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Showing 1-30 of 120 results for "E-076" within Papers
Christopher S Crean et al.
International journal of clinical pharmacology and therapeutics, 51(11), 847-853 (2013-09-18)
Ezogabine (EZG) is a potassium-channel opener that has been approved as adjunctive treatment for partial-onset seizures in adults with epilepsy. This Phase I clinical study evaluated the pharmacokinetics (PK), safety, and tolerability of coadministration of EZG and a combined oral
F Z Stanczyk et al.
Contraception, 59(1), 17-23 (1999-05-26)
The interaction between smoking and oral contraceptive (OC) use with respect to thrombogenesis was investigated by studying the effects of OC and smoking on urinary prostacyclin (PGI2) and thromboxane A2 (TxA2) metabolite levels in smokers and nonsmokers. Sixty healthy women
Vivian Dickerson
The Journal of reproductive medicine, 47(11 Suppl), 985-993 (2002-12-25)
The new combined oral contraceptive containing ethinyl estradiol and drospirenone has the potential for improving a woman's quality of life. Drospirenone's antiandrogenic activity, for example, makes it effective in reducing acne and seborrhea. The majority of reproductive-age women suffer from
Sophie Massart et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 57-69 (2014-12-03)
Fish are exposed to endocrine-disrupting chemicals (EDC), which are well known to disturb not only the reproductive system but also the immune system in vertebrates. However, the mechanisms by which these compounds are able to modify fish immunity are not
M Eide et al.
Aquatic toxicology (Amsterdam, Netherlands), 153, 110-115 (2013-11-26)
The Atlantic cod (Gadus morhua) is an economically important species commonly consumed by humans. The widespread distribution of cod in the North Atlantic Ocean makes it vulnerable to effluents from human activities, such as coastal industries and offshore petroleum exploration.
Bernardine H Stegeman et al.
BMJ (Clinical research ed.), 347, f5298-f5298 (2013-09-14)
To provide a comprehensive overview of the risk of venous thrombosis in women using different combined oral contraceptives. Systematic review and network meta-analysis. PubMed, Embase, Web of Science, Cochrane, Cumulative Index to Nursing and Allied Health Literature, Academic Search Premier
Andrea J Rapkin et al.
Drugs of today (Barcelona, Spain : 1998), 44(2), 133-145 (2008-04-05)
Drospirenone 3 mg/ethinyl estradiol 20 microg (24/4) is a new unique oral contraceptive formulation that combines in a novel dosing regimen the lowest dosage of ethinyl estradiol commonly used today with drospirenone, an innovative progestin. Drospirenone is a compound closely
Rogério Bonassi Machado et al.
Women's health (London, England), 7(1), 19-30 (2010-12-24)
Considerable advances have been made in the field of combined oral contraceptives since their introduction 50 years ago. This ongoing evolution has been focused on reducing the estrogen dose and synthesizing new progestogens. A recently launched combination of ethinylestradiol 20
D Kaufer et al.
Nature neuroscience, 7(9), 947-953 (2004-08-10)
Glucocorticoids, the adrenal steroids released during stress, compromise the ability of neurons to survive neurological injury. In contrast, estrogen protects neurons against such injuries. We designed three genetic interventions to manipulate the actions of glucocorticoids, which reduced their deleterious effects
Eiji Koike et al.
Congenital anomalies, 53(1), 9-17 (2013-03-14)
Unrecognizable exposure to estrogenic substance may cause estrogen-dependent diseases, endometriosis and cancer. Pregnant mice (ICR/Jcl, CLEA) were exposed to 0.01 mg ethinyl estradiol (EE2 )/kg per day or vehicle (olive oil) through oral intubation from day 11 to 17 of
Ethinylestradiol + cyproterone. Good riddance.
Prescrire international, 22(139), 151-151 (2013-07-20)
Peter A Bain et al.
Environmental toxicology and chemistry, 33(10), 2297-2307 (2014-07-01)
Changes in the endocrine potency of municipal wastewater at 3 wastewater treatment plants (WWTPs) in Australia were investigated using a panel of in vitro receptor-driven transactivation assays. The assays were based on human estrogen receptor α, androgen receptor, progesterone receptor
Toni M Dando et al.
Drugs, 65(16), 2299-2306 (2005-11-04)
Low-dose ethinylestradiol/levonorgestrel 20 microg/100 microg is a combined oral contraceptive that prevents pregnancy primarily by inhibiting ovulation. The Pearl index (pregnancies per 100 woman-years of use) with ethinylestradiol/levonorgestrel 20 microg/100 microg was 0.88 and the cumulative pregnancy rate was 1.9%
Laura Moro et al.
Blood, 105(1), 115-121 (2004-06-17)
The impact of estrogens on the cardiovascular system and their ability to regulate platelet function are matters of controversy. The recent finding that estrogen receptors are expressed in human platelets renders these cells an excellent model for studying the nongenomic
Willi Cawello et al.
Epilepsia, 54(3), 530-536 (2013-01-31)
To determine whether the antiepileptic drug lacosamide affects the pharmacokinetics or pharmacodynamics of a combined oral contraceptive (OC; ethinylestradiol 0.03 mg plus levonorgestrel 0.15 mg). This was an open-label trial in healthy female volunteers. Eligible women entered cycle 1 of the trial
Karen L Goa et al.
Treatments in endocrinology, 2(3), 191-206 (2005-06-22)
Ethinylestradiol 20 microg/day plus norelgestromin 150 microg/day have been formulated into a transdermal patch for hormonal contraception. The predominant mechanism of action for transdermal ethinylestradiol/norelgestromin (Ortho Evra, Evra) is inhibition of ovulation by suppression of gonadotropins. It suppresses follicular development
Javier González-Sálamo et al.
Journal of separation science, 38(15), 2692-2699 (2015-05-28)
In this work, we have compared the selectivity of two commercial molecularly imprinted polymers (AFFINIMIP®SPE Estrogens and AFFINIMIP®SPE Zearalenone) for the extraction of 12 estrogenic compounds of interest (i.e. 17α-estradiol, 17β-estradiol, estrone, hexestrol, 17α-ethynylestradiol, diethylstibestrol, dienestrol, zearalenone, α-zearalanol, β-zearalanol, α-zearalenol
F S vom Saal et al.
Science (New York, N.Y.), 220(4603), 1306-1309 (1983-06-17)
In the house mouse (Mus musculus), fetuses may develop in utero next to siblings of the same or opposite sex. The amniotic fluid of the female fetuses contains higher concentrations of estradiol than that of male fetuses. Male fetuses that
Hongjian Zhang et al.
Clinical pharmacokinetics, 46(2), 133-157 (2007-01-27)
17alpha-Ethinylestradiol (EE) is widely used as the estrogenic component of oral contraceptives (OC). In vitro and in vivo metabolism studies indicate that EE is extensively metabolised, primarily via intestinal sulfation and hepatic oxidation, glucuronidation and sulfation. Cytochrome P450 (CYP)3A4-mediated EE
Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity.
Arias A, Rigalli JP, Villanueva SS, et al.
Toxicology, 320, 46-55 (2014)
Frank Z Stanczyk et al.
Contraception, 87(6), 706-727 (2013-02-05)
The need to seek improved combined oral contraceptive (COC) efficacy, with fewer health risks and better acceptability, has been ongoing since the introduction of COCs more than 50 years ago. New progestin formulations combined with lower doses of ethinyl estradiol
G V Nikitina et al.
Farmakologiia i toksikologiia, 43(2), 196-199 (1980-03-01)
It was shown in experiments on rats and rabbits that a new derivative of 17 alpha-acetoxyprogesterone--mepregnol diacetate--combined with ethinyl estradiol in varied doses and ratios elicits a pronounced contraceptive effect. This steroid combination exerts neither antigonadotropic nor antiovulatory action. The
F Z Stanczyk
Contraception, 55(5), 273-282 (1997-05-01)
The purpose of the present report is to summarize the most important pharmacokinetic features of the new progestogens. In addition, the question of whether or not gestodene, in comparison to desogestrel, has an influence on the pharmacokinetics of ethinylestradiol (EE2)
Laura P Stabile et al.
Cancer research, 62(7), 2141-2150 (2002-04-04)
Lung cancer is becoming increasingly common in women and in the United States accounts for more female cancer deaths annually than breast cancer. Many epidemiological studies have provided evidence that women are more susceptible than men to the adverse effects
C Piérard-Franchimont et al.
Maturitas, 22(2), 151-154 (1995-09-01)
The effects of menopause and hormone replacement therapy (HRT) on the epidermis are largely unknown. The aim of this study was to model and measure the influence of estrogen-transdermal HRT on subtle physiological changes taking place in the epidermis during
Yohana M Velasco-Santamaría et al.
Environmental pollution (Barking, Essex : 1987), 178, 189-196 (2013-04-16)
The interaction of xenobiotics is common in aquatic ecosystems; therefore, we wanted to evaluate if trenbolone (TB) modulates the effects of 17α-ethinylestradiol (EE2). Male eelpout (Zoarces viviparus) were exposed to 5 ng L(-1) EE2 continuously for 19 d (EE2-C) or discontinuously (11 d, EE2-D)
Kristina Gemzell-Danielsson et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29 Suppl 1, 1-14 (2013-03-06)
There have been numerous attempts to control fertility after unprotected sexual intercourse (UPSI). From very bizarre methods like the vaginal application of Coca Cola to the more serious attempts using calcium antagonists influencing fertility parameters in sperm to hormonal methods
Jeremy A Leonard et al.
Aquatic toxicology (Amsterdam, Netherlands), 150, 103-116 (2014-03-29)
The endocrine disrupting effects of estrogenic compounds in surface waters on fish, such as feminization of males and altered sex ratios, may also occur in aquatic invertebrates. However, the underlying mechanisms of action and toxicity, especially in native freshwater mussels
Lisa Baumann et al.
Toxicology and applied pharmacology, 278(3), 230-237 (2014-05-17)
The aim of the present study was to investigate the persistence of the feminizing effects of discontinued 17α-ethinylestradiol (EE2) exposure on zebrafish (Danio rerio). An exposure scenario covering the sensitive phase of sexual differentiation, as well as final gonad maturation
Liqiao Zhong et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 1-7 (2014-02-20)
Vitellogenin (VTG), the precursor of yolk proteins, is a sensitive biomarker of estrogenic contamination in aquatic environments. Traditionally, VTG was believed to be synthesized under the control of estrogen in the livers of mature females and then secreted into the
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