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Showing 1-30 of 2856 results for "861677" within Papers
Yao Jin et al.
Acta pharmacologica Sinica, 40(1), 75-85 (2018-06-21)
Toosendanin (TSN) is the main active compound in Toosendan Fructus and Meliae Cortex, two commonly used traditional Chinese medicines. TSN has been reported to induce hepatotoxicity, but its mechanism remains unclear. In this study, we demonstrated the critical role of
Dayoung Ryu et al.
Archives of pharmacal research, 43(12), 1297-1310 (2020-11-27)
Transforming growth factor-β1 (TGF-β1) is a multifaceted factor in cancer biology that regulates cell proliferation and migration. Overactivation of nuclear factor erythroid 2-like 2 (NFE2L2; NRF2) in cancers has been associated with facilitated tumor growth and therapy resistance; however, role
Hong Miao et al.
Nanoscale, 10(17), 8139-8145 (2018-04-21)
Although a number of methods to perform assays of tetracyclines using fluorescent probes have been reported, approaches for discriminating and detecting tetracyclines are few. Herein, bright-blue fluorescent carbon dots (CDs) with a quantum yield (QY) of up to ∼27.9% were
Thomas Petry et al.
Regulatory toxicology and pharmacology : RTP, 84, 64-76 (2016-12-27)
The skin sensitization potential of chemicals has traditionally been evaluated in vivo according to OECD testing guidelines in guinea pigs or the mouse local lymph node assay. There has lately been a great emphasis on establishing in vitro test methods reflecting the
Rory T Steven et al.
Analytica chimica acta, 1051, 110-119 (2019-01-22)
Matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) at atmospheric pressure (AP) is, with a few notable exceptions, overshadowed by its vacuum based forms and AP transmission mode (TM) MALDI-MS lacks the up-take its potential benefits might suggest. The reasons
Safal Shrestha et al.
Science signaling, 13(639) (2020-07-09)
Aberrant regulation of metabolic kinases by altered redox homeostasis substantially contributes to aging and various diseases, such as diabetes. We found that the catalytic activity of a conserved family of fructosamine-3-kinases (FN3Ks), which are evolutionarily related to eukaryotic protein kinases
Suman Mukhopadhyay et al.
Cancer research, 80(8), 1630-1643 (2020-01-09)
Pancreatic cancer is a disease with limited therapeutic options. Resistance to chemotherapies poses a significant clinical challenge for patients with pancreatic cancer and contributes to a high rate of recurrence. Oncogenic KRAS, a critical driver of pancreatic cancer, promotes metabolic
Junmei Bian et al.
PloS one, 14(11), e0225261-e0225261 (2019-11-22)
Human bocavirus (HBoV) is a member of the genus Bocavirus, family Parvoviridae, and subfamily Parvovirus and was first identified in nasopharyngeal aspirates of Swedish children with acute respiratory tract infection (ARTI) in 2005. It is the causative agent of nasopharyngeal
Paula Roszczenko et al.
BMC microbiology, 15, 135-135 (2015-07-05)
In the genome of H. pylori 26695, 149 proteins containing the CXXC motif characteristic of thioldisulfide oxidoreductases have been identified to date. However, only two of these proteins have a thioredoxin-like fold (i.e., HP0377 and HP0231) and are periplasm-located. We
Levi Gadye et al.
Cell stem cell, 21(6), 775-790 (2017-11-28)
Tissue homeostasis and regeneration are mediated by programs of adult stem cell renewal and differentiation. However, the mechanisms that regulate stem cell fates under such widely varying conditions are not fully understood. Using single-cell techniques, we assessed the transcriptional changes
Qingsu Cheng et al.
Scientific reports, 5, 13685-13685 (2015-09-09)
To date, in situ visualization of microbial density has remained an open problem. Here, functionalized buckyballs (e.g., C60-pyrrolidine tris acid) are shown to be a versatile platform that allows internalization within a microorganism without either adhering to the cell wall
Yu Wu et al.
Biochemical and biophysical research communications, 464(4), 1275-1281 (2015-07-30)
The osteoblastic expression of RANKL, which is essential for the communication between osteoblastic cells and osteoclastogenic cells, is stimulated by locally acting or circulating osteotropic cytokines and hormones such as PTH and 1,25-(OH)2-D3 during the bone remodeling process. However, mechanisms
Uchechukwu I Okafor et al.
Food science & nutrition, 6(2), 424-439 (2018-03-23)
Maize was cofermented with pigeon pea for ogi production and evaluated for nutritional (proximate composition, minerals, vitamins, and amino acid profile analyses) and antinutritional (phytate, tannin, and trypsin inhibitor activity analyses) qualities. White maize and pigeon pea were mixed at
Urska Repnik et al.
The Journal of biological chemistry, 290(22), 13800-13811 (2015-04-03)
Cysteine cathepsins are primarily lysosomal proteases involved in general protein turnover, but they also have specific proteolytic functions in antigen presentation and bone remodeling. Cathepsins are most stable at acidic pH, although growing evidence indicates that they have physiologically relevant
Andrea Sacconi et al.
Journal of experimental & clinical cancer research : CR, 39(1), 200-200 (2020-09-25)
SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in normal tissues from oral cavity, pharynx, larynx
V O Okoh et al.
British journal of cancer, 112(10), 1687-1702 (2015-05-13)
17β-Oestradiol (E2)-induced reactive oxygen species (ROS) have been implicated in regulating the growth of breast cancer cells. However, the underlying mechanism of this is not clear. Here we show how ROS through a novel redox signalling pathway involving nuclear respiratory
Akriti Kharbanda et al.
Science signaling, 13(621) (2020-03-05)
Non-small cell lung cancer (NSCLC) is often characterized by mutually exclusive mutations in the epidermal growth factor receptor (EGFR) or the guanosine triphosphatase KRAS. We hypothesized that blocking EGFR palmitoylation, previously shown to inhibit EGFR activity, might alter downstream signaling
Simon P Keam et al.
The Prostate, 78(8), 563-575 (2018-03-10)
The development of radioresistance in prostate cancer (PCa) is an important clinical issue and is still largely uninformed by personalized molecular characteristics. The aim of this study was to establish a platform that describes the early oncoproteomic response of human
Swati Singh et al.
International journal of biological macromolecules, 103, 355-359 (2017-05-16)
Several infectious pathogens are found in human whose detection is essential for rapid cure of diseases. The most commonly found pathogen in human is Streptococcus pyogenes which leads to a wide range of infections from mild pharyngitis to rheumatic heart
Ling Chien et al.
Biochimica et biophysica acta. Molecular basis of disease, 1864(9 Pt B), 3001-3012 (2018-06-19)
Due to the inhibitory microenvironment and reduced intrinsic growth capacity of neurons, neuronal regeneration of central nervous system remains challenging. Neurons are highly energy demanding and require sufficient mitochondria to support cellular activities. In response to stimuli, mitochondria undergo fusion/fission
Parker M Pennington et al.
Journal of equine veterinary science, 88, 102938-102938 (2020-04-19)
Insulin resistance (IR) is characterized by an increase in biomarkers of systemic inflammation and susceptibility to laminitis in horses. Impacts on reproduction include a lengthened interovulatory period in horses. Dietary omega-3 (docosahexaenoic acid [DHA]) promotes anti-inflammatory processes, has been implicated
Hui Liu et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 258(8), 1717-1725 (2020-05-24)
Oxidative stress is widely known to be a major contributor in the pathogenesis of dry eye disease (DED). 4-Hydroxynonenal (4-HNE), a well-known byproduct frequently measured as an indicator of oxidative stress-induced lipid peroxidation, has been shown to be elevated in
Zhenqing Liu et al.
Cell death and differentiation, 24(1), 98-110 (2016-11-12)
Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated anion channel capable of conducting both Cl- and HCO3-, mutations of which cause cystic fibrosis (CF), a common autosomal recessive disease. Although CF patients are known to have varied degree of
Jennifer Kuschelewski et al.
Biotechnology progress, 33(3), 759-770 (2017-03-08)
The ability of cell culture media components to generate reactive species as well as their sensitivity to oxidative degradation, affects the overall stability of media and the behavior of cells cultured in vitro. This study investigates the influence of thiazolidine
Antonella Tramutola et al.
Biochimica et biophysica acta. Molecular basis of disease, 1864(10), 3309-3321 (2018-07-22)
PET scan analysis demonstrated the early reduction of cerebral glucose metabolism in Alzheimer disease (AD) patients that can make neurons vulnerable to damage via the alteration of the hexosamine biosynthetic pathway (HBP). Defective HBP leads to flawed protein O-GlcNAcylation coupled
Chang Liu et al.
Nature communications, 11(1), 79-79 (2020-01-09)
Mice are widely used as experimental models for gut microbiome (GM) studies, yet the majority of mouse GM members remain uncharacterized. Here, we report the construction of a mouse gut microbial biobank (mGMB) that contains 126 species, represented by 244
Jie Ying Chan et al.
Molecular cancer therapeutics, 16(7), 1324-1334 (2017-05-05)
Insulin receptor (InsR) and the type I insulin-like growth factor (IGF1R) are homologous receptors necessary for signal transduction by their cognate ligands insulin, IGF-I and IGF-II. IGF1R mAbs, intended to inhibit malignant phenotypic signaling, failed to show benefit in patients
Christoph Cerny et al.
Food chemistry, 337, 128008-128008 (2020-09-14)
This study investigated the role of furfuryl alcohol (FFA) in the formation of furfurylthiol (FFT), the most important odorant in roasted coffee, using in-bean and spiking experiments. Green beans were spiked with FFA, and after roasting FFT was quantified by
Yuya Sakamoto et al.
European journal of pharmacology, 800, 48-56 (2017-02-22)
Vancomycin (VCM) is a first-line antibiotic for serious infections caused by methicillin-resistant Staphylococcus aureus. However, nephrotoxicity is one of the most complaint in VCM therapy. We previously reported that VCM induced apoptosis in a porcine proximal tubular epithelial cell line
Anna Feldman-Salit et al.
The New phytologist, 222(3), 1392-1404 (2019-01-27)
Sulfur assimilation is central to the survival of plants and has been studied under different environmental conditions. Multiple studies have been published trying to determine rate-limiting or controlling steps in this pathway. However, the picture remains inconclusive with at least
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