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Showing 1-30 of 369 results for "C2618" within Papers
Björn F Vahsen et al.
Nature communications, 14(1), 5898-5898 (2023-09-22)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic variant is a hexanucleotide repeat expansion (HRE) mutation in C9orf72. Here, we
Amrita Das et al.
PLoS neglected tropical diseases, 8(8), e3091-e3091 (2014-08-22)
With the paucity of new drugs and HIV co-infection, vaccination remains an unmet research priority to combat visceral leishmaniasis (VL) requiring strong cellular immunity. Protein vaccination often suffers from low immunogenicity and poor generation of memory T cells for long-lasting
Thibault G Sana et al.
mBio, 6(3), e00712-e00712 (2015-06-04)
Invasion of nonphagocytic cells through rearrangement of the actin cytoskeleton is a common immune evasion mechanism used by most intracellular bacteria. However, some pathogens modulate host microtubules as well by a still poorly understood mechanism. In this study, we aim
Sarah Escuin et al.
Journal of cell science, 128(14), 2468-2481 (2015-06-05)
The cytoskeleton is widely considered essential for neurulation, yet the mouse spinal neural tube can close despite genetic and non-genetic disruption of the cytoskeleton. To investigate this apparent contradiction, we applied cytoskeletal inhibitors to mouse embryos in culture. Preventing actomyosin
Chris P Verschoor et al.
Human immunology, 75(12), 1192-1196 (2014-12-03)
The advanced-age, frail elderly are especially vulnerable to developing pneumococcal infection and disease. Macrophages are critical mediators in the defence against Streptococcus pneumoniae at the upper respiratory tract, however, little is known of their anti-pneumococcal capacity in the elderly. Herein
Kristen Whalen et al.
Molecular biology of the cell, 23(18), 3663-3672 (2012-08-03)
Fertilization changes the structure and function of the cell surface. In sea urchins, these changes include polymerization of cortical actin and a coincident, switch-like increase in the activity of the multidrug efflux transporter ABCB1a. However, it is not clear how
Luc H Boudreau et al.
Blood, 124(14), 2173-2183 (2014-08-02)
Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found outside the cells in blood in various pathologies. Platelets are abundant in blood where they promote hemostasis. Although lacking a nucleus, platelets contain functional mitochondria. On activation
Johannes Rheinlaender et al.
Thrombosis and haemostasis, 113(2), 305-311 (2014-10-31)
Platelet activation plays a critical role in haemostasis and thrombosis. It is well-known that platelets generate contractile forces during activation. However, their mechanical material properties have rarely been investigated. Here, we use scanning ion conductance microscopy (SICM) to visualise morphological
Guido H Wabnitz et al.
Journal of immunological methods, 423, 29-39 (2015-03-22)
The actin cytoskeleton is a main component to preserve the cell shape. It represents a cellular machinery that enables morphological changes and orchestrates important dynamic cellular functions. Thereby, it supports T-cell migration, immune synapse formation, activation and execution of effector
Adam G Peres et al.
Infection and immunity, 83(4), 1587-1597 (2015-02-04)
Staphylococcus aureus is a Gram-positive bacterium that is carried by a quarter of the healthy human population and that can cause severe infections. This pathobiosis has been linked to a balance between Toll-like receptor 2 (TLR2)-dependent pro- and anti-inflammatory responses.
Timothy H Scott-Taylor et al.
Clinical immunology (Orlando, Fla.), 175, 1-9 (2016-11-20)
Peripheral monocytes from patients with common variable immunodeficiency (CVID) had on average a 2 fold greater tendency to form giant cells in medium without additional cytokines. Giant cell formation was faster and 3 to 5 fold higher in most CVID
Dongdong Li et al.
The Journal of physiology, 593(13), 2807-2832 (2015-04-14)
Mouse cortical astrocytes express VAMP3 but not VAMP2. VAMP3 vesicles undergo Ca(2+) -independent exo- and endocytotic cycling at the plasma membrane. VAMP3 vesicle traffic regulates the recycling of plasma membrane glutamate transporters. cAMP modulates VAMP3 vesicle cycling and glutamate uptake.
Rimi Lee et al.
Scientific reports, 6, 33668-33668 (2016-09-20)
Nanoparticles have shown great potential as vehicles for the delivery of drugs, nucleic acids, and therapeutic proteins; an efficient, high-throughput screening method to analyze nanoparticle interaction with the cytomembrane would substantially improve the efficiency and accuracy of the delivery. Here
Kagayaki Nogami et al.
Chembiochem : a European journal of chemical biology, 15(17), 2571-2576 (2014-09-23)
Managing protein-protein interactions is essential for resolving unknown biological events at the molecular level and developing drugs. We have designed and synthesized a side-chain-crosslinked helical peptides based on the binding domain of a pro-apoptotic protein (Bad) that induces programmed cell
Inflammatory macrophage to hepatocyte signals can be prevented by extracellular vesicle reprogramming.
Ghosh, et al.
Journal of Cell Science, 136 (2023)
Glenn J Rapsinski et al.
Infection and immunity, 83(2), 693-701 (2014-11-26)
Amyloids are proteins with cross-β-sheet structure that contribute to pathology and inflammation in complex human diseases, including Alzheimer's disease, Parkinson's disease, type II diabetes, and secondary amyloidosis. Bacteria also produce amyloids as a component of their extracellular matrix during biofilm
Yuechuan Lin et al.
Nature communications, 13(1), 3465-3465 (2022-06-18)
Quantitative characterisation of micro-scale mechanical properties of the extracellular matrix (ECM) and dynamic cell-ECM interactions can significantly enhance fundamental discoveries and their translational potential in the rapidly growing field of mechanobiology. However, quantitative 3D imaging of ECM mechanics with cellular-scale
Yukio Ohtsuka et al.
Development (Cambridge, England), 141(20), 3889-3899 (2014-09-19)
The neural crest and neurogenic placodes are thought to be a vertebrate innovation that gives rise to much of the peripheral nervous system (PNS). Despite their importance for understanding chordate evolution and vertebrate origins, little is known about the evolutionary
Chun-Ru Hsu et al.
Infection and immunity, 83(2), 769-779 (2014-12-03)
Klebsiella pneumoniae is an important pathogen that causes hospital-acquired septicemia and is associated with the recent emergence of community-acquired pyogenic liver abscess (PLA). Clinical typing suggests that K. pneumoniae infections originate from the gastrointestinal reservoir. However, the underlying mechanism remains
Michael J Shannon et al.
Journal of cell science, 133(5) (2019-09-01)
Effector T-cells rely on integrins to drive adhesion and migration to facilitate their immune function. The heterodimeric transmembrane integrin LFA-1 (αLβ2 integrin) regulates adhesion and migration of effector T-cells through linkage of the extracellular matrix with the intracellular actin treadmill
Georgia K Atkin-Smith et al.
Nature communications, 6, 7439-7439 (2015-06-16)
Disassembly of apoptotic cells into smaller fragments (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic debris and intercellular communication. However, the mechanism underpinning this process is unclear. While observing monocytes undergoing apoptosis by time-lapse microscopy
Ting Wang et al.
Colloids and surfaces. B, Biointerfaces, 126, 520-530 (2015-01-24)
To develop an effective, convenient and stable mucosal vaccine against hepatitis B virus (HBV), the mannose-PEG-cholesterol/lipid A-liposomes (MLLs) loaded with HBsAg were prepared by the procedure of emulsification-lyophilization and, subsequently, filled into the microholes of microneedle array reverse molds and
Jens B Bosse et al.
mBio, 5(5), e01909-e01914 (2014-10-09)
A considerable part of the herpesvirus life cycle takes place in the host nucleus. While much progress has been made to understand the molecular processes required for virus replication in the nucleus, much less is known about the temporal and
Z Wang et al.
Osteoarthritis and cartilage, 23(2), 289-299 (2014-12-03)
Osteoarthritis (OA) is associated with a gradual reduction in the interstitial osmotic pressure within articular cartilage. The aim of this study was to compare the effects of sudden and gradual hypo-osmotic challenge on chondrocyte morphology and biomechanics. Bovine articular chondrocytes
The effect of kinase, actin, myosin and dynamin inhibitors on host cell egress by Toxoplasma gondii.
Lucio Ayres Caldas et al.
Parasitology international, 62(5), 475-482 (2013-04-30)
Toxoplasma gondii is a protozoan parasite that can infect the nucleated cells of all warm-blooded animals. Despite its medical and veterinary importance, the egress of T. gondii from host cells has not been fully elucidated. This process is usually studied
Rosarita Tatè et al.
International journal of oncology, 51(6), 1851-1859 (2017-10-19)
Statins are a class of drugs that inhibit the rate-limiting steps in the cholesterol biosynthesis pathway. They act by inhibiting 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate. Blocking of mevalonate synthesis leads to inhibition of
Francesco Pisani et al.
Cell death & disease, 13(7), 582-582 (2022-07-06)
Crosstalk mechanisms between pericytes, endothelial cells, and astrocytes preserve integrity and function of the blood-brain-barrier (BBB) under physiological conditions. Long intercellular channels allowing the transfer of small molecules and organelles between distant cells called tunneling nanotubes (TNT) represent a potential
Antonio Delgado-Gonzalez et al.
STAR protocols, 3(2), 101425-101425 (2022-06-14)
Trogocytosis is an active transport mechanism by which one cell extracts a plasma membrane fragment with embedded molecules from an adjacent cell in a contact-dependent process leading to the acquisition of a new function. Our protocol, which has general applicability
Qin Zhang et al.
Nature cell biology, 23(12), 1240-1254 (2021-12-11)
Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct from exomeres and display a markedly greater uptake in
Jianjian Shi et al.
Cell death & disease, 4, e483-e483 (2013-02-09)
This study, using mouse embryonic fibroblast (MEF) cells derived from ROCK1(-/-) and ROCK2(-/-) mice, is designed to dissect roles for ROCK1 and ROCK2 in regulating actin cytoskeleton reorganization induced by doxorubicin, a chemotherapeutic drug. ROCK1(-/-) MEFs exhibited improved actin cytoskeleton
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