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Showing 1-30 of 237 results for "78246" within Papers
Kunal Jain et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 17(5), 579-591 (2013-08-03)
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological
Hongbin Ni et al.
The Journal of surgical research, 187(2), 646-652 (2014-02-04)
The present study aimed to investigate the effects of curcumin on the levels of spinal cord labile zinc (Zn) and inflammatory cytokines in rats after traumatic spinal cord injury (SCI). Adult male Sprague-Dawley rats were subjected to laminectomy at T8-T9
Khajeelak Chiablaem et al.
Anticancer research, 34(4), 1857-1864 (2014-04-03)
Vasculogenic mimicry (VM) refers to the process in which highly invasive cancer cells mimic endothelial cells by forming blood channels. In the present study, we investigated the effect of curcumin, a natural product from turmeric, on VM of SK-Hep-1 human
Thitita Unahabhokha et al.
Pharmaceutical biology, 53(3), 457-463 (2014-10-22)
Keloid is an excessive dermal scar occurring in response to skin injuries. Several therapeutic strategies have been proposed to ease the aggressiveness of keloid scarring. Even though the principle mechanism underlying the disease propagation still remains unidentified, several signaling pathways
Investigations of curcumin and resveratrol on neurite outgrowth: perspectives on spinal muscular atrophy.
Bora-Tatar G, Erdem-Yurter H, et al.
BioMed Research International, 2014, 709108-709108 (2014)
Phyllis Langone et al.
International journal of cancer, 135(3), 710-719 (2013-10-22)
Current therapies for glioblastoma are largely palliative, involving surgical resection followed by chemotherapy and radiation therapy, which yield serious side effects and very rarely produce complete recovery. Curcumin, a food component, blocked brain tumor formation but failed to eliminate established
Bopaiah Cheppudira et al.
Expert opinion on investigational drugs, 22(10), 1295-1303 (2013-08-02)
Managing burn injury-associated pain and wounds is a major unresolved clinical problem. Opioids, nonsteroidal antiinflammatory drugs (NSAIDs), antidepressants and anticonvulsants remain the most common forms of analgesic therapy to treat burn patients. However, prolonged treatment with these drugs leads to
Mingxiang Ye et al.
Cancer letters, 357(1), 196-205 (2014-12-03)
Curcumin has attracted increasing interest as an anti-cancer drug for decades. The mechanisms of action involve multiple cancer-related signaling pathways. Recent studies highlighted curcumin has epigenetic regulatory effects on miRNA in cancers. In the present study, we demonstrated the proapoptotic
Zhi-guo Zhang et al.
Chinese journal of integrative medicine, 21(2), 115-122 (2013-10-25)
To re-analyze the data published in order to explore plausible biological pathways that can be used to explain the anti-aging effect of curcumin. Microarray data generated from other study aiming to investigate effect of curcumin on extending lifespan of Drosophila
Shusuke Toden et al.
Carcinogenesis, 36(3), 355-367 (2015-02-06)
Resistance to cytotoxic chemotherapy is a major cause of mortality in colorectal cancer (CRC) patients. Chemoresistance has been linked primarily to a subset of cancer cells undergoing epithelial-mesenchymal transition (EMT). Curcumin, a botanical with antitumorigenic properties, has been shown to
Mei-Chi Chang et al.
PloS one, 9(7), e101959-e101959 (2014-07-23)
Chewing of betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSF), possibly by BQ-induced toxicity and induction of inflammatory response in oral mucosa. Primary gingival keratinocytes (GK cells) were exposed to areca nut (AN) components
Thomas Kalinski et al.
PloS one, 9(6), e99296-e99296 (2014-06-06)
Interleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved
Gokhan Kurt et al.
Journal of neurosurgery. Spine, 20(4), 464-470 (2014-01-28)
The object of this study was to conduct a prospective, randomized, laboratory investigation of the neuroprotective effects of curcumin functionally, biochemically, and histologically in an experimental acute spinal cord ischemia-reperfusion injury on rabbits. Eighteen rabbits were randomly assigned to 1
Yildiz Öner-İyidoğan et al.
Canadian journal of physiology and pharmacology, 92(10), 805-812 (2014-09-12)
High fat diet (HFD) is associated with oxidative stress induced fatty liver. Curcumin, an extract of Curcuma longa, has been shown to possess potent antioxidant and hypolipidemic properties. In this study, we investigated the effect of curcumin treatment on hepatic
Feng Xu et al.
The clinical respiratory journal, 9(1), 87-97 (2014-01-28)
Curcumin has remarkable anti-inflammatory and antioxidant properties. However, its effects on bacterium-induced acute lung injury (ALI) are not fully understood. To investigate the protective effects of curcumin on a mouse model of S. aureus-induced ALI. Mice were pretreated with intraperitoneal injection
Dami An et al.
Biomolecules & therapeutics, 22(4), 355-362 (2014-08-22)
We have developed a fully automated high throughput drug screening (HTDS) system based on the microfluidic cell culture array to perform combinational chemotherapy. This system has 64 individually addressable cell culture chambers where the sequential combinatorial concentrations of two different
Jang Hoon Kim et al.
Bioorganic & medicinal chemistry, 22(21), 6047-6052 (2014-10-04)
Clostridium perfringens is a Gram-positive spore-forming bacterium that causes food poisoning. The neuraminidase (NA) protein of C. perfringens plays a pivotal role in bacterial proliferation and is considered a novel antibacterial drug target. Based on screens for novel NA inhibitors
Youcai Tang et al.
Laboratory investigation; a journal of technical methods and pathology, 94(5), 503-516 (2014-03-13)
Non-alcoholic steatohepatitis (NASH) is a major risk factor for hepatic fibrogenesis. NASH is often found in diabetic patients with hyperglycemia. Hyperglycemia induces non-enzymatic glycation of proteins, yielding advanced glycation end-products (AGEs). Effects of AGEs are mainly mediated by two categories
Touqeer Ahmed et al.
Phytotherapy research : PTR, 28(4), 517-525 (2013-07-23)
Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high cost. Hence, newer and alternate treatment options are being
R Afrin et al.
Free radical research, 49(3), 279-289 (2014-12-24)
We investigated the effect of curcumin on liver injury in diabetic rats induced by streptozotocin (STZ) through modulation of endoplasmic reticulum stress (ERS) and unfolded protein response (UPR). Experimental diabetes was induced by a single intraperitoneal injection of STZ (55
Rana Tarzemany et al.
PloS one, 10(1), e0115524-e0115524 (2015-01-15)
Connexins (C×s) are a family of transmembrane proteins that form hemichannels and gap junctions (GJs) on the cell membranes, and transfer small signaling molecules between the cytoplasm and extracellular space and between connecting cells, respectively. Among C×s, suppressing C×43 expression
Ai-Jun Jiang et al.
Molecular biology reports, 42(1), 267-275 (2014-09-30)
Melanoma is the most malignant skin cancer and is highly resistant to chemotherapy and radiotherapy. Curcumin is a component of turmeric, the yellow spice derived from the rhizome of Curcuma longa. It has been demonstrated to modulate multiple cell signaling
Min Ruan et al.
International journal of oncology, 44(6), 2103-2110 (2014-03-29)
Increasing evidence suggests that communication between tumor and immune cells can alter the tumor microenvironment in ways that promote tumor development. The purpose of this study was to characterize the immune response elicited by TLR-9-activated OSCC cells, to identify the
Dai-Ying Zhou et al.
Biological & pharmaceutical bulletin, 37(6), 1029-1034 (2014-03-22)
Four curcumin analogues ((2E,6E)-2,6-bis(thiophen-3-methylene) cyclohexanone (AS), (2E,5E)-2,5-bis(thiophen-3-methylene) cyclopentanone (BS), (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydropyran-4-one (ES) and (3E,5E)-3,5-bis(thiophen-3-methylene)-tetrahydrothiopyran-4-one (FS) as shown in Fig. 1) with different linker groups were investigated for their effects in human prostate cancer CWR-22Rv1 and PC-3 cells. Compounds FS and ES
Fangyuan Chen et al.
Journal of cardiovascular pharmacology, 63(6), 544-552 (2014-04-09)
This study aimed to investigate the effects of curcumin on macrophages polarization and possible mechanism involved, and to analyze the molecular basis of its antiatherosclerosis activity. RAW264.7 macrophages (M0) and M1 macrophages were treated with curcumin at 0, 6.25, 12.5
Deepak Yadav et al.
International journal of pharmaceutics, 477(1-2), 564-577 (2014-12-03)
The present work aims to investigate applicability of antisolvent precipitation method for preparation of nanosized curcumin and to control their characteristics by determining the influence of process and solvents on solid-state properties of curcumin nanoparticles. Effects of different experimental parameters
Lei Chong et al.
Inflammation, 37(5), 1476-1485 (2014-04-08)
Curcumin, a natural product derived from the plant Curcuma longa, has been found to have anti-inflammatory, antineoplastic and antifibrosis effects. It has been reported that curcumin attenuates allergic airway inflammation in mice through inhibiting NF-κB and its downstream transcription factor
Manish Kumar Jeengar et al.
Inflammation, 37(6), 2139-2155 (2014-07-17)
The purpose of the present study is to evaluate the effect of emu oil on bioavailability of curcumin when co-administered and to evaluate the property that enhances the anti-inflammatory potential of curcumin. Oral bioavailability of curcumin in combination with emu
Bin Chen et al.
The Journal of steroid biochemistry and molecular biology, 143, 11-18 (2014-02-04)
Curcumin can inhibit cell proliferation of breast cancer, but the mechanism for this inhibition remains unclear. Over-expression of Flap endonuclease 1 (Fen1), a DNA repair-specific nuclease, is involved in the development of breast cancer. Nrf2 is a master regulator of
Dan Gao et al.
Journal of the American Society for Mass Spectrometry, 26(4), 686-694 (2015-01-17)
The identification of drug metabolites is very important in drug development. Nowadays, the most widely used methods are isotopes and mass spectrometry. However, the commercial isotopic labeled reagents are usually very expensive, and the rapid and convenient identification of metabolites
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