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Showing 1-30 of 331 results for "H4522" within Papers
Mats Leeman et al.
Analytical and bioanalytical chemistry, 413(1), 117-127 (2020-10-25)
Coupling of surface plasmon resonance (SPR) detection to asymmetric flow field-flow fractionation (AF4) offers the possibility to study active fractions of bio-separations on real samples, such as serum and saliva, including the assessment of activity of possibly aggregated species. The
Quantitative and Multiplex Detection of Extracellular Vesicle-Derived MicroRNA via Rolling Circle Amplification within Encoded Hydrogel Microparticles.
Al Sulaiman, et al.
Advanced Healthcare Materials, 11, e2102332-e2102332 (2023)
Ewa Guzniczak et al.
Biotechnology and bioengineering, 117(7), 2032-2045 (2020-02-27)
Cell-based therapeutics, such as in vitro manufactured red blood cells (mRBCs), are different to traditional biopharmaceutical products (the final product being the cells themselves as opposed to biological molecules such as proteins) and that presents a challenge of developing new
Daniele Vinciguerra et al.
Journal of controlled release : official journal of the Controlled Release Society, 295, 223-236 (2019-01-07)
Well-defined, heterotelechelic polymer prodrugs for combination therapy were synthesized by using a combination of the "drug-initiated" nitroxide-mediated polymerization from a gemcitabine-alkoxyamine initiator and the nitroxide exchange reaction using TEMPO-bearing drugs to end-cap the drug-polymer chain-end by a second drug. This
Archana Shubhakar et al.
Glycoconjugate journal (2018-06-18)
Glycosylation is considered one of the most complex and structurally diverse post-translational modifications of proteins. Glycans play important roles in many biological processes such as protein folding, regulation of protein stability, solubility and serum half-life. One of the ways to
Maryam Hojjat Jodaylami et al.
Scientific reports, 11(1), 21601-21601 (2021-11-10)
SARS-CoV-2 variants of concern (VOCs) have emerged worldwide, with implications on the spread of the pandemic. Characterizing the cross-reactivity of antibodies against these VOCs is necessary to understand the humoral response of non-hospitalized individuals previously infected with SARS-CoV-2, a population
Ken-Ichiro Matsunaga et al.
Scientific reports, 11(1), 18000-18000 (2021-09-11)
Serologic tests to detect specific IgGs to antigens related to viral infections are urgently needed for diagnostics and therapeutics. We present a diagnostic method for serotype-specific IgG identification of dengue infection by a competitive enzyme-linked immunosorbent assay (ELISA), using high-affinity
Stefano Pierini et al.
JCI insight, 5(16) (2020-08-21)
Granulosa cell tumors (GCT) are rare ovarian malignancies. Due to the lack of effective treatment in late relapse, there is a clear unmet need for novel therapies. Forkhead Box L2 (FOXL2) is a protein mainly expressed in granulosa cells (GC)
Archita Mishra et al.
Cell, 184(13), 3394-3409 (2021-06-03)
The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their contribution toward activation of memory T cells in fetal tissues. We
Alessandro Zorzi et al.
Nature communications, 8, 16092-16092 (2017-07-18)
The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a 'piggy-back' strategy in
Nima Rajabi et al.
ACS medicinal chemistry letters, 11(10), 1886-1892 (2020-10-17)
The sirtuin enzymes are potential drug targets for intervention in a series of diseases. Efforts to inhibit enzymes of this class with thioamide- and thiourea-containing, substrate-mimicking entities have produced a number of high-affinity binders. However, less attention has been dedicated
Stefan Schrittwieser et al.
Scientific reports, 7(1), 4752-4752 (2017-07-08)
Detecting biomarkers from complex sample solutions is the key objective of molecular diagnostics. Being able to do so in a simple approach that does not require laborious sample preparation, sophisticated equipment and trained staff is vital for point-of-care applications. Here
Yahya Sohrabi et al.
Frontiers in immunology, 11, 353-353 (2020-03-27)
The concept of trained innate immunity describes a long-term proinflammatory memory in innate immune cells. Trained innate immunity is regulated through reprogramming of cellular metabolic pathways including cholesterol and fatty acid synthesis. Here, we have analyzed the role of Liver
Andrea Maglioco et al.
Parasite immunology, 41(12), e12674-e12674 (2019-09-27)
Cystic echinococcosis (CE) can be diagnosed by means of several serological approaches, but their results vary among laboratories due to the molecular characteristics of the reference antigens used. Thus, this study aimed to address both the relevance of an EGPE
Alexander K Tsai et al.
Cancer immunology research, 5(9), 790-803 (2017-08-05)
Combination therapies have the potential to improve outcomes in melanoma patients but have not yet been clinically efficacious. Here, we used high-throughput flow cytometry-based screening to identify and characterize candidate therapies that might synergize with and augment T-cell immunotherapy efficacy.
Roopa Hebbandi Nanjundappa et al.
Cell, 171(3), 655-667 (2017-10-21)
The gut microbiota contributes to the development of normal immunity but, when dysregulated, can promote autoimmunity through various non-antigen-specific effects on pathogenic and regulatory lymphocytes. Here, we show that an integrase expressed by several species of the gut microbial genus
Xiao Li et al.
Advanced healthcare materials, 5(11), 1326-1335 (2016-04-29)
Microfluidic paper-based analytical devices (μPADs) represent a promising platform technology for point-of-care diagnosis. Highly sensitive, rapid, and easy-to-perform immunoassays implemented on μPADs are desirable to fulfill the promise of the μPAD technology. This article reports the first microfluidic paper-based origami
Liang Tian et al.
Biosensors & bioelectronics, 122, 43-50 (2018-09-22)
Herein, we report a facile enzyme-free microRNA (miRNA) target-triggered strand displacement reaction (SDR) amplification strategy with ferrocene (Fc) as a signal molecule to fabricate a two-dimensional electroactive molybdenum carbide (Mo2C)-based biosensor. In the presence of miRNA-21, SDR was initiated and
Vera Adema et al.
Blood cancer discovery (2022-08-05)
SF3B1 mutations, which occur in 20% of patients with myelodysplastic syndromes (MDS), are the hallmarks of a specific MDS subtype, MDS with ringed sideroblasts (MDS-RS), which is characterized by the accumulation of erythroid precursors in the bone marrow and primarily
Le-Minh Dao et al.
Journal of neurology, 268(6), 2123-2131 (2021-01-15)
Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is the most common autoimmune encephalitis with psychosis, amnesia, seizures and dyskinesias. The disease is mediated by pathogenic autoantibodies against the NR1 subunit that disrupt NMDAR function. Antibody infusion into mouse brains can recapitulate encephalitis symptoms, while
Walid Shalata et al.
Cancers, 13(14) (2021-07-25)
The new era of cancer treatments has made immune checkpoint inhibitors (ICIs) and emerging multikinase inhibitors (TKIs) the standards of care, thus drastically improving patient prognoses. Pembrolizumab is an anti-programmed cell death-1 antibody drug, and lenvatinib is a TKI with
Walaa Khushaim et al.
Biosensors, 12(10) (2022-10-28)
Two-dimensional (2D) layered materials functionalized with monometallic or bimetallic dopants are excellent materials to fabricate clinically useful biosensors. Herein, we report the synthesis of ruthenium nanoparticles (RuNPs) and nickel molybdate nanorods (NiMoO4 NRs) functionalized porous graphitic carbon nitrides (PCN) for
Danlin Yang et al.
Antibodies (Basel, Switzerland), 8(1) (2019-09-24)
Practically, IgG charge can contribute significantly to thermodynamic nonideality, and hence to solubility and viscosity. Biologically, IgG charge isomers exhibit differences in clearance and potency. It has been known since the 1930s that all immunoglobulins carry a weak negative charge
Zsuzsanna Darula et al.
Glycoconjugate journal, 33(3), 435-445 (2016-01-06)
In this work O-linked glycopeptides bearing mucin core-1 type structures were enriched from human serum. Since about 70 % of the O-glycans in human serum bind to the plant lectin Jacalin, we tested a previously successful protocol that combined Jacalin affinity
Elecia B Johnston et al.
Bioanalysis, 6(4), 465-476 (2014-02-27)
The increasing prevalence of food allergies requires development of specific and sensitive tests capable of identifying the allergen responsible for the disease. The development of serologic tests that can detect specific IgE antibodies to allergenic proteins would, therefore, be highly
Sinan Mermer et al.
Journal of global antimicrobial resistance, 22, 147-151 (2020-02-19)
The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. The antibacterial activity of ceftaroline was compared with vancomycin in
Maria M Klicznik et al.
Scientific reports, 10(1), 11164-11164 (2020-07-09)
Human skin contains a population of memory T cells that supports tissue homeostasis and provides protective immunity. The study of human memory T cells is often restricted to in vitro studies and to human PBMC serving as primary cell source.
Manki Son et al.
Biosensors & bioelectronics, 78, 87-91 (2015-11-26)
Here we propose a carbon nanotube (CNT) field-effect transistor (FET) functionalized with aquaporin-4 (AQP4) extracellular loop peptides for the rapid detection of AQP4 antibody without pretreatment. Neuromyelitis optica (NMO) is a rare disease of the central nerve system that affects
Tuang Yeow Poh et al.
Chest, 158(2), 512-522 (2020-03-19)
Chitinase activity is an important innate immune defence mechanism against infection that includes fungi. The 2 human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase are associated to allergy, asthma, and COPD; however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO)
Emily C Britt et al.
Nature metabolism, 4(3), 389-403 (2022-03-30)
Neutrophils are cells at the frontline of innate immunity that can quickly activate effector functions to eliminate pathogens upon stimulation. However, little is known about the metabolic adaptations that power these functions. Here we show rapid metabolic alterations in neutrophils
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