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Showing 1-30 of 104 results for "D-081" within Papers
Takeshi Inoue et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(17), 5927-5937 (2014-04-25)
LMTK3 belongs to the LMTK family of protein kinases that are predominantly expressed in the brain. Physiological functions of LMTK3 and other members of the LMTK family in the CNS remain unknown. In this study, we performed a battery of
P Teismann
Deutsche medizinische Wochenschrift (1946), 139(3), 99-102 (2013-11-28)
Myeloperoxidase (MPO) is a hemoprotein which is involved in the unspecific immune response. In this process hypochloric acid is released. Hypochloric acid can react with lipids and proteins and thus lead to cell damage. We were able to show that
Veronica Francardo et al.
Brain : a journal of neurology, 137(Pt 7), 1998-2014 (2014-04-24)
The sigma-1 receptor, an endoplasmic reticulum-associated molecular chaperone, is attracting great interest as a potential target for neuroprotective treatments. We provide the first evidence that pharmacological modulation of this protein produces functional neurorestoration in experimental parkinsonism. Mice with intrastriatal 6-hydroxydopamine
Kuo-Chen Wu et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(1), 37-47 (2014-09-25)
This study was to investigate the influence of age on the expression of organic cation transporters (OCTs) that belong to the SLC22 family in brain microvessels (BMVs) and its implications for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity in mice. Here, we showed
Rajesh Narendran et al.
The American journal of psychiatry, 171(8), 881-888 (2014-05-31)
Basic studies have demonstrated that optimal levels of prefrontal cortical dopamine are critical to various executive functions such as working memory, attention, inhibitory control, and risk/reward decisions, all of which are impaired in addictive disorders such as alcoholism. Based on
Hong Zheng et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(2), R138-R148 (2013-12-07)
The study was conducted to investigate the role for dopamine in the centrally mediated sympathoexcitatory response in rats with Type 2 diabetes (T2D). T2D was induced by a combination of high-fat diet (HFD) and low-dose streptozotocin (STZ). HFD/STZ treatment for
Chiyako Shimada et al.
Anticancer research, 34(7), 3543-3548 (2014-07-02)
A total of 12 phenylpropanoid amides were subjected to quantitative structure-activity relationship (QSAR) analysis, based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to investigate on their biological activities. Cytotoxicity against four human oral squamous cell carcinoma (OSCC)
A new drug war.
Emily Underwood
Science (New York, N.Y.), 347(6221), 469-473 (2015-01-31)
Yanru Bu et al.
Journal of nanoscience and nanotechnology, 13(9), 5992-5996 (2013-11-12)
Silver nanoparticles (Ag NPs) prepared by the citrate reduction method were examined as surface-enhanced Raman scattering (SERS) substrates in the detection of dopamine (DA) molecules at different hydrogen ion concentrations. The aggregation of Ag NPs was influenced by the crosslinking
Neuroscience. Jump-starting natural resilience reverses stress susceptibility.
Allyson Friedman
Science (New York, N.Y.), 346(6209), 555-555 (2014-11-02)
Can lithium unmask the preclinical Parkinsonian features?
S Bhattacharjee et al.
Irish medical journal, 106(8), 254-254 (2013-11-29)
Vasopressor dosing in septic shock.
Cesar Alaniz et al.
Critical care medicine, 41(12), e483-e484 (2013-11-28)
Koichi Hirata et al.
Brain and nerve = Shinkei kenkyu no shinpo, 65(11), 1391-1399 (2013-11-10)
The symptoms of restless legs syndrome (RLS) can be managed effectively by treatment. The pathophysiology of primary RLS is only partly understood; however, a strong association with brain iron deficiency, which possibly impairs dopaminergic function, has been identified. Dopamine agonists
Kenji Takahashi et al.
Experimental cell research, 323(2), 337-345 (2014-03-19)
2-Aminoethoxydiphenyl borate (2-APB) is used as a pharmacological tool because it antagonizes inositol 1,4,5-trisphosphate receptors and store-operated Ca(2+) (SOC) channels, and activates some TRP channels. Recently, we reported that 2-APB enhanced the increase in cytotoxic [Ca(2+)]i, resulting in cell death
Lars Tatenhorst et al.
Journal of neuropathology and experimental neurology, 73(8), 770-779 (2014-07-09)
Chronic degeneration of nigrostriatal projections, followed by nigral dopaminergic cell death, is a key feature of Parkinson disease (PD). This study examines the neuroprotective potential of the rho kinase inhibitor fasudil in the 6-hydroxydopamine (6-OHDA) mouse model of PD in
Colter Mitchell et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 5944-5949 (2014-04-09)
Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety of contexts
Teruko Danjo et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6455-6460 (2014-04-17)
Dopamine (DA) transmission from the ventral tegmental area (VTA) is critical for controlling both rewarding and aversive behaviors. The transient silencing of DA neurons is one of the responses to aversive stimuli, but its consequences and neural mechanisms regarding aversive
James K Rilling et al.
Science (New York, N.Y.), 345(6198), 771-776 (2014-08-16)
Parents know the transformative nature of having and caring for a child. Among many mammals, giving birth leads from an aversion to infant stimuli to irresistible attraction. Here, we review the biological mechanisms governing this shift in parental motivation in
Peter J Hamilton et al.
Nature chemical biology, 10(7), 582-589 (2014-06-02)
Phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates the function of ion channels and transporters. Here, we demonstrate that PIP2 directly binds the human dopamine (DA) transporter (hDAT), a key regulator of DA homeostasis and a target of the psychostimulant amphetamine (AMPH). This binding
Adenosine transiently modulates stimulated dopamine release in the caudate-putamen via A1 receptors.
Ashley E Ross et al.
Journal of neurochemistry, 132(1), 51-60 (2014-09-16)
Adenosine modulates dopamine in the brain via A1 and A2A receptors, but that modulation has only been characterized on a slow time scale. Recent studies have characterized a rapid signaling mode of adenosine that suggests a possible rapid modulatory role.
A Jon Stoessl et al.
Lancet (London, England), 384(9942), 532-544 (2014-06-24)
Recent advances in structural and functional imaging have greatly improved our ability to assess normal functions of the basal ganglia, diagnose parkinsonian syndromes, understand the pathophysiology of parkinsonism and other movement disorders, and detect and monitor disease progression. Radionuclide imaging
Mohammad Kanafi et al.
Journal of cellular physiology, 229(10), 1369-1377 (2014-01-31)
Dental pulp originating from the neural crest is considered a better source of postnatal stem cells for cell-based therapies in neurodegenerative diseases. Dental Pulp Stem Cells (DPSCs) have been shown to differentiate into cell-types of cranial neural crest ontology; however
Chris A Oosterhof et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 585-595 (2014-09-17)
Brexpiprazole, a compound sharing structural molecular characteristics with aripiprazole, is currently under investigation for the treatment of schizophrenia and depression. Using electrophysiologic techniques, the present study assessed the in vivo action of brexpiprazole on serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B
Arnaud Muller et al.
Nature methods, 11(12), 1245-1252 (2014-10-27)
The neuronal coding of stimulus-to-action sequences is believed to involve the release of dopamine (DA) and norepinephrine (NE). The electrochemical similarity of these monoamines, however, confounds real-time measurements of their release. Here we report cell-based neurotransmitter fluorescent engineered reporters (CNiFERs)
Alexandra B Nelson et al.
Neuron, 82(1), 63-70 (2014-03-13)
Striatal cholinergic interneurons are implicated in motor control, associative plasticity, and reward-dependent learning. Synchronous activation of cholinergic interneurons triggers large inhibitory synaptic currents in dorsal striatal projection neurons, providing one potential substrate for control of striatal output, but the mechanism
Kelly P Cosgrove et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16851-16855 (2014-12-17)
Cigarette smoking is a major public health danger. Women and men smoke for different reasons and cessation treatments, such as the nicotine patch, are preferentially beneficial to men. The biological substrates of these sex differences are unknown. Earlier PET studies
Cinzia Nasuti et al.
Chemosphere, 112, 496-502 (2014-07-23)
A positive effect of estrogen treatment has been observed in neurodegenerative diseases such as Parkinson's disease. Since 17β-estradiol can modulate positively dopaminergic system, here we sought to evaluate the effect of 17β-estradiol supplementation on an animal model developing dopaminergic alterations
Patrick Oeckl et al.
Experimental neurology, 257, 1-9 (2014-04-22)
The orphan G-protein coupled receptor 6 (GPR6) is a constitutively active receptor which is positively coupled to the formation of cyclic adenosine-3',5'-monophosphate (cAMP). GPR6 is predominantly expressed in striatopallidal neurons. Here, we investigated neurochemical and behavioural effects of Gpr6 deficiency
Denis E Bragin et al.
Critical care medicine, 42(12), 2582-2590 (2014-10-08)
The lower limit of cerebral blood flow autoregulation is the critical cerebral perfusion pressure at which cerebral blood flow begins to fall. It is important that cerebral perfusion pressure be maintained above this level to ensure adequate cerebral blood flow
Oliver Grimm et al.
JAMA psychiatry, 71(5), 531-539 (2014-03-14)
Attenuated ventral striatal response during reward anticipation is a core feature of schizophrenia that is seen in prodromal, drug-naive, and chronic schizophrenic patients. Schizophrenia is highly heritable, raising the possibility that this phenotype is related to the genetic risk for
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