B1760

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Showing 1-30 of 224 results for "B1760" within Papers

PCB153, TCDD and estradiol compromise the benzo[a]pyrene-induced p53-response via FoxO3a.

Lauy Al-Anati et al.

Chemico-biological interactions, 219, 159-167 (2014-06-24)

TCDD, polychlorinated biphenyls (PCB) and polycyclic aromatic hydrocarbons (PAH) coexist in the environment. However, there are few studies on combined effects of these compounds. We have studied the effect of TCDD, PCB153 and estradiol on p53 signaling induced by PAHs.

High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity.

Florian Caiment et al.

Nucleic acids research, 43(5), 2525-2534 (2015-02-19)

The chain of events leading from a toxic compound exposure to carcinogenicity is still barely understood. With the emergence of high-throughput sequencing, it is now possible to discover many different biological components simultaneously. Using two different RNA libraries, we sequenced

Basal and benzo[a]pyrene-induced expression profile of phase I and II enzymes and ABC transporter mRNA in the early life stage of Chinese rare minnows (Gobiocypris rarus).

Lilai Yuan et al.

Ecotoxicology and environmental safety, 106, 86-94 (2014-05-20)

ATP-binding cassette (ABC) transporters together with phase I and II detoxification enzymes have been considered as included in a cellular detoxification system. Previous studies have highlighted the involvement of aryl hydrocarbon receptor (AHR) and Cyp1a in PAH-induced embryo toxicity. However

UVA radiation induced ultrafast electron transfer from a food carcinogen benzo[a]pyrene to organic molecules, biological macromolecules, and inorganic nano structures.

Soma Banerjee et al.

The journal of physical chemistry. B, 117(14), 3726-3737 (2013-03-15)

Reactions involving electron transfer (ET) and reactive oxygen species (ROS) play a pivotal role in carcinogenesis and cancer biochemistry. Our present study emphasizes UVA radiation induced ET reaction as one of the key aspects of a potential carcinogen, benzo[a]pyrene (BP)

Morphological transformation induced by silver nanoparticles in a Balb/c 3T3 A31-1-1 mouse cell model to evaluate in vitro carcinogenic potential.

Wunhak Choo et al.

Environmental health and toxicology, 32, e2017016-e2017016 (2017-10-14)

Carcinogenesis is a complex process involved in genotoxic and non-genotoxic pathways. The carcinogenic potential of silver nanoparticles (AgNPs) has been predicted by examining their genotoxic effects using several in vitro and in vivo models. However, there is no little information

Oxidative DNA damage and disturbance of antioxidant capacity by alternariol in Caco-2 cells.

Celia Fernández-Blanco et al.

Toxicology letters, 235(2), 61-66 (2015-04-02)

Oxidative stress occurs as a consequence of an imbalance between the prooxidant/antioxidant systems, causing an increase of intracellular generation of reactive oxygen species. Alternariol (AOH), a mycotoxin produced by Alternaria sp. can alter the action of glutathione (GSH) and the

A Compendium of Mutational Signatures of Environmental Agents.

Jill E Kucab et al.

Cell, 177(4), 821-836 (2019-04-16)

Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS human-induced pluripotent stem cells exposed to 79 known or suspected environmental carcinogens. Forty-one yielded characteristic

Development of high internal phase emulsion polymeric monoliths for highly efficient enrichment of trace polycyclic aromatic hydrocarbons from large-volume water samples.

Rihui Su et al.

Journal of chromatography. A, 1405, 23-31 (2015-06-17)

In this work, polymerized high internal phase emulsion (polyHIPE) monoliths were prepared and applied as monolithic adsorbent materials for proconcentration of trace polycyclic aromatic hydrocarbons (PAHs) from large-volume water samples. The monolithic polyHIPE columns were prepared by in situ polymerization

Antimigraine Drug Avitriptan Is a Ligand and Agonist of Human Aryl Hydrocarbon Receptor That Induces CYP1A1 in Hepatic and Intestinal Cells.

Barbora Vyhlídalová et al.

International journal of molecular sciences, 21(8) (2020-04-23)

The efforts for therapeutic targeting of the aryl hydrocarbon receptor (AhR) have emerged in recent years. We investigated the effects of available antimigraine triptan drugs, having an indole core in their structure, on AhR signaling in human hepatic and intestinal

Correlations between PAH bioavailability, degrading bacteria, and soil characteristics during PAH biodegradation in five diffusely contaminated dissimilar soils.

M Crampon et al.

Environmental science and pollution research international, 21(13), 8133-8145 (2014-03-29)

The natural biodegradation of seven polycyclic aromatic hydrocarbons (PAHs) by native microorganisms was studied in five soils from Normandy (France) from diffusely polluted areas, which can also pose a problem in terms of surfaces and amounts of contaminated soils. Bioavailability

P-glycoprotein and CYP1A protein expression patterns in Nile tilapia (Oreochromis niloticus) tissues after waterborne exposure to benzo(a)pyrene (BaP).

Joana Costa et al.

Environmental toxicology and pharmacology, 36(2), 611-625 (2013-07-10)

The protein levels and tissue distribution patterns of P-glycoprotein (Pgp) and cytochrome P450 (CYP1A) were investigated in Nile tilapia (Oreochromis niloticus) after waterborne exposure to different benzo(a)pyrene (BaP) concentrations, using immunochemical approaches. The Pgp mammalian monoclonal antibody (mAb) C219 cross

Association of aryl hydrocarbon receptor gene polymorphism with the neurobehavioral function and autonomic nervous system function changes induced by benzo[a]pyrene exposure in coke oven workers.

Hongmei Zhang et al.

Journal of occupational and environmental medicine, 55(3), 265-271 (2013-02-27)

To analyze the association of aryl hydrocarbon receptor (AhR) gene polymorphism and the neurotoxicity induced by benzo[a]pyrene (B[a]P) in coke oven workers. Subjects, 214 coke oven workers and 81 controls, were detected for neurobehavioral function and autonomic nervous system (ANS)

Tanshinone IIA and Baicalin inhibiting the formation of benzo[a]pyrene and benzo[a]pyrene induced cytotoxicity: correlation with scavenging free radical.

Shixiang Wang et al.

Environmental toxicology and pharmacology, 36(2), 403-410 (2013-06-15)

Benzo[a]pyrene (BaP), a ubiquitous environmental pollutant, is formed by incomplete combustion of organic materials, and causes oxidative damage to cells and tissues due to reactive oxygen species (ROS). The purpose of this study is to investigate the inhibition of Tanshinone

Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.

Lior Izhar et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1462-E1469 (2013-03-27)

DNA lesions can block replication forks and lead to the formation of single-stranded gaps. These replication complications are mitigated by DNA damage tolerance mechanisms, which prevent deleterious outcomes such as cell death, genomic instability, and carcinogenesis. The two main tolerance

Benzopyrene serum concentration after endovenous laser ablation of the great saphenous vein.

T M A L Klem et al.

Vascular and endovascular surgery, 47(3), 213-215 (2013-02-27)

During endovenous laser ablation (EVLA) of the great saphenous vein, patients often involuntarily mention an uncomfortable "burnt" smell and taste. When applying intense heat to proteins and carbohydrates, it is inevitable that polycyclic aromatic hydrocarbons (PAHs) are formed. This group

Tissue-, sex- and development-specific transcription profiles of eight UDP-glucuronosyltransferase genes in zebrafish (Danio rerio) and their regulation by activator of aryl hydrocarbon receptor.

Verena Christen et al.

Aquatic toxicology (Amsterdam, Netherlands), 150, 93-102 (2014-03-29)

UDP-Glucuronosyltransferases (Ugts) are phase II biotransformation enzymes that glucuronidate numerous endogenous and xenobiotic substrates. Based on the reported zebrafish Ugt gene repertoire, primers for the Ugt1a and Ugt1b family and for individual Ugt5a1, Ugt5a3, Ugt5a4, Ugt5a5, Ugt5c2 and Ugt5c3 were

The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy.

Gui-Zhen Wang et al.

Nature communications, 10(1), 1125-1125 (2019-03-10)

Whether tobacco carcinogens enable exposed cells immune escape resulting in carcinogenesis, and why patients who smoke respond better to immunotherapies than non-smokers, remains poorly understood. Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on

Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Escitalopram Oxalate and Clonazepam.

Kakde RB, Satone DD, Gadapayale KK, Kakde MG.

Journal of Chromatographic Science (2012)

Toward an understanding of the role of DNA adduct conformation in defining mutagenic mechanism based on studies of the major adduct (formed at N(2)-dG) of the potent environmental carcinogen, benzo[a]pyrene.

R Kozack et al.

Mutation research, 450(1-2), 41-59 (2000-06-06)

The process of carcinogenesis is initiated by mutagenesis, which often involves replication past damaged DNA. One question - what exactly is a DNA polymerase seeing when it incorrectly copies a damaged DNA base (e.g., inserting dATP opposite a dG adduct)?

Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis.

Qi Zhang et al.

Molecular carcinogenesis, 52(9), 686-691 (2012-03-30)

Betanin, also called beetroot red, has been extensively used as a food colorant. In this study, the chemopreventive activity of betanin by oral consumption was investigated in two mouse lung tumor models. Vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) were used

Determination of benzo[a]pyrene levels in ambient air and the source of polycyclic aromatic hydrocarbons using a diagnostic ratio method in Ghana.

Nesta Bortey-Sam et al.

The Japanese journal of veterinary research, 61 Suppl, S72-S74 (2013-05-02)

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants produced from incomplete combustion of fuel or vegetation fires. Their presence in air deserves attention because they can produce carcinogenic and mutagenic effects. As an industrialized and economically significant city in Ghana, Kumasi

Review on proteomic analyses of benzo[a]pyrene toxicity.

Nisha Verma et al.

Proteomics, 12(11), 1731-1755 (2012-05-25)

Benzo[a]pyrene (BaP), a five-ring polycyclic aromatic hydrocarbon, is a well-recognized environmental pollutant. Coal-processing waste products, petroleum sludge, asphalt, creosote, and tobacco smoke, all contain high levels of BaP. Exposure to BaP elicits many adverse biological effects, including tumor formation, immunosuppression

DNA-damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots.

Khuraman Mustafayeva et al.

Journal of natural products, 73(2), 99-103 (2010-01-09)

Gentiopicroside (1) is the major secoiridoid glucoside constituent of Cephalaria kotschyi roots. The mutagenicity, DNA-damaging capacities, and clastogenicity of this molecule were evaluated by the Salmonella typhimurium mutagenicity assay (Ames test) on tester strains TA97a, TA98, TA100, and TA102, the

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization.

Barbora Vyhlídalová et al.

International journal of molecular sciences, 21(7) (2020-04-15)

We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed substantially, comprising

Sensitivity of Salmonella YG5161 for detecting PAH-associated mutagenicity in air particulate matter.

Gisela A Umbuzeiro et al.

Environmental and molecular mutagenesis, 55(6), 510-517 (2014-03-01)

The Salmonella/microsome assay is the most used assay for the evaluation of air particulate matter (PM) mutagenicity and a positive correlation between strain TA98 responses and benzo[a]pyrene (B[a]P) levels in PM has been found. However, it seems that the major

Combined genotoxic effects of a polycyclic aromatic hydrocarbon (B(a)P) and an heterocyclic amine (PhIP) in relation to colorectal carcinogenesis.

Emilien L Jamin et al.

PloS one, 8(3), e58591-e58591 (2013-03-14)

Colorectal neoplasia is the third most common cancer worldwide. Environmental factors such as diet are known to be involved in the etiology of this cancer. Several epidemiological studies have suggested that specific neo-formed mutagenic compounds related to meat consumption are

Effects of ageing and soil properties on the oral bioavailability of benzo[a]pyrene using a swine model.

Luchun Duan et al.

Environment international, 70, 192-202 (2014-06-18)

Oral bioavailability of benzo[a]pyrene (B[a]P) was studied in a swine model using eight spiked soil samples after incubation for 50 and/or 90 days. Silica sand was used as a reference material and the relative bioavailability (RB) of B[a]P in soils

Tissue-specific antioxidant responses in pale chub (Zacco platypus) exposed to copper and benzo[a]pyrene.

Woo-Keun Kim et al.

Bulletin of environmental contamination and toxicology, 92(5), 540-545 (2014-01-31)

In this study, antioxidant responses including lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST), were evaluated in the liver, gill and muscle tissues of pale chub (Zacco platypus) exposed to copper (Cu) and benzo[a]pyrene (BaP). Cu

Spanish honeys protect against food mutagen-induced DNA damage.

Ana Isabel Haza et al.

Journal of the science of food and agriculture, 93(12), 2995-3000 (2013-03-19)

Honey contains a variety of polyphenols and represents a good source of antioxidants, while the human diet often contains compounds that can cause DNA damage. The present study investigated the protective effect of three commercial honey samples of different floral

Synthesis of alkylated potato starch derivatives and their potential in the aqueous solubilization of benzo[a]pyrene.

Ana-Maria Rosu et al.

Carbohydrate polymers, 93(1), 184-190 (2013-03-08)

For the development of renewable bioproducts able to solubilize organic persistent pollutant such as benzo[a]pyrene (BaP), modified potato starch was synthesized by alkylation. The addition of alkyl chains was performed with three different alkylation agents: epoxyalkane, alkenyl succinic anhydride and

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