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Showing 1-30 of 104 results for "D-081" within Papers
Max F K Happel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1234-1247 (2014-01-24)
Dopaminergic neurotransmission in primary auditory cortex (AI) has been shown to be involved in learning and memory functions. Moreover, dopaminergic projections and D1/D5 receptor distributions display a layer-dependent organization, suggesting specific functions in the cortical circuitry. However, the circuit effects
E R Gasenzer et al.
Deutsche medizinische Wochenschrift (1946), 139(51-52), 2642-2650 (2014-12-10)
Purpose of this essay is to provide a historical overview how music has dealt with the emotion and sensation of pain, as well as an overview over the more recent medical research into the relationship of music and pain. Since
Hellmuth Lilienthal et al.
Toxicology letters, 224(1), 32-39 (2014-01-25)
Since knowledge about toxic effects of non-dioxinlike (NDL) PCBs is fragmentary, regulatory panels have concluded that risk assessment of these congeners is hampered or impossible. As the dopaminergic system is one of the main targets in PCB-related neurotoxic effects after
Kevin Wilhelmsen et al.
The Journal of biological chemistry, 289(19), 13079-13100 (2014-03-20)
Although cannabinoids, such as Δ(9)-tetrahydrocannabinol, have been studied extensively for their psychoactive effects, it has become apparent that certain cannabinoids possess immunomodulatory activity. Endothelial cells (ECs) are centrally involved in the pathogenesis of organ injury in acute inflammatory disorders, such
Hongwon Kim et al.
Biochemical and biophysical research communications, 446(4), 1211-1218 (2014-04-01)
Midbrain dopaminergic (DA) neurons are involved in the regulation of voluntary movement and in emotion-related behaviors and are affected in Parkinson's disease (PD). The homeodomain transcription factor Pitx3, which is uniquely expressed in midbrain DA neurons, plays a critical role
Toshihiko Shirafuji et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9268-9280 (2014-07-11)
Protein kinase C (PKC) has been implicated in the control of neurotransmitter release. The AS/AGU rat, which has a nonsense mutation in PKCγ, shows symptoms of parkinsonian syndrome, including dopamine release impairments in the striatum. Here, we found that the
Arati A Inamdar et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(48), 19561-19566 (2013-11-13)
Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been
Tiziana Alberio et al.
Biochimica et biophysica acta, 1842(9), 1816-1822 (2014-07-08)
Altered dopamine homeostasis plays a key role in the pathogenesis of Parkinson's disease. The generation of reactive oxygen species by spontaneous dopamine oxidation impairs mitochondrial function, causing in turn an enhancement of oxidative stress. Recent findings have highlighted the role
Florian Ponzio et al.
Journal of colloid and interface science, 459, 29-35 (2015-08-12)
Polydopamine (PDA) coatings appear as a universal functionalization methodology allowing to coat the surface of almost all kinds of known materials with a conformal, stable, robust and reactive material. Relatively few investigations were dedicated to the incorporation of other molecules
Jin Wu et al.
Journal of leukocyte biology, 97(1), 191-200 (2014-10-25)
MDSCs accumulate in tumor-bearing animals and cancer patients and are a major factor responsible for cancer-induced immunosuppression that limits effective cancer immunotherapy. Strategies aimed at effectively inhibiting the function of MDSCs are expected to enhance host anti-tumor immunity and improve
Moe H Aung et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(3), 726-736 (2014-01-17)
Dopamine (DA) functions as an essential neuromodulator in the brain and retina such that disruptions in the dopaminergic system are associated with common neurologic disorders such as Parkinson's disease. Although a reduction in DA content has been observed in diabetes
Kelly M Lohr et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(27), 9977-9982 (2014-07-01)
Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been implicated in a variety of neurodegenerative and neuropsychiatric conditions. Here, we report a novel mouse model of enhanced vesicular function via bacterial artificial chromosome (BAC)-mediated overexpression of the vesicular monoamine
Xiaofang Wu et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 34(2), 188-193 (2014-05-03)
To study the effect of Qilongtoutong granule (QLTT) on plasma calcitonin gene-related peptide (CGRP), beta-endorphin (beta-EP), 5-HT, dopamine (DA), noradrenalin (NE), and blood viscosity in migraine model rats and mice. Both the acute blood stasis model group and nitroglycerin-induced migraine
Hanneke E M den Ouden et al.
Neuron, 80(4), 1090-1100 (2013-11-26)
Serotonin and dopamine are speculated to subserve motivationally opponent functions, but this hypothesis has not been directly tested. We studied the role of these neurotransmitters in probabilistic reversal learning in nearly 700 individuals as a function of two polymorphisms in
David Vauzour et al.
The Biochemical journal, 463(1), 41-52 (2014-06-19)
Parkinson's disease is characterized by the progressive and selective loss of dopaminergic neurons in the substantia nigra. It has been postulated that endogenously formed CysDA (5-S-cysteinyldopamine) and its metabolites may be, in part, responsible for this selective neuronal loss, although
Shoji Yano et al.
The Journal of pediatrics, 165(1), 184-189 (2014-05-27)
To determine whether additional supplementation of tryptophan (Trp) and tyrosine (Tyr) improve serotonin and dopamine metabolism in individuals with phenylketonuria treated with large neutral amino acid (LNAA) tablets. Ten adult individuals with phenylketonuria participated in a randomized, double-blind, placebo-controlled cross-over
Tanya Chotibut et al.
Molecular pharmacology, 86(6), 675-685 (2014-09-12)
Pharmacological dopamine (DA) replacement with Levodopa [L-dihydroxyphenylalanine (L-DOPA)] is the gold standard treatment of Parkinson's disease (PD). However, long-term L-DOPA treatment is complicated by eventual debilitating abnormal involuntary movements termed L-DOPA-induced dyskinesia (LID), a clinically significant obstacle for the majority
Andrew S Hart et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(3), 698-704 (2014-01-17)
Making predictions about the rewards associated with environmental stimuli and updating those predictions through feedback is an essential aspect of adaptive behavior. Theorists have argued that dopamine encodes a reward prediction error (RPE) signal that is used in such a
Jackson J Cone et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4905-4913 (2014-04-04)
Brief, high-concentration (phasic) spikes in nucleus accumbens dopamine critically participate in aspects of food reward. Although physiological state (e.g., hunger, satiety) and associated hormones are known to affect dopamine tone in general, whether they modulate food-evoked, phasic dopamine specifically is
Shana M Augustin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(19), 6692-6699 (2014-05-09)
Recent experimental evidence suggests that the low dopamine conditions in Parkinson's disease (PD) cause motor impairment through aberrant motor learning. Those data, along with computational models, suggest that this aberrant learning results from maladaptive corticostriatal plasticity and learned motor inhibition.
Christopher O Boyson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(19), 6659-6667 (2014-05-09)
The nature of neuroadaptations in the genesis of escalated cocaine taking remains a topic of considerable interest. Intermittent social defeat stress induces both locomotor and dopaminergic cross-sensitization to cocaine, as well as escalated cocaine self-administration. The current study examines the
Martin Sarter et al.
Experimental neurology, 257, 120-129 (2014-05-09)
Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls
Marta E Soden et al.
Neuron, 80(4), 997-1009 (2013-11-12)
The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between
Gabrielle R Wilson et al.
American journal of human genetics, 95(6), 729-735 (2014-12-01)
Advances in understanding the etiology of Parkinson disease have been driven by the identification of causative mutations in families. Genetic analysis of an Australian family with three males displaying clinical features of early-onset parkinsonism and intellectual disability identified a ∼45
Martin Gevonden et al.
JAMA psychiatry, 71(12), 1364-1372 (2014-10-02)
An increased risk for psychosis is observed in people with hearing impairment. According to the social defeat hypothesis, the long-term experience of exclusion leads to enhanced baseline activity and/or sensitization of the dopamine system and puts the individual at increased
Natsuka Tashiro et al.
Biochemical and biophysical research communications, 449(4), 412-418 (2014-05-27)
The freshwater planarian Dugesia japonica has a simple central nervous system (CNS) and can regenerate complete organs, even a functional brain. Recent studies demonstrated that there is a great variety of neuronal-related genes, specifically expressed in several domains of the
Mark J Ferris et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), E2751-E2759 (2014-07-01)
The majority of neurotransmitter systems shows variations in state-dependent cell firing rates that are mechanistically linked to variations in extracellular levels, or tone, of their respective neurotransmitter. Diurnal variation in dopamine tone has also been demonstrated within the striatum, but
Shuhei Konagaya et al.
Biochimica et biophysica acta, 1850(1), 22-32 (2014-10-05)
Dopamine neurons derived from induced pluripotent stem cells have been widely studied for the treatment of Parkinson's disease. However, various difficulties remain to be overcome, such as tumor formation, fragility of dopamine neurons, difficulty in handling large numbers of dopamine
Debra A Cooper et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 144-152 (2014-05-13)
Disulfiram has shown promise as a pharmacotherapy for cocaine dependence in clinical settings, although it has many targets, and the behavioral and molecular mechanisms underlying its efficacy are unclear. One of many biochemical actions of disulfiram is inhibition of dopamine
[In vitro pharmacology of antipsychotics at human dopamine D2 and D3 receptors].
Yoshihiro Tadori et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144(6), 265-271 (2014-12-11)
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