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Showing 1-30 of 240 results for "I2752" within Papers
A Ferreira et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 38(3), 502-509 (2001-09-05)
The present study evaluates renal dopaminergic activity in 23 patients with heart failure (HF), 10 age-matched controls, and 10 young subjects during normal-salt (NS) intake and after 8 days of low-salt (LS) intake (patients with HF and age-matched controls only).
Tadla Vijeetha et al.
Journal of oleo science, 64(7), 705-712 (2015-05-23)
The study involved synthesis of five novel amino acid derivatives of phosphatidylethanolamine isolated from egg yolk lecithin employing a three step procedure i) N-protection of L-amino acids with BOC anhydride in alkaline medium ii) condensation of - CO2H group of
Daiki Asakawa et al.
Journal of the American Society for Mass Spectrometry, 24(2), 297-300 (2013-01-12)
MALDI in-source decay (ISD) has been used for top-down sequencing of proteins. The use of the matrix 1,5-diaminonapthalene (1,5-DAN) gave abundant w ions, which are formed from the unimolecular dissociation of z• radical fragments via α cleavage reaction and thus
Li Feng et al.
Oncotarget, 6(36), 39151-39164 (2015-10-17)
MicroRNAs (miRNAs) regulate disease-relevant metabolic pathways. However, most current pathway identification methods fail to consider miRNAs in addition to genes when analyzing pathways. We developed a powerful method called Subpathway-GMir to construct miRNA-regulated metabolic pathways and to identify miRNA-mediated subpathways
Jung-Hyuk Yim et al.
Analytical and bioanalytical chemistry, 406(18), 4401-4409 (2014-05-21)
Herein, we describe an accurate method for protein quantification based on conventional acid hydrolysis and an isotope dilution-ultra performance liquid chromatography-tandem mass spectrometry method. The analyte protein, recombinant human erythropoietin (rhEPO), was effectively hydrolyzed by incubation with 8 mol/L hydrochloric
Chih-Chiang Chang et al.
Current opinion in structural biology, 23(1), 125-133 (2012-12-26)
Type IIA topoisomerases catalyze the passage of two DNA duplexes across each other to resolve the entanglements and coiling of cellular DNA. The ability of these enzymes to interact simultaneously but differentially with two DNA segments is central to their
O Søvik
Journal of inherited metabolic disease, 16(1), 46-54 (1993-01-01)
A review is presented of 22 published cases of verified or probable mitochondrial 2-methylacetoacetyl-CoA thiolase deficiency, a disorder of isoleucine and ketone body metabolism. The clinical expression, characterized by ketoacidosis, vomiting and lethargy, is highly variable. Typical age of onset
Stefania De Domenico et al.
Plant physiology and biochemistry : PPB, 61, 115-122 (2012-11-13)
Drought is one of the major constraints in subtropical agriculture. Therefore improving water stress tolerance is of great importance to breed for drought tolerance in future. The first plant organ sensing dehydration is the root. Aim of the present work
Kirkwood F Adams et al.
Journal of the American College of Cardiology, 39(6), 946-953 (2002-03-19)
We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. Digitalis glycosides have been used for 200
Meena Haribal et al.
The Journal of experimental biology, 218(Pt 23), 3797-3806 (2015-12-04)
Plant roots incorporate inorganic nitrogen into the amino acids glutamine, glutamic acid, asparagine and aspartic acid, which together serve as the primary metabolites of nitrogen transport to other tissues. Given the preponderance of these four amino acids, phloem sap is
Hikaru Nishida et al.
PloS one, 10(6), e0128805-e0128805 (2015-06-19)
Branched-chain amino acids (BCAAs) and IGF-I, the secretion of which is stimulated by growth hormone (GH), prevent muscle atrophy. mTOR plays a pivotal role in the protective actions of BCAA and IGF-1. The pathway by which BCAA activates mTOR is
M V Spanaki et al.
Neurology, 53(7), 1518-1522 (1999-10-26)
To investigate the effect of vigabatrin (VGB; gamma-vinyl gamma-aminobutyric acid [GABA]), a selective irreversible GABA-transaminase inhibitor, on cerebral metabolic rate for glucose (CMRGlc) and cerebral blood flow (CBF) measured with 18F-fluorodeoxyglucose (FDG) PET and 15O water PET. Antiepileptic drugs (AEDs)
Morgane Auboiron et al.
STAR protocols, 2(2), 100557-100557 (2021-06-08)
Tracking the inheritance patterns of proteins (TrIPP) is a live-cell imaging technique used for tracking maternal protein segregation patterns between mother and daughter cells during asymmetric divisions of budding yeast. We use the photo-convertible fluorescent protein Dendra2 fused to a
Markus Mund et al.
Cell, 174(4), 884-896 (2018-07-31)
Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven by a self-assembled macromolecular machine of over 50 different proteins in tens to hundreds of copies. How these proteins are organized to produce endocytic vesicles with high precision
Taisuke Sugii et al.
Journal of bioscience and bioengineering, 118(4), 367-371 (2014-04-20)
Thermophilic enzymes are potentially useful for industrial processes because they are generally more stable than are mesophilic or psychrophilic enzymes. However, a crucial drawback for their use in such processes is that most thermophilic enzymes are nearly inactive at moderate
S R Perosa et al.
Epilepsia, 43 Suppl 5, 159-161 (2002-07-18)
This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE). The GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA). The hippocampus of
C T Peng et al.
European journal of cancer (Oxford, England : 1990), 41(8), 1158-1163 (2005-05-25)
Cerebrospinal fluid (CSF) amino acid concentrations were measured in 45 children with acute lymphoblastic leukemia (ALL). Central nervous system (CNS) disease was absent in 34 and present in 11 (Groups L and M, respectively) at diagnosis. Thirty-two otherwise healthy children
N Megha Karanth et al.
Biochemistry, 52(1), 70-83 (2012-12-05)
The solution structure of IlvN, the regulatory subunit of Escherichia coli acetohydroxyacid synthase I, in the valine-bound form has been determined using high-resolution multidimensional, multinuclear nuclear magnetic resonance (NMR) methods. IlvN in the presence or absence of the effector molecule
Ryo Muramatsu et al.
Journal of pharmaceutical and biomedical analysis, 31(5), 979-987 (2003-04-10)
Protein modification generally occurs by addition to the amino acid side-chains of protein at the post-translational stage, for example, by enzymatic or chemical reactions after polypeptide synthesis. Recently, the recombinant hirudin analog CX-397, a potent thrombin inhibitor, was found to
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite
K Kobayashi et al.
No to shinkei = Brain and nerve, 34(8), 769-774 (1982-08-01)
Using reversed-phase high-performance liquid chromatography and electrochemical detection with a rapid one-step purification on Sephadex G-10 column, we have developed a sensitive technique to measure p-hydroxyphenylacetic acid (PHPA), the oxidatively deaminated metabolite of p-tyramine, in cerebrospinal fluid (CSF). The method
Yun Wei et al.
Biological procedures online, 21, 23-23 (2019-12-05)
Lysine post-translational modifications are important regulators of protein function. Proteomic and biochemical approaches have resulted in identification of several lysine modifications, including acetylation, crotonylation, and succinylation. Here, we developed an approach for surveying amide-bonded lysine modifications in the proteome of
Nikolaos Psychogios et al.
PloS one, 6(2), e16957-e16957 (2011-03-02)
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal
Uriel Heresco-Levy et al.
Schizophrenia research, 91(1-3), 14-21 (2007-02-06)
Prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating, is decreased in schizophrenia. The validity of a glutamatergic, N-methyl-d-aspartate receptor (NMDAR)-mediated model of PPI disruption is presently equivocal. The NMDAR antagonist ketamine disrupts PPI in rodents, but
P Rosenfelder et al.
Journal of animal science, 93(3), 1133-1144 (2015-05-29)
A study with growing pigs was conducted to determine the chemical composition and standardized ileal digestibility (SID) of CP and AA of 8 wheat genotypes that have recently been added to the German Descriptive Variety List. These genotypes included Tabasco
Amino Acid Biosynthesis Is Regulated by Feedback Inhibition
Biochemistry (5th Edition) null
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Elaine F Walker et al.
Neuropsychiatry, neuropsychology, and behavioral neurology, 15(1), 10-17 (2002-03-06)
To examine plasma cortisol, adrencorticotropin hormone, and indicators of catecholamine activity in monozygotic twins discordant for schizophrenia or major affective disorders. Previous research has suggested that catecholamines play a role in the etiology of major mental illness. Several findings have
K Q Do et al.
Journal of neurochemistry, 65(6), 2652-2662 (1995-12-01)
HPLC and gas chromatography-mass spectrometry analyses of 18 amino acids, N-acetylaspartate, N-acetylaspartylglutamate, and 5-hydroxyindoleacetic acid, derived from serotonin, and homovanillic acid, derived from dopamine, were performed in CSF collected from a group of patients with schizophrenia who either had been
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