemical reactions on the order of microseconds. Two streams of micrometer-size droplets collide with one another. The droplets that fused (13 μm in
Dequina A Nicholas et al.
Mediators of inflammation, 2015, 196297-196297 (2015-12-04)
High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA
Kristina B Jäpelt et al.
Microbial cell factories, 14, 132-132 (2015-09-05)
Quenching in cold buffered methanol at -40 °C has long been the preferred method for sub-second inactivation of cell metabolism during metabolic fingerprinting. However, methanol is known to cause intracellular metabolite leakage of microbial cells, making the distinction between intra-
Maddalena Parafati et al.
The Journal of nutritional biochemistry, 26(9), 938-948 (2015-05-31)
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in industrialized countries. Defective autophagy of lipid droplets (LDs) in hepatocytes, also known as lipophagy, has recently been identified as a possible pathophysiological mechanism of NAFLD. Experimental and epidemiological
Fairoz Algaar et al.
Analytical chemistry, 87(16), 8394-8398 (2015-07-08)
Crimean-Congo hemorrhagic fever (CCHF) is a severe viral disease with high fatality rate. CCHF virus is endemic in parts of Africa, Asia, the Middle East, and southeastern Europe. Rapid diagnostics of CCHF is vital for appropriate clinical management and prevention
Sarah Afshordel et al.
Pharmacological research, 91, 69-77 (2014-12-17)
Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production
V P Stankov-Jovanović et al.
Journal of pharmaceutical and biomedical analysis, 111, 78-90 (2015-04-12)
Extracts of different polarity obtained from various plant parts (root, leaf, flower and fruit) of Seseli rigidum were studied by different antioxidant assays: DPPH and ABTS radical scavenging activity, by total reducing power method as well as via total content
Adam Byron et al.
Nature communications, 6, 6135-6135 (2015-01-23)
Integrin activation, which is regulated by allosteric changes in receptor conformation, enables cellular responses to the chemical, mechanical and topological features of the extracellular microenvironment. A global view of how activation state converts the molecular composition of the region proximal
Mariane Lutz et al.
Archivos latinoamericanos de nutricion, 65(2), 71-78 (2016-01-29)
The Chilean National School Feeding Program (NSFP) delivers breakfast and lunch meals that supply 250 and 450 kcal, respectively, along the country. In the last decades, a significant increase of obesity has been observed in primary education children, and it
Nazeh M Al-Abd et al.
Asian Pacific journal of tropical medicine, 8(9), 705-709 (2015-10-05)
To determine the prevalence of the filarial parasites,ie.,Brugia malayi, Brugia, Brugia pahangi(B. pahangi), Dirofilaria immitisandDirofilaria repens (D. repens) in domestic and stray cats. A total of 170 blood sample were collected from domestic and stray cats and examined for filarial worm parasites
Ravindra V Badhe et al.
Carbohydrate polymers, 130, 213-221 (2015-06-17)
A new chitosan-based tri-block conjugate, O-PEG-chitosan-N-cysteine was synthesized using microwave irradiation. For synthesis of this derivative, chitosan was modified to a PEG-chitosan conjugate followed by PEG-chitosan-cysteine using 6-O PEGylation and 2-N-thiolation, respectively. The synthesized derivative was characterized using various analytical
Wenzhuan Ma et al.
Journal of pharmaceutical and biomedical analysis, 111, 215-221 (2015-04-25)
A specific, sensitive and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for simultaneous quantification of doxorubicin and curcumin in rat plasma after intravenous administration. The analytes of doxorubicin and curcumin were extracted with methanol
Muhammad Azeemuddin et al.
JPMA. The Journal of the Pakistan Medical Association, 62(10), 1099-1101 (2013-07-23)
Methanol is a highly toxic substance and acute methanol poisoning produces severe metabolic acidosis and serious neurological symptoms, including severe visual impairment, extrapyramidal signs and coma. We present three cases of accidental methanol intoxication and discuss the MRI findings.
Ling Chen et al.
Oncology reports, 34(1), 447-454 (2015-05-16)
Endocannabinoids and ceramides have demonstrated growth inhibition, cell death induction and pro-apoptotic activity in cancer research. In the present study, we describe the profiles of two major endocannabinoids, ceramides, free fatty acids and relevant metabolic enzymes in 47 pairs of
Giancarlo Vanini et al.
The European journal of neuroscience, 40(1), 2264-2273 (2014-03-29)
The oral part of the pontine reticular formation (PnO) contributes to the regulation of sleep, anesthesia and pain. The role of PnO γ-aminobutyric acid (GABA) in modulating these states remains incompletely understood. The present study used time to loss and
Selena Ahmed et al.
PloS one, 9(10), e109126-e109126 (2014-10-07)
Climate change is impacting agro-ecosystems, crops, and farmer livelihoods in communities worldwide. While it is well understood that more frequent and intense climate events in many areas are resulting in a decline in crop yields, the impact on crop quality
Chunlan Tang et al.
Biomedical chromatography : BMC, 29(12), 1913-1920 (2015-05-27)
Parishin is a dominant active ingredient originating from Gastrodia elata Blume, and has good neuroprotective effects against brain disorders. In the present study, the metabolic profile of parishin by in vitro and in vivo experiments was investigated using ultra-high performance
A T Hughes et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 106-112 (2014-06-22)
Alkaptonuria (AKU) is a rare debilitating autosomal recessive disorder of tyrosine metabolism. Deficiency of homogentisate 1,2-dioxygenase results in increased homogentisic acid (HGA) which although excreted in gram quantities in the urine, is deposited as an ochronotic pigment in connective tissues
Daisuke Masuda et al.
Molecular medicine reports, 12(5), 7303-7309 (2015-10-16)
Ki-67 is a nuclear protein that is expressed during the G1, S, G2 and M phases of the mitotic cell cycle. A previous study categorized tumor infiltration patterns (INF), of which INFc indicated cancer nests exhibiting infiltrative growth and an
Paramesh Ramulu Lambadi et al.
International journal of nanomedicine, 10, 2155-2171 (2015-04-04)
Infectious diseases cause a huge burden on healthcare systems worldwide. Pathogenic bacteria establish infection by developing antibiotic resistance and modulating the host's immune system, whereas opportunistic pathogens like Pseudomonas aeruginosa adapt to adverse conditions owing to their ability to form
Zofia Olszowy et al.
Archiwum medycyny sadowej i kryminologii, 53(1), 3-7 (2003-12-13)
In the paper the authors have presented a possible use of formic acid detection in biological specimens in the diagnosis of methanol poisonings. Formic acid was determined as a volatile methyl formate ester by the gas chromatographic head-space method. Based
Raúl Pérez-Ortuño et al.
Analytical and bioanalytical chemistry, 407(28), 8463-8473 (2015-09-08)
A straightforward, high-throughput method was developed and fully validated for the simultaneous determination of the specific tobacco biomarkers nicotine and its main metabolite cotinine in a wide dynamic range and supporting the most common human biological matrices (urine, oral fluid
Morten P Oksvold et al.
Experimental hematology, 43(5), 352-363 (2015-02-03)
Dasatinib inhibits B-cell receptor-Abelson murine leukemia viral oncogene homologue 1, Src, and other tyrosine kinases. Few studies have addressed the impact of dasatinib on normal blood cells, especially in vivo. Here we show that dasatinib leads to a reduced number
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