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Showing 1-30 of 331 results for "h4522" within Papers
Seunghyeon Kim et al.
ACS sensors, 6(5), 1891-1898 (2021-04-07)
Rapid and inexpensive serological tests for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies are essential to conduct large-scale seroprevalence surveys and can potentially complement nucleic acid or antigen tests at the point of care. During the COVID-19 pandemic, extreme demand
Rikke Sick Andersen et al.
Cancer immunology, immunotherapy : CII, 60(2), 227-234 (2010-10-29)
With the aim to identify cyclin B1-derived peptides with high affinity for HLA-A2, we used three in silico prediction algorithms to screen the protein sequence for possible HLA-A2 binders. One peptide scored highest in all three algorithms, and the high
Ruochong Zhang et al.
ACS sensors, 3(12), 2550-2557 (2018-11-30)
A novel "guide star" assisted photoacoustic (GSPA) method for noninvasive glucose measurement has been proposed. Instead of receiving PA signals that are directly generated by tissue, a virtual photodiode is employed to amplify the PA signal difference regarding amplitude and
Mikael Lehtihet et al.
Frontiers in sports and active living, 4, 829940-829940 (2022-04-19)
It has been suggested to longitudinally monitor Insulin-like growth factor I (IGF-I) as a biomarker for the detection of recombinant growth hormone (GH). Subsequently, it is of interest to understand any confounders of endogenous IGF-I. Herein we have studied if
Marina Buyanova et al.
Journal of medicinal chemistry, 64(17), 13038-13053 (2021-08-21)
The Ras subfamily of small GTPases is mutated in ∼30% of human cancers and represents compelling yet challenging anticancer drug targets owing to their flat protein surface. We previously reported a bicyclic peptidyl inhibitor, cyclorasin B3, which binds selectively to
Benjamin P Sullivan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1163, 122494-122494 (2021-01-06)
Nucleic acid amplification tests (NAATs) are a crucial diagnostic and monitoring tool for infectious diseases. A key procedural step for NAATs is sample preparation: separating and purifying target nucleic acids from crude biological samples prior to nucleic acid amplification and
Megan Davis-Fields et al.
Biophysical journal, 117(8), 1496-1507 (2019-10-07)
Biofilm infections can consist of bacterial aggregates that are an order of magnitude larger than neutrophils, phagocytic immune cells that densely surround aggregates but do not enter them. Because a neutrophil is too small to engulf the entire aggregate, it
Jeffrey Pido-Lopez et al.
PLoS pathogens, 7(12), e1002396-e1002396 (2011-12-07)
The upper respiratory tract mucosa is the location for commensal Streptococcus (S.) pneumoniae colonization and therefore represents a major site of contact between host and bacteria. The CD4(+) T cell response to pneumococcus is increasingly recognised as an important mediator
Lucie Labied et al.
Analytica chimica acta, 1185, 339081-339081 (2021-10-30)
The knowledge of the fate of metal-containing nanoparticles in biological media in aqueous media is of utmost importance for the future use of these promising theranostic agents for clinical applications. A methodology based on the combination of TDA-ICP-MS and CE-ICP-MS
Janis C Weeks et al.
International journal for parasitology. Drugs and drug resistance, 6(3), 314-328 (2016-10-19)
The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device ('chip') that records non-invasively the tiny electrophysiological signals generated
Kuo-Yen Huang et al.
EMBO molecular medicine, 13(1), e12828-e12828 (2020-11-08)
To circumvent the devastating pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, a humanized decoy antibody (ACE2-Fc fusion protein) was designed to target the interaction between viral spike protein and its cellular receptor, angiotensin-converting enzyme 2 (ACE2).
Michelle Baker et al.
Scientific reports, 7(1), 8329-8329 (2017-08-23)
In worldwide conditions of increasingly antibiotic-resistant hospital infections, it is important to research alternative therapies. Bdellovibrio bacteriovorus bacteria naturally prey on Gram-negative pathogens, including antibiotic-resistant strains and so B. bacteriovorus have been proposed as "living antibiotics" to combat antimicrobially-resistant pathogens.
Sun Sang Kwon et al.
Biosensors & bioelectronics, 192, 113519-113519 (2021-08-02)
We report the improvement in the sensing performance of electrolyte-gated graphene field-effect transistor (FET) sensors capable of detecting tau protein through a simplified, linker-free, anti-tau antibody immobilization process. For most of the graphene-based immunosensor, linkers, such as pyrenebutanoic acid, succinimidyl
Arthur J Vaught et al.
Experimental hematology, 44(5), 390-398 (2016-02-28)
HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe variant of pre-eclampsia whose pathogenesis remains unclear. Recent evidence and clinical similarities suggest a link to atypical hemolytic uremic syndrome, a disease of excessive activation of the alternative
Cigdem Atay et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(9), 2783-2794 (2019-02-16)
BRAF and MEK inhibitors (BRAFi and MEKi) are actively used for the treatment of metastatic melanoma in patients with BRAFV600E mutation in their tumors. However, the development of resistance to BRAFi and MEKi remains a difficult clinical challenge with limited
Caitriona M McEvoy et al.
Nature communications, 13(1), 7634-7634 (2022-12-11)
Knowledge of the transcriptional programs underpinning the functions of human kidney cell populations at homeostasis is limited. We present a single-cell perspective of healthy human kidney from 19 living donors, with equal contribution from males and females, profiling the transcriptome
Kasturi Banerjee et al.
mSphere, 6(2) (2021-03-05)
Capsular polysaccharide (CPS) heterogeneity within carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strain sequence type 258 (ST258) must be considered when developing CPS-based vaccines. Here, we sought to characterize CPS-specific antibody responses elicited by CR-Kp-infected patients. Plasma and bacterial isolates were collected from
Donelly A van Schalkwyk et al.
The Journal of antimicrobial chemotherapy, 72(11), 3051-3058 (2017-09-30)
The simian malaria parasite Plasmodium knowlesi is now a well-recognized pathogen of humans in South-East Asia. Clinical infections appear adequately treated with existing drug regimens, but the evidence base for this practice remains weak. The availability of P. knowlesi cultures
Asli Kocaoemer et al.
Stem cells (Dayton, Ohio), 25(5), 1270-1278 (2007-01-27)
MSCs are currently in focus regarding their clinical potential in cell therapy and tissue engineering. However, most isolation and expansion protocols for clinical-scale production of MSCs use fetal calf serum (FCS) as a supplement, which poses a potential risk for
Maiken Mellergaard et al.
The Journal of biological chemistry, 295(33), 11803-11821 (2020-07-02)
Staphylococcus aureus is among the leading causes of bacterial infections worldwide. The pathogenicity and establishment of S. aureus infections are tightly linked to its ability to modulate host immunity. Persistent infections are often associated with mutant staphylococcal strains that have
Hyeon Ji Kim et al.
Experimental & molecular medicine, 53(1), 136-149 (2021-01-22)
Infection with rapidly growing nontuberculous mycobacteria is emerging as a global health issue; however, key host factors remain elusive. Here, we investigated the characteristic immune profiles of peripheral blood mononuclear cells (PBMCs) from patients infected with Mycobacteroides abscessus subsp. abscessus
Uwe Reusch et al.
mAbs, 7(3), 584-604 (2015-04-16)
To harness the potent tumor-killing capacity of T cells for the treatment of CD19(+) malignancies, we constructed AFM11, a humanized tetravalent bispecific CD19/CD3 tandem diabody (TandAb) consisting solely of Fv domains. The molecule exhibits good manufacturability and stability properties. AFM11
Ruochong Zhang et al.
The Analyst, 145(24), 7964-7972 (2020-10-10)
Photoacoustic (PA) effect is the product of light-ultrasound interactions and its time-domain waveform contains rich information. Besides optical absorption, the PA waveform inherently consists of other mechanical and thermal properties of the sample. They also have correlation with the target
J E Burton et al.
Journal of virological methods, 250, 34-40 (2017-09-25)
The 2014 Ebola outbreak in West Africa required the rapid testing of clinical material for the presence of potentially high titre Ebola virus (EBOV). Safe, fast and effective methods for the inactivation of such clinical samples are required so that
Hoa Thi Le et al.
Journal of analytical methods in chemistry, 2018, 7832987-7832987 (2018-11-14)
We developed a new method for MALDI-TOF MS detection of N-glycans derived from human serum. The synergistic combination of microwave-assisted Girard T derivatization, solid-phase extraction desalting, and an ionic liquid matrix (2, 5-dihydroxybenzoic acid/aniline) (GT-SPE-DHB/An) allowed of more sensitive N-glycans
Simon J Clark et al.
Frontiers in immunology, 8, 1778-1778 (2018-01-10)
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world and affects nearly 200 million people globally. Local inflammation driven by complement system dysregulation is currently a therapeutic target. Bruch's membrane (BrM) is a sheet of
Surasak Kasetsirikul et al.
The Analyst, 145(23), 7680-7686 (2020-09-26)
This work reports the development of a rapid, simple and inexpensive colorimetric paper-based assay for the detection of the severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) humanized antibody. The paper device was prepared with lamination for easy sample handling and
Yen-Hung Lin et al.
Advanced materials (Deerfield Beach, Fla.), 34(3), e2104608-e2104608 (2021-11-06)
Solid-state transistor sensors that can detect biomolecules in real time are highly attractive for emerging bioanalytical applications. However, combining upscalable manufacturing with the required performance remains challenging. Here, an alternative biosensor transistor concept is developed, which relies on a solution-processed
Alicia Gomez-Lopez et al.
Diagnostic microbiology and infectious disease, 92(1), 78-83 (2018-05-21)
We describe the development and validation of a novel liquid chromatography assay (HPLC/PDA) for simultaneous quantification of voriconazole, itraconazole, and posaconazole, as well as some of their major metabolites, voriconazole N-oxide and hydroxy-itraconazole, in human serum. Analytes were detected using
Liaqat Ali et al.
BioTechniques, 68(4), 185-190 (2020-02-26)
Aim: The humanized anti-CD52 monoclonal antibody alemtuzumab depletes lymphocytes and is currently used to treat relapsing multiple sclerosis. During treatment, anti-alemtuzumab antibodies may develop and reduce effective lymphocyte depletion in future treatment cycles. Results: Alemtuzumab-Alexa Fluor 488 conjugate binding to
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