ADC and bioconjugation

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Polybrene® is a well-known anti-heparin agent. Also known as 1,5-dimethyl-1,5-diazaundecamethylene polymethobromide and hexadimethrine bromide, this positively charged polymer produces non-specific red blood cell agglutination by neutralizing the red blood cell net negative charge.

Triazolylphenylglyoxal Reagents: Arginine-Directed Bioconjugation

Chemical ligation strategies are widely utilized for the modification of biological macromolecules in biotechnology and medicine, and in for the development of functional materials. In particular, reagents that can modify the surface of proteins, typically through reactive side chains, have

Click Chemistry in Drug Discovery

Drug discovery process by utilizing chemistry reaction of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes with organoazides to yield 1,4-disubstituted 1,2,3-triazoles.

Introduction to Click Chemistry

Click chemistry is an approach to the synthesis of drug-like molecules that can accelerate the drug discovery process by using a few practical and reliable reactions.

Click Chemistry in Drug Discovery

Drug discovery process by utilizing chemistry reaction of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes with organoazides to yield 1,4-disubstituted 1,2,3-triazoles.

Copper-Free Click Chemistry

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

Guanylation of Amines by Bis(tert-butoxycarbonyl)thiopseudourea, Polymer-Bound

1 Introduction of a guanidinyl group can be achieved by the reaction of substituted amines with various guanylation reagents.2,3,4 One such guanylating reagent is bis(tert-butoxycarbonyl)thiopseudourea, polymer-bound.

GlycoProfile™ Azido Sugars

The GlycoProfile™ Azido Sugar portfolio consists of three peracetylated azido sugars that may be incorporated into glycan structures chemically or by using existing biosynthetic pathways of mammalian cells.

Staudinger Ligation Synthetic Method

The Staudinger Ligation: A High-Yield, Chemoselective, and Mild Synthetic Method.

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.