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Showing 1-30 of 239 results for "I2752" within Papers
Kirkwood F Adams et al.
Journal of the American College of Cardiology, 39(6), 946-953 (2002-03-19)
We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. Digitalis glycosides have been used for 200
Ze-Yun Li et al.
PloS one, 10(3), e0120950-e0120950 (2015-03-19)
Curcumin, a principle bioactive component of Curcuma longa L, is well known for its anti-hyperlipidemia effect. However, no holistic metabolic information of curcumin on hyperlipidemia models has been revealed, which may provide us an insight into the underlying mechanism. In
Elena Larrieta-Carrasco et al.
Gene, 520(2), 185-188 (2013-03-21)
Non-alcoholic fatty liver disease (NAFLD) and elevated alanine transaminase (ALT) levels are common in obese Hispanic adults and children. Recently, a PNPLA3 gene variant (I148M) was strongly associated with NAFLD and higher ALT levels in obese adults, including Hispanics. The
P Krumpochova et al.
Journal of pharmaceutical and biomedical analysis, 114, 398-407 (2015-06-27)
The analysis of amino acids has become a central task in many aspects. While amino acid analysis has traditionally mainly been carried out using either gas chromatography (GC) in combination with flame ionization detection or liquid chromatography (LC) with either
Nivedita Natarajan et al.
The Analyst, 140(10), 3445-3464 (2015-03-31)
The fresh water planarian species Schmidtea mediterranea is an emerging stem cell model because of its capability to regenerate a whole animal from a small piece of tissue. It is one of the best model systems to address the basic
P Schadewaldt et al.
Journal of inherited metabolic disease, 22(6), 706-722 (1999-09-03)
In maple syrup urine disease (MSUD), branched-chain L-amino (BCAA) and 2-oxo acids (BCOA) accumulate in body fluids owing to an inherited deficiency of branched-chain 2-oxo acid dehydrogenase complex activity. In MSUD, little information is available on the significance of urinary
Ingrid Richter et al.
Toxicon : official journal of the International Society on Toxinology, 95, 13-22 (2015-01-01)
Marine microalgae can produce biotoxins that cause widespread poisoning in marine ecosystems and may also affect human health. While established microalgal biotoxins are detectable using chemical methods, a need remains for robust, inexpensive bioassays. Ligand-binding domains (LBDs) from a tunicate
Maren Diether et al.
Molecular systems biology, 15(8), e9008-e9008 (2019-08-30)
Metabolite binding to proteins regulates nearly all cellular processes, but our knowledge of these interactions originates primarily from empirical in vitro studies. Here, we report the first systematic study of interactions between water-soluble proteins and polar metabolites in an entire biological
Sung Woo Cho et al.
Journal of the American Heart Association, 3(2), e000693-e000693 (2014-03-15)
Cardiomyocytes that differentiate from pluripotent stem cells (PSCs) provide a crucial cellular resource for cardiac regeneration. The mechanisms of mitochondrial metabolic and redox regulation for efficient cardiomyocyte differentiation are, however, still poorly understood. Here, we show that inhibition of the
Kristin L Patrick et al.
Cell systems, 7(3), 323-338 (2018-08-06)
Intracellular bacterial pathogens secrete a repertoire of effector proteins into host cells that are required to hijack cellular pathways and cause disease. Despite decades of research, the molecular functions of most bacterial effectors remain unclear. To address this gap, we
V Samuel Raj et al.
Antimicrobial agents and chemotherapy, 58(8), 4283-4289 (2014-02-20)
We present here the novel ketolide RBx 14255, a semisynthetic macrolide derivative obtained by the derivatization of clarithromycin, for its in vitro and in vivo activities against sensitive and macrolide-resistant Streptococcus pneumoniae. RBx 14255 showed excellent in vitro activity against
E B Cady et al.
Magnetic resonance in medicine, 32(6), 764-767 (1994-12-01)
Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan-1,2-diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal
Hong Zhang et al.
Chemical research in toxicology, 28(6), 1196-1204 (2015-05-06)
The present study investigated the human constitutive androstane receptor (CAR) binding activities of 23 phthalate esters and 10 phthalate monoesters using a fast and sensitive human CAR yeast two-hybrid assay. Of 23 phthalate esters, 16 were evaluated as positive, and
K Kobayashi et al.
No to shinkei = Brain and nerve, 34(8), 769-774 (1982-08-01)
Using reversed-phase high-performance liquid chromatography and electrochemical detection with a rapid one-step purification on Sephadex G-10 column, we have developed a sensitive technique to measure p-hydroxyphenylacetic acid (PHPA), the oxidatively deaminated metabolite of p-tyramine, in cerebrospinal fluid (CSF). The method
M N Haque et al.
Journal of dairy science, 96(1), 420-430 (2012-11-21)
An ideal profile of essential AA (EAA) can improve the efficiency of metabolizable protein (or PDIE, the equivalent in the INRA feeding system) utilization in dairy cows. Compared with other EAA, existing recommendations for the requirements of Arg, Ile, and
Uriel Heresco-Levy et al.
Schizophrenia research, 91(1-3), 14-21 (2007-02-06)
Prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating, is decreased in schizophrenia. The validity of a glutamatergic, N-methyl-d-aspartate receptor (NMDAR)-mediated model of PPI disruption is presently equivocal. The NMDAR antagonist ketamine disrupts PPI in rodents, but
Libo He et al.
BMC genomics, 16, 184-184 (2015-04-19)
Compensatory growth is accelerated compared with normal growth and occurs when growth-limiting conditions are overcome. Most animals, especially fish, are capable of compensatory growth, but the mechanisms remain unclear. Further investigation of the mechanism of compensatory growth in fish is
K Q Do et al.
Journal of neurochemistry, 65(6), 2652-2662 (1995-12-01)
HPLC and gas chromatography-mass spectrometry analyses of 18 amino acids, N-acetylaspartate, N-acetylaspartylglutamate, and 5-hydroxyindoleacetic acid, derived from serotonin, and homovanillic acid, derived from dopamine, were performed in CSF collected from a group of patients with schizophrenia who either had been
O Søvik
Journal of inherited metabolic disease, 16(1), 46-54 (1993-01-01)
A review is presented of 22 published cases of verified or probable mitochondrial 2-methylacetoacetyl-CoA thiolase deficiency, a disorder of isoleucine and ketone body metabolism. The clinical expression, characterized by ketoacidosis, vomiting and lethargy, is highly variable. Typical age of onset
Stefania De Domenico et al.
Plant physiology and biochemistry : PPB, 61, 115-122 (2012-11-13)
Drought is one of the major constraints in subtropical agriculture. Therefore improving water stress tolerance is of great importance to breed for drought tolerance in future. The first plant organ sensing dehydration is the root. Aim of the present work
Zohar A Arnon et al.
iScience, 24(7), 102695-102695 (2021-07-15)
Luminescence of biomolecules in the visible range of the spectrum has been experimentally observed upon aggregation, contrary to their monomeric state. However, the physical basis for this phenomenon is still elusive. Here, we systematically examine all coded amino acids to
Mioara Larion et al.
PLoS biology, 10(12), e1001452-e1001452 (2012-12-29)
Glucokinase (GCK) catalyzes the rate-limiting step of glucose catabolism in the pancreas, where it functions as the body's principal glucose sensor. GCK dysfunction leads to several potentially fatal diseases including maturity-onset diabetes of the young type II (MODY-II) and persistent
Yuwen Li et al.
Frontiers in plant science, 12, 628328-628328 (2021-09-08)
Amino acids are the building blocks of biomacromolecules in organisms, among which isoleucine (Ile) is the precursor of JA-Ile, an active molecule of phytohormone jasmonate (JA). JA is essential for diverse plant defense responses against biotic and abiotic stresses. Botrytis
Shunsuke Kawamura et al.
Bioscience, biotechnology, and biochemistry, 77(3), 560-565 (2013-03-09)
Ile58 of hen egg-white lysozyme (HEL) is buried in the interior of the molecule and is considered to participate in sugar residue binding at subsite C through hydrophobic interaction. The contribution of Ile58 to lysozyme function and stability was investigated
Jinyu Chen et al.
Cancer research, 75(3), 554-565 (2014-12-17)
Breast cancer brain metastasis is resistant to therapy and a particularly poor prognostic feature in patient survival. Altered metabolism is a common feature of cancer cells, but little is known as to what metabolic changes benefit breast cancer brain metastases.
Christopher Oelkrug et al.
Anticancer research, 35(4), 2085-2091 (2015-04-12)
The electrical current exclusion (ECE) principle provides an alternative to common methods of cell diameter measurement and especially in atrophy and cancer associated cachexia research. C2C12 myoblasts were differentiated into myotubes and treated with 100 μM dexamethasone to induce atrophy
Chhavy Tep et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(2), 397-410 (2013-01-11)
The lack of effective therapies for spinal cord injury points to the need for identifying novel targets for therapeutic intervention. Here we report that a small molecule, LM11A-31, developed to block proNGF-p75 interaction and p75-mediated cell death crosses the blood-brain
X-Y He et al.
Endocrine, metabolic & immune disorders drug targets, 6(1), 95-102 (2006-04-14)
Human type 10 17beta-hydroxysteroid dehydrogenase (HSD) is a homotetrameric protein located in mitochondria. This enzyme was alternatively named short chain L-3-hydroxyacyl-CoA dehydrogenase (SCHSD). This NAD(H)-dependent dehydrogenase is essential for the metabolism of branched-chain fatty acids and isoleucine, and is expressed
James N Dodds et al.
Analytical chemistry, 89(22), 12176-12184 (2017-10-19)
Here we examine the relationship among resolving power (Rp), resolution (Rpp), and collision cross section (CCS) for compounds analyzed in previous ion mobility (IM) experiments representing a wide variety of instrument platforms and IM techniques. Our previous work indicated these
Yumi Endo et al.
Japanese journal of clinical oncology, 44(7), 619-623 (2014-05-08)
Human epidermal growth factor receptor 2 (HER2) gene amplification is a major therapeutic target in breast cancer, and has been introduced as a predictive biomarker to identify patients who may benefit from therapy with anti-human epidermal growth factor receptor 2
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