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Showing 31-60 of 6394 results for "71717" within Papers
Alexander Hellqvist et al.
Biomedical chromatography : BMC, 29(4), 504-513 (2014-08-12)
Renal function can be monitored by estimation of the glomerular filtration rate (GFR), for example, through measurement of the plasma clearance of a marker that is freely filtrated through the kidney without reabsorption. It has been proposed that iohexol is
Magdalena Grill et al.
Glia, 63(10), 1738-1752 (2015-04-24)
Interleukin-6 (IL-6) participates in the host response to injury and infection in the central nervous system (CNS). We identified strawberry notch homolog 2 (Sbno2) as an IL-6-stimulated gene in murine astrocytes. Sbno2 is a mouse homolog of the sno gene
Mukta Kulkarni et al.
International journal of nanomedicine, 10, 1359-1373 (2015-03-04)
Titanium and titanium alloys are considered to be one of the most applicable materials in medical devices because of their suitable properties, most importantly high corrosion resistance and the specific combination of strength with biocompatibility. In order to improve the
Angélica Maria de Sousa Leal et al.
BMC microbiology, 15, 115-115 (2015-06-07)
Violacein is a purple pigment from Chromobacterium violaceum that possesses diverse biological and pharmacological properties. Among these, pro-oxidant and antioxidant activities have been suggested. However, the cytotoxic mechanisms induced by violacein are poorly understood and the improvement in knowledge regarding
Simon A Ramsbottom et al.
PLoS genetics, 10(12), e1004871-e1004871 (2014-12-19)
Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well
Kayla M Borland et al.
Bioorganic & medicinal chemistry, 23(8), 1869-1881 (2015-03-18)
Current FDA-approved chemotherapeutic antimetabolites elicit severe side effects that warrant their improvement; therefore, we designed compounds with mechanisms of action focusing on inhibiting DNA replication rather than targeting multiple pathways. We previously discovered that 5-(α-substituted-2-nitrobenzyloxy)methyluridine-5'-triphosphates were exquisite DNA synthesis terminators;
Mohammad Azad et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 372-385 (2015-06-17)
Drug nanoparticles in suspensions can form aggregates leading to physical instability, which is traditionally mitigated using soluble polymers and surfactants. The aim of this paper was to explore common superdisintegrants, i.e., sodium starch glycolate (SSG), croscarmellose sodium (CCS), and crospovidone
Y Gui et al.
Oncogene, 34(46), 5718-5728 (2015-03-03)
Suppressor of cytokine signaling 1 (SOCS1) is considered as a tumor suppressor protein in hepatocellular carcinoma (HCC), but the underlying mechanisms remain unclear. Previously, we have shown that SOCS1-deficient hepatocytes displayed increased responsiveness to hepatocyte growth factor (HGF) due to
Chao Yang et al.
Oncotarget, 6(17), 15311-15320 (2015-05-07)
Long non-coding RNA (lncRNA) H19 is involved in tumor development, progression, and metastasis. This case-control study assessed the association between H19 genetic variants and susceptibility to gastric cancer (GC) in a Chinese Han population. We genotyped four lncRNA H19 single
Terutaka Noda et al.
International journal of oncology, 46(4), 1535-1542 (2015-01-28)
Obesity correlates with an increased risk of developing prostate cancer (PCa) and leptin plays an important role in PCa progression. Since leptin is produced by adipocytes, the serum leptin level is higher in obese than in non-obese individuals. However, the
Emilie Degagné et al.
The Journal of clinical investigation, 124(12), 5368-5384 (2014-10-28)
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain incompletely understood. Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and is highly expressed in enterocytes but downregulated in
Weicheng Liu et al.
Digestive diseases and sciences, 60(8), 2304-2315 (2015-03-10)
Recent evidence suggests that colonic macrophages and microRNAs play important roles in motor activity in the gastrointestinal tract. However, there are almost no data concerning colonic macrophages and microRNAs in slow transit constipation. The purpose of this study was to
Ping Yang et al.
PloS one, 10(5), e0127772-e0127772 (2015-05-21)
We have previously demonstrated the growth-promoting effect of intrathecal delivery of recombinant rat IL-6 immediately after corticospinal tract (CST) injury. Our present study aims to further clarify whether intrathecal delivery of IL-6 after CST injury could reactivate the intrinsic growth
Stela Vujosevic et al.
Investigative ophthalmology & visual science, 56(6), 3913-3918 (2015-06-19)
To identify early biomarkers of retinal Müller cell activation in diabetic eyes with or without clinically detectable signs of diabetic retinopathy (DR). This study was a cross-sectional comparative case series. The aqueous humor (AH) of 34 eyes was collected in
Lalita Wattanachanya et al.
Experimental cell research, 333(2), 289-302 (2015-02-24)
G protein-coupled receptor (GPCR) signaling in osteoblasts (OBs) is an important regulator of bone formation. We previously described a mouse model expressing Rs1, an engineered constitutively active Gs-coupled GPCR, under the control of the 2.3 kb Col I promoter. These
Kelsey N Schafer et al.
The Journal of biological chemistry, 288(45), 32599-32611 (2013-09-28)
Small-molecule Tau aggregation inhibitors are under investigation as potential therapeutic agents against Alzheimer disease. Many such inhibitors have been identified in vitro, but their potency-driving features, and their molecular targets in the Tau aggregation pathway, have resisted identification. Previously we
Sachio Yamamoto et al.
Analytical and bioanalytical chemistry, 407(20), 6201-6206 (2015-06-06)
A novel method was developed for D/L-isomeric separation of aldopentoses and aldohexoses as their (S)-(+)-4-(N,N-dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole derivatives using phenylboronate buffer containing sodium dodecyl sulfate as a background electrolyte. The combination of derivatization with a chiral labeling reagent and micellar electrokinetic chromatography
H-D Chae et al.
Leukemia, 29(6), 1379-1389 (2014-12-30)
CREB (cyclic AMP response element-binding protein) is a transcription factor overexpressed in normal and neoplastic myelopoiesis and regulates cell cycle progression, although its oncogenic mechanism has not been well characterized. Replication factor C3 (RFC3) is required for chromatin loading of
Deepa Selvi Rani et al.
DNA and cell biology, 34(5), 350-359 (2015-01-22)
Mutations in sarcomeric genes are the leading cause for cardiomyopathies. However, not many genetic studies have been carried out on Indian cardiomyopathy patients. We performed sequence analyses of a thin filament sarcomeric gene, α-tropomyosin (TPM1), in 101 hypertrophic cardiomyopathy (HCM)
Gina L Razidlo et al.
Cancer research, 75(14), 2907-2915 (2015-05-16)
Pancreatic cancer, one of the most lethal forms of human cancer, is largely resistant to many conventional chemotherapeutic agents. Although many therapeutic approaches focus on tumor growth, metastasis is a primary factor contributing to lethality. Therefore, novel therapies to target
Anne Groboillot et al.
International journal of molecular sciences, 12(3), 1787-1806 (2011-06-16)
To decontaminate dredged harbor sediments by bioremediation or electromigration processes, adding biosurfactants could enhance the bioavailability or mobility of contaminants in an aqueous phase. Pure amphisin from Pseudomonas fluorescens DSS73 displays increased effectiveness in releasing polycyclic aromatic hydrocarbons (PAHs) strongly
Hassan M Albishri et al.
Journal of chromatographic science, 53(7), 1123-1130 (2014-12-30)
Two cyclodextrin micellar liquid chromatographic methods were developed and applied to the simultaneous determination of bisoprolol/hydrochlorothiazide and atenolol/chlorthalidone combinations in urine matrices without sample pretreatment. These combined β-blockers and diuretics chemotherapies are commonly used in the treatment of hypertension and
Nils C Gassen et al.
Science signaling, 8(404), ra119-ra119 (2015-11-26)
Epigenetic processes, such as DNA methylation, and molecular chaperones, including FK506-binding protein 51 (FKBP51), are independently implicated in stress-related mental disorders and antidepressant drug action. FKBP51 associates with cyclin-dependent kinase 5 (CDK5), which is one of several kinases that phosphorylates
Papichaya Phompradit et al.
The American journal of tropical medicine and hygiene, 91(2), 361-366 (2014-06-04)
CYP2A6, CYP2B6, and UGT1A9 genetic polymorphisms and treatment response after a three-day course of artesunate-mefloquine was investigated in 71 Burmese patients with uncomplicated Plasmodium falciparum malaria. Results provide evidence for the possible link between CYP2A6 and CYP2B6 polymorphisms and plasma
Juliana Lucena Schussel et al.
Cancer biomarkers : section A of Disease markers, 15(1), 11-17 (2014-12-20)
DACT genes regulates Wnt as well TGF-β pathway, and were already associated with hepatocellular and lung cancer. Alterations on Wnt/β-catenin were associated with head and neck cancer through β-catenin cytoplasmatic accumulation. The aim of the study was to evaluate DACT1
Janneke Keemink et al.
International journal of pharmaceutics, 491(1-2), 78-90 (2015-06-06)
Compound libraries that are screened for biological activity commonly contain heterocycles. Besides potency, drug-like properties need to be evaluated to ensure in vivo efficacy of test compounds. In this context, we determined hepatic and intestinal disposition profiles for 17 heterocyclic
Naoko Kito et al.
BioMed research international, 2015, 465479-465479 (2015-06-25)
MicroRNAs (miRNAs) are small noncoding RNAs of 18-23 nucleotides that regulate gene expression. Recently, plasma miRNAs have been investigated as biomarkers for various physiological and pathological conditions. The present study details the conserved miRNA expression profiles of tubular tissues, and
Haiyu Tian et al.
Analytica chimica acta, 768, 136-142 (2013-03-12)
In this paper, two colorimetric and turn-on fluorescent probes N-[2-(2-hydroxy)-ethoxy] ethyl-4-azido-1,8-naphthalimide (SS1) and N-butyl-4-azido-1,8-naphthalimide (SS2) for selective recognition of H2S were designed and synthesized. The probes were constructed by incorporating an azido group into the naphthalimide fluorophore as a specifical
Lu Kang et al.
American journal of physiology. Heart and circulatory physiology, 308(11), H1402-H1413 (2015-03-31)
The present study examined the heme oxygenase (HO) system in an in vivo murine model of pathological shear stress induced by partial carotid artery ligation. In this model, along with upregulation of vasculopathic genes, HO-1 is induced in the endothelium
Marjorie Fullerton et al.
Molecular and biochemical parasitology, 199(1-2), 9-18 (2015-03-21)
Trypanosoma brucei, the causative agent for African trypanosomiasis, possesses a single mitochondrion that imports hundreds of proteins from the cytosol. However, the parasite only possesses a few homologs of the canonical protein translocases found in fungi and animals. We recently
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