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Showing 1-30 of 9173 results for "E6758" within Papers
Noriko Takahashi et al.
Nature communications, 6, 8531-8531 (2015-10-07)
It remains unclear how readiness for Ca(2+)-dependent exocytosis depends on varying degrees of SNARE complex assembly. Here we directly investigate the SNARE assembly using two-photon fluorescence lifetime imaging (FLIM) of Förster resonance energy transfer (FRET) between three pairs of neuronal
Daniela Michlmayr et al.
Journal of virology, 88(17), 9553-9567 (2014-06-06)
The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains unclear which
Tae Mi Yoon et al.
Oncology reports, 33(4), 1717-1722 (2015-02-25)
The transcription factor, early growth response 1 (EGR1) belongs to the early growth response family. EGR1 regulates the transactivation of genes involved in growth inhibition and apoptosis by ionizing radiation. The aims of the present study were to evaluate the expression
Fuyao Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(30), 3676-3685 (2015-04-29)
Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic
Abdulkader Albasri et al.
Anticancer research, 34(8), 3969-3974 (2014-07-31)
To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression. P-FAK expression was assessed using immunohistochemistry in 462 CRC cases arrayed on
Yoon Kyung Kwon et al.
Chemical & pharmaceutical bulletin, 63(12), 1076-1080 (2015-12-04)
The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used
William F Borschel et al.
The Journal of biological chemistry, 290(44), 26846-26855 (2015-09-16)
Among glutamate-gated channels, NMDA receptors produce currents that subside with unusually slow kinetics, and this feature is essential to the physiology of central excitatory synapses. Relative to the homologous AMPA and kainate receptors, NMDA receptors have additional intersubunit contacts in
Shuai Wu et al.
Molecules (Basel, Switzerland), 20(10), 18704-18716 (2015-10-27)
Tongmai formula (TMF) is a well-known Chinese medicinal preparation that contains isoflavones as its major bioactive constituents. As traditional Chinese medicines (TCMs) are usually used by oral administration, their fate inside the intestinal lumen, including their biotransformation by human intestinal
Heather A Vatter et al.
Virology, 474, 186-198 (2014-12-03)
Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. Although it was previously estimated that 1% of baboons are SHFV-positive, more than 10% of wild-caught and captive-bred baboons
Lucie Šťovíčková et al.
The Analyst, 140(7), 2266-2272 (2015-01-20)
The current diagnostic tools are insufficient for the early detection of many diseases, including type 1 diabetes mellitus. The disease is accompanied not only by a permanently elevated level of blood glucose and altered levels of other biomarkers, but also
Marina Zieger et al.
PloS one, 9(9), e106562-e106562 (2014-09-06)
We aimed to investigate fractalkine (CX3CL1) protein expression in wild type (wt) retina and its alterations during retinal degeneration in mouse model (rd10) of retinitis pigmentosa. Forms of retinal protein CX3CL1, total protein and mRNA levels of CX3CL1 were analyzed
Masato Nakatsuji et al.
PLoS genetics, 11(10), e1005542-e1005542 (2015-10-07)
Prostaglandin E2 plays important roles in the maintenance of colonic homeostasis. The recently identified prostaglandin E receptor (EP) 4-associated protein (EPRAP) is essential for an anti-inflammatory function of EP4 signaling in macrophages in vitro. To investigate the in vivo roles
Tanya D Russell et al.
The American journal of pathology, 185(11), 3076-3089 (2015-09-08)
We describe a preclinical model that investigates progression of early-stage ductal carcinoma in situ (DCIS) and report that compromised myoepithelial cell differentiation occurs before transition to invasive disease. Human breast cancer MCF10DCIS.com cells were delivered into the mouse mammary teat
Lukas Aeberhard et al.
PLoS pathogens, 11(6), e1004883-e1004883 (2015-06-05)
Chlamydia trachomatis is an important human pathogen that replicates inside the infected host cell in a unique vacuole, the inclusion. The formation of this intracellular bacterial niche is essential for productive Chlamydia infections. Despite its importance for Chlamydia biology, a
Wenxiao Liu et al.
Scientific reports, 5, 10864-10864 (2015-08-06)
The response regulator OtpR is critical for the growth, morphology and virulence of Brucella melitensis. Compared to its wild type strain 16 M, B. melitensis 16 MΔotpR mutant has decreased tolerance to acid stress. To analyze the genes regulated by OtpR under
Lisa Frehn et al.
PloS one, 9(9), e106750-e106750 (2014-09-13)
Inflammatory bowel disease (IBD) is associated with a defective intestinal barrier and enhanced adaptive immune responses against commensal microbiota. Immune responses against food antigens in IBD patients remain poorly defined. IgG and IgA specific for food and microfloral antigens (wheat
Marie-Hélène Avelange-Macherel et al.
Plant, cell & environment, 38(7), 1299-1311 (2014-11-05)
LEAM, a late embryogenesis abundant protein, and HSP22, a small heat shock protein, were shown to accumulate in the mitochondria during pea (Pisum sativum L.) seed development, where they are expected to contribute to desiccation tolerance. Here, their expression was
Yuichiro Kanno et al.
Biochemical and biophysical research communications, 459(1), 143-147 (2015-02-28)
The constitutive androstane receptor (CAR) plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters. In this study, we demonstrated that protein arginine methyltransferase 5 (PRMT5) is a novel CAR-interacting protein. Furthermore, the PRMT-dependent
Kang Chen et al.
Journal of cellular biochemistry, 116(3), 467-475 (2014-11-02)
Eph receptor (Eph)-ephrin signaling plays an important role in organ development and tissue regeneration. Bidirectional signaling of EphB4-ephrinB2 regulates cardiovascular development. To assess the role of EphB4-ephrinB2 signaling in cardiac lineage development, we utilized two GFP reporter systems in embryonic
An Xiang et al.
Antiviral research, 120, 7-15 (2015-05-06)
We previously reported that hepatitis B virus core protein (HBc) can bind to the Enhancer I (Enh I) domain and can accumulate with transcription coactivator cAMP response element (CRE). This raises the possibility that HBc may interact with CRE/CREB and
Donald MacGlashan
PloS one, 10(5), e0126435-e0126435 (2015-05-12)
Human basophils are an accessible participant of the human allergic reaction. There is natural variation in various functional endpoints and in signaling molecule expression but there has been only a limited effort to place this information in the context of
Patricia Langjahr et al.
PloS one, 9(12), e104624-e104624 (2014-12-23)
Toll-like receptor (TLR) 2, a type I membrane receptor that plays a key role in innate immunity, recognizes conserved molecules in pathogens, and triggering an inflammatory response. It has been associated with inflammatory and autoimmune diseases. Soluble TLR2 (sTLR2) variants
Chenghai Wang et al.
Development, growth & differentiation, 57(6), 466-473 (2015-06-23)
Long noncoding RNAs (LncRNAs) are longer than 200 nucleotide noncoding RNAs without apparent functional coding capacity that function as regulators of cell growth and development. In recent years, increasing evidence implicates the involvement of LncRNAs in erythropoiesis. shlnc-EC6 is a
Gary S Laco
Biochimie, 118, 90-103 (2015-08-25)
A key target in the treatment of HIV-1/AIDS has been the viral protease. Here we first studied in silico the evolution of protease resistance. Primary active site resistance mutations were found to weaken interactions between protease and both inhibitor and
Seong-Jun Park et al.
PloS one, 10(11), e0142253-e0142253 (2015-11-07)
Eight aminoacyl-tRNA synthetases (M, K, Q, D, R, I, EP and LARS) and three auxiliary proteins (AIMP1, 2 and 3) are known to form a multi-tRNA synthetase complex (MSC) in mammalian cells. We combined size exclusion chromatography (SEC) with reversed-phase
Yong Cheng et al.
Molecular medicine reports, 12(2), 2009-2014 (2015-04-23)
The aim of the present study was to investigate the role of sentrin/small ubiquitin-like modifier (SUMO)-specific protease 5 (SENP5) in oral squamous cell carcinoma (OSCC), as the overexpression of SENP5 has been observed in 31 OSCC tissue specimens. CAL-27 OSCC
Nadiah Ghazalli et al.
Stem cells and development, 24(17), 1995-2008 (2015-05-06)
Postnatal pancreas is a potential source for progenitor cells to generate endocrine β-cells for treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas harbors multipotent progenitors capable of differentiating into duct, acinar, and endocrine cells. Laminin is
Emma J Davies et al.
Scientific reports, 5, 17187-17187 (2015-12-10)
Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells from solid tumours together with their native microenvironment. They offer a low throughput but high content in vitro experimental platform. Using mouse models as surrogates for three
Syed Kashif Nawaz et al.
Vascular, 23(3), 270-276 (2014-07-25)
Reduced production of nitric oxide due to rs1799983 single nucleotide polymorphism in nitric oxide synthase 3 gene (NOS3) may enhance the risk of coronary artery disease. The association of rs1799983 polymorphism with coronary artery disease was investigated in the local
Pratik Chandrani et al.
BMC genomics, 16, 936-936 (2015-11-18)
Several statistical tools have been developed to identify genes mutated at rates significantly higher than background, indicative of positive selection, involving large sample cohort studies. However, studies involving smaller sample sizes are inherently restrictive due to their limited statistical power
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