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Showing 1-30 of 156 results for "C5042" within Papers
Deanna M Patmore et al.
Developmental cell, 54(4), 455-470 (2020-06-20)
DEAD-Box Helicase 3 X-Linked (DDX3X) is frequently mutated in the Wingless (WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma-the commonest malignant childhood brain tumor, but whether DDX3X functions as a medulloblastoma oncogene or tumor suppressor gene is not known. Here
Vahid Esmaeili et al.
Cell reports, 27(11), 3167-3181 (2019-06-13)
Tactile working memory engages a broad network of cortical regions in primates. To assess whether the conclusions drawn from primates apply to rodents, we examined the vibrissal primary somatosensory cortex (vS1) and the prelimbic cortex (PL) in a delayed comparison
Chinnasamy Dhanalakshmi et al.
Neurobiology of disease, 149, 105224-105224 (2020-12-29)
The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of TAF1 are associated with neurodevelopmental disorders. Previously, we found that CRISPR/Cas9 based editing of
Sung In Cho et al.
Bioelectromagnetics, 33(7), 568-574 (2012-04-13)
Our previous study has shown that an extremely low-frequency magnetic field (ELF-MF) induces nitric oxide (NO) synthesis by Ca(2+) -dependent NO synthase (NOS) in rat brain. The present study was designed to confirm that ELF-MF affects neuronal NOS (nNOS) in
Maria Pia Giannoccaro et al.
Brain : a journal of neurology, 142(7), 2000-2012 (2019-05-13)
Serum antibodies that bind to the surface of neurons or glia are associated with a wide range of rare but treatable CNS diseases. In many, if not most instances, the serum levels are higher than CSF levels yet most of
Yanhui Cai et al.
iScience, 23(5), 101136-101136 (2020-05-24)
Astrocytic glycogen is an important energy reserve in the brain and is believed to supply fuel during energy crisis. However, the pattern of glycogen metabolism in ischemic stroke and its potential therapeutic impact on neurological outcomes are still unknown. Here
Shrstha Sinha et al.
Neurochemistry international, 141, 104877-104877 (2020-10-14)
Protein malnutrition (PMN) is a global health issue but most prevalent in Africa and Asia. It exerts detrimental effect on structural and physiological aspects of hippocampal circuitry. Despite accumulating evidence for PMN induced changes in nervous system, relatively very little
Géraldine Gontier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(33), 11500-11513 (2015-08-21)
Alzheimer's disease (AD) is a frequent and irreversible age-related neurodegeneration without efficient treatment. Experimental AD in mice responds positively to decreased insulin-like growth factor I (IGF-I) signaling, a pathway also implicated in aging. Here we aimed to protect the aging
Virginia Platt et al.
Methods in molecular biology (Clifton, N.J.), 1010, 213-230 (2013-06-12)
Many trinucleotide repeat disorders exhibit region-specific toxicity within tissues, the basis of which cannot be explained by traditional methods. For example, in Huntington's Disease (HD), the toxic disease-causing protein is ubiquitously expressed. However, only the medium spiny neurons in the
Priscilla Hirst et al.
Neural plasticity, 2012, 197264-197264 (2012-07-14)
Recent studies suggest that exposure to only one component of audiovisual events can lead to cross-modal cortical activation. However, it is not certain whether such crossmodal recruitment can occur in the absence of explicit conditioning, semantic factors, or long-term associations.
Suman K Guha et al.
Journal of neuroimmunology, 348, 577363-577363 (2020-09-13)
Children residing in high malaria transmission regions are particularly susceptible to malaria. This early-life window is also a critical period for development and maturation of the nervous system, and inflammatory insults during this period may evoke a persistent increase in
Sang Hun Lee et al.
Neuron, 108(4), 676-690 (2020-09-07)
Amyloid precursor protein (APP) is associated with both familial and sporadic forms of Alzheimer's disease. Despite its importance, the role of APP family in neuronal function and survival remains unclear because of perinatal lethality exhibited by knockout mice lacking all
Eric E Abrahamson et al.
Restorative neurology and neuroscience, 37(3), 245-263 (2019-06-10)
Altered glutamatergic neurotransmission after traumatic brain injury (TBI) contributes to excitotoxic cell damage and death. Prevention or suppression of such changes is a desirable goal for treatment of TBI. Memantine (3,5-dimethyl-1-adamantanamine), an uncompetitive NMDA receptor antagonist with voltage-dependent open channel
Vincent Coulombe et al.
Frontiers in neuroanatomy, 15, 627656-627656 (2021-09-07)
The human brainstem harbors neuronal aggregates that ensure the maintenance of several vital functions. It also acts as a major relay structure for the neuronal information that travels between the cerebral cortex, the cerebellum and the spinal cord. As such
Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis.
McMillan MT, et al.
American Journal of Physiology: Renal Physiology, 307, F612-F622 (2014)
Hossein Baharvand et al.
The International journal of developmental biology, 51(5), 371-378 (2007-07-10)
Understanding how to direct human embryonic stem cells (hESCs) toward a specific lineage pathway and generate appropriate cell types robustly is very important, not only for the study of developmental biology but also for potentially using these cells to treat
Nowruz Najafzadeh et al.
Neural regeneration research, 8(36), 3365-3372 (2014-09-11)
Emerging studies of treating spinal cord injury (SCI) with adult stem cells led us to evaluate the effects of transplantation of hair follicle stem cells in rats with a compression-induced spinal cord lesion. Here, we proposed a hypothesis that rat
Johannes Bohacek et al.
Environmental epigenetics, 2(1), dvv015-dvv015 (2016-02-08)
We developed a simple, noninvasive artificial insemination technique to study epigenetic germline inheritance in mice. This technique avoids interfering factors introduced by superovulation, surgery, in vitro culture or mating that can confound the transmission of acquired epigenetic information through the germline.
Hyo Jeong Yong et al.
Scientific reports, 10(1), 3969-3969 (2020-03-04)
Neurodevelopment and mature brain function are spatiotemporally regulated by various cytokines and chemokines. The chemokine-like neuropeptide FAM19A1 is a member of family with sequence similarity 19 (FAM19), which is predominantly expressed in the brain. Its highly conserved amino acid sequence
Chenglin Miao et al.
Cell, 171(3), 507-521 (2017-10-03)
The medial entorhinal cortex (MEC) contains several discrete classes of GABAergic interneurons, but their specific contributions to spatial pattern formation in this area remain elusive. We employed a pharmacogenetic approach to silence either parvalbumin (PV)- or somatostatin (SOM)-expressing interneurons while
Thomas Ridler et al.
eLife, 9 (2020-11-27)
Dementia is associated with severe spatial memory deficits which arise from dysfunction in hippocampal and parahippocampal circuits. For spatially sensitive neurons, such as grid cells, to faithfully represent the environment these circuits require precise encoding of direction and velocity information.
Erina Hara et al.
PloS one, 7(1), e29457-e29457 (2012-01-13)
Spoken language and learned song are complex communication behaviors found in only a few species, including humans and three groups of distantly related birds--songbirds, parrots, and hummingbirds. Despite their large phylogenetic distances, these vocal learners show convergent behaviors and associated
C A Smith et al.
Neuroscience, 193, 100-108 (2011-07-26)
The distribution of CA3 hippocampal axonal terminal fields undergo a period of widespread connectivity-based changes in the early postnatal stages of life. The purpose of the current study was to examine the effect of acute phthalate exposure during this period
Alexandra V Ulyanova et al.
Frontiers in neuroscience, 13, 397-397 (2019-05-14)
Decoding laminar information across deep brain structures and cortical regions is necessary in order to understand the neuronal ensembles that represent cognition and memory. Large animal models are essential for translational research due to their gyrencephalic neuroanatomy and significant white
Yelena Golubeva et al.
Methods in molecular biology (Clifton, N.J.), 931, 213-257 (2012-10-03)
Laser capture microdissection (LCM) allows the precise procurement of enriched cell populations from a heterogeneous tissue, or live cell culture, under direct microscopic visualization. Histologically enriched cell populations can be procured by harvesting cells of interest directly or isolating specific
Samsoon Inayat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(20), 7992-8003 (2015-05-23)
The superior colliculus (SC) is a layered midbrain structure important for multimodal integration and sensorimotor transformation. Its superficial layers are purely visual and receive depth-specific projections from distinct subtypes of retinal ganglion cells. Here we use two-photon calcium imaging to
Michael K Schuhmann et al.
Journal of neuroinflammation, 18(1), 46-46 (2021-02-20)
In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra. The penumbra can be salvaged by timely thrombolysis/thrombectomy
Yun Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(33), 11514-11531 (2015-08-21)
Protein aggregates containing ubiquitin (Ub) are commonly observed in neurodegenerative disorders, implicating the involvement of the ubiquitin proteasome system (UPS) in their pathogenesis. Here, we aimed to generate a mouse model for monitoring UPS function using a green fluorescent protein
Brunno Rocha Levone et al.
Neurobiology of stress, 14, 100331-100331 (2021-05-18)
Current antidepressants are suboptimal due incomplete understanding of the neurobiology underlying their behavioral effects. However, imaging studies suggest the hippocampus is a key brain region underpinning antidepressant action. There is increasing attention on the functional segregation of the hippocampus into
Min-Tae Jeon et al.
British journal of pharmacology, 177(3), 668-686 (2019-10-29)
We recently reported that AAV1-Rheb(S16H) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (BDNF) in the rat hippocampus in vivo. It is still unclear how neuronal BDNF produced by AAV1-Rheb(S16H) transduction induces neuroprotective effects in the
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