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Showing 1-30 of 2860 results for "h1758" within Papers
Dana J Levine et al.
ACS chemical biology, 10(5), 1269-1277 (2015-02-20)
The phosphotungstate anion (PTA) is widely used to facilitate the precipitation of disease-causing prion protein (PrP(Sc)) from infected tissue for applications in structural studies and diagnostic approaches. However, the mechanism of this precipitation is not understood. In order to elucidate
Sheng Xiao et al.
Oncology letters, 20(3), 2143-2152 (2020-08-13)
The Warburg effect explains the large amount of lactic acid that tumour cells produce to establish and maintain the acidic characteristics of the tumour microenvironment, which contributes to the migration, invasion and angiogenesis of tumour cells. Monocarboxylate transporter 4 (MCT-4)
Vikranth Volli et al.
Journal of hazardous materials, 297, 101-111 (2015-05-10)
This work discusses the utilization of flyash for synthesis of heterogeneous catalyst for transesterification. Different types of zeolites were synthesized from alkali fusion followed by hydrothermal treatment of coal flyash as source material. The synthesis conditions were optimized to obtain
Yiwei Li et al.
Lab on a chip, 15(15), 3203-3210 (2015-07-02)
Active control over the cell gradient is essential for understanding biological systems and the reconstitution of the functionality of many types of tissues, particularly for organ-on-a-chip. Here, we propose a three-dimensional (3D) microfluidic strategy for generating controllable cell gradients. In
Xiaoning Yuan et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 182-192 (2014-10-14)
To study the interactions between vascular endothelial cells and meniscal fibrochondrocytes from the inner avascular and outer vascular regions of the meniscus and to identify angiogenic factors that enhance cell migration and integrative repair. Bovine meniscal fibrochondrocytes (bMFCs) from the
Hassan A Alhazmi et al.
Journal of pharmaceutical and biomedical analysis, 107, 311-317 (2015-02-02)
In this work, the behavior of several metal ions with different globular proteins was investigated by affinity capillary electrophoresis. Screening was conducted by applying a proper rinsing protocol developed by our group. The use of 0.1M EDTA in the rinsing
Jakob Kreye et al.
Cell, 183(4), 1058-1069 (2020-10-16)
The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed characterization of virus-neutralizing antibodies and target epitopes is needed to understand COVID-19 pathophysiology and guide immunization strategies. Among 598
Andreas K O Åslund et al.
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 287-294 (2015-11-01)
The blood-brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug delivery across the BBB. Furthermore, focused ultrasound
Fan-Yu Lin et al.
International journal of hematology, 102(3), 312-317 (2015-06-28)
Adipokines play a role in carcinogenesis in a variety of malignancies. These findings were established with regard to serum adipokines and malignancies. However, the expression of adipokines in bone marrow fluid remains unclear, and an investigation of the correlation between
Satoshi Wada et al.
Histochemistry and cell biology, 144(1), 13-20 (2015-03-31)
Cell differentiation is controlled by specific transcription factors. The functions and expression levels of these transcription factors are regulated by epigenetic modifications, such as histone modifications and cytosine methylation of the genome. In tendon tissue, tendon-specific transcription factors have been
Rand R Hafidh et al.
BMC complementary and alternative medicine, 15, 179-179 (2015-06-13)
New sources for discovering novel antiviral agents are desperately needed. The current antiviral products are both expensive and not very effective. The antiviral activity of methanol extract of mung bean sprouts (MBS), compared to Ribavarin and Acyclovir, on respiratory syncytial
Zofia Iskierko et al.
Biosensors & bioelectronics, 74, 526-533 (2015-07-18)
A novel recognition unit of chemical sensor for selective determination of the inosine, renal disfunction biomarker, was devised and prepared. For that purpose, inosine-templated molecularly imprinted polymer (MIP) film was deposited on an extended-gate field-effect transistor (EG-FET) signal transducing unit.
Alexander Hellqvist et al.
Biomedical chromatography : BMC, 29(4), 504-513 (2014-08-12)
Renal function can be monitored by estimation of the glomerular filtration rate (GFR), for example, through measurement of the plasma clearance of a marker that is freely filtrated through the kidney without reabsorption. It has been proposed that iohexol is
Rakhshinda Sadiq et al.
Drug and chemical toxicology, 38(2), 152-161 (2014-06-05)
Metallic nanoparticles (NPs) have a variety of applications in different industries including pharmaceutical industry where these NPs are used mainly for image analysis and drug delivery. The increasing interest in nanotechnology is largely associated with undefined risks to the human
Jason R Klug et al.
eLife, 7 (2018-05-02)
Striatal cholinergic (ChAT) and parvalbumin (PV) interneurons exert powerful influences on striatal function in health and disease, yet little is known about the organization of their inputs. Here using rabies tracing, electrophysiology and genetic tools, we compare the whole-brain inputs
Mustapha Aouida et al.
Journal of bioscience and bioengineering, 120(4), 364-371 (2015-04-25)
Targeted engineering of microbial genomes holds much promise for diverse biotechnological applications. Transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats/Cas9 systems are capable of efficiently editing microbial genomes, including that of Saccharomyces cerevisiae. Here, we demonstrate
Jascha Brettschneider et al.
Journal of visualized experiments : JoVE, (146) (2019-05-07)
Lipid droplets (LDs) are bioactive organelles found within the cytosol of the most eukaryotic and some prokaryotic cells. LDs are composed of neutral lipids encased by a monolayer of phospholipids and proteins. Hepatic LD lipids, such as ceramides, and proteins
Hui Chan Kwak et al.
Biochemical pharmacology, 96(3), 256-266 (2015-06-07)
The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocysteine and methionine, but not glutathione (GSH) were markedly
Yong Ma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 202-211 (2015-08-19)
A sensitive UPLC-MS/MS method was established and validated for the quantitation of celecoxib and its metabolites in rat blood. The analytes were extracted from rat blood samples by a salting-out liquid-liquid extraction method followed by the UPLC chromatography. The mass
Shimaa El-Metwaly et al.
Heliyon, 5(12), e02710-e02710 (2019-12-25)
Acute lung injury (ALI) is a severe life-threatening disease causing uncontrolled pulmonary inflammation and oxidative damage. There are still no effective therapies for this disease. The aim of this study was to evaluate the protective role of mesenchymal stem cells
Felisa Reyes-Ortega et al.
Acta biomaterialia, 23, 103-115 (2015-05-30)
The article deals with the design, preparation, and evaluation of a new bilayered dressing for application in the healing of compromised wounds. The system is based on the sequential release of two complementary bioactive components to enhance the activation of
Angela E Vinturache et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 15(4), 450-457 (2014-01-24)
It was hypothesized that in the immediate newborn period, when the renin-angiotensin system (RAS) is activated, angiotensin type 2 receptors (AT2Rs) buffer the haemodynamic effects of angiotensin type 1 receptors (AT1Rs), as occurs in adult animals when the RAS is
Jay G Hosking et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 1005-1015 (2014-10-21)
Successful decision making often requires weighing a given option's costs against its associated benefits, an ability that appears perturbed in virtually every severe mental illness. Animal models of such cost/benefit decision making overwhelmingly implicate mesolimbic dopamine in our willingness to
Inés Racamonde et al.
Analytica chimica acta, 865, 22-30 (2015-03-04)
Fabric phase sorptive extraction (FPSE) is a new, yet very promising member of the sorbent-based sorptive microextraction family. It has simultaneously improved both the extraction sensitivity and the speed of the extraction by incorporating high volume of sol-gel hybrid inorganic-organic
Jordan T Gladman et al.
Human molecular genetics, 24(1), 251-264 (2014-08-30)
RNA toxicity is implicated in a number of disorders; especially those associated with expanded repeat sequences, such as myotonic dystrophy (DM1). Previously, we have shown increased NKX2-5 expression in RNA toxicity associated with DM1. Here, we investigate the relationship between
Lucy Yan Pan et al.
Analytical chemistry, 87(11), 5669-5676 (2015-05-06)
We present the results of a hydrogen/deuterium exchange mass spectrometric (HDX-MS) investigation of an antibody-drug conjugate (ADC) comprised of drug-linkers conjugated to cysteine residues that have been engineered into heavy chain (HC) fragment crystallizable (Fc) domain at position 239. A
Maribel Reyes et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 139-149 (2014-09-05)
1. Ponesimod [(R)-5-[3-chloro-4-(-2,3-dihydroxy-propoxy)-benzylidene]-2-propylimino-3-o-tolyl-thiazolidin-4-one] is an orally administered, selective S1P1 receptor modulator that blocks the egress of lymphocytes from lymphoid organs and reduces the availability of circulating effector T/B-cells. 2. The mass balance, pharmacokinetics and metabolism of 40 mg (14)C-ponesimod were investigated in six
Christina Nassenstein et al.
International immunopharmacology, 29(1), 173-180 (2015-08-19)
In addition to quantal, vesicular release of acetylcholine (ACh), there is also non-quantal release at the motor endplate which is insufficient to evoke postsynaptic responses unless acetylcholinesterase (AChE) is inhibited. We here addressed potential non-quantal release in the mouse trachea
Lisa K Lunde et al.
Brain structure & function, 220(4), 2087-2101 (2014-04-30)
Astrocytes are highly polarised cells with processes that ensheath microvessels, cover the brain surface, and abut synapses. The endfoot membrane domains facing microvessels and pia are enriched with aquaporin-4 water channels (AQP4) and other members of the dystrophin associated protein
Matthieu Waeles et al.
Rapid communications in mass spectrometry : RCM, 29(19), 1795-1804 (2015-09-04)
Understanding the fate of metals in agricultural land is an important issue for agronomic sustainability. This study aimed at quantifying the export/retention of metals in a temperate watershed subject to important manuring activities. The chemical composition of the Penzé stream
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