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Showing 1-30 of 156 results for "C5042" within Papers
R Intartaglia et al.
Physical chemistry chemical physics : PCCP, 15(9), 3075-3082 (2012-12-01)
A picosecond laser ablation approach has been developed for the synthesis of ligand-free AuAg bimetallic NPs where the relative amount of Ag is controlled in situ through a laser shielding effect. Various measurements, such as optical spectroscopy, transmission electron microscopy
Francesco Blasi et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(6), 977-984 (2015-02-05)
Small white-matter infarcts of the internal capsule are clinically prevalent but underrepresented among currently available animal models of ischemic stroke. In particular, the assessment of long-term outcome, a primary end point in clinical practice, has been challenging due to mild
Da Hee Jung et al.
Life (Basel, Switzerland), 10(10) (2020-10-18)
Electroacupuncture (EA) therapy via alternating current stimulation on the scalp over the motor cortex is used for the treatment of brain disorders. Perinatal hypoxia-ischemia (HI), a brain injury in newborns, leads to long-term neurologic complications. Here, we investigated whether EA
Ines Leca et al.
PLoS genetics, 16(11), e1009104-e1009104 (2020-11-03)
Microtubules play a critical role in multiple aspects of neurodevelopment, including the generation, migration and differentiation of neurons. A recurrent mutation (R402H) in the α-tubulin gene TUBA1A is known to cause lissencephaly with cerebellar and striatal phenotypes. Previous work has
R J Macias-Velez et al.
Journal of molecular neuroscience : MN, 68(4), 590-602 (2019-05-06)
Erythropoietin, a multitarget molecule exhibited neuroprotective properties, especially against cerebral ischemia. However, little effort has been made to determinate both the administration pathway and doses that diminishes neuronal damage. In this study, we investigate the effect on CA1 region of
Mohd Salman et al.
Disease models & mechanisms, 13(8) (2020-06-17)
Pramipexole (PPX), a D2-like receptor agonist, is generally used in the treatment of Parkinson's disease and restless leg syndrome. Its neuroprotective effects have been shown against various neurological disorders. Recent research work has demonstrated that PPX exerts neuroprotection through mitochondria.
Min-Tae Jeon et al.
British journal of pharmacology, 177(3), 668-686 (2019-10-29)
We recently reported that AAV1-Rheb(S16H) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (BDNF) in the rat hippocampus in vivo. It is still unclear how neuronal BDNF produced by AAV1-Rheb(S16H) transduction induces neuroprotective effects in the
Kyung-Ok Cho et al.
Nature communications, 6, 6606-6606 (2015-03-27)
Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult-generated neurons in the development of chronic seizures or associated cognitive deficits remains to be
Verena Schropp et al.
Journal of neuroinflammation, 16(1), 111-111 (2019-05-30)
In a subgroup of patients suffering from progressive multiple sclerosis (MS), which is an inflammation-mediated neurodegenerative disease of the central nervous system (CNS), B cell aggregates were discovered within the meninges. Occurrence of these structures was associated with a more
Xiao-Feng Zhao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(40), 7593-7608 (2020-09-02)
Excessive activation of mammalian target of rapamycin (mTOR) signaling is epileptogenic in genetic epilepsy. However, the exact role of microglial mTOR in acquired epilepsy remains to be clarified. In the present study, we found that mTOR is strongly activated in
Qin-Ming Zhou et al.
CNS neuroscience & therapeutics, 23(5), 375-385 (2017-02-24)
To evaluate the therapeutic effects of n-butylidenephthalide (BP) in SOD1G93A mouse model of amyotrophic lateral sclerosis and explore the possible mechanisms. The SOD1G93A mice were treated by oral administration of BP (q.d., 400 mg/kg d) starting from 60 days of age and continuing
Emily A Jones et al.
Cell reports, 29(8), 2123-2133 (2019-11-21)
Alzheimer's disease (AD) is characterized by progressive memory loss, and there is a pressing need to identify early pathophysiological alterations that predict subsequent memory impairment. Hippocampal sharp-wave ripples (SWRs)-electrophysiological signatures of memory reactivation in the hippocampus-are a compelling candidate for
Alicia Flores-Cuadrado et al.
Acta neuropathologica communications, 7(1), 56-56 (2019-04-17)
Parkinson's disease is characterized by a proteinopathy that includes aggregates of α-synuclein. A recent hypothesis proposes a prion-like spreading mechanism for this α-synucleinopathy. Early neuropathological deposits occur, among others, in the anterior olfactory nucleus (AON). This study investigates the anterograde
Tomas Lindholm et al.
Frontiers in neurology, 8, 49-49 (2017-03-09)
Dorsal root injury is a situation not expected to be followed by a strong regenerative growth, or growth of the injured axon into the central nervous system of the spinal cord, if the central axon of the dorsal root is
Valentyna Dubovyk et al.
Frontiers in behavioral neuroscience, 13, 98-98 (2019-05-30)
Psychosis is a clinical state that encompasses a range of abnormal conditions, including distortions in sensory information processing and the resultant delusional thinking, emotional discordance and cognitive impairments. Upon developing this condition, the rate at which cognitive and behavioral deteriorations
Estelle Rousselet et al.
Journal of visualized experiments : JoVE, (69)(69), doi:10-doi:10 (2012-11-22)
Stroke is the third cause of mortality and the leading cause of disability in the World. Ischemic stroke accounts for approximately 80% of all strokes. However, the thrombolytic tissue plasminogen activator (tPA) is the only treatment of acute ischemic stroke
Jiang Li et al.
eNeuro, 5(5) (2018-09-27)
Reproductive endocrine disorders are prominent comorbidities of temporal lobe epilepsy (TLE) in both men and women. The neural mechanisms underlying these comorbidities remain unclear, but hypothalamic gonadotropin-releasing hormone (GnRH) neurons may be involved. Here, we report the first direct demonstrations
Pishan Chang et al.
Cell reports, 30(4), 1152-1163 (2020-01-30)
Altered neural dynamics in the medial prefrontal cortex (mPFC) and hippocampus may contribute to cognitive impairments in the complex chromosomal disorder Down syndrome (DS). Here, we demonstrate non-overlapping behavioral differences associated with distinct abnormalities in hippocampal and mPFC electrophysiology during
Wen Wen et al.
Frontiers in molecular neuroscience, 13, 560020-560020 (2020-10-20)
Neurite outgrowth is essential for brain development and the recovery of brain injury and neurodegenerative diseases. In this study, we examined the role of the neurotrophic factor MANF in regulating neurite outgrowth. We generated MANF knockout (KO) neuro2a (N2a) cell
Johannes van der Merwe et al.
Scientific reports, 9(1), 3506-3506 (2019-03-07)
Preterm birth is the most significant problem in contemporary obstetrics accounting for 5-18% of worldwide deliveries. Encephalopathy of prematurity encompasses the multifaceted diffuse brain injury resulting from preterm birth. Current animal models exploring the underlying pathophysiology of encephalopathy of prematurity
Brunno Rocha Levone et al.
Neurobiology of stress, 14, 100331-100331 (2021-05-18)
Current antidepressants are suboptimal due incomplete understanding of the neurobiology underlying their behavioral effects. However, imaging studies suggest the hippocampus is a key brain region underpinning antidepressant action. There is increasing attention on the functional segregation of the hippocampus into
Michael K Schuhmann et al.
Journal of neuroinflammation, 18(1), 46-46 (2021-02-20)
In acute ischemic stroke, cessation of blood flow causes immediate tissue necrosis within the center of the ischemic brain region accompanied by functional failure in the surrounding brain tissue designated the penumbra. The penumbra can be salvaged by timely thrombolysis/thrombectomy
Yelena Golubeva et al.
Methods in molecular biology (Clifton, N.J.), 931, 213-257 (2012-10-03)
Laser capture microdissection (LCM) allows the precise procurement of enriched cell populations from a heterogeneous tissue, or live cell culture, under direct microscopic visualization. Histologically enriched cell populations can be procured by harvesting cells of interest directly or isolating specific
Samsoon Inayat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(20), 7992-8003 (2015-05-23)
The superior colliculus (SC) is a layered midbrain structure important for multimodal integration and sensorimotor transformation. Its superficial layers are purely visual and receive depth-specific projections from distinct subtypes of retinal ganglion cells. Here we use two-photon calcium imaging to
Alexandra V Ulyanova et al.
Frontiers in neuroscience, 13, 397-397 (2019-05-14)
Decoding laminar information across deep brain structures and cortical regions is necessary in order to understand the neuronal ensembles that represent cognition and memory. Large animal models are essential for translational research due to their gyrencephalic neuroanatomy and significant white
Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis.
McMillan MT, et al.
American Journal of Physiology: Renal Physiology, 307, F612-F622 (2014)
Hossein Baharvand et al.
The International journal of developmental biology, 51(5), 371-378 (2007-07-10)
Understanding how to direct human embryonic stem cells (hESCs) toward a specific lineage pathway and generate appropriate cell types robustly is very important, not only for the study of developmental biology but also for potentially using these cells to treat
Nowruz Najafzadeh et al.
Neural regeneration research, 8(36), 3365-3372 (2014-09-11)
Emerging studies of treating spinal cord injury (SCI) with adult stem cells led us to evaluate the effects of transplantation of hair follicle stem cells in rats with a compression-induced spinal cord lesion. Here, we proposed a hypothesis that rat
Yun Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(33), 11514-11531 (2015-08-21)
Protein aggregates containing ubiquitin (Ub) are commonly observed in neurodegenerative disorders, implicating the involvement of the ubiquitin proteasome system (UPS) in their pathogenesis. Here, we aimed to generate a mouse model for monitoring UPS function using a green fluorescent protein
Daniel Komnig et al.
Journal of neurochemistry, 147(5), 678-691 (2018-08-29)
Parkinson's disease (PD) is characterized by the loss of midbrain dopaminergic neurons and aggregates of α-synuclein termed Lewy bodies. Fingolimod (FTY720) is an agonist of sphingosine-1 phosphate receptors and an approved oral treatment for multiple sclerosis. Fingolimod elevates brain-derived neurotrophic
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