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Showing 1-30 of 188 results for "E4876" within Papers
Analysis of 17-beta-estradiol and 17-alpha-ethinylestradiol in biological and environmental matrices?a review
Barreiros L, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 126, 243-262 (2016)
Per Hallgren et al.
Environmental toxicology and chemistry, 33(4), 930-936 (2014-03-13)
Endocrine-disrupting chemicals are known to alter the fitness of individual organisms via changes in growth, behavior, and reproduction. It is largely unknown, however, whether these effects cascade through the food web and indirectly affect other, less sensitive organisms. The authors
Sahar M El-Haggar et al.
Endocrine, 49(3), 820-827 (2014-12-30)
This study aimed to evaluate the associated cardiovascular risk in Egyptian healthy consumers of different types of combined oral contraceptives pills (COCPs) via determination of lipids profiles, Castelli index I, leptin, adiponectin, and resistin concentrations as cardiovascular risk factors. In
F Z Stanczyk
Contraception, 55(5), 273-282 (1997-05-01)
The purpose of the present report is to summarize the most important pharmacokinetic features of the new progestogens. In addition, the question of whether or not gestodene, in comparison to desogestrel, has an influence on the pharmacokinetics of ethinylestradiol (EE2)
Yohana M Velasco-Santamaría et al.
Environmental pollution (Barking, Essex : 1987), 178, 189-196 (2013-04-16)
The interaction of xenobiotics is common in aquatic ecosystems; therefore, we wanted to evaluate if trenbolone (TB) modulates the effects of 17α-ethinylestradiol (EE2). Male eelpout (Zoarces viviparus) were exposed to 5 ng L(-1) EE2 continuously for 19 d (EE2-C) or discontinuously (11 d, EE2-D)
Lisa Baumann et al.
Toxicology and applied pharmacology, 278(3), 230-237 (2014-05-17)
The aim of the present study was to investigate the persistence of the feminizing effects of discontinued 17α-ethinylestradiol (EE2) exposure on zebrafish (Danio rerio). An exposure scenario covering the sensitive phase of sexual differentiation, as well as final gonad maturation
Liqiao Zhong et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 1-7 (2014-02-20)
Vitellogenin (VTG), the precursor of yolk proteins, is a sensitive biomarker of estrogenic contamination in aquatic environments. Traditionally, VTG was believed to be synthesized under the control of estrogen in the livers of mature females and then secreted into the
C Piérard-Franchimont et al.
Maturitas, 22(2), 151-154 (1995-09-01)
The effects of menopause and hormone replacement therapy (HRT) on the epidermis are largely unknown. The aim of this study was to model and measure the influence of estrogen-transdermal HRT on subtle physiological changes taking place in the epidermis during
Kristina Gemzell-Danielsson et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29 Suppl 1, 1-14 (2013-03-06)
There have been numerous attempts to control fertility after unprotected sexual intercourse (UPSI). From very bizarre methods like the vaginal application of Coca Cola to the more serious attempts using calcium antagonists influencing fertility parameters in sperm to hormonal methods
Jeremy A Leonard et al.
Aquatic toxicology (Amsterdam, Netherlands), 150, 103-116 (2014-03-29)
The endocrine disrupting effects of estrogenic compounds in surface waters on fish, such as feminization of males and altered sex ratios, may also occur in aquatic invertebrates. However, the underlying mechanisms of action and toxicity, especially in native freshwater mussels
Laura P Stabile et al.
Cancer research, 62(7), 2141-2150 (2002-04-04)
Lung cancer is becoming increasingly common in women and in the United States accounts for more female cancer deaths annually than breast cancer. Many epidemiological studies have provided evidence that women are more susceptible than men to the adverse effects
Ikumi Hirakawa et al.
Journal of applied toxicology : JAT, 33(9), 1001-1010 (2012-11-07)
Several endocrine-disrupting chemicals with estrogenic activity can affect sexual development and reproduction in aquatic wildlife. The occurrence of oocytes in the testis (testis-ova) is one reproductive disorder and can be used as a valid endpoint when studying disruptive effects of
Aldehyde oxidase: an enzyme of emerging importance in drug discovery.
David C Pryde et al.
Journal of medicinal chemistry, 53(24), 8441-8460 (2010-09-22)
Nareshkumar Jain et al.
Journal of medicinal chemistry, 49(11), 3056-3059 (2006-05-26)
A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma cholesterol and bone metabolism while maintaining
Noriko Nakamura et al.
The Journal of toxicological sciences, 44(10), 667-679 (2019-10-08)
The assessment of xenobiotic-induced testicular toxicity is important in drug development. Nonetheless, in vitro models to test drugs and chemicals that may cause testicular toxicity are lacking, requiring the continued use of animal models for those studies. We previously evaluated
Newer non-oral hormonal contraception.
Deborah Bateson et al.
BMJ (Clinical research ed.), 346, f341-f341 (2013-02-16)
Edith Bellavance et al.
Journal of medicinal chemistry, 52(23), 7488-7502 (2009-09-24)
17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3beta-diol), therefore modulating the level of mitogenic estrogens and androgens in humans. By classical and parallel chemistry, we generated several
Matteo Morotti et al.
European journal of obstetrics, gynecology, and reproductive biology, 183, 178-182 (2014-12-03)
To evaluate the effect of a desogestrel progestogen-only pill (POP) compared to continuous combined oral contraception (COC) on migraine patterns in women with migraine without aura. A retrospective analysis of prospective headache charts from migrainous women who used the POP
E Fontana et al.
Current drug metabolism, 6(5), 413-454 (2005-10-27)
The inhibition of human cytochrome P450s (CYPs) is one of the most common mechanisms which can lead to drug-drug interactions. The inhibition of CYPs can be reversible (competitive or non-competitive) or irreversible. Irreversible inhibition usually derives from activation of a
Jie Han et al.
Water research, 47(7), 2273-2284 (2013-03-08)
This study demonstrates that ethinylestradiol (EE2), a priority estrogenic contaminant in water, can be rapidly and selectively removed from aqueous solutions using industrial-grade polyamide 612 (PA612) particles as adsorbents. Isothermal studies showed that nonporous low surface area (20 m(2) g(-1)) PA612 particles
Xuefang Liang et al.
Environmental pollution (Barking, Essex : 1987), 189, 184-193 (2014-04-01)
Assessing protein responses to endocrine disrupting chemicals is critical for understanding the mechanisms of chemical action and for the assessment of hazards. In this study, the response of the liver proteome of male rare minnows (Gobiocypris rarus) treated with 17β-estradiol
S T Cameron et al.
Human reproduction (Oxford, England), 30(7), 1566-1572 (2015-05-23)
What is the effect on ovarian activity of a preceding intake of ulipristal acetate (UPA) when starting a combined oral contraceptive (COC) in the mid- to late-follicular phase of the cycle? This study shows that UPA does not affect the
Jenni Küblbeck et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1759-1765 (2015-07-19)
Discovery of receptor-dependent mechanisms for regulation of drug metabolism has provided a new way to evaluate the propensity of drug candidates to cause induction of cytochrome P450 enzymes. Therefore, receptor-based reporter assays have become common in early stages of drug
Andrew M Kaunitz et al.
Obstetrics and gynecology, 123(2 Pt 1), 295-303 (2014-01-10)
To compare a new low-dose levonorgestrel and ethinyl estradiol contraceptive patch (Patch) with a combination oral contraceptive (Pill; 100 micrograms levonorgestrel, 20 micrograms ethinyl estradiol) regarding efficacy, safety, compliance, and unscheduled uterine bleeding. Women (17-40 years; body mass index 16-60)
Hongjian Zhang et al.
Clinical pharmacokinetics, 46(2), 133-157 (2007-01-27)
17alpha-Ethinylestradiol (EE) is widely used as the estrogenic component of oral contraceptives (OC). In vitro and in vivo metabolism studies indicate that EE is extensively metabolised, primarily via intestinal sulfation and hepatic oxidation, glucuronidation and sulfation. Cytochrome P450 (CYP)3A4-mediated EE
Jaeyeon Choi et al.
Environmental toxicology and pharmacology, 38(1), 51-57 (2014-06-09)
Childhood obesity, a major public health concern, has increased worldwide. Endocrine-disrupting chemicals (EDCs) have recently received attention as a cause of obesity. A cross-sectional study using logistic regression was conducted to investigate the association between some endocrine disrupting chemicals and
Robert W Flick et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 353-360 (2014-05-13)
Vitellogenin is frequently used as a biomarker of exposure to environmental estrogens due to its specificity and sensitivity. Appropriate incorporation of this biomarker into environmental monitoring and assessment necessitates evaluation of its critical performance parameters. In this study, we characterize
K W Ward et al.
Xenobiotica; the fate of foreign compounds in biological systems, 35(2), 191-210 (2005-07-16)
The prediction of human pharmacokinetics is often based on in vivo preclinical pharmacokinetic data. However, to date, no clear guidance has been available about the relative ability of the major preclinical species to estimate human oral exposure. The study was
U Täuber et al.
American journal of obstetrics and gynecology, 163(4 Pt 2), 1414-1420 (1990-10-01)
The pharmacokinetic and protein-binding properties of gestodene and ethinyl estradiol have been investigated after single and multiple dosing in several studies in 83 healthy, young women. After oral administration, gestodene is completely absorbed and bioavailable and exhibits dose-linear pharmacokinetics. During
Xiangdong Li et al.
Endocrinology, 147(3), 1271-1277 (2005-11-25)
Our previous studies have shown that transgenic male mice expressing human P450 aromatase (AROM+) are infertile. In the present study, we followed the testis phenotype up to 15 months of age in these mice. The testes of the old AROM+
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