B17905

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Showing 1-30 of 76 results for "B17905" within Papers

One-pot thioetherification of aryl halides with thiourea and benzyl bromide in water catalyzed by Cu-grafted furfural imine-functionalized mesoporous SBA-15.

John Mondal et al.

Chemical communications (Cambridge, England), 48(64), 8000-8002 (2012-07-10)

Surface functionalization of SBA-15 followed by its reaction with Cu(OAc)(2) has been carried out to develop a new Cu-grafted functionalized mesoporous material, which catalyzes one-pot three component coupling of different aryl halides with thiourea and benzyl bromide in aqueous medium

Synthesis of the chiral selector heptakis(6-O-methyl)-β-cyclodextrin by phase-transfer catalysis and hydrazine-mediated transfer-hydrogenation.

Mihály Bálint et al.

Electrophoresis, 40(15), 1941-1950 (2019-03-21)

The exhaustive primary-side alkylation of cyclodextrins has never been achieved directly. The undesired and simultaneous derivatization of the secondary hydroxyl moieties generates intricate isomeric mixtures that are challenging to purify, analyse and characterize. The aim of this study was to

First Total Synthesis of (β-5)-(β-O-4) Dihydroxytrimer and Dihydrotrimer of Coniferyl Alcohol (G): Advanced Lignin Model Compounds.

Amandine L Flourat et al.

Frontiers in chemistry, 7, 842-842 (2020-01-11)

To investigate lignin degradation, scientists commonly use model compounds. Unfortunately, these models are most of the time simple β-O-4 dimers and do not sufficiently mimic the wide complexity of lignin structure (i.e., aliphatic side chains and robust C-C bonds). Herein

Efficient synthesis of the structural core of tetracyclines by a palladium-catalyzed domino Tsuji-Trost-Heck-Mizoroki reaction.

Lutz F Tietze et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 14(8), 2527-2535 (2008-01-18)

The Pd-catalyzed domino Tsuji-Trost-Heck-Mizoroki reactions of compounds 18, 27, and 34, respectively, each containing an allyl acetate and a halogen aryl moiety, lead to the formation of hexahydronaphthacenes 2 and 3 and octahydroanthracene 4 in 62-81 % yield. The octahydroanthracene

Indole diterpene synthetic studies. Total synthesis of (+)-nodulisporic acid F and construction of the heptacyclic cores of (+)-nodulisporic acids A and B and (-)-nodulisporic acid D.

Amos B Smith et al.

The Journal of organic chemistry, 72(13), 4596-4610 (2007-05-22)

A first-generation strategy for construction of (+)-nodulisporic acids A (1) and B (2) is described. The strategy entails union of the eastern and western hemisphere subtargets via the indole synthesis protocol developed in our laboratory. Subsequent elaboration of rings E

Facile assembly and loading of theranostic polymersomes via multi-impingement flash nanoprecipitation.

Sean Allen et al.

Journal of controlled release : official journal of the Controlled Release Society, 262, 91-103 (2017-07-25)

Flash nanoprecipitation (FNP) has proven to be a powerful tool for the rapid and scalable assembly of solid-core nanoparticles from block copolymers. The process can be performed using a simple confined impingement jets mixer and provides an efficient and reproducible

A stage-specific cancer chemotherapy strategy through flexible combination of reduction-activated charge-conversional core-shell nanoparticles.

Lingfei Han et al.

Theranostics, 9(22), 6532-6549 (2019-10-08)

Precision medicine has increased the demand for stage-specific cancer chemotherapy. Drugs with different properties are needed for different stages of tumor development, which is, inducing rapid destruction in the early stage and facilitating deep penetration in the advanced stage. Herein

Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators That Delay Preterm Birth.

Fatemeh M Mir et al.

Journal of medicinal chemistry, 62(9), 4500-4525 (2019-04-02)

Peptide mimicry employing a combination of aza-amino acyl proline and indolizidinone residues has been used to develop allosteric modulators of the prostaglandin F2α receptor. The systematic study of the N-terminal phenylacetyl moiety and the conformation and side chain functions of

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

Simon J Mountford et al.

Organic & biomolecular chemistry, 15(34), 7173-7180 (2017-08-16)

The first total synthesis of a polypeptin, PE2, as well as its solution structure is reported. Synthesis in optically pure form confirms the proposed stereochemistry of the polypeptins at the 3-position on the 3-hydroxy depsipeptide moiety. We have also determined

Non-Cytotoxic Dibenzyl and Difluoroborate Curcuminoid Fluorophores Allow Visualization of Nucleus or Cytoplasm in Bioimaging.

Marco A Obregón-Mendoza et al.

Molecules (Basel, Switzerland), 25(14) (2020-07-18)

Curcumin, the most important secondary metabolite isolated from Curcuma longa, is known for its numerous purported therapeutic properties and as a natural dye. Herein, based on curcumin's intrinsic fluorescence, a search for improved curcumin-based fluorophores was conducted. Within the set

Comparative evaluation of chemical composition and biological activities of tropical fruits consumed in Manaus, central Amazonia, Brazil.

Jéssica V Faria et al.

Food research international (Ottawa, Ont.), 139, 109836-109836 (2021-01-30)

Fruits are widely recognized as sources of biologically active metabolites, such as antioxidant compounds. In this context, fruits commonly consumed in the central Amazonia, especially in its biggest metropolis (Manaus - AM/Brazil), are attractive as potential sources of antioxidant compounds

The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis.

Virender Kumar et al.

Theranostics, 9(25), 7537-7555 (2019-11-07)

Rationale: Hedgehog (Hh) pathway plays an essential role in liver fibrosis by promoting the proliferation of hepatic stellate cells (HSCs) by enhancing their metabolism via yes-associated protein 1 (YAP1). Despite the presence of several inhibitors, Hh signaling cannot be controlled

New Caffeic Acid Derivatives as Antimicrobial Agents: Design, Synthesis, Evaluation and Docking.

Maia Merlani et al.

Current topics in medicinal chemistry, 19(4), 292-304 (2019-01-25)

Phenolic acids (caffeic-, ferulic and p-coumaric acid) are widely distributed in the plant kingdom and exhibit broad spectrum of biological activities, including antimicrobial activity. The goal of this paper is the synthesis of some caffeic acid derivatives selected based on

First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3: structural analogues of D-myo-inositol 1,4,5-trisphosphate.

Graeme Horne et al.

Carbohydrate research, 339(1), 51-65 (2003-12-09)

Novel, structurally modified potential mimics of the second messenger D-myo-inositol 1,4,5-trisphosphate, based on the biologically active regioisomer D-myo-inositol 1,4,6-trisphosphate, were synthesised. DL-5-O-Benzyl-1,4,6-tri-O-p-methoxybenzyl-myo-inositol was the key intermediate for the preparation of the following compounds: DL-3-deoxy-, DL-3-deoxy-2-O-methyl-, DL-3-O-(2-hydroxyethyl)-, DL-3-O-(3-hydroxypropyl)- and DL-3-O-(4-hydroxybutyl)-myo-inositol 1,4,6-trisphosphate.

Poly(ionic liquid) embedded particles as efficient solid phase microextraction phases of polar and aromatic analytes.

David J S Patinha et al.

Talanta, 198, 193-199 (2019-03-17)

In this work, a facile preparation of SPME fibers with increased surface area is presented. The SPME fibers were prepared by grinding poly(ionic liquids) (PILs) to obtain particles of 1-16 µm and, with the aid of a silicon adhesive, attach these

(79)Br NMR spectroscopy as a practical tool for kinetic analysis.

Si Jia Chan et al.

Magnetic resonance in chemistry : MRC, 47(4), 342-347 (2009-02-04)

(79)Br NMR spectroscopy has been used to monitor a series of reactions in which the bromide ion is produced, including the Menschutkin reaction of pyridine with a range of substituted benzyl bromides and a Heck coupling process. In cases where

Chimeric RNA Oligonucleotides with Triazole and Phosphate Linkages: Synthesis and RNA Interference.

Tomoko Fujino et al.

Chemistry, an Asian journal, 10(12), 2683-2688 (2015-08-08)

Chimeric RNA oligonucleotides with an artificial triazole linker were synthesized using solution-phase click chemistry and solid-phase automated synthesis. Scalable synthesis methods for jointing units for the chimeric structure have been developed, and after click-coupling of the jointing units with triazole

Ni-catalyzed direct carboxylation of benzyl halides with CO2.

Thierry León et al.

Journal of the American Chemical Society, 135(4), 1221-1224 (2013-01-11)

A novel Ni-catalyzed carboxylation of benzyl halides with CO(2) has been developed. The described carboxylation reaction proceeds under mild conditions (atmospheric CO(2) pressure) at room temperature. Unlike other routes for similar means, our method does not require well-defined and sensitive

Solid-phase synthesis of chiral bicyclic guanidinium oligomers.

Vera Martos et al.

Journal of combinatorial chemistry, 11(3), 410-421 (2009-03-10)

A simple solid-phase synthesis of thioether-linked chiral bicyclic guanidinium oligomers for cell internalization purposes has been developed. The approach is based on a Merrifield-like peptide synthesis on Rinkamide-p-methylbenzhydrylamine resin functionalized with Cys(methoxytrityl). A difunctionalized bicyclic guanidinium synthon, bearing both electrophile

Synthesis, characterization, and antifungal evaluation of novel 1,2,3-triazolium-functionalized starch derivative.

Wenqiang Tan et al.

International journal of biological macromolecules, 101, 845-851 (2017-04-05)

1,2,3-Triazolium-functionalized starch derivative was obtained by straightforward quaternization of the synthesized starch derivative bearing 1,2,3-triazole with benzyl bromide by combining the robust attributes of cuprous-catalyzed azide-alkyne cycloaddition. These novel starch derivatives were characterized by FTIR, UV-vis

Thermal and Mechanical Interfacial Behaviors of Graphene Oxide-Reinforced Epoxy Composites Cured by Thermal Latent Catalyst.

Shahina Riaz et al.

Materials (Basel, Switzerland), 12(8) (2019-04-28)

A series of composites was prepared from a diglycidyl ether of bisphenol A (DGEBA) with different graphene filler contents to improve their mechanical performance and thermal stability. Graphene oxide (GO) and GO modified with hexamethylene tetraamine (HMTA) were selected as

Synthesis of functionalized 1,2-dihydroisoquinolines via multicomponent one-pot reaction of 2-alkynylbenzaldehyde, amine, zinc, and allylic bromide or benzyl bromide.

Ke Gao et al.

The Journal of organic chemistry, 72(22), 8611-8613 (2007-10-09)

A multicomponent one-pot reaction of 2-alkynylbenzaldehydes, amines, zinc, and allylic bromide or benzyl bromide using the combination of Mg(ClO4)2/Cu(OTf)2 as catalyst in THF/DCE (1:20) is described, which provides an efficient and practical route for the synthesis of functionalized 1,2-dihydroisoquinolines.

Synthesis, oral bioavailability evaluation and antiplatelet aggregation activity of three derivatives of 3,4‑dihydroxyacetophenone.

Na Sun et al.

International journal of molecular medicine, 45(3), 919-930 (2020-01-28)

3,4‑Dihydroxyacetophenone (DHAP) exerts therapeutic effects on cardiovascular disease and pulmonary heart disease. However, it is not utilized as a clinical drug due to its rapid metabolism, short‑acting effect and low oral bioavailability. In the present study, three derivatives of DHAP

Photoracemization-Based Viedma Ripening of a BINOL Derivative.

Giuseppe Belletti et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 26(4), 839-844 (2019-10-31)

Viedma ripening is a deracemization process that has been used to deracemize a range of chiral molecules. The method has two major requirements: the compound needs to crystallize as a conglomerate and it needs to be racemizable under the crystallization

π-π-Stacked Poly(ε-caprolactone)-b-poly(ethylene glycol) Micelles Loaded with a Photosensitizer for Photodynamic Therapy.

Yanna Liu et al.

Pharmaceutics, 12(4) (2020-04-15)

To improve the in vivo stability of poly(-caprolactone)-b-poly(ethylene glycol) (PCL-PEG)-based micelles and cargo retention by π-π stacking interactions, pendant aromatic rings were introduced by copolymerization of -caprolactone with benzyl 5-methyl-2-oxo-1,3-dioxane-5-carboxylate (TMC-Bz). It was shown that the incorporation of aromatic rings

Enantioselective nickel-catalyzed cross-coupling reactions of trialkynylindium reagents with racemic secondary benzyl bromides.

Jorge Caeiro et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 14(2), 741-746 (2007-10-12)

The first enantioselective sp-sp3 cross-coupling reaction between alkynyl organometals and racemic benzyl bromides is reported. The coupling is performed at room temperature by using NiBr2diglyme and (S)-(iPr)-Pybox as the catalytic system and trialkynylindium reagents as nucleophiles. The reaction is stereoconvergent

Different Routes to Ampholytic Polydehydroalanine: Orthogonal versus Simultaneous Deprotection.

Jan-Hendrik Kruse et al.

Macromolecular rapid communications, 40(10), e1800857-e1800857 (2019-01-18)

Polydehydroalanine (PDha) is a polyampholyte featuring both a -NH2 and a -COOH in every repeat unit and with that presents a rather high charge density. The synthesis and polymerization of two monomers, benzyl 2-tert-butoxycarbonylaminoacrylate and methyl 2-benzyloxycarbonylaminoacrylate is herein reported

Transformation of alcohols to esters promoted by hydrogen bonds using oxygen as the oxidant under metal-free conditions.

Mingyang Liu et al.

Science advances, 4(10), eaas9319-eaas9319 (2018-10-13)

One-pot oxidative transformation of alcohols into esters is very attractive, but metal-based catalysts are used in the reported routes. We discovered that the basic ionic liquid 1-ethyl-3-methylimidazolium acetate ([EMIM] OAc) could effectively catalyze this kind of reaction using O2 as

4-N,N-Dimethylaminopyridine promoted selective oxidation of methyl aromatics with molecular oxygen.

Zhan Zhang et al.

Molecules (Basel, Switzerland), 17(4), 3957-3968 (2012-04-03)

4-N,N-Dimethylaminopyridine (DMAP) as catalyst in combination with benzyl bromide was developed for the selective oxidation of methyl aromatics. DMAP exhibited higher catalytic activity than other pyridine analogues, such as 4-carboxypyridine, 4-cyanopyridine and pyridine. The sp3 hybrid carbon-hydrogen (C-H) bonds of

Palladium-catalyzed cross coupling reaction of benzyl bromides with diazoesters for stereoselective synthesis of (E)-alpha,beta-diarylacrylates.

Wing-Yiu Yu et al.

Organic letters, 11(2), 469-472 (2008-12-23)

A Pd-catalyzed cross-coupling reaction of benzyl bromides with alpha-aryldiazoesters is described, and E-alpha,beta-diarylacrylates were obtained in good yields and excellent E-to-Z selectivity (>20:1).

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