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Showing 1-30 of 104 results for "D-081" within Papers
Frank J Meye et al.
Trends in pharmacological sciences, 35(1), 31-40 (2013-12-18)
Overconsumption of high caloric food plays an important role in the etiology of obesity. Several factors drive such hedonic feeding. High caloric food is often palatable. In addition, when an individual is sated, stress and food-related cues can serve as
Martin Sarter et al.
Experimental neurology, 257, 120-129 (2014-05-09)
Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls
Celia Herrera-Rincon et al.
NPJ Regenerative medicine, 5, 2-2 (2020-02-13)
Infections have numerous effects on the brain. However, possible roles of the brain in protecting against infection, and the developmental origin and role of brain signaling in immune response, are largely unknown. We exploited a unique Xenopus embryonic model to
Natsuka Tashiro et al.
Biochemical and biophysical research communications, 449(4), 412-418 (2014-05-27)
The freshwater planarian Dugesia japonica has a simple central nervous system (CNS) and can regenerate complete organs, even a functional brain. Recent studies demonstrated that there is a great variety of neuronal-related genes, specifically expressed in several domains of the
Martin Gevonden et al.
JAMA psychiatry, 71(12), 1364-1372 (2014-10-02)
An increased risk for psychosis is observed in people with hearing impairment. According to the social defeat hypothesis, the long-term experience of exclusion leads to enhanced baseline activity and/or sensitization of the dopamine system and puts the individual at increased
Marquitta L Smith et al.
Life sciences, 110(1), 1-7 (2014-06-01)
The molecular mechanisms for the loss of 3,4-dihydroxyphenylalanine (l-dopa) efficacy during the treatment of Parkinson's disease (PD) are unknown. Modifications related to catecholamine metabolism such as changes in l-dopa and dopamine (DA) metabolism, the modulation of catecholamine enzymes and the
T Karayannis et al.
Nature, 511(7508), 236-240 (2014-05-30)
Although considerable evidence suggests that the chemical synapse is a lynchpin underlying affective disorders, how molecular insults differentially affect specific synaptic connections remains poorly understood. For instance, Neurexin 1a and 2 (NRXN1 and NRXN2) and CNTNAP2 (also known as CASPR2)
Marta E Soden et al.
Neuron, 80(4), 997-1009 (2013-11-12)
The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between
Graeme Eisenhofer et al.
Clinical chemistry, 60(12), 1486-1499 (2014-10-22)
Pheochromocytomas and paragangliomas (PPGLs) are potentially lethal yet usually surgically curable causes of endocrine hypertension; therefore, once clinical suspicion is aroused it is imperative that clinicians choose the most appropriate laboratory tests to identify the tumors. Compelling evidence now indicates
Jesús Pérez-H et al.
Toxicology, 319, 38-43 (2014-03-13)
Parkinson's disease (PD) is a neurodegenerative disease secondary to the loss of dopaminergic neurons in the substantia nigra. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces in mice and primates histopathological changes similar to PD in humans. A common feature of PD and MPTP models
Zhen Qi et al.
Toxicology, 315, 92-101 (2013-11-26)
Pesticides, such as rotenone and paraquat, are suspected in the pathogenesis of Parkinson's disease (PD), whose hallmark is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Thus, compounds expected to play a role in the pathogenesis
Gambling on the brain.
Ferris Jabr
Scientific American, 309(5), 28-28 (2013-11-29)
[The reward system of the brain: the brain loves surprises].
Claudia Bruhn
Deutsche medizinische Wochenschrift (1946), 139(18), 928-929 (2014-06-03)
Debra A Cooper et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 144-152 (2014-05-13)
Disulfiram has shown promise as a pharmacotherapy for cocaine dependence in clinical settings, although it has many targets, and the behavioral and molecular mechanisms underlying its efficacy are unclear. One of many biochemical actions of disulfiram is inhibition of dopamine
Andrew S Hart et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(3), 698-704 (2014-01-17)
Making predictions about the rewards associated with environmental stimuli and updating those predictions through feedback is an essential aspect of adaptive behavior. Theorists have argued that dopamine encodes a reward prediction error (RPE) signal that is used in such a
Jackson J Cone et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4905-4913 (2014-04-04)
Brief, high-concentration (phasic) spikes in nucleus accumbens dopamine critically participate in aspects of food reward. Although physiological state (e.g., hunger, satiety) and associated hormones are known to affect dopamine tone in general, whether they modulate food-evoked, phasic dopamine specifically is
Nenad Medic et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16856-16864 (2014-12-17)
Although there is a rich literature on the role of dopamine in value learning, much less is known about its role in using established value estimations to shape decision-making. Here we investigated the effect of dopaminergic modulation on value-based decision-making
Gabrielle R Wilson et al.
American journal of human genetics, 95(6), 729-735 (2014-12-01)
Advances in understanding the etiology of Parkinson disease have been driven by the identification of causative mutations in families. Genetic analysis of an Australian family with three males displaying clinical features of early-onset parkinsonism and intellectual disability identified a ∼45
[In vitro pharmacology of antipsychotics at human dopamine D2 and D3 receptors].
Yoshihiro Tadori et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144(6), 265-271 (2014-12-11)
Mark J Ferris et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), E2751-E2759 (2014-07-01)
The majority of neurotransmitter systems shows variations in state-dependent cell firing rates that are mechanistically linked to variations in extracellular levels, or tone, of their respective neurotransmitter. Diurnal variation in dopamine tone has also been demonstrated within the striatum, but
Shuhei Konagaya et al.
Biochimica et biophysica acta, 1850(1), 22-32 (2014-10-05)
Dopamine neurons derived from induced pluripotent stem cells have been widely studied for the treatment of Parkinson's disease. However, various difficulties remain to be overcome, such as tumor formation, fragility of dopamine neurons, difficulty in handling large numbers of dopamine
Magali Cazade et al.
Molecular pharmacology, 85(2), 218-225 (2013-11-12)
T-type calcium channels (T/Ca(v)3-channels) are implicated in various physiologic and pathophysiologic processes such as epilepsy, sleep disorders, hypertension, and cancer. T-channels are the target of endogenous signaling lipids including the endocannabinoid anandamide, the ω3-fatty acids, and the lipoamino-acids. However, the
Christopher O Boyson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(19), 6659-6667 (2014-05-09)
The nature of neuroadaptations in the genesis of escalated cocaine taking remains a topic of considerable interest. Intermittent social defeat stress induces both locomotor and dopaminergic cross-sensitization to cocaine, as well as escalated cocaine self-administration. The current study examines the
Eashita Das et al.
FEBS letters, 588(9), 1706-1714 (2014-03-25)
MicroRNA (miRNA) regulates expression of protein coding genes and has been implicated in diverse cellular processes including neuronal differentiation, cell growth and death. To identify the role of miRNA in neuronal differentiation, SH-SY5Y and IMR-32 cells were treated with dopamine
Dopamine vs nesiritide for acute heart failure with renal dysfunction.
Sachin Kumar
JAMA, 311(15), 1565-1565 (2014-04-17)
The authors reply.
Djillali Annane et al.
Critical care medicine, 41(12), e484-e484 (2013-11-28)
Shoji Yano et al.
The Journal of pediatrics, 165(1), 184-189 (2014-05-27)
To determine whether additional supplementation of tryptophan (Trp) and tyrosine (Tyr) improve serotonin and dopamine metabolism in individuals with phenylketonuria treated with large neutral amino acid (LNAA) tablets. Ten adult individuals with phenylketonuria participated in a randomized, double-blind, placebo-controlled cross-over
Tanya Chotibut et al.
Molecular pharmacology, 86(6), 675-685 (2014-09-12)
Pharmacological dopamine (DA) replacement with Levodopa [L-dihydroxyphenylalanine (L-DOPA)] is the gold standard treatment of Parkinson's disease (PD). However, long-term L-DOPA treatment is complicated by eventual debilitating abnormal involuntary movements termed L-DOPA-induced dyskinesia (LID), a clinically significant obstacle for the majority
Amy K Wagner et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(8), 1328-1339 (2014-05-23)
Dopamine (DA) neurotransmission influences cognition and recovery after traumatic brain injury (TBI). We explored whether functional genetic variants affecting the DA transporter (DAT) and D2 receptor (DRD2) impacted in vivo dopaminergic binding with positron emission tomography (PET) using [(11)C]βCFT and
Hongwon Kim et al.
Biochemical and biophysical research communications, 446(4), 1211-1218 (2014-04-01)
Midbrain dopaminergic (DA) neurons are involved in the regulation of voluntary movement and in emotion-related behaviors and are affected in Parkinson's disease (PD). The homeodomain transcription factor Pitx3, which is uniquely expressed in midbrain DA neurons, plays a critical role
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