I601

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Showing 1-23 of 23 results for "I601" within Papers

On the appearance of polyadenylate polymerase activity in blood serum of animals exposed to a short-term influence by N,N'-ethylenethiourea, a well known hepatic carcinogen: a preliminary report.

D A Kuznetsov et al.

Cancer letters, 34(1), 61-66 (1987-01-01)

Daily intragastric administration of a carcinogen N,N'-ethylenethiourea (ETU) (85 mg/kg body wt, congruent to 0.1 DL50) leads to significant polyadenylate polymerase (PAP) activity in rat blood serum by the 10th day of experiment. A similar course of N,N'-ethyleneurea (EU) fails

Permanent press allergy in an active duty U.S. Army soldier.

Shelley L Aldrich et al.

Military medicine, 176(5), 584-585 (2011-06-04)

Ethylene urea/melamine formaldehyde resin (permanent press) is a common fabric finishing agent added to Army Combat Uniforms for a wrinkle-free appearance and to strengthen the fabric. We describe the case of an active duty U.S. Army soldier with a diffuse

Residues of mancozeb, 2-imidazoline, and ethyleneurea in tomato and potato crops after field treatment with mancozeb.

W H Newsome

Journal of agricultural and food chemistry, 27(6), 1188-1190 (1979-11-01)

New Synthesis of Aryl and Heteroaryl N-Acylureas via Microwave-Assisted Palladium-Catalyzed Carbonylation

D. Liptrot, et al.,

Advanced Synthesis & Catalysis, 352, 2183-2188 (2010)

Synthesis and antimicrobial activity of new heterocycles obtained using cyanoacetylation

Sh. M. Abu-Bakr, et al.,

Pharmaceutical Chemistry Journal, 44, 433-437 (2010)

Development of a highly water-soluble peptide-based human neutrophil elastase inhibitor; AE-3763 for treatment of acute organ injury.

Yasunao Inoue et al.

Bioorganic & medicinal chemistry, 17(21), 7477-7486 (2009-10-09)

A series of peptide-based transition-state human neutrophil elastase (HNE) inhibitors with N-terminal acidic moieties were synthesized and their inhibitory activity against HNE was evaluated both in vitro and in vivo. Our results show that compounds containing cyclic amide bridged acidic

Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics.

Charlotte L Sutherell et al.

Chemical communications (Cambridge, England), 48(79), 9834-9836 (2012-09-01)

We describe the design and synthesis of a non-peptidic β-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain

Synthesis of new unsymmetrical 4,5-dihydroxy-2-imidazolidinones. Dynamic NMR spectroscopic study of the prototropic tautomerism in 1-(2-benzimidazolyl)-3-phenyl-4,5-dihydroxy-2-imidazolidinone.

Mehdi Ghandi et al.

Molecules (Basel, Switzerland), 11(10), 768-775 (2007-11-01)

The acid-catalyzed cyclocondensation in refluxing acetonitrile of aqueous glyoxal with N-heteroaryl-N'-phenylureas 4a-f (heteroaryl = 2-thiazolyl, 2-pyrimidinyl,2-pyrazinyl, 2-pyridinyl, 3-pyridinyl and 2-benzimidazolyl) led to the formation of the corresponding 1-heteroaryl-3-phenyl-4,5-dihydroxy-2-imidazolidinones 5a-f. All the products were characterized by elemental and spectroscopic analyses. The

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.

Julie A Spicer et al.

Journal of medicinal chemistry, 56(23), 9542-9555 (2013-11-08)

A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of the lymphocyte-expressed pore-forming protein perforin. Structure-activity relationships were explored through variation of an isoindolinone or 3,4-dihydroisoquinolinone subunit on a fixed 2-thioxoimidazolidin-4-one/thiophene core. The ability of the resulting compounds to inhibit

[Polyadenylate polymerase in the diagnosis of the early stages of chemical carcinogenesis].

N V Zav'ialov et al.

Gigiena truda i professional'nye zabolevaniia, (2)(2), 25-28 (1988-02-01)

Oxidative amidation of activated alkenes using Pd(OAc)2 as a catalyst precursor

X. Liu and K. K. Hii,

European Journal of Organic Chemistry, 27, 5181-5189 (2010)

Pd-catalyzed C-N bond formation with heteroaromatic tosylates.

Mette L H Mantel et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 16(18), 5437-5442 (2010-04-09)

A protocol for the palladium(0)-catalyzed amidation of heteroaromatic tosylates was successfully developed. The methodology proved to be effective for a variety of heteroaryl tosylates including the pyridine, pyrimidine, quinoline and quinoxaline ring systems. Successful carbon-nitrogen bond formation with these heteroaryl

Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones.

Alaa A-M Abdel-Aziz et al.

Bioorganic & medicinal chemistry letters, 22(5), 2008-2014 (2012-02-10)

Novel series of 1-(arenesulfonyl)imidazolidin-2-one (3a-i) and 1,3-bis(arenesulfonyl)imidazolidin-2-one (5a-i) have been synthesized and tested for their antitumor activity against 60 tumor cell lines taken from nine different organs. A significant inhibition for cancer cells was observed with series 5a-i compounds compared

[Synthesis and structural study of 5-arylidene thiazolidine-2,4-diones and 3-substituted-4-thio-imidazolidine-2-ones].

J F Albuquerque et al.

Annales pharmaceutiques francaises, 53(5), 209-214 (1995-01-01)

The synthesis and the physico-chemical properties of four 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones, two 3-(4-bromobenzyl)-5-arylidene-thiazolidine-2,4-diones and seven 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones were described. These products were synthetized by the aldolisation-crotonisation reaction between aromatic aldehydes and substituted thiazolidinediones or thio-imidazolidinones.

Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds.

Juan Z Dávalos et al.

The journal of physical chemistry. A, 114(34), 9237-9245 (2010-08-05)

A computational study of the structural and thermochemical properties of N-phenyl (open) and N-alkyl (cyclic) ureas, through the use of M05-2X and B3LYP density functional theory calculations has been carried out. The consistency of the literature experimental results has been

Synthesis and Diels-Alder cycloadditions of exo-imidazolidin-2-one dienes.

Rafael Bautista et al.

The Journal of organic chemistry, 76(19), 7901-7911 (2011-08-17)

An efficient and versatile synthesis of novel exo-imidazolidin-2-one dienes is described. This involves the base-assisted condensation/cyclization cascade reaction of the monoimino derivatives of diacetyl with a series of isocyanates. This methodology enables preparation of symmetrical dienes, as long as the

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

J N Cumming et al.

Bioorganic & medicinal chemistry letters, 18(11), 3236-3241 (2008-05-13)

Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted

The measurement of ethylenethiourea and ethyleneurea in the rat and common marmoset Callithrix jacchus after zineb (zinc ethylenebisdithiocarbamate) dosing.

A J Searle et al.

Xenobiotica; the fate of foreign compounds in biological systems, 17(6), 733-740 (1987-06-01)

The metabolism of the fungicide zineb, (zinc ethylenebisdithiocarbamate), has been studied in the rat and the marmoset. 2. It was found in both species that a relatively large proportion (21-22%) of the original zineb administered was detectable in the excreta

[Pharmacologic studies of new derivatives of imidazoline, 2-imidazolidinone and imidazolidine-2-thione].

I Zebrowska-Lupina et al.

Acta poloniae pharmaceutica, 43(2), 180-188 (1986-01-01)

Induction in urothermal synthesis of chiral porous materials from achiral precursors.

Yao Kang et al.

Chemical communications (Cambridge, England), 47(17), 4950-4952 (2011-03-29)

Special asymmetric crystallization of porous framework materials from achiral precursors under urothermal conditions is successfully achieved by using an enantiopure liquid as a co-solvent and chirality induction agent, which provides a new strategy for the synthesis of homochiral porous materials

Difference in teratogenic potency of ethylenethiourea in rats and mice: relative contribution of embryonic and maternal factors.

G P Daston et al.

Teratology, 40(6), 555-566 (1989-12-01)

Ethylenethiourea (ETU) is a potent teratogen in the rat but not in the mouse or any other species tested. Embryotoxic and teratogenic effects are produced in mice only after exposure to 10-40 times the teratogenic dose of ETU in rats.

[Pharmacological studies of the central effects of new ethylguanidine, imidazolidine and imidazolidinone-2 derivatives].

I Zebrowska-Lupina et al.

Acta poloniae pharmaceutica, 44(1), 107-115 (1987-01-01)

[Preliminary pharmacological evaluation of new imidazolidinone-2, ethylenediamine and imidazoline derivatives].

E Jagiełło-Wójtowicz et al.

Acta poloniae pharmaceutica, 41(4), 495-504 (1984-01-01)

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