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Showing 1-30 of 332 results for "h4522" within Papers
Alessandro Zorzi et al.
Nature communications, 8, 16092-16092 (2017-07-18)
The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a 'piggy-back' strategy in
Andrea Maglioco et al.
Parasite immunology, 41(12), e12674-e12674 (2019-09-27)
Cystic echinococcosis (CE) can be diagnosed by means of several serological approaches, but their results vary among laboratories due to the molecular characteristics of the reference antigens used. Thus, this study aimed to address both the relevance of an EGPE
Alexander K Tsai et al.
Cancer immunology research, 5(9), 790-803 (2017-08-05)
Combination therapies have the potential to improve outcomes in melanoma patients but have not yet been clinically efficacious. Here, we used high-throughput flow cytometry-based screening to identify and characterize candidate therapies that might synergize with and augment T-cell immunotherapy efficacy.
Roopa Hebbandi Nanjundappa et al.
Cell, 171(3), 655-667 (2017-10-21)
The gut microbiota contributes to the development of normal immunity but, when dysregulated, can promote autoimmunity through various non-antigen-specific effects on pathogenic and regulatory lymphocytes. Here, we show that an integrase expressed by several species of the gut microbial genus
Maryam Hojjat Jodaylami et al.
Scientific reports, 11(1), 21601-21601 (2021-11-10)
SARS-CoV-2 variants of concern (VOCs) have emerged worldwide, with implications on the spread of the pandemic. Characterizing the cross-reactivity of antibodies against these VOCs is necessary to understand the humoral response of non-hospitalized individuals previously infected with SARS-CoV-2, a population
Yahya Sohrabi et al.
Frontiers in immunology, 11, 353-353 (2020-03-27)
The concept of trained innate immunity describes a long-term proinflammatory memory in innate immune cells. Trained innate immunity is regulated through reprogramming of cellular metabolic pathways including cholesterol and fatty acid synthesis. Here, we have analyzed the role of Liver
Daniele Vinciguerra et al.
Journal of controlled release : official journal of the Controlled Release Society, 295, 223-236 (2019-01-07)
Well-defined, heterotelechelic polymer prodrugs for combination therapy were synthesized by using a combination of the "drug-initiated" nitroxide-mediated polymerization from a gemcitabine-alkoxyamine initiator and the nitroxide exchange reaction using TEMPO-bearing drugs to end-cap the drug-polymer chain-end by a second drug. This
Nima Rajabi et al.
ACS medicinal chemistry letters, 11(10), 1886-1892 (2020-10-17)
The sirtuin enzymes are potential drug targets for intervention in a series of diseases. Efforts to inhibit enzymes of this class with thioamide- and thiourea-containing, substrate-mimicking entities have produced a number of high-affinity binders. However, less attention has been dedicated
Stefan Schrittwieser et al.
Scientific reports, 7(1), 4752-4752 (2017-07-08)
Detecting biomarkers from complex sample solutions is the key objective of molecular diagnostics. Being able to do so in a simple approach that does not require laborious sample preparation, sophisticated equipment and trained staff is vital for point-of-care applications. Here
Stefano Pierini et al.
JCI insight, 5(16) (2020-08-21)
Granulosa cell tumors (GCT) are rare ovarian malignancies. Due to the lack of effective treatment in late relapse, there is a clear unmet need for novel therapies. Forkhead Box L2 (FOXL2) is a protein mainly expressed in granulosa cells (GC)
Archita Mishra et al.
Cell, 184(13), 3394-3409 (2021-06-03)
The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their contribution toward activation of memory T cells in fetal tissues. We
Ken-Ichiro Matsunaga et al.
Scientific reports, 11(1), 18000-18000 (2021-09-11)
Serologic tests to detect specific IgGs to antigens related to viral infections are urgently needed for diagnostics and therapeutics. We present a diagnostic method for serotype-specific IgG identification of dengue infection by a competitive enzyme-linked immunosorbent assay (ELISA), using high-affinity
Archana Shubhakar et al.
Glycoconjugate journal (2018-06-18)
Glycosylation is considered one of the most complex and structurally diverse post-translational modifications of proteins. Glycans play important roles in many biological processes such as protein folding, regulation of protein stability, solubility and serum half-life. One of the ways to
Tsung-Heng Tsai et al.
Proteomics, 15(13), 2369-2381 (2015-03-18)
Associating changes in protein levels with the onset of cancer has been widely investigated to identify clinically relevant diagnostic biomarkers. In the present study, we analyzed sera from 205 patients recruited in the United States and Egypt for biomarker discovery
U Eletxigerra et al.
Biosensors & bioelectronics, 70, 34-41 (2015-03-21)
A highly sensitive amperometric magnetoimmunosensor for the determination of ErbB2 protein, a well-known biomarker related to high-impact high-incidence diseases such as breast cancer, is described. A sandwich format involving the covalent immobilization of a specific capture antibody onto magnetic beads
Quantitative and Multiplex Detection of Extracellular Vesicle-Derived MicroRNA via Rolling Circle Amplification within Encoded Hydrogel Microparticles.
Al Sulaiman, et al.
Advanced Healthcare Materials, 11, e2102332-e2102332 (2023)
Ewa Guzniczak et al.
Biotechnology and bioengineering, 117(7), 2032-2045 (2020-02-27)
Cell-based therapeutics, such as in vitro manufactured red blood cells (mRBCs), are different to traditional biopharmaceutical products (the final product being the cells themselves as opposed to biological molecules such as proteins) and that presents a challenge of developing new
Keven Hoerster et al.
Frontiers in immunology, 11, 586168-586168 (2021-02-16)
Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells. However, harvesting sufficient numbers of T cells is often challenging in heavily pre-treated patients with malignancies and perturbed
Hye-Ra Lee et al.
mBio, 11(2) (2020-04-16)
To overcome increasing bacterial resistance to conventional antibiotics, many antimicrobial peptides (AMPs) derived from host defense proteins have been developed. However, there are considerable obstacles to their application to systemic infections because of their low bioavailability. In the present study
Mohamed I Abdelwahab Hassan et al.
Computational and structural biotechnology journal, 19, 880-896 (2021-02-19)
Fungal infections caused by the ancient lineage Mucorales are emerging and increasingly reported in humans. Comprehensive surveys on promising attributes from a multitude of possible virulence factors are limited and so far, focused on Mucor and Rhizopus. This study addresses
Emily C Britt et al.
Nature metabolism, 4(3), 389-403 (2022-03-30)
Neutrophils are cells at the frontline of innate immunity that can quickly activate effector functions to eliminate pathogens upon stimulation. However, little is known about the metabolic adaptations that power these functions. Here we show rapid metabolic alterations in neutrophils
Xiao Li et al.
Advanced healthcare materials, 5(11), 1326-1335 (2016-04-29)
Microfluidic paper-based analytical devices (μPADs) represent a promising platform technology for point-of-care diagnosis. Highly sensitive, rapid, and easy-to-perform immunoassays implemented on μPADs are desirable to fulfill the promise of the μPAD technology. This article reports the first microfluidic paper-based origami
Tuang Yeow Poh et al.
Chest, 158(2), 512-522 (2020-03-19)
Chitinase activity is an important innate immune defence mechanism against infection that includes fungi. The 2 human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase are associated to allergy, asthma, and COPD; however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO)
Manki Son et al.
Biosensors & bioelectronics, 78, 87-91 (2015-11-26)
Here we propose a carbon nanotube (CNT) field-effect transistor (FET) functionalized with aquaporin-4 (AQP4) extracellular loop peptides for the rapid detection of AQP4 antibody without pretreatment. Neuromyelitis optica (NMO) is a rare disease of the central nerve system that affects
Sinan Mermer et al.
Journal of global antimicrobial resistance, 22, 147-151 (2020-02-19)
The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. The antibacterial activity of ceftaroline was compared with vancomycin in
Elecia B Johnston et al.
Bioanalysis, 6(4), 465-476 (2014-02-27)
The increasing prevalence of food allergies requires development of specific and sensitive tests capable of identifying the allergen responsible for the disease. The development of serologic tests that can detect specific IgE antibodies to allergenic proteins would, therefore, be highly
Maria M Klicznik et al.
Scientific reports, 10(1), 11164-11164 (2020-07-09)
Human skin contains a population of memory T cells that supports tissue homeostasis and provides protective immunity. The study of human memory T cells is often restricted to in vitro studies and to human PBMC serving as primary cell source.
Lang Lin et al.
Molecular therapy. Nucleic acids, 31, 88-104 (2023-01-10)
Rheumatoid arthritis (RA) is an inflammatory disease that leads to disability; however, existing therapies are still unsatisfactory. Activated fibroblast-like synoviocytes (FLSs) play an essential role in synovitis formation and joint destruction in RA. The Hedgehog signaling pathway is aberrantly activated
Adam Pap et al.
Analytical and bioanalytical chemistry, 409(2), 539-550 (2016-10-22)
Growing evidence on the diverse biological roles of extracellular glycosylation as well as the need for quality control of protein pharmaceuticals make glycopeptide analysis both exciting and important again after a long hiatus. High-throughput O-glycosylation studies have to tackle the
Thais S Alves et al.
Materials science & engineering. C, Materials for biological applications, 105, 110048-110048 (2019-09-25)
A simple, inexpensive, highly sensitive, selective, and novel electrochemical method was developed for determination of the Bisphenol A in samples of tap water, blood serum, and urine using a bentonite-modified carbon paste electrode. The graphite, bentonite and the working electrodes
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