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Poster - Interaction of thermal and rheological parameters critical for the processability of polyvinyl alcohol-based systems during hot melt extrusion
left: PVA 3-82 and PVA 3-82/plasticizer systems;
right: PVA 4-88 and PVA 4-88/plasticizer systems, mean of n=3.
Figure 2.
Phase angle δ against temperature left: PVA 3-82 and PVA 3-82/plasticizer systems
Poster- Solubility enhancement via amorphous solid dispersions
torque is lower for 3-82 then for
4-88. Several conducted HME trials both with 3-82 and 4-88
proved that the process range of 3-82 is feasible at 130–210 °C*
and 150–230 °C* for 4-88, which correlates to
Parteck® MXP Brochure: two polymers, unparalleled value
hydrolysis grade of 82 %, while Parteck® MXP 4 - 88 shows a
viscosity of 4 mPa • s and a hydrolysis grade of 88%.
Hydrophilic group
Hydrophobic group
With a
The Effective Use of Protein Kinase Inhibitors
98 86 95 95 92 99 93 89 92 100 91 70 99 98 97 3 4 7
PDK1 104 115 92 36 70 99 85 86 89 87 88 76 81 110 105 98 84 85 69
Poster - Hydrophilic polymers in spray dried amorphous dispersions
dried dispersion using PVA 3-82 shows a tenfold increase
in release at the final timepoint followed by PVA 4-88.
The maximum peak of drug release from the ASD using
PVA 3-82 is reached after 15 minutes
The Effective Use of Protein Kinase Inhibitors
98 86 95 95 92 99 93 89 92 100 91 70 99 98 97 3 4 7
PDK1 104 115 92 36 70 99 85 86 89 87 88 76 81 110 105 98 84 85 69
Enhancing the Solubility of Active Pharmaceutical Ingredients Using Hot Melt Extrusion and Polyvinyl Alcohol
physiologically relevant timescales,
even for the most challenging DCS Class IIb APIs.
Parteck® MXP 4-88 PVA contains 88% hydroxyl
groups and 12% acetate groups. This higher hydrolysis
grade makes it more hydrophilic
Anti-Calpain-94 (Domain II) Large Submit antibody produced in rabbit (C3364)
detects all
isoforms of human calpain 94, including the LP82, 85,
88, and 90 forms. The antibody also detects isoforms
82, 85, 88, and 90 of rat calpain 94. The antibody
recognizes latent and active
Anti-Calpain-94 (LP828588 90 Isoforms) (Domain I) Large Subunit antibody produced in rabbit (C3739)
variants of calpain 94 include
replacement of domain I with an aminoterminal end
unique to the LP 82, 85, 88, and 90 isoforms.2 The lens
contains isoforms LP82 and LP85. The latent large
subunit is 94 kDa
Investigation of Various Polymers for SLS 3D-Printing of Solid Oral Dosage Forms
pharmaceutical-grade polymers (PVA 4-88 (Parteck® MXP),
PVP-VA1 (Kollidon VA64®), PVP-VA2 (Plasdone™ S-630)).
• Usage conditions of dedicated PVA based polymers P1
(PVA3-82) and P2 (PVA5-74) in SLS printing
Product Information Sheet - 80476
deg C
Run-Time acceleration with temp
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Data Sheet - SAB4200859
Microbiol Immunol., 54,
769-77 (2010).
4. Pontzer CH., et al., Proc Natl Acad Sci U S A., 88,
125-8 (1991).
5. Alefantis T., et al., Mol Cell Probes, 18,
379-82 (2004).
6. Karauzum
Data Sheet - SAB4200883
Microbiol Immunol., 54,
769-77 (2010).
4. Pontzer CH., et al., Proc Natl Acad Sci U S A., 88,
125-8 (1991).
5. Alefantis T., et al., Mol Cell Probes, 18, 379-82
(2004).
6. Karauzum H.
Data Sheet - A164
. Wt.: 292.21 (anhyd.)
m.p.: 98-99 °C
CAS Registry No.: 60719-82-6 (free base)
Chemical Name: D,L-Alanine, 2-(4-Chlorophenyl)-1,1-dimethylethyl ester hydrochloride
Physical Properties
MF-Millipore Filters: A biologically inert mixture of cellulose acetate and cellulose nitrate
150 150 150 150 150 135 135
18 32 60 60 140 190 190 270 320 580 620
2 3 4 4 9 16 16 20 30 32 65
75 77 79 79 81 82 82 82
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Data Sheet - H7157
(1990).
4. Weidner, K., et al., Proc. Natl. Acad. Sci. USA, 88,
7001 (1991).
5. Fukuyama, R., et al., Genomics, 11, 410 (1991).
6. Rubin, J., et al., Proc. Natl. Acad. Sci. USA, 88, 415
(1991
Acetylcholinesterase (C0663)
1975).
4. Low, M.G., and Finean, J.B., FEBS Letts., 82, 143-
146 (1977).
5. Toutant, J-P., et al., Eur. J. Biochem., 180, 503-508
(1989).
6. Ellman, G.L., et al., Biochem Pharmacol., 7, 88-95
Data Sheet - F0550
D., Crit. Rev. Oncog. 4,
595-613 (1993).
2. Rosnet, O., et al., D., Blood, 82, 1110-1119 (1993).
3. Small, D., et al., Proc. Natl. Acad. Sci. USA, 91,
459-463 (1994).
4. Rosnet, O., et al., Oncogene
The HydroCorr Integrity Test
5442-
9736 Analytical
9737 BioProcess
9734 Lab Water
9738 Microelectr.
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Webinar: Strategies and Enabling Technologies for Enhancing API Solubility
hydrophilic
Natural origin
Synthetic
Polyvinyl alcohol
PVA
PVA
PVA
PVA 4-88 / 3-82
Stable high drug loadsPVA
Various options to modify release profilePVA
Strategies and
Product Information Sheet - C9705
against several fungi and
yeasts, but not against bacteria. Concanamycins A, B,
and C caused 99%, 82%, and 88% inhibition,
respectively, of the incorporation of tritiated thymidine
into cells when used at
Aldrich Polymer Products Application - Transitions
methacrylate -10
2-Ethylhexyl vinyl ether -66
Ethyl methacrylate 65
Ethyl vinyl ether -43 86
4-Fluorostyrene 95
Formaldehyde -82 181
Hexadecyl acrylate 35
Hexadecyl methacrylate 15
Hexyl acrylate 57
Hexyl methacrylate
Data Sheet - 58030
in soil.
Soil Bol. Biochem. 22, 81-88 (1990).
13. Suh Y.-A., ARNOLD R.S., Cell transformation by the superoxide-generating oxidase Mox1,
Nature 401, 79 - 82 (1999)
Data Sheet - C6611
not crossreact with other
calpain family members (µ-calpain, m-calpain, LP-82/85
calpain, nCL-2, nCL-3, etc.). The rat 88 kDa and 90
kDa calpains share the insert #1, and the antibody may
cross-react
Product Information Sheet-11271156001
05
21
.1
12
74
82
10
01
11
4. Supplementary Information
y Version: 11 Tumor Necrosis Factor-α, mouse (mTNF-α) recombinant (E. coli)
6 sigma-aldrich.com
4. Supplementary Information
Data Sheet - C6486
does not crossreact with other
calpain family members (µ-calpain, m-calpain, LP-82/85
calpain, nCL-2, nCL-3, etc). The rat 88 kDa and 90 kDa
forms of calpain-3 share the insert 1 and the antibody
may crossreact
Data Sheet - C6361
not crossreact with other calpain family members
(µ-calpain, M-calpain, LP-82/85 calpain, nCL-2, nCL-3,
etc.). The rat 88 kDa and 90 kDa calpains share the
insert 1 and the antibody may crossreact with
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