CN
Search Within
721956
Applied Filters:
Keyword:'721956'
Showing 1-30 of 6965 results for "721956" within Papers
Robert T Dauchy et al.
Journal of the American Association for Laboratory Animal Science : JAALAS, 54(1), 40-50 (2015-02-05)
Early studies on rodents showed that short-term exposure to high-intensity light (> 70 lx) above 600 nm (red-appearing) influences circadian neuroendocrine and metabolic physiology. Here we addressed the hypothesis that long-term, low-intensity red light exposure at night (rLEN) from a
Ellen P Preece et al.
Environmental monitoring and assessment, 187(2), 12-12 (2015-01-27)
Ingestion of water contaminated with the cyanotoxin, microcystin (MC), can pose serious health risks to humans. MC is also known to accumulate in seafood; however, this exposure pathway is much less understood. A fundamental element of this uncertainty is related
Guyue Cheng et al.
PloS one, 9(9), e106769-e106769 (2014-09-04)
T-2 toxin, one of the type A trichothecenes, presents a potential hazard to human and animal health. Our previous work demonstrated that porcine cytochrome P450 3A29 (CYP3A29) played an important role in the hydroxylation of T-2 toxin. To identify amino
Leila Maringer et al.
Electrophoresis, 36(2), 348-354 (2014-10-14)
The combination of CE and MS is now a widely used tool that can provide a combination of high resolution separations with detailed structural information. Recently, we highlighted the benefits of an approach to add further functionality to this well-established
Nur Farhana Ahmad Sopian et al.
International journal of molecular sciences, 16(7), 15800-15810 (2015-07-18)
Dietary omega-3 fatty acids have been recognized to improve brain cognitive function. Deficiency leads to dysfunctional zinc metabolism associated with learning and memory impairment. The objective of this study is to explore the effect of short-term dietary omega-3 fatty acids
Petra C Lindholm-Lehto et al.
Environmental science and pollution research international, 22(21), 17209-17223 (2015-07-04)
The presence of five different pharmaceuticals, consisting of four anti-inflammatory and one antiepileptic drug, was determined in influent and effluent of a municipal wastewater treatment plant (WWTP) near the city of Jyväskylä, Finland, and in the receiving water, northern Lake
HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.
Davide Valente et al.
Oncotarget, 6(12), 10320-10334 (2015-04-15)
HIPK2, a cell fate decision kinase inactivated in several human cancers, is thought to exert its oncosuppressing activity through its p53-dependent and -independent apoptotic function. However, a HIPK2 role in cell proliferation has also been described. In particular, HIPK2 is
Sabine H van Rijt et al.
ACS nano, 9(3), 2377-2389 (2015-02-24)
Nanoparticles allow for controlled and targeted drug delivery to diseased tissues and therefore bypass systemic side effects. Spatiotemporal control of drug release can be achieved by nanocarriers that respond to elevated levels of disease-specific enzymes. For example, matrix metalloproteinase 9
Timothy Paul Wood et al.
Environmental pollution (Barking, Essex : 1987), 199, 235-243 (2015-02-15)
The study and quantification of personal care products, such as pharmaceuticals, in surface water has become popular in recent years; yet very little description of these compounds' presence in South African surface water exists in the literature. Antiretrovirals (ARVs), used
Hye Jeong Yang et al.
European journal of nutrition, 54(1), 77-88 (2014-04-05)
Brain insulin resistance is related to both diabetes and Alzheimer's disease. We investigated whether both chungkookjangs, soybeans fermented in a traditional method (TFC) and with Bacillus lichenifomis (SFC), can protect against cognitive dysfunction and glucose dysregulation in rats with Alzheimer's
M Serrano et al.
Talanta, 143, 71-76 (2015-06-17)
In the last decades, the assessment of polycyclic aromatic hydrocarbons' exposure has generated great interest and 1-hydroxypyrene (1-OHP) has been commonly used as a biological indicator of exposure to PAHs in many studies in environmental and occupational health. In this
Qingnian Goh et al.
Experimental cell research, 331(2), 292-308 (2014-10-05)
We previously demonstrated that the expression of intercellular adhesion molecule-1 (ICAM-1) by skeletal muscle cells after muscle overload contributes to ensuing regenerative and hypertrophic processes in skeletal muscle. The objective of the present study is to reveal mechanisms through which
Ugo Bussy et al.
Analytical and bioanalytical chemistry, 406(28), 7253-7260 (2014-09-23)
Electrochemistry combined with (liquid chromatography) high resolution mass spectrometry was used to simulate the general reductive metabolism of three biologically important nitro aromatic molecules: 3-trifluoromethyl-4-nitrophenol (TFM), niclosamide, and nilutamide. TFM is a pesticide used in the Laurential Great Lakes while
Jae Kyoo Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), 3898-3903 (2015-03-17)
We investigated the fusion of high-speed liquid droplets as a way to record the kinetics of liquid-phase chemical reactions on the order of microseconds. Two streams of micrometer-size droplets collide with one another. The droplets that fused (13 μm in
Dequina A Nicholas et al.
Mediators of inflammation, 2015, 196297-196297 (2015-12-04)
High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA
Ilona Joniec-Maciejak et al.
Pharmacological reports : PR, 66(4), 660-669 (2014-06-21)
The aim of this study was to examine the effect of AAV2-hIL-10 (vector containing cDNA for human interleukin 10) on dopaminergic system activity (measured as DA levels and TH mRNA expression in mouse striata), and other monoamine and amino acid
María-Ángeles Del-Castillo-Alonso et al.
Journal of the science of food and agriculture, 95(2), 409-416 (2014-05-14)
Ultraviolet (UV) radiation induces adaptive responses that can be used for plant production improvement. The aim of this study was to assess the effect of solar UV exclusion on the physiology and phenolic compounds of leaves and berry skins of
Sheng-Chun Chiu et al.
International journal of molecular sciences, 15(9), 15622-15637 (2014-09-06)
Tanshinone IIA (Tan-IIA), one of the major lipophilic components isolated from the root of Salviae Miltiorrhizae, has been found to exhibit anticancer activity in various cancer cells. We have demonstrated that Tan-IIA induces apoptosis in several human cancer cells through
Paramesh Ramulu Lambadi et al.
International journal of nanomedicine, 10, 2155-2171 (2015-04-04)
Infectious diseases cause a huge burden on healthcare systems worldwide. Pathogenic bacteria establish infection by developing antibiotic resistance and modulating the host's immune system, whereas opportunistic pathogens like Pseudomonas aeruginosa adapt to adverse conditions owing to their ability to form
Zofia Olszowy et al.
Archiwum medycyny sadowej i kryminologii, 53(1), 3-7 (2003-12-13)
In the paper the authors have presented a possible use of formic acid detection in biological specimens in the diagnosis of methanol poisonings. Formic acid was determined as a volatile methyl formate ester by the gas chromatographic head-space method. Based
Raúl Pérez-Ortuño et al.
Analytical and bioanalytical chemistry, 407(28), 8463-8473 (2015-09-08)
A straightforward, high-throughput method was developed and fully validated for the simultaneous determination of the specific tobacco biomarkers nicotine and its main metabolite cotinine in a wide dynamic range and supporting the most common human biological matrices (urine, oral fluid
Mitsuru Tanaka et al.
Molecular nutrition & food research, 59(8), 1541-1549 (2015-03-27)
The basic dipeptide, Trp-His, was found to show an in vivo anti-atherosclerotic effect when orally administered to apo E-deficient mice. In addition, this dipeptide causes vasorelaxation in contracted rat aorta via suppression of intracellular Ca(2+) signaling cascades. In this study
Morten P Oksvold et al.
Experimental hematology, 43(5), 352-363 (2015-02-03)
Dasatinib inhibits B-cell receptor-Abelson murine leukemia viral oncogene homologue 1, Src, and other tyrosine kinases. Few studies have addressed the impact of dasatinib on normal blood cells, especially in vivo. Here we show that dasatinib leads to a reduced number
Shveta Bathla et al.
Journal of proteomics, 127(Pt A), 193-201 (2015-05-30)
Urine is a non-invasive source of biological fluid, which reflects the physiological status of the mammals. We have profiled the cow urinary proteome and analyzed its functional significance. The urine collected from three healthy cows was concentrated by diafiltration (DF)
Alexandros G Asimakopoulos et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 85-93 (2015-03-01)
A rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and optimized for the simultaneous determination of bisphenol A, 4-t-octylphenol and 4-nonylphenol in human blood serum. For the first time, the electrospray ionization (ESI) parameters of probe position, voltage potential
Xinzhu Deng et al.
PloS one, 10(6), e0127862-e0127862 (2015-06-30)
Mammalian NOTCH1-4 receptors are all associated with human malignancy, although exact roles remain enigmatic. Here we employ glp-1(ar202), a temperature-sensitive gain-of-function C. elegans NOTCH mutant, to delineate NOTCH-driven tumor responses to radiotherapy. At ≤20°C, glp-1(ar202) is wild-type, whereas at 25°C
Errin Johnson et al.
Scientific reports, 5, 9583-9583 (2015-04-01)
We introduce a method for correlative in-resin super-resolution fluorescence and electron microscopy (EM) of biological structures in mammalian culture cells. Cryo-fixed resin embedded samples offer superior structural preservation, performing in-resin super-resolution, however, remains a challenge. We identified key aspects of
Li-hua Fan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 18-22 (2015-02-24)
A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of acacetin in rat plasma. Sample preparation was accomplished through a simple one-step deproteinization procedure with 0.2 mL
Ivana Massud et al.
The Journal of antimicrobial chemotherapy, 70(5), 1473-1481 (2015-01-30)
Pharmacokinetic studies in animal models are important for assessing the prophylactic potential of antiretroviral drugs for HIV prevention. This study sought to identify clinically relevant doses of the marketed integrase inhibitors raltegravir, elvitegravir and dolutegravir in macaques and investigate drug
Rebeca Penalva et al.
Journal of agricultural and food chemistry, 63(23), 5603-5611 (2015-06-02)
Resveratrol offers pleiotropic health benefits including a reported ability to inhibit lipopolysaccharide (LPS)-induced cytokine production. The aim of this work was to prepare, characterize, and evaluate a resveratrol nanoparticulate formulation based on zein. For this purpose, the oral bioavailability of
Page 1 of 233