I5281

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Showing 1-30 of 187 results for "I5281" within Papers

Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.

Beatrice Bocca et al.

Annali dell'Istituto superiore di sanita, 41(2), 197-203 (2005-10-26)

The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p <

Interdependence of threonine, methionine and isoleucine metabolism in plants: accumulation and transcriptional regulation under abiotic stress.

Vijay Joshi et al.

Amino acids, 39(4), 933-947 (2010-02-27)

Pathways regulating threonine, methionine and isoleucine metabolism are very efficiently interconnected in plants. As both threonine and methionine serve as substrates for isoleucine synthesis, their synthesis and catabolism under different developmental and environmental conditions also influence isoleucine availability. Together, methionine

Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis.

Xiaohu Tang et al.

PLoS genetics, 11(4), e1005158-e1005158 (2015-04-08)

Besides being building blocks for protein synthesis, amino acids serve a wide variety of cellular functions, including acting as metabolic intermediates for ATP generation and for redox homeostasis. Upon amino acid deprivation, free uncharged tRNAs trigger GCN2-ATF4 to mediate the

Liver functional metabolomics discloses an action of L-leucine against Streptococcus iniae infection in tilapias.

Yan-Mei Ma et al.

Fish & shellfish immunology, 45(2), 414-421 (2015-05-11)

Streptococcus iniae seriously affects the intensive farming of tilapias. Much work has been conducted on prevention and control of S. iniae infection, but little published information on the metabolic response is available in tilapias against the bacterial infection, and no metabolic

Administration of Exogenous Growth Hormone Is Associated with Changes in Plasma and Intracellular Mammary Amino Acid Profiles and Abundance of the Mammary Gland Amino Acid Transporter SLC3A2 in Mid-Lactation Dairy Cows.

Quentin L Sciascia et al.

PloS one, 10(7), e0134323-e0134323 (2015-08-01)

The objectives of this study were to (1) identify changes in plasma and mammary intracellular amino acid (AA) profiles in dairy cows treated with growth hormone (GH), and (2) evaluate the expression of mammary gland genes involved in the transport

Plant defense elicitors: analogues of jasmonoyl-isoleucine conjugate.

Jirí Svoboda et al.

Phytochemistry, 71(13), 1445-1449 (2010-06-24)

Our understanding of plant defensive mechanisms against herbivore and pathogen attack has significantly increased over the past decade. The complex cascade of defensive events is initiated and controlled by a network of interacting plant hormones. Especially, the conjugate of jasmonate

The importance of association between angiotensin-converting enzyme (ACE) Gene I/D polymorphism and diabetic peripheral neuropathy.

Ahmet Inanir et al.

Gene, 530(2), 253-256 (2013-08-27)

Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus (DM) due to decreasing quality of life. In the present study, it is aimed to evaluate angiotensin-converting enzyme (ACE) Gene I/D polymorphism in Turkish population. Two hundred and thirty-five

Resveratrol prevents oxidative stress-induced senescence and proliferative dysfunction by activating the AMPK-FOXO3 cascade in cultured primary human keratinocytes.

Yasuo Ido et al.

PloS one, 10(2), e0115341-e0115341 (2015-02-04)

The aging process is perceived as resulting from a combination of intrinsic factors such as changes in intracellular signaling and extrinsic factors, most notably environmental stressors. In skin, the relationship between intrinsic changes and keratinocyte function is not clearly understood.

Progranulin reduction is associated with increased tau phosphorylation in P301L tau transgenic mice.

Masato Hosokawa et al.

Journal of neuropathology and experimental neurology, 74(2), 158-165 (2015-01-13)

Granulin (GRN) mutations have been identified in familial frontotemporal lobar degeneration patients with ubiquitin pathology. GRN transcript haploinsufficiency is proposed as a disease mechanism that leads to the loss of functional progranulin (PGRN) protein. Thus, these mutations are strongly involved

Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.

D Rating et al.

Journal of neurology, 230(4), 217-225 (1983-01-01)

In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined. While the mean for CSF GABA concentrations for all epileptic children was unchanged [144 (range: 73-285) pmol/ml; controls:

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.

Paul J Kennedy et al.

Psychopharmacology, 232(8), 1357-1371 (2014-10-24)

A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine

Construction of L-lysine-, L-threonine-, and L-isoleucine-overproducing strains of Corynebacterium glutamicum.

H Sahm et al.

Annals of the New York Academy of Sciences, 782, 25-39 (1996-05-15)

The gram-negative bacterium Corynebacterium glutamicum is used for the industrial production of amino acids, for example, of L-glutamate and L-lysine. By cloning and expressing the various genes of the L-lysine pathway in C. glutamicum, we would demonstrate that an increase

Metabolomics beyond spectroscopic databases: a combined MS/NMR strategy for the rapid identification of new metabolites in complex mixtures.

Kerem Bingol et al.

Analytical chemistry, 87(7), 3864-3870 (2015-02-13)

A novel strategy is introduced that combines high-resolution mass spectrometry (MS) with NMR for the identification of unknown components in complex metabolite mixtures encountered in metabolomics. The approach first identifies the chemical formulas of the mixture components from accurate masses

Indirect pulsed electrochemical detection of aliphatic carboxylate-containing analytes following high performance anion-exchange chromatography.

Loryn R Keating et al.

Talanta, 146, 594-602 (2015-12-24)

The mechanism of detection in pulsed electrochemical detection (PED) requires preadsorption of the analyte to the working electrode prior to its subsequent oxidation. Indirect detection is accomplished by the addition of a PED-active reagent to the mobile phase, whose signal

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2.

Anna L Vestergaard et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(14), E1334-E1343 (2014-04-08)

P4-ATPases (flippases) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the cell membrane to the cytosolic leaflet, upholding an essential membrane asymmetry. The mechanism of flipping this giant substrate has remained an enigma. We have investigated the

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

Involvement of a di-leucine motif in targeting of ABCC1 to the basolateral plasma membrane of polarized epithelial cells.

Yoshikazu Emi et al.

Biochemical and biophysical research communications, 441(1), 89-95 (2013-10-17)

Localization of ATP-binding cassette transporter isoform C1 (ABCC1) to the basolateral membrane of polarized cells is crucial for export of a variety of cellular metabolites; however, the mechanism regulating basolateral targeting of the transporter is poorly understood. Here we describe

Surprises from an unusual CLC homolog.

Sabrina Phillips et al.

Biophysical journal, 103(9), L44-L46 (2012-12-04)

The chloride channel (CLC) family is distinctive in that some members are Cl(-) ion channels and others are Cl(-)/H(+) antiporters. The molecular mechanism that couples H(+) and Cl(-) transport in the antiporters remains unknown. Our characterization of a novel bacterial

¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure.

Seok-Min Kang et al.

Clinical biochemistry, 44(4), 293-299 (2010-12-21)

We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with

1H and (13)C NMR spectroscopic analysis of human saliva.

C J L Silwood et al.

Journal of dental research, 81(6), 422-427 (2002-07-05)

We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Mark G Jones et al.

Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)

Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is

Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia.

K J Bär et al.

Neurobiology of aging, 24(2), 333-338 (2002-12-25)

Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of

Leucine/isoleucine zipper coordination of ion channel macromolecular signaling complexes in the heart. Roles in inherited arrhythmias.

R S Kass et al.

Trends in cardiovascular medicine, 13(2), 52-56 (2003-02-15)

The sympathetic nervous system controls the force and rate of contraction of the heart. The rapid response to stress and exercise mediated by increased sympathetic nervous system (SNS) activity requires the coordinated regulation of several ion channels in response to

Partial deficiency of isoleucine impairs root development and alters transcript levels of the genes involved in branched-chain amino acid and glucosinolate metabolism in Arabidopsis.

Hailan Yu et al.

Journal of experimental botany, 64(2), 599-612 (2012-12-12)

Isoleucine is one of the branched-chain amino acids (BCAAs) that are essential substrates for protein synthesis in all organisms. Although the metabolic pathway for isoleucine has been well characterized in higher plants, it is not known whether it plays a

Proline localized to the interaction interface can mediate self-association of transmembrane domains.

Neta Sal-Man et al.

Biochimica et biophysica acta, 1838(9), 2313-2318 (2014-05-21)

Assembly of transmembrane domains (TMDs) is a critical step in the function of membrane proteins. In recent years, the role of specific amino acids in TMD-TMD interactions has been better characterized, with more emphasis on polar and aromatic residues. Despite

Systematic identification of the lysine succinylation in the protozoan parasite Toxoplasma gondii.

Xiaolong Li et al.

Journal of proteome research, 13(12), 6087-6095 (2014-11-08)

Lysine succinylation is a new posttranslational modification identified in histone proteins of Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa. However, very little is known about their scope and cellular distribution. Here, using LC-MS/MS to identify parasite peptides

A Comparative Metabolomic Evaluation of Behcet's Disease with Arthritis and Seronegative Arthritis Using Synovial Fluid.

Joong Kyong Ahn et al.

PloS one, 10(8), e0135856-e0135856 (2015-08-14)

Behcet's disease (BD) with arthritis is often confused with seronegative arthritis (SNA) because of shared clinical symptoms and the lack of definitive biomarkers for BD. To investigate possible metabolic patterns and potential biomarkers of BD with arthritis, metabolomic profiling of

Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients.

Edyta Reszka et al.

Journal of cancer research and clinical oncology, 140(10), 1723-1731 (2014-06-13)

NRF2 transcription factor is involved in modulation of various antioxidant and metabolic genes and, therefore, may modulate anti-carcinogenic potential. Association between polymorphisms of NRF2 and five NRF2-regulated genes and urinary bladder cancer (BC) risk was analyzed. The study group included

Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment.

C Härnryd et al.

Psychopharmacology, 64(2), 131-134 (1979-08-08)

The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG.

Enantioseparation of (DL)-tryptophan by spiral tube assembly counter-current chromatography and evaluation of mass transfer rate for enantiomers.

Shengqiang Tong et al.

Journal of chromatography. A, 1374, 77-84 (2014-12-06)

Spiral tube assembly counter-current chromatography was successfully applied in enantioseparation of dl-tryptophan using bovine serum albumin as chiral selector. An improved biphasic aqueous-aqueous solvent system 12.0% (w/w) polyethyleneglycol 8000-9.0% (w/w) dibasic potassium phosphate-0.1% ammonia-78.9% water was used as the solvent

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