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Keyword:'cd45'
Showing 1-30 of 2914 results for "cd45" within Papers
Juana Gil et al.
Medicina clinica, 125(1), 10-11 (2005-06-18)
A mutation (C77G) in exon 4 of the CD45 gene is the most common cause of CD45 abnormal splicing in European populations, which has been associated with an increased susceptibility to human immunodeficiency virus infection. We aimed to analyze the
Jian Yang et al.
Journal of immunological methods, 337(2), 81-87 (2008-07-08)
We have produced and characterised reporter knock-in CD45-YFP and CD45-Cre mice that drive expression of yellow fluorescent protein (YFP) and Cre-recombinase, respectively under control of the haematopoietic CD45 locus. CD45-YFP expression was characterised in various haematopoietic cells populations. The activity
Joseph L Roberts et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(26), 10456-10461 (2012-06-13)
Analysis of the molecular etiologies of SCID has led to important insights into the control of immune cell development. Most cases of SCID result from either X-linked or autosomal recessive inheritance of mutations in a known causative gene. However, in
María C Lópeza et al.
Annals of the New York Academy of Sciences, 1029, 355-357 (2005-02-01)
Healthy CD45 KO mice show a Th2-type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1-type profile, suggesting that diet can alter cytokine secretion.
Tamara Vyshkina et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 10(6), 614-617 (2004-12-09)
The 77C-->G polymorphism in exon 4 of CD45 or protein tyrosine phosphatase receptor-type C (PTPRC) has been investigated in families with multiple sclerosis (MS) and in several cohorts of sporadic patients and controls, however, with conflicting results. To better understand
T Mustelin et al.
European journal of immunology, 25(4), 942-946 (1995-04-01)
Two classes of protein tyrosine kinases (PTK) are utilized by the T cell antigen receptor (TcR)/CD3 complex for initiation of the signaling cascade, the Src-family PTK p56lck and p59fyn, and the Syk-family PTK p70zap and p72syk. In addition, the CD45
Nicholas D Huntington et al.
Immunology letters, 94(3), 167-174 (2004-07-28)
The protein tyrosine phosphatase (PTP) CD45 is abundantly expressed on all nucleated hematopoietic cells and is critical for classical antigen receptor signalling indicated by the arrested development of B and T cells in mice deficient for CD45. Despite its clear
A Vogel et al.
Genes and immunity, 4(1), 79-81 (2003-02-22)
Autoimmune hepatitis is a chronic immune-mediated disease characterized by a loss of tolerance against liver resident antigens. The genetic background of autoimmune hepatitis is considered to be polygenic. Here we analyzed the genetic association of the tyrosine phosphatase CD45 and
H Walzel et al.
Immunology letters, 67(3), 193-202 (1999-06-16)
Galectin-1 binds preferentially to N-acetyllactosamine residues on oligosaccharides associated with several cell surface glycoconjugates. In the present work, placental galectin-1 has been identified to be a natural ligand for the receptor-type protein tyrosine phosphatase CD45. The binding of galectin-1 to
Stefanie Kirchberger et al.
Blood, 112(4), 1240-1248 (2008-05-31)
CD45 is the prototypic transmembrane protein tyrosine phosphatase (PTP), which is expressed on all nucleated hematopoietic cells and plays a central role in the integration of environmental signals into immune cell responses. Here we report an alternative function for the
Mabel Pang et al.
Journal of immunology (Baltimore, Md. : 1950), 182(11), 7001-7008 (2009-05-21)
Disassembly and phagocytic removal of dying cells is critical to maintain immune homeostasis. The factors that regulate fragmentation and uptake of dying lymphocytes are not well understood. Degradation of fodrin, a cytoskeletal linker molecule that attaches CD45 to the actin
Dennis C Lefebvre et al.
Biochimica et biophysica acta, 1650(1-2), 40-49 (2003-08-19)
The Src-family tyrosine kinase, Lck, contains two key regulatory phosphotyrosine residues, tyrosine 394 (Tyr-394) and tyrosine 505 (Tyr-505), both of which can be dephosphorylated by CD45. Here, the interaction of CD45 with its substrate, Lck, was determined to be complex
A Symons et al.
Glycobiology, 10(6), 559-563 (2000-05-18)
Galectin-1 is a sugar binding protein specific for beta-galactosides and not requiring metal ions for binding activity. It exists as a soluble protein which forms a noncovalent homodimer and is expressed with a broad tissue distribution. Recently, galectin-1 has been
Shoham Shivtiel et al.
European journal of immunology, 32(8), 2264-2273 (2002-09-05)
B cell receptor signaling threshold regulates negative selection of autoreactive B cells and determines the mechanism of B cell tolerance. Using mice carrying immunoglobulin transgene specific for MHC class I antigen K(k) (3-83 Tg mice), and IL-7-driven bone marrow (BM)
Maria Montoya et al.
European journal of immunology, 36(8), 2150-2158 (2006-07-21)
CD45 is a leukocyte tyrosine phosphatase, essential for normal immune responses. We have studied the function of splenic dendritic cells of CD45(+/+), CD45(-/-), CD45RABC and CD45RO transgenic mice. We show that there are increased numbers of plasmacytoid dendritic cells in
Elma Z Tchilian et al.
International immunology, 16(9), 1323-1332 (2004-08-11)
Transgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45-/- background. Phenotypic analysis and in vivo challenge of these mice with influenza and lymphocytic choriomeningitis viruses shows that T cell differentiation and
Ditte Caroline Andersen et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 81(1), 72-80 (2011-10-13)
The skeletal muscle-derived side population (mSP) which highly excludes Hoechst 33342 is composed of CD45(+) and CD45(-) subpopulations; yet, rareness of mSP cells in general has complicated extensive quantitative analysis of gene expression profiles in primarily isolated mSP cells. Here
Molecular basis of antigenic differences between the RT7 alleles of rat CD45.
A Symons et al.
Immunogenetics, 51(8-9), 747-750 (2000-08-15)
R Schwinzer et al.
Genes and immunity, 4(2), 168-169 (2003-03-06)
A point mutation in exon A (C to G transversion at position 77) of human PTPRC (CD45) has recently been associated with the development of multiple sclerosis (MS) for at least a subgroup of patients. In the present report, we
J G Cyster et al.
Nature, 381(6580), 325-328 (1996-05-23)
Elimination of self-reactive B cells must be balanced against the need for B-cell diversity for antibody responses to pathogens. To analyse factors that determine the extent of B-cell negative selection, we crossed CD45-deficient mice with mice carrying immunoglobulin transgenes specific
Lily C Filip et al.
Molecular biology and evolution, 21(8), 1504-1511 (2004-03-12)
CD45, encoded by PTPRC in humans, is the most abundantly expressed protein on the surface of many lymphocytes. We investigated whether the extracellular region of CD45 was under positive selection in Old World primates, and whether there was differential selection
Marc Jacobsen et al.
Immunogenetics, 54(3), 158-163 (2002-06-20)
CD45, encoded by the protein tyrosine phosphatase receptor type C ( PTPRC) gene, is essentially involved in maturation, activation, and migration of immune cells. Lack of CD45 results in severe immunodeficiency, and alterations of the receptor may result in autoimmunity.
I Ding et al.
European journal of immunology, 29(12), 3956-3961 (1999-12-22)
The role of the CD45-associated phosphoprotein (LPAP / CD45-AP) during an immune response remains unclear. To understand better the function of LPAP we generated LPAP-deficient mice by disrupting exon 2 of the LPAP gene. LPAP-null mice were healthy and did
András Bratincsák et al.
Stem cells (Dayton, Ohio), 25(11), 2820-2826 (2007-07-28)
The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by
Michelle L Hermiston et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(2), 546-551 (2009-01-09)
The cooperative activity of protein tyrosine kinases and phosphatases plays a central role in regulation of T cell receptor (TCR) signal strength. Perturbing this balance, and thus the threshold for TCR signals, has profound impacts on T cell development and
J P Wood et al.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics, 29(1), 73-74 (2002-02-14)
A point mutation in the leukocyte common antigen (CD45, C-->G77, exon 4) was investigated in patients with type 1 diabetes (IDDM), patients with Graves' disease and controls. The distribution did not differ significantly between patients and controls. This CD45 variant
Roberta Fajka-Boja et al.
Immunology letters, 82(1-2), 149-154 (2002-05-15)
Galectin-1 (Gal-1) is an endogenous mammalian S-type lectin with highly pleiotropic effect on different tissues. The viability of the lymphoid cells is reduced by gal-1 by triggering apoptosis, however, the mechanism of the gal-1 induced apoptosis is still under investigation.
C Kung et al.
European journal of immunology, 29(12), 3951-3955 (1999-12-22)
CD45 is a transmembrane protein tyrosine phosphatase required for signaling through the T-and B-cell antigen receptors. In lymphocytes, CD45 interacts with CD45-associated protein (CD45AP), a 32 000 Mr phosphoprotein, through their respective transmembrane domains. To determine whether CD45AP affects the
L F Barcellos et al.
Nature genetics, 29(1), 23-24 (2001-08-31)
A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism
T Furukawa et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(23), 10928-10932 (1994-11-08)
The CD45 transmembrane protein-tyrosine phosphatase (PTPase, EC 3.1.3.48) plays an essential role in T-cell activation by activating the Lck and/or Fyn protein-tyrosine kinases. However, numerous experiments have indicated that CD45 may have both stimulatory and inhibitory roles in T-cell activation.
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